Amino acid dipepetide frequency for Cryptosporangium aurantiacum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.438AlaAla: 23.438 ± 0.174	0.967AlaCys: 0.967 ± 0.02	9.176AlaAsp: 9.176 ± 0.071	8.742AlaGlu: 8.742 ± 0.07	3.641AlaPhe: 3.641 ± 0.048	13.529AlaGly: 13.529 ± 0.072	2.54AlaHis: 2.54 ± 0.032	4.599AlaIle: 4.599 ± 0.046	2.352AlaLys: 2.352 ± 0.043	15.267AlaLeu: 15.267 ± 0.106	2.315AlaMet: 2.315 ± 0.026	2.032AlaAsn: 2.032 ± 0.026	7.4AlaPro: 7.4 ± 0.07	3.519AlaGln: 3.519 ± 0.041	10.207AlaArg: 10.207 ± 0.082	6.47AlaSer: 6.47 ± 0.052	7.928AlaThr: 7.928 ± 0.06	13.129AlaVal: 13.129 ± 0.087	1.914AlaTrp: 1.914 ± 0.028	2.568AlaTyr: 2.568 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.974CysAla: 0.974 ± 0.02	0.081CysCys: 0.081 ± 0.006	0.468CysAsp: 0.468 ± 0.015	0.334CysGlu: 0.334 ± 0.01	0.211CysPhe: 0.211 ± 0.008	0.823CysGly: 0.823 ± 0.015	0.157CysHis: 0.157 ± 0.008	0.163CysIle: 0.163 ± 0.007	0.076CysLys: 0.076 ± 0.005	0.681CysLeu: 0.681 ± 0.017	0.092CysMet: 0.092 ± 0.006	0.102CysAsn: 0.102 ± 0.006	0.422CysPro: 0.422 ± 0.014	0.153CysGln: 0.153 ± 0.007	0.579CysArg: 0.579 ± 0.016	0.369CysSer: 0.369 ± 0.012	0.418CysThr: 0.418 ± 0.013	0.587CysVal: 0.587 ± 0.015	0.116CysTrp: 0.116 ± 0.006	0.145CysTyr: 0.145 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	9.073AspAla: 9.073 ± 0.074	0.327AspCys: 0.327 ± 0.011	4.17AspAsp: 4.17 ± 0.041	3.992AspGlu: 3.992 ± 0.037	1.391AspPhe: 1.391 ± 0.022	6.259AspGly: 6.259 ± 0.049	1.269AspHis: 1.269 ± 0.021	1.546AspIle: 1.546 ± 0.025	0.824AspLys: 0.824 ± 0.022	6.568AspLeu: 6.568 ± 0.051	0.627AspMet: 0.627 ± 0.015	0.845AspAsn: 0.845 ± 0.02	4.779AspPro: 4.779 ± 0.043	1.631AspGln: 1.631 ± 0.026	5.277AspArg: 5.277 ± 0.046	2.247AspSer: 2.247 ± 0.029	2.873AspThr: 2.873 ± 0.031	5.773AspVal: 5.773 ± 0.046	0.95AspTrp: 0.95 ± 0.019	1.149AspTyr: 1.149 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.78GluAla: 6.78 ± 0.054	0.314GluCys: 0.314 ± 0.01	2.422GluAsp: 2.422 ± 0.032	2.641GluGlu: 2.641 ± 0.036	1.541GluPhe: 1.541 ± 0.022	3.33GluGly: 3.33 ± 0.033	1.366GluHis: 1.366 ± 0.021	2.301GluIle: 2.301 ± 0.03	1.157GluLys: 1.157 ± 0.026	6.39GluLeu: 6.39 ± 0.049	0.81GluMet: 0.81 ± 0.018	1.013GluAsn: 1.013 ± 0.02	3.523GluPro: 3.523 ± 0.04	2.099GluGln: 2.099 ± 0.031	5.187GluArg: 5.187 ± 0.05	2.474GluSer: 2.474 ± 0.032	2.83GluThr: 2.83 ± 0.036	4.49GluVal: 4.49 ± 0.04	0.823GluTrp: 0.823 ± 0.019	1.158GluTyr: 1.158 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.951PheAla: 3.951 ± 0.04	0.267PheCys: 0.267 ± 0.01	2.035PheAsp: 2.035 ± 0.026	1.321PheGlu: 1.321 ± 0.022	0.813PhePhe: 0.813 ± 0.02	3.2PheGly: 3.2 ± 0.034	0.533PheHis: 0.533 ± 0.015	0.67PheIle: 0.67 ± 0.017	0.365PheLys: 0.365 ± 0.011	2.693PheLeu: 2.693 ± 0.036	0.321PheMet: 0.321 ± 0.012	0.512PheAsn: 0.512 ± 0.014	1.352PhePro: 1.352 ± 0.022	0.6PheGln: 0.6 ± 0.014	1.967PheArg: 1.967 ± 0.027	1.449PheSer: 1.449 ± 0.026	1.865PheThr: 1.865 ± 0.025	2.551PheVal: 2.551 ± 0.036	0.432PheTrp: 0.432 ± 0.012	0.595PheTyr: 0.595 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.34GlyAla: 11.34 ± 0.077	0.735GlyCys: 0.735 ± 0.019	4.894GlyAsp: 4.894 ± 0.046	4.445GlyGlu: 4.445 ± 0.039	2.847GlyPhe: 2.847 ± 0.038	8.315GlyGly: 8.315 ± 0.075	1.943GlyHis: 1.943 ± 0.03	3.384GlyIle: 3.384 ± 0.042	1.886GlyLys: 1.886 ± 0.031	9.741GlyLeu: 9.741 ± 0.062	1.657GlyMet: 1.657 ± 0.025	1.632GlyAsn: 1.632 ± 0.026	5.423GlyPro: 5.423 ± 0.063	2.557GlyGln: 2.557 ± 0.038	7.708GlyArg: 7.708 ± 0.07	5.256GlySer: 5.256 ± 0.046	5.689GlyThr: 5.689 ± 0.051	8.216GlyVal: 8.216 ± 0.057	1.831GlyTrp: 1.831 ± 0.026	2.347GlyTyr: 2.347 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.46HisAla: 2.46 ± 0.029	0.17HisCys: 0.17 ± 0.007	1.293HisAsp: 1.293 ± 0.02	1.012HisGlu: 1.012 ± 0.02	0.559HisPhe: 0.559 ± 0.014	2.077HisGly: 2.077 ± 0.032	0.616HisHis: 0.616 ± 0.016	0.491HisIle: 0.491 ± 0.013	0.244HisLys: 0.244 ± 0.009	2.238HisLeu: 2.238 ± 0.03	0.221HisMet: 0.221 ± 0.008	0.31HisAsn: 0.31 ± 0.012	1.68HisPro: 1.68 ± 0.025	0.557HisGln: 0.557 ± 0.015	2.042HisArg: 2.042 ± 0.029	0.864HisSer: 0.864 ± 0.019	1.04HisThr: 1.04 ± 0.017	1.674HisVal: 1.674 ± 0.026	0.337HisTrp: 0.337 ± 0.01	0.442HisTyr: 0.442 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.323IleAla: 5.323 ± 0.048	0.284IleCys: 0.284 ± 0.01	2.479IleAsp: 2.479 ± 0.029	2.035IleGlu: 2.035 ± 0.032	0.75IlePhe: 0.75 ± 0.017	3.881IleGly: 3.881 ± 0.039	0.6IleHis: 0.6 ± 0.013	0.871IleIle: 0.871 ± 0.02	0.527IleLys: 0.527 ± 0.013	2.718IleLeu: 2.718 ± 0.035	0.375IleMet: 0.375 ± 0.013	0.716IleAsn: 0.716 ± 0.015	1.847IlePro: 1.847 ± 0.029	0.735IleGln: 0.735 ± 0.016	2.561IleArg: 2.561 ± 0.03	1.754IleSer: 1.754 ± 0.023	2.21IleThr: 2.21 ± 0.031	3.378IleVal: 3.378 ± 0.037	0.451IleTrp: 0.451 ± 0.013	0.606IleTyr: 0.606 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.258LysAla: 2.258 ± 0.036	0.087LysCys: 0.087 ± 0.006	0.868LysAsp: 0.868 ± 0.021	0.787LysGlu: 0.787 ± 0.019	0.412LysPhe: 0.412 ± 0.014	1.144LysGly: 1.144 ± 0.025	0.382LysHis: 0.382 ± 0.011	0.692LysIle: 0.692 ± 0.017	0.512LysLys: 0.512 ± 0.018	1.675LysLeu: 1.675 ± 0.025	0.26LysMet: 0.26 ± 0.009	0.385LysAsn: 0.385 ± 0.012	1.169LysPro: 1.169 ± 0.021	0.553LysGln: 0.553 ± 0.015	1.26LysArg: 1.26 ± 0.024	0.949LysSer: 0.949 ± 0.022	1.069LysThr: 1.069 ± 0.022	1.442LysVal: 1.442 ± 0.028	0.214LysTrp: 0.214 ± 0.008	0.397LysTyr: 0.397 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	16.343LeuAla: 16.343 ± 0.096	0.772LeuCys: 0.772 ± 0.017	6.947LeuAsp: 6.947 ± 0.052	4.549LeuGlu: 4.549 ± 0.037	2.782LeuPhe: 2.782 ± 0.03	9.632LeuGly: 9.632 ± 0.069	2.088LeuHis: 2.088 ± 0.029	3.743LeuIle: 3.743 ± 0.039	1.399LeuLys: 1.399 ± 0.023	11.35LeuLeu: 11.35 ± 0.086	1.349LeuMet: 1.349 ± 0.023	1.705LeuAsn: 1.705 ± 0.026	6.404LeuPro: 6.404 ± 0.058	2.173LeuGln: 2.173 ± 0.028	8.931LeuArg: 8.931 ± 0.059	5.428LeuSer: 5.428 ± 0.047	7.141LeuThr: 7.141 ± 0.048	10.024LeuVal: 10.024 ± 0.072	1.278LeuTrp: 1.278 ± 0.023	1.712LeuTyr: 1.712 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.996MetAla: 1.996 ± 0.026	0.097MetCys: 0.097 ± 0.006	0.718MetAsp: 0.718 ± 0.015	0.556MetGlu: 0.556 ± 0.015	0.458MetPhe: 0.458 ± 0.014	1.021MetGly: 1.021 ± 0.02	0.288MetHis: 0.288 ± 0.011	0.622MetIle: 0.622 ± 0.014	0.318MetLys: 0.318 ± 0.01	1.652MetLeu: 1.652 ± 0.023	0.234MetMet: 0.234 ± 0.009	0.339MetAsn: 0.339 ± 0.013	0.971MetPro: 0.971 ± 0.02	0.363MetGln: 0.363 ± 0.012	1.223MetArg: 1.223 ± 0.019	1.188MetSer: 1.188 ± 0.019	1.508MetThr: 1.508 ± 0.021	1.208MetVal: 1.208 ± 0.02	0.163MetTrp: 0.163 ± 0.008	0.211MetTyr: 0.211 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.28AsnAla: 2.28 ± 0.031	0.137AsnCys: 0.137 ± 0.007	0.939AsnAsp: 0.939 ± 0.021	0.784AsnGlu: 0.784 ± 0.014	0.454AsnPhe: 0.454 ± 0.013	1.773AsnGly: 1.773 ± 0.027	0.345AsnHis: 0.345 ± 0.009	0.583AsnIle: 0.583 ± 0.015	0.315AsnLys: 0.315 ± 0.011	1.741AsnLeu: 1.741 ± 0.022	0.235AsnMet: 0.235 ± 0.009	0.385AsnAsn: 0.385 ± 0.012	1.414AsnPro: 1.414 ± 0.026	0.497AsnGln: 0.497 ± 0.015	1.362AsnArg: 1.362 ± 0.021	0.832AsnSer: 0.832 ± 0.019	1.065AsnThr: 1.065 ± 0.019	1.466AsnVal: 1.466 ± 0.023	0.276AsnTrp: 0.276 ± 0.01	0.395AsnTyr: 0.395 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.923ProAla: 8.923 ± 0.092	0.276ProCys: 0.276 ± 0.01	4.958ProAsp: 4.958 ± 0.045	3.984ProGlu: 3.984 ± 0.041	1.618ProPhe: 1.618 ± 0.024	6.461ProGly: 6.461 ± 0.067	1.242ProHis: 1.242 ± 0.024	1.874ProIle: 1.874 ± 0.028	0.964ProLys: 0.964 ± 0.021	5.429ProLeu: 5.429 ± 0.046	0.942ProMet: 0.942 ± 0.017	1.016ProAsn: 1.016 ± 0.021	4.145ProPro: 4.145 ± 0.067	1.483ProGln: 1.483 ± 0.03	3.961ProArg: 3.961 ± 0.044	3.469ProSer: 3.469 ± 0.045	3.882ProThr: 3.882 ± 0.047	5.65ProVal: 5.65 ± 0.054	0.889ProTrp: 0.889 ± 0.02	1.246ProTyr: 1.246 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.375GlnAla: 3.375 ± 0.043	0.156GlnCys: 0.156 ± 0.008	1.099GlnAsp: 1.099 ± 0.024	1.121GlnGlu: 1.121 ± 0.021	0.779GlnPhe: 0.779 ± 0.017	1.726GlnGly: 1.726 ± 0.033	0.595GlnHis: 0.595 ± 0.016	1.16GlnIle: 1.16 ± 0.02	0.505GlnLys: 0.505 ± 0.015	3.097GlnLeu: 3.097 ± 0.036	0.443GlnMet: 0.443 ± 0.012	0.508GlnAsn: 0.508 ± 0.015	1.755GlnPro: 1.755 ± 0.04	1.076GlnGln: 1.076 ± 0.021	2.504GlnArg: 2.504 ± 0.033	1.189GlnSer: 1.189 ± 0.02	1.32GlnThr: 1.32 ± 0.023	2.406GlnVal: 2.406 ± 0.032	0.441GlnTrp: 0.441 ± 0.012	0.6GlnTyr: 0.6 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.406ArgAla: 10.406 ± 0.084	0.572ArgCys: 0.572 ± 0.016	4.419ArgAsp: 4.419 ± 0.05	4.148ArgGlu: 4.148 ± 0.041	2.41ArgPhe: 2.41 ± 0.027	5.767ArgGly: 5.767 ± 0.045	1.861ArgHis: 1.861 ± 0.025	3.301ArgIle: 3.301 ± 0.039	1.318ArgLys: 1.318 ± 0.023	8.815ArgLeu: 8.815 ± 0.064	1.712ArgMet: 1.712 ± 0.026	1.418ArgAsn: 1.418 ± 0.023	5.117ArgPro: 5.117 ± 0.053	2.259ArgGln: 2.259 ± 0.029	8.279ArgArg: 8.279 ± 0.079	4.4ArgSer: 4.4 ± 0.047	5.203ArgThr: 5.203 ± 0.048	6.35ArgVal: 6.35 ± 0.053	1.598ArgTrp: 1.598 ± 0.025	1.958ArgTyr: 1.958 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.132SerAla: 7.132 ± 0.059	0.349SerCys: 0.349 ± 0.012	2.968SerAsp: 2.968 ± 0.032	2.434SerGlu: 2.434 ± 0.032	1.468SerPhe: 1.468 ± 0.023	5.869SerGly: 5.869 ± 0.059	0.865SerHis: 0.865 ± 0.019	1.748SerIle: 1.748 ± 0.026	0.818SerLys: 0.818 ± 0.019	4.659SerLeu: 4.659 ± 0.042	0.964SerMet: 0.964 ± 0.019	0.844SerAsn: 0.844 ± 0.018	3.271SerPro: 3.271 ± 0.045	1.117SerGln: 1.117 ± 0.022	3.74SerArg: 3.74 ± 0.041	2.864SerSer: 2.864 ± 0.037	3.25SerThr: 3.25 ± 0.036	4.389SerVal: 4.389 ± 0.038	0.902SerTrp: 0.902 ± 0.019	1.107SerTyr: 1.107 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	8.628ThrAla: 8.628 ± 0.059	0.364ThrCys: 0.364 ± 0.012	3.676ThrAsp: 3.676 ± 0.033	3.099ThrGlu: 3.099 ± 0.041	1.753ThrPhe: 1.753 ± 0.029	6.273ThrGly: 6.273 ± 0.057	1.084ThrHis: 1.084 ± 0.02	2.295ThrIle: 2.295 ± 0.03	0.991ThrLys: 0.991 ± 0.023	6.277ThrLeu: 6.277 ± 0.054	0.96ThrMet: 0.96 ± 0.018	1.087ThrAsn: 1.087 ± 0.022	4.203ThrPro: 4.203 ± 0.043	1.316ThrGln: 1.316 ± 0.022	3.947ThrArg: 3.947 ± 0.035	3.113ThrSer: 3.113 ± 0.039	4.1ThrThr: 4.1 ± 0.051	6.212ThrVal: 6.212 ± 0.049	0.918ThrTrp: 0.918 ± 0.018	1.212ThrTyr: 1.212 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	12.697ValAla: 12.697 ± 0.071	0.672ValCys: 0.672 ± 0.015	5.844ValAsp: 5.844 ± 0.055	4.961ValGlu: 4.961 ± 0.053	2.462ValPhe: 2.462 ± 0.031	7.657ValGly: 7.657 ± 0.051	1.798ValHis: 1.798 ± 0.026	3.006ValIle: 3.006 ± 0.037	1.381ValLys: 1.381 ± 0.023	10.489ValLeu: 10.489 ± 0.066	1.162ValMet: 1.162 ± 0.022	1.708ValAsn: 1.708 ± 0.022	5.477ValPro: 5.477 ± 0.053	1.992ValGln: 1.992 ± 0.025	7.245ValArg: 7.245 ± 0.056	4.567ValSer: 4.567 ± 0.041	6.037ValThr: 6.037 ± 0.054	9.491ValVal: 9.491 ± 0.073	1.143ValTrp: 1.143 ± 0.023	1.498ValTyr: 1.498 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.773TrpAla: 1.773 ± 0.027	0.15TrpCys: 0.15 ± 0.007	0.853TrpAsp: 0.853 ± 0.018	0.681TrpGlu: 0.681 ± 0.016	0.498TrpPhe: 0.498 ± 0.014	1.044TrpGly: 1.044 ± 0.023	0.359TrpHis: 0.359 ± 0.012	0.622TrpIle: 0.622 ± 0.014	0.288TrpLys: 0.288 ± 0.01	1.889TrpLeu: 1.889 ± 0.028	0.274TrpMet: 0.274 ± 0.009	0.384TrpAsn: 0.384 ± 0.011	0.856TrpPro: 0.856 ± 0.02	0.542TrpGln: 0.542 ± 0.014	1.351TrpArg: 1.351 ± 0.024	0.944TrpSer: 0.944 ± 0.019	1.011TrpThr: 1.011 ± 0.023	1.161TrpVal: 1.161 ± 0.02	0.369TrpTrp: 0.369 ± 0.012	0.336TrpTyr: 0.336 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.588TyrAla: 2.588 ± 0.03	0.171TyrCys: 0.171 ± 0.009	1.343TyrAsp: 1.343 ± 0.025	1.022TyrGlu: 1.022 ± 0.02	0.646TyrPhe: 0.646 ± 0.016	2.068TyrGly: 2.068 ± 0.03	0.395TyrHis: 0.395 ± 0.013	0.431TyrIle: 0.431 ± 0.014	0.276TyrLys: 0.276 ± 0.009	2.38TyrLeu: 2.38 ± 0.033	0.181TyrMet: 0.181 ± 0.008	0.338TyrAsn: 0.338 ± 0.011	1.205TyrPro: 1.205 ± 0.023	0.632TyrGln: 0.632 ± 0.016	1.981TyrArg: 1.981 ± 0.028	0.932TyrSer: 0.932 ± 0.017	1.065TyrThr: 1.065 ± 0.021	1.689TyrVal: 1.689 ± 0.028	0.34TyrTrp: 0.34 ± 0.012	0.449TyrTyr: 0.449 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8789 proteins (2911538 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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