Amino acid dipepetide frequency for Coprinopsis marcescibilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.712AlaAla: 7.712 ± 0.057	1.053AlaCys: 1.053 ± 0.016	3.663AlaAsp: 3.663 ± 0.028	4.487AlaGlu: 4.487 ± 0.03	3.177AlaPhe: 3.177 ± 0.024	5.274AlaGly: 5.274 ± 0.04	1.892AlaHis: 1.892 ± 0.018	4.235AlaIle: 4.235 ± 0.033	3.901AlaLys: 3.901 ± 0.029	8.149AlaLeu: 8.149 ± 0.044	1.698AlaMet: 1.698 ± 0.017	3.029AlaAsn: 3.029 ± 0.025	4.816AlaPro: 4.816 ± 0.037	3.245AlaGln: 3.245 ± 0.027	4.674AlaArg: 4.674 ± 0.033	7.431AlaSer: 7.431 ± 0.041	5.069AlaThr: 5.069 ± 0.031	5.259AlaVal: 5.259 ± 0.036	1.067AlaTrp: 1.067 ± 0.015	2.078AlaTyr: 2.078 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.901CysAla: 0.901 ± 0.013	0.267CysCys: 0.267 ± 0.007	0.632CysAsp: 0.632 ± 0.011	0.559CysGlu: 0.559 ± 0.01	0.514CysPhe: 0.514 ± 0.009	0.938CysGly: 0.938 ± 0.014	0.338CysHis: 0.338 ± 0.009	0.724CysIle: 0.724 ± 0.012	0.549CysLys: 0.549 ± 0.011	1.29CysLeu: 1.29 ± 0.018	0.277CysMet: 0.277 ± 0.006	0.492CysAsn: 0.492 ± 0.01	0.755CysPro: 0.755 ± 0.015	0.469CysGln: 0.469 ± 0.01	0.794CysArg: 0.794 ± 0.013	1.009CysSer: 1.009 ± 0.015	0.758CysThr: 0.758 ± 0.012	0.828CysVal: 0.828 ± 0.013	0.208CysTrp: 0.208 ± 0.007	0.35CysTyr: 0.35 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.315AspAla: 4.315 ± 0.029	0.601AspCys: 0.601 ± 0.011	4.056AspAsp: 4.056 ± 0.037	4.124AspGlu: 4.124 ± 0.031	2.055AspPhe: 2.055 ± 0.021	3.872AspGly: 3.872 ± 0.029	1.229AspHis: 1.229 ± 0.016	3.133AspIle: 3.133 ± 0.027	2.222AspLys: 2.222 ± 0.022	5.039AspLeu: 5.039 ± 0.035	1.144AspMet: 1.144 ± 0.013	1.854AspAsn: 1.854 ± 0.018	3.443AspPro: 3.443 ± 0.024	1.656AspGln: 1.656 ± 0.017	2.837AspArg: 2.837 ± 0.024	4.282AspSer: 4.282 ± 0.027	2.757AspThr: 2.757 ± 0.019	3.736AspVal: 3.736 ± 0.028	0.848AspTrp: 0.848 ± 0.013	1.488AspTyr: 1.488 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	5.022GluAla: 5.022 ± 0.041	0.69GluCys: 0.69 ± 0.011	4.102GluAsp: 4.102 ± 0.034	5.314GluGlu: 5.314 ± 0.055	1.937GluPhe: 1.937 ± 0.016	3.803GluGly: 3.803 ± 0.03	1.397GluHis: 1.397 ± 0.013	2.901GluIle: 2.901 ± 0.025	3.129GluLys: 3.129 ± 0.025	5.305GluLeu: 5.305 ± 0.033	1.233GluMet: 1.233 ± 0.015	2.001GluAsn: 2.001 ± 0.02	2.724GluPro: 2.724 ± 0.03	2.207GluGln: 2.207 ± 0.019	3.928GluArg: 3.928 ± 0.036	4.171GluSer: 4.171 ± 0.029	3.153GluThr: 3.153 ± 0.024	3.555GluVal: 3.555 ± 0.031	0.909GluTrp: 0.909 ± 0.014	1.563GluTyr: 1.563 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.959PheAla: 2.959 ± 0.024	0.557PheCys: 0.557 ± 0.009	2.248PheAsp: 2.248 ± 0.021	2.138PheGlu: 2.138 ± 0.02	1.626PhePhe: 1.626 ± 0.018	2.675PheGly: 2.675 ± 0.027	0.957PheHis: 0.957 ± 0.015	1.929PheIle: 1.929 ± 0.018	1.677PheLys: 1.677 ± 0.017	3.55PheLeu: 3.55 ± 0.025	0.744PheMet: 0.744 ± 0.01	1.575PheAsn: 1.575 ± 0.014	2.106PhePro: 2.106 ± 0.022	1.356PheGln: 1.356 ± 0.015	2.016PheArg: 2.016 ± 0.019	3.216PheSer: 3.216 ± 0.022	2.18PheThr: 2.18 ± 0.02	2.497PheVal: 2.497 ± 0.019	0.579PheTrp: 0.579 ± 0.009	1.082PheTyr: 1.082 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	4.825GlyAla: 4.825 ± 0.039	0.867GlyCys: 0.867 ± 0.014	3.35GlyAsp: 3.35 ± 0.026	3.408GlyGlu: 3.408 ± 0.027	2.531GlyPhe: 2.531 ± 0.022	5.559GlyGly: 5.559 ± 0.059	1.714GlyHis: 1.714 ± 0.019	3.266GlyIle: 3.266 ± 0.025	3.363GlyLys: 3.363 ± 0.03	5.848GlyLeu: 5.848 ± 0.031	1.407GlyMet: 1.407 ± 0.018	2.528GlyAsn: 2.528 ± 0.026	3.374GlyPro: 3.374 ± 0.027	2.445GlyGln: 2.445 ± 0.024	4.1GlyArg: 4.1 ± 0.038	5.783GlySer: 5.783 ± 0.033	3.916GlyThr: 3.916 ± 0.031	4.338GlyVal: 4.338 ± 0.03	1.078GlyTrp: 1.078 ± 0.014	1.9GlyTyr: 1.9 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.89HisAla: 1.89 ± 0.018	0.351HisCys: 0.351 ± 0.009	1.216HisAsp: 1.216 ± 0.013	1.211HisGlu: 1.211 ± 0.015	0.958HisPhe: 0.958 ± 0.014	1.612HisGly: 1.612 ± 0.018	0.941HisHis: 0.941 ± 0.017	1.388HisIle: 1.388 ± 0.016	0.959HisLys: 0.959 ± 0.013	2.588HisLeu: 2.588 ± 0.024	0.456HisMet: 0.456 ± 0.009	0.943HisAsn: 0.943 ± 0.013	1.929HisPro: 1.929 ± 0.022	1.051HisGln: 1.051 ± 0.015	1.668HisArg: 1.668 ± 0.018	2.195HisSer: 2.195 ± 0.02	1.442HisThr: 1.442 ± 0.017	1.525HisVal: 1.525 ± 0.014	0.368HisTrp: 0.368 ± 0.007	0.701HisTyr: 0.701 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.094IleAla: 4.094 ± 0.032	0.751IleCys: 0.751 ± 0.012	2.802IleAsp: 2.802 ± 0.026	2.707IleGlu: 2.707 ± 0.023	1.978IlePhe: 1.978 ± 0.019	2.979IleGly: 2.979 ± 0.027	1.289IleHis: 1.289 ± 0.015	2.569IleIle: 2.569 ± 0.023	2.108IleLys: 2.108 ± 0.02	4.789IleLeu: 4.789 ± 0.031	0.915IleMet: 0.915 ± 0.013	1.802IleAsn: 1.802 ± 0.018	3.379IlePro: 3.379 ± 0.024	2.018IleGln: 2.018 ± 0.02	2.981IleArg: 2.981 ± 0.024	4.129IleSer: 4.129 ± 0.025	2.812IleThr: 2.812 ± 0.026	3.363IleVal: 3.363 ± 0.025	0.723IleTrp: 0.723 ± 0.01	1.421IleTyr: 1.421 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.094LysAla: 4.094 ± 0.029	0.51LysCys: 0.51 ± 0.009	2.679LysAsp: 2.679 ± 0.024	3.317LysGlu: 3.317 ± 0.031	1.464LysPhe: 1.464 ± 0.016	2.99LysGly: 2.99 ± 0.024	1.166LysHis: 1.166 ± 0.013	2.153LysIle: 2.153 ± 0.018	3.029LysLys: 3.029 ± 0.037	4.136LysLeu: 4.136 ± 0.029	0.882LysMet: 0.882 ± 0.014	1.585LysAsn: 1.585 ± 0.018	2.743LysPro: 2.743 ± 0.024	1.732LysGln: 1.732 ± 0.017	3.464LysArg: 3.464 ± 0.026	3.469LysSer: 3.469 ± 0.025	2.664LysThr: 2.664 ± 0.02	2.825LysVal: 2.825 ± 0.022	0.661LysTrp: 0.661 ± 0.011	1.247LysTyr: 1.247 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.206LeuAla: 8.206 ± 0.054	1.271LeuCys: 1.271 ± 0.016	5.376LeuAsp: 5.376 ± 0.032	5.823LeuGlu: 5.823 ± 0.037	3.457LeuPhe: 3.457 ± 0.03	5.709LeuGly: 5.709 ± 0.03	2.492LeuHis: 2.492 ± 0.021	3.979LeuIle: 3.979 ± 0.03	4.476LeuLys: 4.476 ± 0.028	8.877LeuLeu: 8.877 ± 0.052	1.724LeuMet: 1.724 ± 0.018	3.381LeuAsn: 3.381 ± 0.024	6.051LeuPro: 6.051 ± 0.034	3.894LeuGln: 3.894 ± 0.031	5.871LeuArg: 5.871 ± 0.038	8.042LeuSer: 8.042 ± 0.037	5.083LeuThr: 5.083 ± 0.032	5.91LeuVal: 5.91 ± 0.037	1.24LeuTrp: 1.24 ± 0.017	2.486LeuTyr: 2.486 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.757MetAla: 1.757 ± 0.016	0.236MetCys: 0.236 ± 0.006	1.202MetAsp: 1.202 ± 0.015	1.164MetGlu: 1.164 ± 0.013	0.753MetPhe: 0.753 ± 0.012	1.242MetGly: 1.242 ± 0.017	0.488MetHis: 0.488 ± 0.009	0.886MetIle: 0.886 ± 0.013	0.938MetLys: 0.938 ± 0.013	1.788MetLeu: 1.788 ± 0.017	0.477MetMet: 0.477 ± 0.011	0.71MetAsn: 0.71 ± 0.012	1.146MetPro: 1.146 ± 0.015	0.772MetGln: 0.772 ± 0.012	1.125MetArg: 1.125 ± 0.015	1.83MetSer: 1.83 ± 0.018	1.133MetThr: 1.133 ± 0.013	1.207MetVal: 1.207 ± 0.014	0.256MetTrp: 0.256 ± 0.006	0.541MetTyr: 0.541 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.221AsnAla: 3.221 ± 0.023	0.453AsnCys: 0.453 ± 0.008	1.919AsnAsp: 1.919 ± 0.017	1.896AsnGlu: 1.896 ± 0.02	1.329AsnPhe: 1.329 ± 0.014	2.813AsnGly: 2.813 ± 0.028	0.984AsnHis: 0.984 ± 0.013	2.038AsnIle: 2.038 ± 0.015	1.481AsnLys: 1.481 ± 0.017	3.562AsnLeu: 3.562 ± 0.027	0.744AsnMet: 0.744 ± 0.011	1.562AsnAsn: 1.562 ± 0.022	2.71AsnPro: 2.71 ± 0.024	1.336AsnGln: 1.336 ± 0.014	2.031AsnArg: 2.031 ± 0.018	2.999AsnSer: 2.999 ± 0.023	2.205AsnThr: 2.205 ± 0.02	2.454AsnVal: 2.454 ± 0.021	0.53AsnTrp: 0.53 ± 0.008	1.001AsnTyr: 1.001 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	5.218ProAla: 5.218 ± 0.036	0.558ProCys: 0.558 ± 0.011	3.108ProAsp: 3.108 ± 0.021	3.594ProGlu: 3.594 ± 0.031	2.291ProPhe: 2.291 ± 0.023	3.951ProGly: 3.951 ± 0.03	1.565ProHis: 1.565 ± 0.017	2.868ProIle: 2.868 ± 0.024	2.631ProLys: 2.631 ± 0.023	5.355ProLeu: 5.355 ± 0.031	1.004ProMet: 1.004 ± 0.013	2.475ProAsn: 2.475 ± 0.021	6.18ProPro: 6.18 ± 0.079	2.623ProGln: 2.623 ± 0.026	3.478ProArg: 3.478 ± 0.029	6.912ProSer: 6.912 ± 0.049	4.556ProThr: 4.556 ± 0.033	3.835ProVal: 3.835 ± 0.028	0.714ProTrp: 0.714 ± 0.013	1.525ProTyr: 1.525 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.223GlnAla: 3.223 ± 0.023	0.514GlnCys: 0.514 ± 0.01	1.969GlnAsp: 1.969 ± 0.02	2.34GlnGlu: 2.34 ± 0.023	1.348GlnPhe: 1.348 ± 0.016	2.356GlnGly: 2.356 ± 0.024	1.172GlnHis: 1.172 ± 0.014	1.833GlnIle: 1.833 ± 0.017	1.72GlnLys: 1.72 ± 0.018	3.611GlnLeu: 3.611 ± 0.028	0.786GlnMet: 0.786 ± 0.012	1.407GlnAsn: 1.407 ± 0.017	2.624GlnPro: 2.624 ± 0.029	2.398GlnGln: 2.398 ± 0.05	2.614GlnArg: 2.614 ± 0.021	3.051GlnSer: 3.051 ± 0.024	2.281GlnThr: 2.281 ± 0.02	2.286GlnVal: 2.286 ± 0.022	0.544GlnTrp: 0.544 ± 0.009	1.07GlnTyr: 1.07 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.5ArgAla: 4.5 ± 0.032	0.811ArgCys: 0.811 ± 0.013	3.135ArgAsp: 3.135 ± 0.027	3.671ArgGlu: 3.671 ± 0.031	2.327ArgPhe: 2.327 ± 0.023	3.543ArgGly: 3.543 ± 0.036	1.598ArgHis: 1.598 ± 0.015	3.067ArgIle: 3.067 ± 0.025	3.389ArgLys: 3.389 ± 0.027	5.719ArgLeu: 5.719 ± 0.038	1.284ArgMet: 1.284 ± 0.015	2.345ArgAsn: 2.345 ± 0.019	3.614ArgPro: 3.614 ± 0.032	2.493ArgGln: 2.493 ± 0.021	5.066ArgArg: 5.066 ± 0.042	5.04ArgSer: 5.04 ± 0.039	3.567ArgThr: 3.567 ± 0.029	3.58ArgVal: 3.58 ± 0.029	0.936ArgTrp: 0.936 ± 0.013	1.667ArgTyr: 1.667 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.744SerAla: 6.744 ± 0.038	0.962SerCys: 0.962 ± 0.015	4.316SerAsp: 4.316 ± 0.03	4.2SerGlu: 4.2 ± 0.031	3.267SerPhe: 3.267 ± 0.024	5.676SerGly: 5.676 ± 0.036	2.06SerHis: 2.06 ± 0.018	4.258SerIle: 4.258 ± 0.028	3.861SerLys: 3.861 ± 0.027	8.041SerLeu: 8.041 ± 0.047	1.673SerMet: 1.673 ± 0.018	3.321SerAsn: 3.321 ± 0.023	6.05SerPro: 6.05 ± 0.054	3.334SerGln: 3.334 ± 0.026	5.259SerArg: 5.259 ± 0.043	9.96SerSer: 9.96 ± 0.089	6.091SerThr: 6.091 ± 0.036	5.094SerVal: 5.094 ± 0.034	1.078SerTrp: 1.078 ± 0.013	2.016SerTyr: 2.016 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	4.881ThrAla: 4.881 ± 0.032	0.749ThrCys: 0.749 ± 0.013	2.621ThrAsp: 2.621 ± 0.02	2.814ThrGlu: 2.814 ± 0.021	2.5ThrPhe: 2.5 ± 0.02	3.917ThrGly: 3.917 ± 0.033	1.409ThrHis: 1.409 ± 0.018	3.163ThrIle: 3.163 ± 0.024	2.473ThrLys: 2.473 ± 0.023	5.733ThrLeu: 5.733 ± 0.032	1.136ThrMet: 1.136 ± 0.014	2.179ThrAsn: 2.179 ± 0.02	4.629ThrPro: 4.629 ± 0.039	2.111ThrGln: 2.111 ± 0.017	3.409ThrArg: 3.409 ± 0.022	5.703ThrSer: 5.703 ± 0.037	4.269ThrThr: 4.269 ± 0.035	3.889ThrVal: 3.889 ± 0.028	0.813ThrTrp: 0.813 ± 0.01	1.549ThrTyr: 1.549 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.181ValAla: 5.181 ± 0.031	0.841ValCys: 0.841 ± 0.013	3.781ValAsp: 3.781 ± 0.028	4.05ValGlu: 4.05 ± 0.042	2.455ValPhe: 2.455 ± 0.022	4.002ValGly: 4.002 ± 0.031	1.597ValHis: 1.597 ± 0.016	3.079ValIle: 3.079 ± 0.026	3.019ValLys: 3.019 ± 0.024	6.077ValLeu: 6.077 ± 0.037	1.213ValMet: 1.213 ± 0.016	2.364ValAsn: 2.364 ± 0.022	3.986ValPro: 3.986 ± 0.029	2.485ValGln: 2.485 ± 0.019	3.42ValArg: 3.42 ± 0.024	4.837ValSer: 4.837 ± 0.03	3.512ValThr: 3.512 ± 0.026	4.707ValVal: 4.707 ± 0.044	0.923ValTrp: 0.923 ± 0.014	1.801ValTyr: 1.801 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.05TrpAla: 1.05 ± 0.012	0.211TrpCys: 0.211 ± 0.006	0.908TrpAsp: 0.908 ± 0.014	0.832TrpGlu: 0.832 ± 0.013	0.575TrpPhe: 0.575 ± 0.011	0.853TrpGly: 0.853 ± 0.011	0.328TrpHis: 0.328 ± 0.007	0.755TrpIle: 0.755 ± 0.011	0.847TrpLys: 0.847 ± 0.012	1.298TrpLeu: 1.298 ± 0.017	0.335TrpMet: 0.335 ± 0.007	0.612TrpAsn: 0.612 ± 0.01	0.587TrpPro: 0.587 ± 0.011	0.472TrpGln: 0.472 ± 0.008	0.951TrpArg: 0.951 ± 0.011	1.069TrpSer: 1.069 ± 0.012	0.908TrpThr: 0.908 ± 0.013	0.873TrpVal: 0.873 ± 0.012	0.274TrpTrp: 0.274 ± 0.008	0.404TrpTyr: 0.404 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.117TyrAla: 2.117 ± 0.018	0.396TyrCys: 0.396 ± 0.007	1.61TyrAsp: 1.61 ± 0.018	1.397TyrGlu: 1.397 ± 0.016	1.124TyrPhe: 1.124 ± 0.013	1.835TyrGly: 1.835 ± 0.021	0.776TyrHis: 0.776 ± 0.011	1.383TyrIle: 1.383 ± 0.015	1.034TyrLys: 1.034 ± 0.015	2.593TyrLeu: 2.593 ± 0.02	0.519TyrMet: 0.519 ± 0.008	1.104TyrAsn: 1.104 ± 0.014	1.598TyrPro: 1.598 ± 0.019	1.049TyrGln: 1.049 ± 0.013	1.666TyrArg: 1.666 ± 0.017	2.134TyrSer: 2.134 ± 0.02	1.593TyrThr: 1.593 ± 0.018	1.569TyrVal: 1.569 ± 0.015	0.394TyrTrp: 0.394 ± 0.009	0.835TyrTyr: 0.835 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.004

Statistics based on 14526 proteins (6217334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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