Amino acid dipepetide frequency for Moraxella caviae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.759AlaAla: 10.759 ± 0.204
1.286AlaCys: 1.286 ± 0.041
6.788AlaAsp: 6.788 ± 0.106
5.173AlaGlu: 5.173 ± 0.106
3.829AlaPhe: 3.829 ± 0.082
7.682AlaGly: 7.682 ± 0.118
2.83AlaHis: 2.83 ± 0.068
6.368AlaIle: 6.368 ± 0.107
7.121AlaLys: 7.121 ± 0.103
11.439AlaLeu: 11.439 ± 0.182
3.178AlaMet: 3.178 ± 0.073
4.673AlaAsn: 4.673 ± 0.099
3.822AlaPro: 3.822 ± 0.087
5.492AlaGln: 5.492 ± 0.12
4.526AlaArg: 4.526 ± 0.091
5.445AlaSer: 5.445 ± 0.111
5.431AlaThr: 5.431 ± 0.112
7.15AlaVal: 7.15 ± 0.12
1.388AlaTrp: 1.388 ± 0.047
2.668AlaTyr: 2.668 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.03CysAla: 1.03 ± 0.047
0.132CysCys: 0.132 ± 0.015
0.603CysAsp: 0.603 ± 0.032
0.618CysGlu: 0.618 ± 0.034
0.422CysPhe: 0.422 ± 0.027
0.806CysGly: 0.806 ± 0.037
0.36CysHis: 0.36 ± 0.025
0.464CysIle: 0.464 ± 0.027
0.361CysLys: 0.361 ± 0.025
0.907CysLeu: 0.907 ± 0.039
0.199CysMet: 0.199 ± 0.018
0.299CysAsn: 0.299 ± 0.022
0.424CysPro: 0.424 ± 0.027
0.54CysGln: 0.54 ± 0.028
0.392CysArg: 0.392 ± 0.024
0.528CysSer: 0.528 ± 0.026
0.473CysThr: 0.473 ± 0.028
0.822CysVal: 0.822 ± 0.036
0.082CysTrp: 0.082 ± 0.012
0.312CysTyr: 0.312 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.277AspAla: 5.277 ± 0.101
0.543AspCys: 0.543 ± 0.025
4.594AspAsp: 4.594 ± 0.111
4.923AspGlu: 4.923 ± 0.093
2.745AspPhe: 2.745 ± 0.077
5.0AspGly: 5.0 ± 0.11
0.862AspHis: 0.862 ± 0.043
3.567AspIle: 3.567 ± 0.08
4.202AspLys: 4.202 ± 0.09
5.217AspLeu: 5.217 ± 0.094
1.357AspMet: 1.357 ± 0.041
2.624AspAsn: 2.624 ± 0.069
1.721AspPro: 1.721 ± 0.047
1.101AspGln: 1.101 ± 0.044
1.989AspArg: 1.989 ± 0.055
2.931AspSer: 2.931 ± 0.074
3.431AspThr: 3.431 ± 0.076
4.957AspVal: 4.957 ± 0.094
0.823AspTrp: 0.823 ± 0.041
2.007AspTyr: 2.007 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.703GluAla: 4.703 ± 0.112
0.505GluCys: 0.505 ± 0.031
2.038GluAsp: 2.038 ± 0.068
2.215GluGlu: 2.215 ± 0.076
2.61GluPhe: 2.61 ± 0.067
2.525GluGly: 2.525 ± 0.075
1.403GluHis: 1.403 ± 0.055
3.509GluIle: 3.509 ± 0.086
3.215GluLys: 3.215 ± 0.096
5.98GluLeu: 5.98 ± 0.122
1.576GluMet: 1.576 ± 0.05
2.716GluAsn: 2.716 ± 0.067
1.868GluPro: 1.868 ± 0.053
3.203GluGln: 3.203 ± 0.08
3.689GluArg: 3.689 ± 0.088
2.448GluSer: 2.448 ± 0.069
2.612GluThr: 2.612 ± 0.063
3.196GluVal: 3.196 ± 0.074
0.675GluTrp: 0.675 ± 0.034
1.782GluTyr: 1.782 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
4.798PheAla: 4.798 ± 0.089
0.562PheCys: 0.562 ± 0.03
3.258PheAsp: 3.258 ± 0.069
2.206PheGlu: 2.206 ± 0.055
1.708PhePhe: 1.708 ± 0.068
3.955PheGly: 3.955 ± 0.089
0.791PheHis: 0.791 ± 0.035
2.566PheIle: 2.566 ± 0.071
1.617PheLys: 1.617 ± 0.051
3.388PheLeu: 3.388 ± 0.096
1.063PheMet: 1.063 ± 0.044
1.706PheAsn: 1.706 ± 0.048
0.972PhePro: 0.972 ± 0.041
0.846PheGln: 0.846 ± 0.032
1.409PheArg: 1.409 ± 0.043
2.589PheSer: 2.589 ± 0.055
2.267PheThr: 2.267 ± 0.058
3.074PheVal: 3.074 ± 0.077
0.574PheTrp: 0.574 ± 0.033
1.387PheTyr: 1.387 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
6.589GlyAla: 6.589 ± 0.12
0.742GlyCys: 0.742 ± 0.037
3.97GlyAsp: 3.97 ± 0.07
4.658GlyGlu: 4.658 ± 0.092
3.362GlyPhe: 3.362 ± 0.071
5.14GlyGly: 5.14 ± 0.126
1.229GlyHis: 1.229 ± 0.049
4.095GlyIle: 4.095 ± 0.079
4.838GlyLys: 4.838 ± 0.088
6.802GlyLeu: 6.802 ± 0.116
2.102GlyMet: 2.102 ± 0.057
2.622GlyAsn: 2.622 ± 0.096
0.761GlyPro: 0.761 ± 0.043
2.475GlyGln: 2.475 ± 0.063
3.243GlyArg: 3.243 ± 0.074
3.689GlySer: 3.689 ± 0.105
3.499GlyThr: 3.499 ± 0.092
6.878GlyVal: 6.878 ± 0.11
0.826GlyTrp: 0.826 ± 0.037
2.295GlyTyr: 2.295 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.744HisAla: 2.744 ± 0.073
0.272HisCys: 0.272 ± 0.018
1.394HisAsp: 1.394 ± 0.043
1.327HisGlu: 1.327 ± 0.044
0.977HisPhe: 0.977 ± 0.036
1.784HisGly: 1.784 ± 0.059
0.837HisHis: 0.837 ± 0.041
1.552HisIle: 1.552 ± 0.055
1.146HisLys: 1.146 ± 0.043
2.28HisLeu: 2.28 ± 0.066
0.419HisMet: 0.419 ± 0.03
0.899HisAsn: 0.899 ± 0.037
1.082HisPro: 1.082 ± 0.042
1.165HisGln: 1.165 ± 0.042
1.155HisArg: 1.155 ± 0.044
1.342HisSer: 1.342 ± 0.046
1.574HisThr: 1.574 ± 0.05
1.122HisVal: 1.122 ± 0.042
0.326HisTrp: 0.326 ± 0.024
0.785HisTyr: 0.785 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
7.077IleAla: 7.077 ± 0.114
0.684IleCys: 0.684 ± 0.036
4.117IleAsp: 4.117 ± 0.092
3.286IleGlu: 3.286 ± 0.079
2.253IlePhe: 2.253 ± 0.067
4.664IleGly: 4.664 ± 0.09
1.341IleHis: 1.341 ± 0.056
3.587IleIle: 3.587 ± 0.095
3.438IleLys: 3.438 ± 0.07
4.822IleLeu: 4.822 ± 0.084
1.323IleMet: 1.323 ± 0.054
2.772IleAsn: 2.772 ± 0.079
1.961IlePro: 1.961 ± 0.062
1.58IleGln: 1.58 ± 0.047
2.481IleArg: 2.481 ± 0.064
3.823IleSer: 3.823 ± 0.081
4.089IleThr: 4.089 ± 0.097
3.929IleVal: 3.929 ± 0.088
0.589IleTrp: 0.589 ± 0.036
1.601IleTyr: 1.601 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.897LysAla: 5.897 ± 0.101
0.296LysCys: 0.296 ± 0.021
3.457LysAsp: 3.457 ± 0.073
2.595LysGlu: 2.595 ± 0.091
1.975LysPhe: 1.975 ± 0.05
3.248LysGly: 3.248 ± 0.08
1.362LysHis: 1.362 ± 0.048
3.368LysIle: 3.368 ± 0.072
2.982LysLys: 2.982 ± 0.088
5.113LysLeu: 5.113 ± 0.094
1.32LysMet: 1.32 ± 0.051
2.826LysAsn: 2.826 ± 0.067
2.696LysPro: 2.696 ± 0.069
2.653LysGln: 2.653 ± 0.066
2.855LysArg: 2.855 ± 0.075
3.489LysSer: 3.489 ± 0.087
3.529LysThr: 3.529 ± 0.072
3.267LysVal: 3.267 ± 0.083
0.501LysTrp: 0.501 ± 0.03
1.43LysTyr: 1.43 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
12.23LeuAla: 12.23 ± 0.162
0.988LeuCys: 0.988 ± 0.044
6.146LeuAsp: 6.146 ± 0.106
4.534LeuGlu: 4.534 ± 0.093
3.704LeuPhe: 3.704 ± 0.097
7.599LeuGly: 7.599 ± 0.12
2.197LeuHis: 2.197 ± 0.061
5.601LeuIle: 5.601 ± 0.093
4.814LeuLys: 4.814 ± 0.091
9.675LeuLeu: 9.675 ± 0.177
2.561LeuMet: 2.561 ± 0.066
4.135LeuAsn: 4.135 ± 0.088
5.304LeuPro: 5.304 ± 0.106
3.935LeuGln: 3.935 ± 0.079
4.131LeuArg: 4.131 ± 0.1
6.992LeuSer: 6.992 ± 0.114
5.975LeuThr: 5.975 ± 0.099
6.399LeuVal: 6.399 ± 0.131
1.136LeuTrp: 1.136 ± 0.043
2.464LeuTyr: 2.464 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.827MetAla: 2.827 ± 0.08
0.192MetCys: 0.192 ± 0.017
1.11MetAsp: 1.11 ± 0.035
0.773MetGlu: 0.773 ± 0.034
0.838MetPhe: 0.838 ± 0.041
1.833MetGly: 1.833 ± 0.054
0.505MetHis: 0.505 ± 0.03
1.479MetIle: 1.479 ± 0.052
1.314MetLys: 1.314 ± 0.046
2.516MetLeu: 2.516 ± 0.069
0.818MetMet: 0.818 ± 0.041
1.275MetAsn: 1.275 ± 0.042
1.222MetPro: 1.222 ± 0.047
1.388MetGln: 1.388 ± 0.044
1.2MetArg: 1.2 ± 0.037
1.772MetSer: 1.772 ± 0.047
1.904MetThr: 1.904 ± 0.054
1.638MetVal: 1.638 ± 0.055
0.205MetTrp: 0.205 ± 0.017
0.586MetTyr: 0.586 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.981AsnAla: 4.981 ± 0.119
0.391AsnCys: 0.391 ± 0.024
2.509AsnAsp: 2.509 ± 0.068
2.172AsnGlu: 2.172 ± 0.058
1.837AsnPhe: 1.837 ± 0.056
2.842AsnGly: 2.842 ± 0.077
1.211AsnHis: 1.211 ± 0.054
2.549AsnIle: 2.549 ± 0.066
2.09AsnLys: 2.09 ± 0.062
4.23AsnLeu: 4.23 ± 0.096
0.846AsnMet: 0.846 ± 0.033
1.672AsnAsn: 1.672 ± 0.063
2.558AsnPro: 2.558 ± 0.062
2.01AsnGln: 2.01 ± 0.07
1.94AsnArg: 1.94 ± 0.058
2.233AsnSer: 2.233 ± 0.068
2.661AsnThr: 2.661 ± 0.104
2.689AsnVal: 2.689 ± 0.076
0.498AsnTrp: 0.498 ± 0.026
1.246AsnTyr: 1.246 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.245ProAla: 4.245 ± 0.102
0.342ProCys: 0.342 ± 0.022
2.415ProAsp: 2.415 ± 0.057
2.353ProGlu: 2.353 ± 0.06
1.642ProPhe: 1.642 ± 0.056
0.895ProGly: 0.895 ± 0.041
0.898ProHis: 0.898 ± 0.034
2.453ProIle: 2.453 ± 0.059
2.615ProLys: 2.615 ± 0.071
3.619ProLeu: 3.619 ± 0.09
1.058ProMet: 1.058 ± 0.038
2.398ProAsn: 2.398 ± 0.06
1.286ProPro: 1.286 ± 0.051
1.433ProGln: 1.433 ± 0.052
1.305ProArg: 1.305 ± 0.048
2.744ProSer: 2.744 ± 0.07
2.473ProThr: 2.473 ± 0.067
2.854ProVal: 2.854 ± 0.072
0.378ProTrp: 0.378 ± 0.026
1.158ProTyr: 1.158 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.5GlnAla: 5.5 ± 0.105
0.288GlnCys: 0.288 ± 0.023
2.288GlnAsp: 2.288 ± 0.061
2.063GlnGlu: 2.063 ± 0.062
1.573GlnPhe: 1.573 ± 0.052
2.839GlnGly: 2.839 ± 0.074
0.962GlnHis: 0.962 ± 0.041
2.959GlnIle: 2.959 ± 0.062
2.628GlnLys: 2.628 ± 0.068
3.689GlnLeu: 3.689 ± 0.073
1.201GlnMet: 1.201 ± 0.038
2.456GlnAsn: 2.456 ± 0.076
1.442GlnPro: 1.442 ± 0.051
1.586GlnGln: 1.586 ± 0.061
1.75GlnArg: 1.75 ± 0.051
2.716GlnSer: 2.716 ± 0.081
3.001GlnThr: 3.001 ± 0.076
2.887GlnVal: 2.887 ± 0.068
0.351GlnTrp: 0.351 ± 0.024
1.107GlnTyr: 1.107 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.403ArgAla: 4.403 ± 0.084
0.403ArgCys: 0.403 ± 0.026
2.036ArgAsp: 2.036 ± 0.065
2.45ArgGlu: 2.45 ± 0.064
2.244ArgPhe: 2.244 ± 0.069
2.558ArgGly: 2.558 ± 0.054
1.393ArgHis: 1.393 ± 0.044
2.762ArgIle: 2.762 ± 0.069
2.152ArgLys: 2.152 ± 0.061
5.592ArgLeu: 5.592 ± 0.106
1.14ArgMet: 1.14 ± 0.043
1.428ArgAsn: 1.428 ± 0.046
1.659ArgPro: 1.659 ± 0.054
2.322ArgGln: 2.322 ± 0.069
2.188ArgArg: 2.188 ± 0.059
2.32ArgSer: 2.32 ± 0.064
2.861ArgThr: 2.861 ± 0.062
2.873ArgVal: 2.873 ± 0.079
0.517ArgTrp: 0.517 ± 0.025
1.754ArgTyr: 1.754 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
6.384SerAla: 6.384 ± 0.12
0.453SerCys: 0.453 ± 0.028
3.679SerAsp: 3.679 ± 0.077
3.393SerGlu: 3.393 ± 0.08
2.286SerPhe: 2.286 ± 0.062
4.159SerGly: 4.159 ± 0.086
1.521SerHis: 1.521 ± 0.049
3.099SerIle: 3.099 ± 0.076
2.716SerLys: 2.716 ± 0.06
5.992SerLeu: 5.992 ± 0.098
1.378SerMet: 1.378 ± 0.039
2.071SerAsn: 2.071 ± 0.071
2.188SerPro: 2.188 ± 0.059
2.835SerGln: 2.835 ± 0.071
2.554SerArg: 2.554 ± 0.07
3.2SerSer: 3.2 ± 0.09
3.12SerThr: 3.12 ± 0.085
4.383SerVal: 4.383 ± 0.1
0.626SerTrp: 0.626 ± 0.033
1.748SerTyr: 1.748 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
6.28ThrAla: 6.28 ± 0.116
0.431ThrCys: 0.431 ± 0.027
3.5ThrAsp: 3.5 ± 0.084
2.408ThrGlu: 2.408 ± 0.066
1.955ThrPhe: 1.955 ± 0.057
4.342ThrGly: 4.342 ± 0.095
1.784ThrHis: 1.784 ± 0.058
3.056ThrIle: 3.056 ± 0.077
2.769ThrLys: 2.769 ± 0.081
6.735ThrLeu: 6.735 ± 0.12
1.042ThrMet: 1.042 ± 0.044
2.32ThrAsn: 2.32 ± 0.07
3.514ThrPro: 3.514 ± 0.091
2.674ThrGln: 2.674 ± 0.077
2.203ThrArg: 2.203 ± 0.054
3.08ThrSer: 3.08 ± 0.076
3.53ThrThr: 3.53 ± 0.119
3.848ThrVal: 3.848 ± 0.1
0.56ThrTrp: 0.56 ± 0.032
1.378ThrTyr: 1.378 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
7.59ValAla: 7.59 ± 0.137
0.812ValCys: 0.812 ± 0.035
3.663ValAsp: 3.663 ± 0.074
3.226ValGlu: 3.226 ± 0.084
2.884ValPhe: 2.884 ± 0.079
5.094ValGly: 5.094 ± 0.105
1.363ValHis: 1.363 ± 0.043
4.37ValIle: 4.37 ± 0.092
3.278ValLys: 3.278 ± 0.075
7.631ValLeu: 7.631 ± 0.122
2.121ValMet: 2.121 ± 0.063
2.884ValAsn: 2.884 ± 0.082
2.75ValPro: 2.75 ± 0.068
3.038ValGln: 3.038 ± 0.072
3.651ValArg: 3.651 ± 0.081
4.531ValSer: 4.531 ± 0.083
2.937ValThr: 2.937 ± 0.089
5.571ValVal: 5.571 ± 0.112
0.825ValTrp: 0.825 ± 0.037
1.962ValTyr: 1.962 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
1.015TrpAla: 1.015 ± 0.042
0.128TrpCys: 0.128 ± 0.013
0.467TrpAsp: 0.467 ± 0.027
0.501TrpGlu: 0.501 ± 0.031
0.572TrpPhe: 0.572 ± 0.03
0.693TrpGly: 0.693 ± 0.036
0.373TrpHis: 0.373 ± 0.026
0.598TrpIle: 0.598 ± 0.033
0.318TrpLys: 0.318 ± 0.022
1.773TrpLeu: 1.773 ± 0.063
0.216TrpMet: 0.216 ± 0.019
0.281TrpAsn: 0.281 ± 0.021
0.129TrpPro: 0.129 ± 0.015
1.274TrpGln: 1.274 ± 0.051
0.702TrpArg: 0.702 ± 0.033
0.467TrpSer: 0.467 ± 0.029
0.505TrpThr: 0.505 ± 0.028
0.873TrpVal: 0.873 ± 0.041
0.166TrpTrp: 0.166 ± 0.016
0.367TrpTyr: 0.367 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.72TyrAla: 2.72 ± 0.064
0.324TyrCys: 0.324 ± 0.022
1.837TyrAsp: 1.837 ± 0.064
1.595TyrGlu: 1.595 ± 0.051
1.317TyrPhe: 1.317 ± 0.048
2.16TyrGly: 2.16 ± 0.071
0.962TyrHis: 0.962 ± 0.04
1.415TyrIle: 1.415 ± 0.04
1.244TyrLys: 1.244 ± 0.049
3.118TyrLeu: 3.118 ± 0.073
0.477TyrMet: 0.477 ± 0.027
1.107TyrAsn: 1.107 ± 0.046
1.205TyrPro: 1.205 ± 0.041
1.735TyrGln: 1.735 ± 0.047
1.696TyrArg: 1.696 ± 0.054
1.446TyrSer: 1.446 ± 0.052
1.537TyrThr: 1.537 ± 0.05
1.769TyrVal: 1.769 ± 0.056
0.372TyrTrp: 0.372 ± 0.022
1.02TyrTyr: 1.02 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2269 proteins (672763 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski