Amino acid dipepetide frequency for Confluentibacter flavum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.77AlaAla: 3.77 ± 0.073	0.576AlaCys: 0.576 ± 0.025	3.159AlaAsp: 3.159 ± 0.053	3.605AlaGlu: 3.605 ± 0.067	3.346AlaPhe: 3.346 ± 0.061	3.84AlaGly: 3.84 ± 0.072	1.023AlaHis: 1.023 ± 0.029	5.519AlaIle: 5.519 ± 0.084	4.422AlaLys: 4.422 ± 0.068	6.155AlaLeu: 6.155 ± 0.072	1.484AlaMet: 1.484 ± 0.036	3.552AlaAsn: 3.552 ± 0.056	1.785AlaPro: 1.785 ± 0.05	2.096AlaGln: 2.096 ± 0.045	1.787AlaArg: 1.787 ± 0.041	4.231AlaSer: 4.231 ± 0.072	3.564AlaThr: 3.564 ± 0.06	3.711AlaVal: 3.711 ± 0.053	0.656AlaTrp: 0.656 ± 0.022	2.443AlaTyr: 2.443 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.457CysAla: 0.457 ± 0.018	0.113CysCys: 0.113 ± 0.009	0.443CysAsp: 0.443 ± 0.022	0.466CysGlu: 0.466 ± 0.022	0.471CysPhe: 0.471 ± 0.021	0.604CysGly: 0.604 ± 0.027	0.222CysHis: 0.222 ± 0.014	0.599CysIle: 0.599 ± 0.021	0.503CysLys: 0.503 ± 0.018	0.677CysLeu: 0.677 ± 0.024	0.167CysMet: 0.167 ± 0.011	0.425CysAsn: 0.425 ± 0.021	0.329CysPro: 0.329 ± 0.02	0.223CysGln: 0.223 ± 0.014	0.205CysArg: 0.205 ± 0.015	0.593CysSer: 0.593 ± 0.026	0.393CysThr: 0.393 ± 0.024	0.453CysVal: 0.453 ± 0.022	0.067CysTrp: 0.067 ± 0.007	0.315CysTyr: 0.315 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.769AspAla: 3.769 ± 0.059	0.393AspCys: 0.393 ± 0.02	3.259AspAsp: 3.259 ± 0.069	3.609AspGlu: 3.609 ± 0.061	3.794AspPhe: 3.794 ± 0.054	3.81AspGly: 3.81 ± 0.082	0.868AspHis: 0.868 ± 0.027	5.194AspIle: 5.194 ± 0.069	4.166AspLys: 4.166 ± 0.069	5.317AspLeu: 5.317 ± 0.076	1.297AspMet: 1.297 ± 0.04	3.383AspAsn: 3.383 ± 0.059	1.645AspPro: 1.645 ± 0.046	1.21AspGln: 1.21 ± 0.033	1.815AspArg: 1.815 ± 0.034	3.294AspSer: 3.294 ± 0.055	2.899AspThr: 2.899 ± 0.049	3.834AspVal: 3.834 ± 0.059	0.755AspTrp: 0.755 ± 0.03	2.944AspTyr: 2.944 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.284GluAla: 4.284 ± 0.067	0.339GluCys: 0.339 ± 0.017	3.794GluAsp: 3.794 ± 0.06	4.133GluGlu: 4.133 ± 0.077	2.924GluPhe: 2.924 ± 0.056	3.597GluGly: 3.597 ± 0.064	1.254GluHis: 1.254 ± 0.034	5.007GluIle: 5.007 ± 0.061	5.348GluLys: 5.348 ± 0.076	6.088GluLeu: 6.088 ± 0.09	1.414GluMet: 1.414 ± 0.035	4.5GluAsn: 4.5 ± 0.068	1.658GluPro: 1.658 ± 0.033	2.134GluGln: 2.134 ± 0.051	2.447GluArg: 2.447 ± 0.047	3.545GluSer: 3.545 ± 0.06	3.815GluThr: 3.815 ± 0.062	3.937GluVal: 3.937 ± 0.063	0.642GluTrp: 0.642 ± 0.023	2.308GluTyr: 2.308 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.836PheAla: 2.836 ± 0.052	0.456PheCys: 0.456 ± 0.019	3.234PheAsp: 3.234 ± 0.06	3.376PheGlu: 3.376 ± 0.055	2.71PhePhe: 2.71 ± 0.06	3.731PheGly: 3.731 ± 0.056	0.863PheHis: 0.863 ± 0.027	4.237PheIle: 4.237 ± 0.074	4.1PheLys: 4.1 ± 0.063	4.699PheLeu: 4.699 ± 0.079	1.174PheMet: 1.174 ± 0.032	3.634PheAsn: 3.634 ± 0.062	1.691PhePro: 1.691 ± 0.037	1.536PheGln: 1.536 ± 0.037	1.613PheArg: 1.613 ± 0.042	3.974PheSer: 3.974 ± 0.055	3.012PheThr: 3.012 ± 0.058	3.068PheVal: 3.068 ± 0.054	0.601PheTrp: 0.601 ± 0.025	2.223PheTyr: 2.223 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.049GlyAla: 4.049 ± 0.067	0.614GlyCys: 0.614 ± 0.029	3.477GlyAsp: 3.477 ± 0.059	3.475GlyGlu: 3.475 ± 0.063	3.767GlyPhe: 3.767 ± 0.056	4.58GlyGly: 4.58 ± 0.098	1.252GlyHis: 1.252 ± 0.031	5.613GlyIle: 5.613 ± 0.078	4.727GlyLys: 4.727 ± 0.07	5.953GlyLeu: 5.953 ± 0.09	1.625GlyMet: 1.625 ± 0.042	3.816GlyAsn: 3.816 ± 0.07	1.421GlyPro: 1.421 ± 0.036	1.786GlyGln: 1.786 ± 0.036	2.074GlyArg: 2.074 ± 0.043	3.958GlySer: 3.958 ± 0.075	3.989GlyThr: 3.989 ± 0.078	4.309GlyVal: 4.309 ± 0.066	0.886GlyTrp: 0.886 ± 0.03	2.814GlyTyr: 2.814 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.019HisAla: 1.019 ± 0.033	0.189HisCys: 0.189 ± 0.012	0.939HisAsp: 0.939 ± 0.027	1.042HisGlu: 1.042 ± 0.029	1.2HisPhe: 1.2 ± 0.034	1.17HisGly: 1.17 ± 0.032	0.502HisHis: 0.502 ± 0.021	1.652HisIle: 1.652 ± 0.042	1.277HisLys: 1.277 ± 0.035	1.86HisLeu: 1.86 ± 0.044	0.365HisMet: 0.365 ± 0.017	1.054HisAsn: 1.054 ± 0.027	0.846HisPro: 0.846 ± 0.026	0.643HisGln: 0.643 ± 0.024	0.602HisArg: 0.602 ± 0.023	1.064HisSer: 1.064 ± 0.029	0.906HisThr: 0.906 ± 0.028	1.083HisVal: 1.083 ± 0.03	0.281HisTrp: 0.281 ± 0.015	0.909HisTyr: 0.909 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.353IleAla: 5.353 ± 0.069	0.675IleCys: 0.675 ± 0.029	5.251IleAsp: 5.251 ± 0.061	5.645IleGlu: 5.645 ± 0.088	3.771IlePhe: 3.771 ± 0.065	5.366IleGly: 5.366 ± 0.076	1.514IleHis: 1.514 ± 0.038	6.841IleIle: 6.841 ± 0.111	6.475IleLys: 6.475 ± 0.08	7.387IleLeu: 7.387 ± 0.098	1.555IleMet: 1.555 ± 0.036	5.37IleAsn: 5.37 ± 0.071	3.415IlePro: 3.415 ± 0.051	2.484IleGln: 2.484 ± 0.045	2.507IleArg: 2.507 ± 0.05	6.04IleSer: 6.04 ± 0.075	4.995IleThr: 4.995 ± 0.067	4.769IleVal: 4.769 ± 0.065	0.775IleTrp: 0.775 ± 0.028	3.052IleTyr: 3.052 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.808LysAla: 4.808 ± 0.074	0.346LysCys: 0.346 ± 0.018	4.743LysAsp: 4.743 ± 0.074	5.707LysGlu: 5.707 ± 0.093	2.955LysPhe: 2.955 ± 0.05	4.473LysGly: 4.473 ± 0.075	1.583LysHis: 1.583 ± 0.038	6.229LysIle: 6.229 ± 0.075	6.357LysLys: 6.357 ± 0.09	6.711LysLeu: 6.711 ± 0.09	1.938LysMet: 1.938 ± 0.042	5.506LysAsn: 5.506 ± 0.076	2.506LysPro: 2.506 ± 0.048	2.811LysGln: 2.811 ± 0.052	2.811LysArg: 2.811 ± 0.052	4.692LysSer: 4.692 ± 0.065	4.886LysThr: 4.886 ± 0.068	4.541LysVal: 4.541 ± 0.068	0.775LysTrp: 0.775 ± 0.024	2.99LysTyr: 2.99 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.447LeuAla: 5.447 ± 0.076	0.721LeuCys: 0.721 ± 0.026	5.169LeuAsp: 5.169 ± 0.074	5.953LeuGlu: 5.953 ± 0.084	4.956LeuPhe: 4.956 ± 0.076	5.834LeuGly: 5.834 ± 0.08	1.564LeuHis: 1.564 ± 0.029	7.403LeuIle: 7.403 ± 0.106	8.121LeuLys: 8.121 ± 0.106	8.481LeuLeu: 8.481 ± 0.113	2.072LeuMet: 2.072 ± 0.039	6.165LeuAsn: 6.165 ± 0.083	3.455LeuPro: 3.455 ± 0.061	3.004LeuGln: 3.004 ± 0.055	2.997LeuArg: 2.997 ± 0.059	6.579LeuSer: 6.579 ± 0.09	5.083LeuThr: 5.083 ± 0.07	5.444LeuVal: 5.444 ± 0.071	0.908LeuTrp: 0.908 ± 0.031	3.342LeuTyr: 3.342 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.684MetAla: 1.684 ± 0.043	0.157MetCys: 0.157 ± 0.01	1.225MetAsp: 1.225 ± 0.033	1.42MetGlu: 1.42 ± 0.035	0.991MetPhe: 0.991 ± 0.03	1.474MetGly: 1.474 ± 0.041	0.44MetHis: 0.44 ± 0.02	1.551MetIle: 1.551 ± 0.037	2.01MetLys: 2.01 ± 0.037	1.973MetLeu: 1.973 ± 0.046	0.581MetMet: 0.581 ± 0.025	1.322MetAsn: 1.322 ± 0.038	0.934MetPro: 0.934 ± 0.028	0.802MetGln: 0.802 ± 0.029	0.797MetArg: 0.797 ± 0.027	1.425MetSer: 1.425 ± 0.035	1.19MetThr: 1.19 ± 0.03	1.492MetVal: 1.492 ± 0.038	0.171MetTrp: 0.171 ± 0.012	0.751MetTyr: 0.751 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.789AsnAla: 3.789 ± 0.065	0.492AsnCys: 0.492 ± 0.023	3.74AsnAsp: 3.74 ± 0.067	3.875AsnGlu: 3.875 ± 0.058	3.145AsnPhe: 3.145 ± 0.067	4.195AsnGly: 4.195 ± 0.075	1.246AsnHis: 1.246 ± 0.034	5.36AsnIle: 5.36 ± 0.074	4.788AsnLys: 4.788 ± 0.069	5.625AsnLeu: 5.625 ± 0.069	1.496AsnMet: 1.496 ± 0.031	4.512AsnAsn: 4.512 ± 0.072	2.905AsnPro: 2.905 ± 0.05	2.325AsnGln: 2.325 ± 0.039	2.138AsnArg: 2.138 ± 0.042	4.067AsnSer: 4.067 ± 0.063	3.916AsnThr: 3.916 ± 0.076	3.601AsnVal: 3.601 ± 0.063	0.774AsnTrp: 0.774 ± 0.029	2.996AsnTyr: 2.996 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.72ProAla: 1.72 ± 0.043	0.202ProCys: 0.202 ± 0.014	2.105ProAsp: 2.105 ± 0.047	2.755ProGlu: 2.755 ± 0.051	1.988ProPhe: 1.988 ± 0.041	1.864ProGly: 1.864 ± 0.046	0.615ProHis: 0.615 ± 0.023	2.94ProIle: 2.94 ± 0.05	2.52ProLys: 2.52 ± 0.049	3.066ProLeu: 3.066 ± 0.046	0.755ProMet: 0.755 ± 0.023	2.51ProAsn: 2.51 ± 0.054	0.885ProPro: 0.885 ± 0.029	1.107ProGln: 1.107 ± 0.029	0.926ProArg: 0.926 ± 0.028	2.193ProSer: 2.193 ± 0.047	1.989ProThr: 1.989 ± 0.035	2.162ProVal: 2.162 ± 0.045	0.388ProTrp: 0.388 ± 0.019	1.479ProTyr: 1.479 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.897GlnAla: 1.897 ± 0.044	0.187GlnCys: 0.187 ± 0.013	1.647GlnAsp: 1.647 ± 0.037	2.069GlnGlu: 2.069 ± 0.043	1.661GlnPhe: 1.661 ± 0.04	1.873GlnGly: 1.873 ± 0.039	0.627GlnHis: 0.627 ± 0.024	2.631GlnIle: 2.631 ± 0.048	2.5GlnLys: 2.5 ± 0.047	3.324GlnLeu: 3.324 ± 0.057	0.746GlnMet: 0.746 ± 0.021	2.096GlnAsn: 2.096 ± 0.041	1.075GlnPro: 1.075 ± 0.03	1.304GlnGln: 1.304 ± 0.039	1.124GlnArg: 1.124 ± 0.03	1.88GlnSer: 1.88 ± 0.04	1.832GlnThr: 1.832 ± 0.042	1.82GlnVal: 1.82 ± 0.037	0.356GlnTrp: 0.356 ± 0.016	1.314GlnTyr: 1.314 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.997ArgAla: 1.997 ± 0.045	0.212ArgCys: 0.212 ± 0.014	1.828ArgAsp: 1.828 ± 0.042	1.995ArgGlu: 1.995 ± 0.046	1.832ArgPhe: 1.832 ± 0.043	1.897ArgGly: 1.897 ± 0.042	0.652ArgHis: 0.652 ± 0.024	2.86ArgIle: 2.86 ± 0.05	2.445ArgLys: 2.445 ± 0.05	3.171ArgLeu: 3.171 ± 0.051	0.859ArgMet: 0.859 ± 0.027	1.965ArgAsn: 1.965 ± 0.039	1.107ArgPro: 1.107 ± 0.035	1.026ArgGln: 1.026 ± 0.028	1.244ArgArg: 1.244 ± 0.043	1.804ArgSer: 1.804 ± 0.04	1.846ArgThr: 1.846 ± 0.036	1.951ArgVal: 1.951 ± 0.043	0.417ArgTrp: 0.417 ± 0.023	1.461ArgTyr: 1.461 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.515SerAla: 3.515 ± 0.062	0.641SerCys: 0.641 ± 0.025	3.495SerAsp: 3.495 ± 0.055	4.088SerGlu: 4.088 ± 0.057	3.711SerPhe: 3.711 ± 0.06	4.644SerGly: 4.644 ± 0.074	1.226SerHis: 1.226 ± 0.036	5.601SerIle: 5.601 ± 0.074	5.253SerLys: 5.253 ± 0.079	5.972SerLeu: 5.972 ± 0.072	1.358SerMet: 1.358 ± 0.033	4.264SerAsn: 4.264 ± 0.07	2.18SerPro: 2.18 ± 0.05	2.184SerGln: 2.184 ± 0.045	2.074SerArg: 2.074 ± 0.042	4.231SerSer: 4.231 ± 0.073	3.49SerThr: 3.49 ± 0.055	3.935SerVal: 3.935 ± 0.056	0.744SerTrp: 0.744 ± 0.024	2.674SerTyr: 2.674 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.411ThrAla: 3.411 ± 0.059	0.419ThrCys: 0.419 ± 0.021	3.228ThrAsp: 3.228 ± 0.062	3.301ThrGlu: 3.301 ± 0.062	3.098ThrPhe: 3.098 ± 0.058	3.973ThrGly: 3.973 ± 0.068	1.049ThrHis: 1.049 ± 0.034	5.249ThrIle: 5.249 ± 0.068	4.001ThrLys: 4.001 ± 0.06	5.402ThrLeu: 5.402 ± 0.065	1.019ThrMet: 1.019 ± 0.031	3.672ThrAsn: 3.672 ± 0.062	2.418ThrPro: 2.418 ± 0.05	1.794ThrGln: 1.794 ± 0.036	1.636ThrArg: 1.636 ± 0.037	3.975ThrSer: 3.975 ± 0.069	3.478ThrThr: 3.478 ± 0.07	3.622ThrVal: 3.622 ± 0.069	0.646ThrTrp: 0.646 ± 0.024	2.514ThrTyr: 2.514 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	3.819ValAla: 3.819 ± 0.067	0.566ValCys: 0.566 ± 0.022	3.554ValAsp: 3.554 ± 0.064	3.727ValGlu: 3.727 ± 0.064	3.373ValPhe: 3.373 ± 0.062	3.769ValGly: 3.769 ± 0.067	0.998ValHis: 0.998 ± 0.027	4.942ValIle: 4.942 ± 0.063	4.352ValLys: 4.352 ± 0.064	5.875ValLeu: 5.875 ± 0.076	1.356ValMet: 1.356 ± 0.036	3.658ValAsn: 3.658 ± 0.064	2.12ValPro: 2.12 ± 0.043	1.599ValGln: 1.599 ± 0.039	1.835ValArg: 1.835 ± 0.042	4.392ValSer: 4.392 ± 0.06	3.645ValThr: 3.645 ± 0.068	4.021ValVal: 4.021 ± 0.069	0.66ValTrp: 0.66 ± 0.026	2.345ValTyr: 2.345 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.638TrpAla: 0.638 ± 0.024	0.114TrpCys: 0.114 ± 0.009	0.683TrpAsp: 0.683 ± 0.027	0.729TrpGlu: 0.729 ± 0.029	0.605TrpPhe: 0.605 ± 0.026	0.766TrpGly: 0.766 ± 0.028	0.257TrpHis: 0.257 ± 0.014	0.804TrpIle: 0.804 ± 0.028	0.821TrpLys: 0.821 ± 0.029	1.056TrpLeu: 1.056 ± 0.035	0.316TrpMet: 0.316 ± 0.018	0.731TrpAsn: 0.731 ± 0.028	0.27TrpPro: 0.27 ± 0.015	0.415TrpGln: 0.415 ± 0.022	0.434TrpArg: 0.434 ± 0.021	0.698TrpSer: 0.698 ± 0.028	0.592TrpThr: 0.592 ± 0.021	0.646TrpVal: 0.646 ± 0.023	0.162TrpTrp: 0.162 ± 0.013	0.465TrpTyr: 0.465 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.046	0.313TyrCys: 0.313 ± 0.018	2.281TyrAsp: 2.281 ± 0.047	2.197TyrGlu: 2.197 ± 0.041	2.473TyrPhe: 2.473 ± 0.045	2.726TyrGly: 2.726 ± 0.051	0.849TyrHis: 0.849 ± 0.025	3.007TyrIle: 3.007 ± 0.049	3.182TyrLys: 3.182 ± 0.053	3.904TyrLeu: 3.904 ± 0.06	0.811TyrMet: 0.811 ± 0.025	2.852TyrAsn: 2.852 ± 0.056	1.525TyrPro: 1.525 ± 0.04	1.483TyrGln: 1.483 ± 0.04	1.501TyrArg: 1.501 ± 0.037	2.646TyrSer: 2.646 ± 0.052	2.384TyrThr: 2.384 ± 0.057	2.207TyrVal: 2.207 ± 0.047	0.538TyrTrp: 0.538 ± 0.024	1.856TyrTyr: 1.856 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3459 proteins (1212577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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