Amino acid dipepetide frequency for Pseudobythopirellula maris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.585AlaAla: 16.585 ± 0.201	1.325AlaCys: 1.325 ± 0.036	7.314AlaAsp: 7.314 ± 0.093	8.898AlaGlu: 8.898 ± 0.105	3.553AlaPhe: 3.553 ± 0.051	10.055AlaGly: 10.055 ± 0.106	1.993AlaHis: 1.993 ± 0.039	5.246AlaIle: 5.246 ± 0.069	3.405AlaLys: 3.405 ± 0.063	10.726AlaLeu: 10.726 ± 0.111	2.844AlaMet: 2.844 ± 0.048	2.846AlaAsn: 2.846 ± 0.05	6.59AlaPro: 6.59 ± 0.1	3.523AlaGln: 3.523 ± 0.06	6.607AlaArg: 6.607 ± 0.091	7.266AlaSer: 7.266 ± 0.08	6.493AlaThr: 6.493 ± 0.084	8.391AlaVal: 8.391 ± 0.093	1.791AlaTrp: 1.791 ± 0.041	2.495AlaTyr: 2.495 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.877CysAla: 0.877 ± 0.032	0.279CysCys: 0.279 ± 0.034	0.756CysAsp: 0.756 ± 0.027	0.76CysGlu: 0.76 ± 0.027	0.344CysPhe: 0.344 ± 0.016	1.155CysGly: 1.155 ± 0.036	0.28CysHis: 0.28 ± 0.018	0.274CysIle: 0.274 ± 0.017	0.259CysLys: 0.259 ± 0.018	1.087CysLeu: 1.087 ± 0.029	0.173CysMet: 0.173 ± 0.012	0.242CysAsn: 0.242 ± 0.013	0.6CysPro: 0.6 ± 0.022	0.328CysGln: 0.328 ± 0.016	0.823CysArg: 0.823 ± 0.023	0.534CysSer: 0.534 ± 0.022	0.416CysThr: 0.416 ± 0.019	0.859CysVal: 0.859 ± 0.027	0.179CysTrp: 0.179 ± 0.011	0.285CysTyr: 0.285 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.232AspAla: 7.232 ± 0.088	0.613AspCys: 0.613 ± 0.024	4.279AspAsp: 4.279 ± 0.073	4.637AspGlu: 4.637 ± 0.061	2.418AspPhe: 2.418 ± 0.05	6.078AspGly: 6.078 ± 0.1	1.37AspHis: 1.37 ± 0.035	1.963AspIle: 1.963 ± 0.047	1.616AspLys: 1.616 ± 0.035	6.13AspLeu: 6.13 ± 0.086	0.937AspMet: 0.937 ± 0.029	1.658AspAsn: 1.658 ± 0.044	4.125AspPro: 4.125 ± 0.057	1.957AspGln: 1.957 ± 0.039	4.6AspArg: 4.6 ± 0.066	3.482AspSer: 3.482 ± 0.062	2.854AspThr: 2.854 ± 0.046	3.554AspVal: 3.554 ± 0.055	1.129AspTrp: 1.129 ± 0.033	1.883AspTyr: 1.883 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.955GluAla: 7.955 ± 0.095	0.541GluCys: 0.541 ± 0.019	2.835GluAsp: 2.835 ± 0.053	4.443GluGlu: 4.443 ± 0.094	2.148GluPhe: 2.148 ± 0.046	5.381GluGly: 5.381 ± 0.072	1.482GluHis: 1.482 ± 0.035	2.981GluIle: 2.981 ± 0.053	2.069GluLys: 2.069 ± 0.044	7.224GluLeu: 7.224 ± 0.085	1.515GluMet: 1.515 ± 0.037	1.678GluAsn: 1.678 ± 0.033	3.947GluPro: 3.947 ± 0.057	2.673GluGln: 2.673 ± 0.049	5.575GluArg: 5.575 ± 0.077	4.236GluSer: 4.236 ± 0.062	3.769GluThr: 3.769 ± 0.057	4.317GluVal: 4.317 ± 0.062	0.943GluTrp: 0.943 ± 0.029	1.437GluTyr: 1.437 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.752PheAla: 3.752 ± 0.046	0.446PheCys: 0.446 ± 0.018	2.789PheAsp: 2.789 ± 0.052	2.329PheGlu: 2.329 ± 0.039	1.224PhePhe: 1.224 ± 0.028	3.354PheGly: 3.354 ± 0.055	0.64PheHis: 0.64 ± 0.021	1.032PheIle: 1.032 ± 0.027	0.758PheLys: 0.758 ± 0.023	2.859PheLeu: 2.859 ± 0.052	0.512PheMet: 0.512 ± 0.02	1.042PheAsn: 1.042 ± 0.028	1.341PhePro: 1.341 ± 0.035	0.877PheGln: 0.877 ± 0.026	2.002PheArg: 2.002 ± 0.04	2.133PheSer: 2.133 ± 0.04	2.027PheThr: 2.027 ± 0.04	2.585PheVal: 2.585 ± 0.051	0.504PheTrp: 0.504 ± 0.02	0.935PheTyr: 0.935 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.021GlyAla: 10.021 ± 0.111	1.066GlyCys: 1.066 ± 0.038	6.232GlyAsp: 6.232 ± 0.103	6.322GlyGlu: 6.322 ± 0.075	3.044GlyPhe: 3.044 ± 0.058	8.43GlyGly: 8.43 ± 0.151	1.602GlyHis: 1.602 ± 0.037	2.522GlyIle: 2.522 ± 0.049	2.808GlyLys: 2.808 ± 0.051	8.164GlyLeu: 8.164 ± 0.088	2.078GlyMet: 2.078 ± 0.045	2.057GlyAsn: 2.057 ± 0.062	3.989GlyPro: 3.989 ± 0.062	2.81GlyGln: 2.81 ± 0.056	5.761GlyArg: 5.761 ± 0.063	5.296GlySer: 5.296 ± 0.085	3.385GlyThr: 3.385 ± 0.056	8.172GlyVal: 8.172 ± 0.088	1.5GlyTrp: 1.5 ± 0.036	2.379GlyTyr: 2.379 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.047	0.27HisCys: 0.27 ± 0.015	1.411HisAsp: 1.411 ± 0.035	1.33HisGlu: 1.33 ± 0.032	0.781HisPhe: 0.781 ± 0.022	1.949HisGly: 1.949 ± 0.039	0.581HisHis: 0.581 ± 0.021	0.603HisIle: 0.603 ± 0.02	0.5HisLys: 0.5 ± 0.02	1.806HisLeu: 1.806 ± 0.042	0.318HisMet: 0.318 ± 0.016	0.592HisAsn: 0.592 ± 0.022	1.184HisPro: 1.184 ± 0.032	0.65HisGln: 0.65 ± 0.021	1.403HisArg: 1.403 ± 0.035	1.104HisSer: 1.104 ± 0.031	1.053HisThr: 1.053 ± 0.028	1.369HisVal: 1.369 ± 0.034	0.372HisTrp: 0.372 ± 0.021	0.624HisTyr: 0.624 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.31IleAla: 5.31 ± 0.061	0.378IleCys: 0.378 ± 0.017	3.7IleAsp: 3.7 ± 0.057	3.479IleGlu: 3.479 ± 0.054	0.981IlePhe: 0.981 ± 0.029	3.938IleGly: 3.938 ± 0.059	0.773IleHis: 0.773 ± 0.024	1.154IleIle: 1.154 ± 0.035	1.061IleLys: 1.061 ± 0.031	2.72IleLeu: 2.72 ± 0.05	0.494IleMet: 0.494 ± 0.021	1.221IleAsn: 1.221 ± 0.032	1.59IlePro: 1.59 ± 0.037	0.966IleGln: 0.966 ± 0.029	2.437IleArg: 2.437 ± 0.046	2.01IleSer: 2.01 ± 0.045	2.209IleThr: 2.209 ± 0.045	3.153IleVal: 3.153 ± 0.054	0.374IleTrp: 0.374 ± 0.016	0.907IleTyr: 0.907 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.884LysAla: 2.884 ± 0.056	0.242LysCys: 0.242 ± 0.015	1.224LysAsp: 1.224 ± 0.033	1.601LysGlu: 1.601 ± 0.044	0.812LysPhe: 0.812 ± 0.026	1.835LysGly: 1.835 ± 0.041	0.692LysHis: 0.692 ± 0.025	1.391LysIle: 1.391 ± 0.036	1.453LysLys: 1.453 ± 0.064	3.153LysLeu: 3.153 ± 0.051	0.604LysMet: 0.604 ± 0.021	0.833LysAsn: 0.833 ± 0.025	2.018LysPro: 2.018 ± 0.046	1.237LysGln: 1.237 ± 0.033	2.219LysArg: 2.219 ± 0.047	1.691LysSer: 1.691 ± 0.038	1.75LysThr: 1.75 ± 0.045	1.818LysVal: 1.818 ± 0.045	0.326LysTrp: 0.326 ± 0.016	0.601LysTyr: 0.601 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.447LeuAla: 13.447 ± 0.131	1.053LeuCys: 1.053 ± 0.028	6.048LeuAsp: 6.048 ± 0.073	6.073LeuGlu: 6.073 ± 0.075	3.065LeuPhe: 3.065 ± 0.052	8.664LeuGly: 8.664 ± 0.087	1.824LeuHis: 1.824 ± 0.039	3.738LeuIle: 3.738 ± 0.06	2.88LeuLys: 2.88 ± 0.051	10.766LeuLeu: 10.766 ± 0.115	2.069LeuMet: 2.069 ± 0.039	2.348LeuAsn: 2.348 ± 0.039	5.179LeuPro: 5.179 ± 0.062	2.621LeuGln: 2.621 ± 0.044	7.331LeuArg: 7.331 ± 0.092	6.309LeuSer: 6.309 ± 0.08	5.663LeuThr: 5.663 ± 0.07	7.992LeuVal: 7.992 ± 0.1	1.322LeuTrp: 1.322 ± 0.037	2.025LeuTyr: 2.025 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.53MetAla: 2.53 ± 0.047	0.134MetCys: 0.134 ± 0.01	0.823MetAsp: 0.823 ± 0.028	0.862MetGlu: 0.862 ± 0.027	0.609MetPhe: 0.609 ± 0.022	1.485MetGly: 1.485 ± 0.038	0.449MetHis: 0.449 ± 0.019	0.964MetIle: 0.964 ± 0.026	0.721MetLys: 0.721 ± 0.024	2.336MetLeu: 2.336 ± 0.044	0.428MetMet: 0.428 ± 0.021	0.61MetAsn: 0.61 ± 0.018	1.392MetPro: 1.392 ± 0.032	0.722MetGln: 0.722 ± 0.024	1.592MetArg: 1.592 ± 0.034	1.361MetSer: 1.361 ± 0.036	1.424MetThr: 1.424 ± 0.037	1.328MetVal: 1.328 ± 0.038	0.191MetTrp: 0.191 ± 0.012	0.341MetTyr: 0.341 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.844AsnAla: 2.844 ± 0.052	0.254AsnCys: 0.254 ± 0.015	1.796AsnAsp: 1.796 ± 0.038	1.563AsnGlu: 1.563 ± 0.04	0.96AsnPhe: 0.96 ± 0.026	2.591AsnGly: 2.591 ± 0.062	0.646AsnHis: 0.646 ± 0.021	0.896AsnIle: 0.896 ± 0.028	0.629AsnLys: 0.629 ± 0.021	2.61AsnLeu: 2.61 ± 0.049	0.399AsnMet: 0.399 ± 0.018	0.942AsnAsn: 0.942 ± 0.034	1.78AsnPro: 1.78 ± 0.036	0.927AsnGln: 0.927 ± 0.029	1.882AsnArg: 1.882 ± 0.044	1.544AsnSer: 1.544 ± 0.04	1.405AsnThr: 1.405 ± 0.041	1.783AsnVal: 1.783 ± 0.037	0.388AsnTrp: 0.388 ± 0.019	0.761AsnTyr: 0.761 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.732ProAla: 6.732 ± 0.098	0.439ProCys: 0.439 ± 0.02	3.178ProAsp: 3.178 ± 0.051	4.195ProGlu: 4.195 ± 0.058	1.716ProPhe: 1.716 ± 0.035	4.7ProGly: 4.7 ± 0.064	1.178ProHis: 1.178 ± 0.033	2.279ProIle: 2.279 ± 0.04	1.539ProLys: 1.539 ± 0.034	5.079ProLeu: 5.079 ± 0.078	1.101ProMet: 1.101 ± 0.03	1.537ProAsn: 1.537 ± 0.036	3.27ProPro: 3.27 ± 0.065	1.86ProGln: 1.86 ± 0.042	3.246ProArg: 3.246 ± 0.056	3.681ProSer: 3.681 ± 0.062	3.393ProThr: 3.393 ± 0.067	3.887ProVal: 3.887 ± 0.063	0.822ProTrp: 0.822 ± 0.028	1.238ProTyr: 1.238 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.832GlnAla: 3.832 ± 0.057	0.295GlnCys: 0.295 ± 0.015	1.447GlnAsp: 1.447 ± 0.036	1.819GlnGlu: 1.819 ± 0.042	0.967GlnPhe: 0.967 ± 0.026	2.478GlnGly: 2.478 ± 0.041	0.708GlnHis: 0.708 ± 0.023	1.522GlnIle: 1.522 ± 0.029	0.924GlnLys: 0.924 ± 0.026	3.426GlnLeu: 3.426 ± 0.05	0.732GlnMet: 0.732 ± 0.026	0.857GlnAsn: 0.857 ± 0.026	1.943GlnPro: 1.943 ± 0.042	1.659GlnGln: 1.659 ± 0.046	2.579GlnArg: 2.579 ± 0.047	2.004GlnSer: 2.004 ± 0.04	1.791GlnThr: 1.791 ± 0.042	2.189GlnVal: 2.189 ± 0.046	0.451GlnTrp: 0.451 ± 0.017	0.728GlnTyr: 0.728 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.265ArgAla: 6.265 ± 0.088	0.763ArgCys: 0.763 ± 0.027	3.929ArgAsp: 3.929 ± 0.064	4.392ArgGlu: 4.392 ± 0.059	2.861ArgPhe: 2.861 ± 0.049	5.11ArgGly: 5.11 ± 0.072	1.516ArgHis: 1.516 ± 0.033	2.852ArgIle: 2.852 ± 0.048	1.936ArgLys: 1.936 ± 0.047	8.728ArgLeu: 8.728 ± 0.112	1.66ArgMet: 1.66 ± 0.039	1.734ArgAsn: 1.734 ± 0.038	3.501ArgPro: 3.501 ± 0.059	2.545ArgGln: 2.545 ± 0.046	6.499ArgArg: 6.499 ± 0.093	4.047ArgSer: 4.047 ± 0.061	3.243ArgThr: 3.243 ± 0.053	5.704ArgVal: 5.704 ± 0.078	1.218ArgTrp: 1.218 ± 0.031	1.9ArgTyr: 1.9 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.192SerAla: 6.192 ± 0.075	0.607SerCys: 0.607 ± 0.028	3.894SerAsp: 3.894 ± 0.062	3.649SerGlu: 3.649 ± 0.054	1.978SerPhe: 1.978 ± 0.038	5.955SerGly: 5.955 ± 0.095	1.363SerHis: 1.363 ± 0.032	2.453SerIle: 2.453 ± 0.042	1.626SerLys: 1.626 ± 0.038	6.298SerLeu: 6.298 ± 0.073	1.214SerMet: 1.214 ± 0.032	1.686SerAsn: 1.686 ± 0.04	3.75SerPro: 3.75 ± 0.06	2.157SerGln: 2.157 ± 0.042	3.959SerArg: 3.959 ± 0.06	3.674SerSer: 3.674 ± 0.062	3.227SerThr: 3.227 ± 0.063	4.348SerVal: 4.348 ± 0.06	0.856SerTrp: 0.856 ± 0.029	1.472SerTyr: 1.472 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.103ThrAla: 6.103 ± 0.071	0.466ThrCys: 0.466 ± 0.021	3.081ThrAsp: 3.081 ± 0.054	2.945ThrGlu: 2.945 ± 0.049	1.669ThrPhe: 1.669 ± 0.041	4.894ThrGly: 4.894 ± 0.084	1.169ThrHis: 1.169 ± 0.032	2.649ThrIle: 2.649 ± 0.051	1.425ThrLys: 1.425 ± 0.041	5.793ThrLeu: 5.793 ± 0.074	0.941ThrMet: 0.941 ± 0.025	1.51ThrAsn: 1.51 ± 0.038	4.156ThrPro: 4.156 ± 0.07	1.558ThrGln: 1.558 ± 0.032	3.031ThrArg: 3.031 ± 0.051	2.995ThrSer: 2.995 ± 0.053	3.311ThrThr: 3.311 ± 0.067	4.268ThrVal: 4.268 ± 0.065	0.599ThrTrp: 0.599 ± 0.019	1.151ThrTyr: 1.151 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.225ValAla: 9.225 ± 0.101	0.857ValCys: 0.857 ± 0.028	5.063ValAsp: 5.063 ± 0.066	5.494ValGlu: 5.494 ± 0.075	2.521ValPhe: 2.521 ± 0.053	6.173ValGly: 6.173 ± 0.074	1.248ValHis: 1.248 ± 0.035	3.074ValIle: 3.074 ± 0.045	1.8ValLys: 1.8 ± 0.043	7.365ValLeu: 7.365 ± 0.092	1.568ValMet: 1.568 ± 0.035	1.929ValAsn: 1.929 ± 0.039	2.914ValPro: 2.914 ± 0.052	1.916ValGln: 1.916 ± 0.034	5.206ValArg: 5.206 ± 0.066	4.586ValSer: 4.586 ± 0.058	4.348ValThr: 4.348 ± 0.064	6.818ValVal: 6.818 ± 0.094	1.256ValTrp: 1.256 ± 0.034	1.884ValTyr: 1.884 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.293TrpAla: 1.293 ± 0.033	0.186TrpCys: 0.186 ± 0.013	0.865TrpAsp: 0.865 ± 0.029	0.72TrpGlu: 0.72 ± 0.021	0.549TrpPhe: 0.549 ± 0.023	1.173TrpGly: 1.173 ± 0.03	0.29TrpHis: 0.29 ± 0.016	0.639TrpIle: 0.639 ± 0.024	0.381TrpLys: 0.381 ± 0.019	1.747TrpLeu: 1.747 ± 0.038	0.332TrpMet: 0.332 ± 0.016	0.461TrpAsn: 0.461 ± 0.02	0.716TrpPro: 0.716 ± 0.024	0.462TrpGln: 0.462 ± 0.019	1.703TrpArg: 1.703 ± 0.046	0.993TrpSer: 0.993 ± 0.029	0.733TrpThr: 0.733 ± 0.024	1.076TrpVal: 1.076 ± 0.028	0.294TrpTrp: 0.294 ± 0.016	0.317TrpTyr: 0.317 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.429TyrAla: 2.429 ± 0.041	0.298TyrCys: 0.298 ± 0.014	1.85TyrAsp: 1.85 ± 0.044	1.638TyrGlu: 1.638 ± 0.038	0.94TyrPhe: 0.94 ± 0.027	2.239TyrGly: 2.239 ± 0.041	0.538TyrHis: 0.538 ± 0.022	0.622TyrIle: 0.622 ± 0.026	0.594TyrLys: 0.594 ± 0.021	2.398TyrLeu: 2.398 ± 0.042	0.383TyrMet: 0.383 ± 0.018	0.815TyrAsn: 0.815 ± 0.028	1.085TyrPro: 1.085 ± 0.029	0.904TyrGln: 0.904 ± 0.025	1.951TyrArg: 1.951 ± 0.041	1.414TyrSer: 1.414 ± 0.037	1.221TyrThr: 1.221 ± 0.039	1.633TyrVal: 1.633 ± 0.034	0.413TyrTrp: 0.413 ± 0.018	0.77TyrTyr: 0.77 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3893 proteins (1431816 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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