Amino acid dipepetide frequency for Dethiobacter alkaliphilus AHT 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.566AlaAla: 9.566 ± 0.154	0.945AlaCys: 0.945 ± 0.038	4.603AlaAsp: 4.603 ± 0.079	6.482AlaGlu: 6.482 ± 0.093	3.196AlaPhe: 3.196 ± 0.065	7.765AlaGly: 7.765 ± 0.114	1.533AlaHis: 1.533 ± 0.047	5.362AlaIle: 5.362 ± 0.085	4.319AlaLys: 4.319 ± 0.085	9.267AlaLeu: 9.267 ± 0.114	2.589AlaMet: 2.589 ± 0.057	2.704AlaAsn: 2.704 ± 0.057	2.692AlaPro: 2.692 ± 0.064	3.203AlaGln: 3.203 ± 0.073	4.48AlaArg: 4.48 ± 0.082	3.862AlaSer: 3.862 ± 0.077	3.871AlaThr: 3.871 ± 0.064	7.748AlaVal: 7.748 ± 0.109	0.737AlaTrp: 0.737 ± 0.029	2.335AlaTyr: 2.335 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.808CysAla: 0.808 ± 0.031	0.172CysCys: 0.172 ± 0.014	0.522CysAsp: 0.522 ± 0.022	0.608CysGlu: 0.608 ± 0.027	0.387CysPhe: 0.387 ± 0.021	1.202CysGly: 1.202 ± 0.037	0.566CysHis: 0.566 ± 0.049	0.564CysIle: 0.564 ± 0.026	0.454CysLys: 0.454 ± 0.023	0.925CysLeu: 0.925 ± 0.032	0.231CysMet: 0.231 ± 0.016	0.415CysAsn: 0.415 ± 0.022	0.625CysPro: 0.625 ± 0.033	0.322CysGln: 0.322 ± 0.019	0.673CysArg: 0.673 ± 0.029	0.637CysSer: 0.637 ± 0.027	0.506CysThr: 0.506 ± 0.027	0.651CysVal: 0.651 ± 0.027	0.089CysTrp: 0.089 ± 0.011	0.329CysTyr: 0.329 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.955AspAla: 3.955 ± 0.075	0.577AspCys: 0.577 ± 0.032	2.648AspAsp: 2.648 ± 0.067	4.218AspGlu: 4.218 ± 0.08	2.386AspPhe: 2.386 ± 0.052	3.943AspGly: 3.943 ± 0.076	0.928AspHis: 0.928 ± 0.034	3.644AspIle: 3.644 ± 0.063	2.836AspLys: 2.836 ± 0.069	5.388AspLeu: 5.388 ± 0.086	1.456AspMet: 1.456 ± 0.044	1.998AspAsn: 1.998 ± 0.052	2.21AspPro: 2.21 ± 0.05	1.305AspGln: 1.305 ± 0.045	2.656AspArg: 2.656 ± 0.058	2.522AspSer: 2.522 ± 0.06	2.624AspThr: 2.624 ± 0.059	4.173AspVal: 4.173 ± 0.067	0.567AspTrp: 0.567 ± 0.027	1.947AspTyr: 1.947 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.402GluAla: 6.402 ± 0.083	0.513GluCys: 0.513 ± 0.023	3.842GluAsp: 3.842 ± 0.069	6.982GluGlu: 6.982 ± 0.131	2.35GluPhe: 2.35 ± 0.049	4.627GluGly: 4.627 ± 0.073	1.397GluHis: 1.397 ± 0.042	5.242GluIle: 5.242 ± 0.079	5.317GluLys: 5.317 ± 0.088	7.273GluLeu: 7.273 ± 0.104	2.356GluMet: 2.356 ± 0.057	3.095GluAsn: 3.095 ± 0.066	2.486GluPro: 2.486 ± 0.062	3.225GluGln: 3.225 ± 0.059	3.876GluArg: 3.876 ± 0.074	2.945GluSer: 2.945 ± 0.058	3.705GluThr: 3.705 ± 0.071	5.468GluVal: 5.468 ± 0.09	0.56GluTrp: 0.56 ± 0.027	2.106GluTyr: 2.106 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.825PheAla: 3.825 ± 0.073	0.469PheCys: 0.469 ± 0.022	2.058PheAsp: 2.058 ± 0.045	2.025PheGlu: 2.025 ± 0.052	2.133PhePhe: 2.133 ± 0.054	3.164PheGly: 3.164 ± 0.065	0.757PheHis: 0.757 ± 0.029	2.852PheIle: 2.852 ± 0.068	1.622PheLys: 1.622 ± 0.046	4.268PheLeu: 4.268 ± 0.086	1.099PheMet: 1.099 ± 0.04	1.528PheAsn: 1.528 ± 0.041	1.748PhePro: 1.748 ± 0.045	1.17PheGln: 1.17 ± 0.037	1.879PheArg: 1.879 ± 0.045	2.938PheSer: 2.938 ± 0.061	2.286PheThr: 2.286 ± 0.05	2.96PheVal: 2.96 ± 0.06	0.504PheTrp: 0.504 ± 0.025	1.395PheTyr: 1.395 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.05GlyAla: 6.05 ± 0.117	1.075GlyCys: 1.075 ± 0.038	3.715GlyAsp: 3.715 ± 0.065	5.463GlyGlu: 5.463 ± 0.073	3.35GlyPhe: 3.35 ± 0.065	5.782GlyGly: 5.782 ± 0.109	1.457GlyHis: 1.457 ± 0.037	5.527GlyIle: 5.527 ± 0.089	4.399GlyLys: 4.399 ± 0.085	7.641GlyLeu: 7.641 ± 0.112	2.351GlyMet: 2.351 ± 0.051	2.587GlyAsn: 2.587 ± 0.063	2.305GlyPro: 2.305 ± 0.053	2.712GlyGln: 2.712 ± 0.059	3.991GlyArg: 3.991 ± 0.066	4.158GlySer: 4.158 ± 0.077	4.183GlyThr: 4.183 ± 0.071	5.685GlyVal: 5.685 ± 0.09	0.809GlyTrp: 0.809 ± 0.031	2.733GlyTyr: 2.733 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.431HisAla: 1.431 ± 0.045	0.301HisCys: 0.301 ± 0.018	0.986HisAsp: 0.986 ± 0.036	1.117HisGlu: 1.117 ± 0.038	0.852HisPhe: 0.852 ± 0.03	1.602HisGly: 1.602 ± 0.042	0.512HisHis: 0.512 ± 0.029	1.192HisIle: 1.192 ± 0.035	0.876HisLys: 0.876 ± 0.028	1.95HisLeu: 1.95 ± 0.046	0.431HisMet: 0.431 ± 0.023	0.846HisAsn: 0.846 ± 0.036	1.087HisPro: 1.087 ± 0.036	0.745HisGln: 0.745 ± 0.028	1.079HisArg: 1.079 ± 0.035	1.115HisSer: 1.115 ± 0.036	1.094HisThr: 1.094 ± 0.034	1.37HisVal: 1.37 ± 0.04	0.216HisTrp: 0.216 ± 0.017	0.774HisTyr: 0.774 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.571IleAla: 5.571 ± 0.088	0.711IleCys: 0.711 ± 0.028	3.394IleAsp: 3.394 ± 0.066	4.016IleGlu: 4.016 ± 0.077	2.87IlePhe: 2.87 ± 0.072	4.597IleGly: 4.597 ± 0.081	1.265IleHis: 1.265 ± 0.042	4.784IleIle: 4.784 ± 0.09	3.285IleLys: 3.285 ± 0.067	6.753IleLeu: 6.753 ± 0.107	1.685IleMet: 1.685 ± 0.047	2.681IleAsn: 2.681 ± 0.059	3.008IlePro: 3.008 ± 0.064	1.805IleGln: 1.805 ± 0.039	3.389IleArg: 3.389 ± 0.064	4.117IleSer: 4.117 ± 0.067	3.819IleThr: 3.819 ± 0.073	4.599IleVal: 4.599 ± 0.086	0.572IleTrp: 0.572 ± 0.024	2.055IleTyr: 2.055 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.279LysAla: 4.279 ± 0.074	0.45LysCys: 0.45 ± 0.024	2.959LysAsp: 2.959 ± 0.069	4.793LysGlu: 4.793 ± 0.082	1.382LysPhe: 1.382 ± 0.043	3.231LysGly: 3.231 ± 0.056	0.933LysHis: 0.933 ± 0.035	3.541LysIle: 3.541 ± 0.07	4.155LysLys: 4.155 ± 0.078	4.914LysLeu: 4.914 ± 0.085	1.59LysMet: 1.59 ± 0.039	2.356LysAsn: 2.356 ± 0.051	2.041LysPro: 2.041 ± 0.056	2.084LysGln: 2.084 ± 0.053	2.753LysArg: 2.753 ± 0.052	2.491LysSer: 2.491 ± 0.056	2.776LysThr: 2.776 ± 0.059	3.853LysVal: 3.853 ± 0.078	0.407LysTrp: 0.407 ± 0.022	1.593LysTyr: 1.593 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	10.197LeuAla: 10.197 ± 0.136	1.033LeuCys: 1.033 ± 0.042	5.375LeuAsp: 5.375 ± 0.076	7.373LeuGlu: 7.373 ± 0.094	4.222LeuPhe: 4.222 ± 0.081	7.755LeuGly: 7.755 ± 0.113	1.97LeuHis: 1.97 ± 0.045	6.035LeuIle: 6.035 ± 0.091	5.042LeuLys: 5.042 ± 0.079	11.173LeuLeu: 11.173 ± 0.17	2.509LeuMet: 2.509 ± 0.049	3.6LeuAsn: 3.6 ± 0.069	4.899LeuPro: 4.899 ± 0.08	4.267LeuGln: 4.267 ± 0.078	5.319LeuArg: 5.319 ± 0.086	6.448LeuSer: 6.448 ± 0.115	5.913LeuThr: 5.913 ± 0.098	7.382LeuVal: 7.382 ± 0.096	0.875LeuTrp: 0.875 ± 0.034	2.912LeuTyr: 2.912 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.641MetAla: 2.641 ± 0.068	0.181MetCys: 0.181 ± 0.013	1.519MetAsp: 1.519 ± 0.041	2.062MetGlu: 2.062 ± 0.048	1.005MetPhe: 1.005 ± 0.033	2.086MetGly: 2.086 ± 0.057	0.485MetHis: 0.485 ± 0.022	1.559MetIle: 1.559 ± 0.044	1.583MetLys: 1.583 ± 0.048	2.862MetLeu: 2.862 ± 0.064	0.738MetMet: 0.738 ± 0.027	0.942MetAsn: 0.942 ± 0.032	1.241MetPro: 1.241 ± 0.042	1.081MetGln: 1.081 ± 0.037	1.392MetArg: 1.392 ± 0.038	1.608MetSer: 1.608 ± 0.043	1.523MetThr: 1.523 ± 0.042	2.126MetVal: 2.126 ± 0.057	0.179MetTrp: 0.179 ± 0.012	0.608MetTyr: 0.608 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.611AsnAla: 2.611 ± 0.061	0.464AsnCys: 0.464 ± 0.023	1.69AsnAsp: 1.69 ± 0.042	2.358AsnGlu: 2.358 ± 0.057	1.396AsnPhe: 1.396 ± 0.046	2.407AsnGly: 2.407 ± 0.059	0.755AsnHis: 0.755 ± 0.03	2.839AsnIle: 2.839 ± 0.058	2.069AsnLys: 2.069 ± 0.058	3.96AsnLeu: 3.96 ± 0.067	1.078AsnMet: 1.078 ± 0.04	1.728AsnAsn: 1.728 ± 0.05	2.118AsnPro: 2.118 ± 0.049	1.3AsnGln: 1.3 ± 0.039	2.101AsnArg: 2.101 ± 0.056	1.813AsnSer: 1.813 ± 0.049	1.829AsnThr: 1.829 ± 0.048	2.735AsnVal: 2.735 ± 0.056	0.409AsnTrp: 0.409 ± 0.021	1.239AsnTyr: 1.239 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.681ProAla: 3.681 ± 0.07	0.393ProCys: 0.393 ± 0.024	2.61ProAsp: 2.61 ± 0.054	3.668ProGlu: 3.668 ± 0.062	1.797ProPhe: 1.797 ± 0.047	3.646ProGly: 3.646 ± 0.066	0.983ProHis: 0.983 ± 0.034	1.959ProIle: 1.959 ± 0.053	1.762ProLys: 1.762 ± 0.048	4.132ProLeu: 4.132 ± 0.068	0.905ProMet: 0.905 ± 0.03	1.27ProAsn: 1.27 ± 0.037	1.585ProPro: 1.585 ± 0.049	1.987ProGln: 1.987 ± 0.05	1.874ProArg: 1.874 ± 0.047	1.722ProSer: 1.722 ± 0.044	1.826ProThr: 1.826 ± 0.044	3.872ProVal: 3.872 ± 0.068	0.438ProTrp: 0.438 ± 0.02	1.356ProTyr: 1.356 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.495GlnAla: 3.495 ± 0.068	0.378GlnCys: 0.378 ± 0.026	1.802GlnAsp: 1.802 ± 0.043	3.202GlnGlu: 3.202 ± 0.073	1.27GlnPhe: 1.27 ± 0.041	2.571GlnGly: 2.571 ± 0.051	0.707GlnHis: 0.707 ± 0.026	2.39GlnIle: 2.39 ± 0.056	2.387GlnLys: 2.387 ± 0.054	3.555GlnLeu: 3.555 ± 0.067	1.122GlnMet: 1.122 ± 0.033	1.495GlnAsn: 1.495 ± 0.043	1.284GlnPro: 1.284 ± 0.042	1.916GlnGln: 1.916 ± 0.065	1.982GlnArg: 1.982 ± 0.051	1.868GlnSer: 1.868 ± 0.052	1.758GlnThr: 1.758 ± 0.042	2.87GlnVal: 2.87 ± 0.061	0.338GlnTrp: 0.338 ± 0.019	1.012GlnTyr: 1.012 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.683ArgAla: 3.683 ± 0.059	0.542ArgCys: 0.542 ± 0.027	2.759ArgAsp: 2.759 ± 0.065	4.503ArgGlu: 4.503 ± 0.085	2.249ArgPhe: 2.249 ± 0.043	3.387ArgGly: 3.387 ± 0.068	1.113ArgHis: 1.113 ± 0.034	3.514ArgIle: 3.514 ± 0.06	2.805ArgLys: 2.805 ± 0.053	5.632ArgLeu: 5.632 ± 0.091	1.438ArgMet: 1.438 ± 0.044	1.857ArgAsn: 1.857 ± 0.052	2.053ArgPro: 2.053 ± 0.049	2.5ArgGln: 2.5 ± 0.058	3.143ArgArg: 3.143 ± 0.064	2.666ArgSer: 2.666 ± 0.053	2.315ArgThr: 2.315 ± 0.056	3.867ArgVal: 3.867 ± 0.073	0.488ArgTrp: 0.488 ± 0.023	1.896ArgTyr: 1.896 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.467SerAla: 4.467 ± 0.076	0.648SerCys: 0.648 ± 0.037	2.497SerAsp: 2.497 ± 0.052	3.437SerGlu: 3.437 ± 0.065	2.501SerPhe: 2.501 ± 0.053	4.883SerGly: 4.883 ± 0.073	1.064SerHis: 1.064 ± 0.035	3.249SerIle: 3.249 ± 0.062	2.286SerLys: 2.286 ± 0.056	5.878SerLeu: 5.878 ± 0.087	1.464SerMet: 1.464 ± 0.038	1.562SerAsn: 1.562 ± 0.047	2.38SerPro: 2.38 ± 0.059	1.959SerGln: 1.959 ± 0.047	3.056SerArg: 3.056 ± 0.055	2.873SerSer: 2.873 ± 0.059	2.548SerThr: 2.548 ± 0.051	4.234SerVal: 4.234 ± 0.072	0.567SerTrp: 0.567 ± 0.028	1.64SerTyr: 1.64 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.705ThrAla: 4.705 ± 0.08	0.532ThrCys: 0.532 ± 0.029	2.707ThrAsp: 2.707 ± 0.06	3.43ThrGlu: 3.43 ± 0.069	2.139ThrPhe: 2.139 ± 0.051	4.697ThrGly: 4.697 ± 0.077	0.971ThrHis: 0.971 ± 0.03	3.215ThrIle: 3.215 ± 0.069	2.143ThrLys: 2.143 ± 0.045	5.513ThrLeu: 5.513 ± 0.076	1.317ThrMet: 1.317 ± 0.036	1.784ThrAsn: 1.784 ± 0.045	2.59ThrPro: 2.59 ± 0.068	1.521ThrGln: 1.521 ± 0.04	2.456ThrArg: 2.456 ± 0.054	2.545ThrSer: 2.545 ± 0.053	2.709ThrThr: 2.709 ± 0.05	4.695ThrVal: 4.695 ± 0.071	0.439ThrTrp: 0.439 ± 0.021	1.558ThrTyr: 1.558 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	7.103ValAla: 7.103 ± 0.104	0.817ValCys: 0.817 ± 0.034	4.181ValAsp: 4.181 ± 0.064	5.402ValGlu: 5.402 ± 0.084	3.292ValPhe: 3.292 ± 0.065	5.469ValGly: 5.469 ± 0.083	1.282ValHis: 1.282 ± 0.038	5.142ValIle: 5.142 ± 0.091	3.591ValLys: 3.591 ± 0.066	8.324ValLeu: 8.324 ± 0.117	2.119ValMet: 2.119 ± 0.054	2.83ValAsn: 2.83 ± 0.061	3.252ValPro: 3.252 ± 0.054	2.424ValGln: 2.424 ± 0.052	3.851ValArg: 3.851 ± 0.065	4.666ValSer: 4.666 ± 0.069	4.407ValThr: 4.407 ± 0.07	6.466ValVal: 6.466 ± 0.109	0.657ValTrp: 0.657 ± 0.029	2.135ValTyr: 2.135 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.608TrpAla: 0.608 ± 0.025	0.091TrpCys: 0.091 ± 0.009	0.506TrpAsp: 0.506 ± 0.021	0.729TrpGlu: 0.729 ± 0.033	0.386TrpPhe: 0.386 ± 0.023	0.686TrpGly: 0.686 ± 0.029	0.211TrpHis: 0.211 ± 0.014	0.51TrpIle: 0.51 ± 0.023	0.347TrpLys: 0.347 ± 0.021	1.184TrpLeu: 1.184 ± 0.038	0.222TrpMet: 0.222 ± 0.014	0.323TrpAsn: 0.323 ± 0.018	0.422TrpPro: 0.422 ± 0.019	0.615TrpGln: 0.615 ± 0.028	0.539TrpArg: 0.539 ± 0.018	0.469TrpSer: 0.469 ± 0.024	0.393TrpThr: 0.393 ± 0.021	0.655TrpVal: 0.655 ± 0.025	0.141TrpTrp: 0.141 ± 0.014	0.287TrpTyr: 0.287 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.181TyrAla: 2.181 ± 0.053	0.392TyrCys: 0.392 ± 0.02	1.611TyrAsp: 1.611 ± 0.053	1.894TyrGlu: 1.894 ± 0.047	1.517TyrPhe: 1.517 ± 0.045	2.475TyrGly: 2.475 ± 0.055	0.686TyrHis: 0.686 ± 0.029	1.854TyrIle: 1.854 ± 0.05	1.304TyrLys: 1.304 ± 0.041	3.704TyrLeu: 3.704 ± 0.065	0.724TyrMet: 0.724 ± 0.029	1.296TyrAsn: 1.296 ± 0.037	1.446TyrPro: 1.446 ± 0.042	1.261TyrGln: 1.261 ± 0.04	1.922TyrArg: 1.922 ± 0.046	1.73TyrSer: 1.73 ± 0.041	1.579TyrThr: 1.579 ± 0.05	2.0TyrVal: 2.0 ± 0.045	0.331TyrTrp: 0.331 ± 0.017	1.122TyrTyr: 1.122 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3162 proteins (920342 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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