Amino acid dipepetide frequency for Corynebacterium durum F0235

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.515AlaAla: 14.515 ± 0.187
1.024AlaCys: 1.024 ± 0.037
6.749AlaAsp: 6.749 ± 0.116
7.0AlaGlu: 7.0 ± 0.107
3.392AlaPhe: 3.392 ± 0.07
8.877AlaGly: 8.877 ± 0.117
2.507AlaHis: 2.507 ± 0.056
5.364AlaIle: 5.364 ± 0.096
3.283AlaLys: 3.283 ± 0.075
11.071AlaLeu: 11.071 ± 0.143
2.568AlaMet: 2.568 ± 0.062
2.759AlaAsn: 2.759 ± 0.064
4.815AlaPro: 4.815 ± 0.092
4.244AlaGln: 4.244 ± 0.074
6.581AlaArg: 6.581 ± 0.11
6.199AlaSer: 6.199 ± 0.098
6.747AlaThr: 6.747 ± 0.117
9.193AlaVal: 9.193 ± 0.111
1.463AlaTrp: 1.463 ± 0.045
2.244AlaTyr: 2.244 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.01CysAla: 1.01 ± 0.034
0.142CysCys: 0.142 ± 0.014
0.564CysAsp: 0.564 ± 0.027
0.48CysGlu: 0.48 ± 0.027
0.301CysPhe: 0.301 ± 0.019
0.938CysGly: 0.938 ± 0.036
0.198CysHis: 0.198 ± 0.018
0.398CysIle: 0.398 ± 0.023
0.17CysLys: 0.17 ± 0.016
0.722CysLeu: 0.722 ± 0.031
0.167CysMet: 0.167 ± 0.013
0.228CysAsn: 0.228 ± 0.015
0.447CysPro: 0.447 ± 0.027
0.243CysGln: 0.243 ± 0.017
0.429CysArg: 0.429 ± 0.027
0.547CysSer: 0.547 ± 0.029
0.588CysThr: 0.588 ± 0.028
0.79CysVal: 0.79 ± 0.031
0.151CysTrp: 0.151 ± 0.016
0.19CysTyr: 0.19 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.409AspAla: 7.409 ± 0.11
0.461AspCys: 0.461 ± 0.024
3.942AspAsp: 3.942 ± 0.082
3.667AspGlu: 3.667 ± 0.087
2.054AspPhe: 2.054 ± 0.048
4.884AspGly: 4.884 ± 0.076
1.359AspHis: 1.359 ± 0.042
3.45AspIle: 3.45 ± 0.068
2.033AspLys: 2.033 ± 0.056
5.319AspLeu: 5.319 ± 0.091
1.4AspMet: 1.4 ± 0.042
2.078AspAsn: 2.078 ± 0.051
3.457AspPro: 3.457 ± 0.072
1.866AspGln: 1.866 ± 0.048
3.274AspArg: 3.274 ± 0.064
3.436AspSer: 3.436 ± 0.067
3.594AspThr: 3.594 ± 0.081
5.362AspVal: 5.362 ± 0.089
0.798AspTrp: 0.798 ± 0.034
1.718AspTyr: 1.718 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.678GluAla: 5.678 ± 0.107
0.432GluCys: 0.432 ± 0.021
3.06GluAsp: 3.06 ± 0.064
3.778GluGlu: 3.778 ± 0.091
1.877GluPhe: 1.877 ± 0.053
3.807GluGly: 3.807 ± 0.081
1.59GluHis: 1.59 ± 0.049
2.862GluIle: 2.862 ± 0.063
2.48GluLys: 2.48 ± 0.067
6.736GluLeu: 6.736 ± 0.108
1.199GluMet: 1.199 ± 0.037
1.751GluAsn: 1.751 ± 0.046
2.514GluPro: 2.514 ± 0.059
2.787GluGln: 2.787 ± 0.063
3.829GluArg: 3.829 ± 0.07
3.076GluSer: 3.076 ± 0.058
2.968GluThr: 2.968 ± 0.058
4.495GluVal: 4.495 ± 0.081
0.818GluTrp: 0.818 ± 0.037
1.38GluTyr: 1.38 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.515PheAla: 3.515 ± 0.067
0.301PheCys: 0.301 ± 0.018
2.402PheAsp: 2.402 ± 0.047
1.648PheGlu: 1.648 ± 0.043
1.41PhePhe: 1.41 ± 0.047
3.298PheGly: 3.298 ± 0.067
0.772PheHis: 0.772 ± 0.031
1.79PheIle: 1.79 ± 0.05
0.797PheLys: 0.797 ± 0.034
3.095PheLeu: 3.095 ± 0.069
0.743PheMet: 0.743 ± 0.029
1.135PheAsn: 1.135 ± 0.033
1.504PhePro: 1.504 ± 0.042
0.89PheGln: 0.89 ± 0.032
1.686PheArg: 1.686 ± 0.043
2.371PheSer: 2.371 ± 0.055
2.347PheThr: 2.347 ± 0.058
2.576PheVal: 2.576 ± 0.062
0.409PheTrp: 0.409 ± 0.023
0.893PheTyr: 0.893 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
8.036GlyAla: 8.036 ± 0.118
0.785GlyCys: 0.785 ± 0.031
4.644GlyAsp: 4.644 ± 0.082
4.525GlyGlu: 4.525 ± 0.073
3.081GlyPhe: 3.081 ± 0.063
6.622GlyGly: 6.622 ± 0.125
1.866GlyHis: 1.866 ± 0.051
4.668GlyIle: 4.668 ± 0.075
3.003GlyLys: 3.003 ± 0.064
7.427GlyLeu: 7.427 ± 0.11
2.231GlyMet: 2.231 ± 0.053
2.407GlyAsn: 2.407 ± 0.063
3.101GlyPro: 3.101 ± 0.063
2.599GlyGln: 2.599 ± 0.058
4.52GlyArg: 4.52 ± 0.087
4.908GlySer: 4.908 ± 0.085
5.287GlyThr: 5.287 ± 0.095
7.292GlyVal: 7.292 ± 0.099
1.356GlyTrp: 1.356 ± 0.041
2.168GlyTyr: 2.168 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.055
0.245HisCys: 0.245 ± 0.019
1.525HisAsp: 1.525 ± 0.048
1.076HisGlu: 1.076 ± 0.035
0.724HisPhe: 0.724 ± 0.032
1.971HisGly: 1.971 ± 0.044
0.712HisHis: 0.712 ± 0.032
1.308HisIle: 1.308 ± 0.04
0.607HisLys: 0.607 ± 0.03
2.018HisLeu: 2.018 ± 0.048
0.571HisMet: 0.571 ± 0.024
0.884HisAsn: 0.884 ± 0.034
1.545HisPro: 1.545 ± 0.042
0.792HisGln: 0.792 ± 0.033
1.51HisArg: 1.51 ± 0.05
1.353HisSer: 1.353 ± 0.042
1.451HisThr: 1.451 ± 0.043
1.794HisVal: 1.794 ± 0.051
0.319HisTrp: 0.319 ± 0.021
0.65HisTyr: 0.65 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.429IleAla: 6.429 ± 0.085
0.426IleCys: 0.426 ± 0.025
3.841IleAsp: 3.841 ± 0.069
2.818IleGlu: 2.818 ± 0.071
1.637IlePhe: 1.637 ± 0.051
4.341IleGly: 4.341 ± 0.073
1.098IleHis: 1.098 ± 0.039
2.865IleIle: 2.865 ± 0.078
1.485IleLys: 1.485 ± 0.052
4.204IleLeu: 4.204 ± 0.072
1.138IleMet: 1.138 ± 0.042
1.845IleAsn: 1.845 ± 0.054
2.939IlePro: 2.939 ± 0.065
1.389IleGln: 1.389 ± 0.039
2.902IleArg: 2.902 ± 0.06
3.189IleSer: 3.189 ± 0.064
3.641IleThr: 3.641 ± 0.072
4.683IleVal: 4.683 ± 0.087
0.49IleTrp: 0.49 ± 0.023
1.099IleTyr: 1.099 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
3.358LysAla: 3.358 ± 0.076
0.166LysCys: 0.166 ± 0.014
2.072LysAsp: 2.072 ± 0.053
2.024LysGlu: 2.024 ± 0.06
0.878LysPhe: 0.878 ± 0.03
2.133LysGly: 2.133 ± 0.056
0.772LysHis: 0.772 ± 0.031
1.661LysIle: 1.661 ± 0.054
1.719LysLys: 1.719 ± 0.069
3.028LysLeu: 3.028 ± 0.073
0.724LysMet: 0.724 ± 0.03
1.286LysAsn: 1.286 ± 0.04
1.739LysPro: 1.739 ± 0.05
1.295LysGln: 1.295 ± 0.043
2.014LysArg: 2.014 ± 0.057
1.632LysSer: 1.632 ± 0.051
1.9LysThr: 1.9 ± 0.047
2.517LysVal: 2.517 ± 0.063
0.375LysTrp: 0.375 ± 0.019
0.716LysTyr: 0.716 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
11.222LeuAla: 11.222 ± 0.135
0.957LeuCys: 0.957 ± 0.036
5.9LeuAsp: 5.9 ± 0.082
4.722LeuGlu: 4.722 ± 0.083
3.128LeuPhe: 3.128 ± 0.066
8.124LeuGly: 8.124 ± 0.117
2.09LeuHis: 2.09 ± 0.045
5.113LeuIle: 5.113 ± 0.092
2.802LeuLys: 2.802 ± 0.068
9.301LeuLeu: 9.301 ± 0.13
2.071LeuMet: 2.071 ± 0.055
2.857LeuAsn: 2.857 ± 0.055
5.255LeuPro: 5.255 ± 0.088
2.816LeuGln: 2.816 ± 0.055
6.221LeuArg: 6.221 ± 0.079
6.176LeuSer: 6.176 ± 0.098
6.082LeuThr: 6.082 ± 0.094
7.776LeuVal: 7.776 ± 0.11
1.239LeuTrp: 1.239 ± 0.043
1.935LeuTyr: 1.935 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.308MetAla: 2.308 ± 0.051
0.212MetCys: 0.212 ± 0.017
1.215MetAsp: 1.215 ± 0.038
1.167MetGlu: 1.167 ± 0.038
0.778MetPhe: 0.778 ± 0.033
1.762MetGly: 1.762 ± 0.051
0.494MetHis: 0.494 ± 0.026
1.185MetIle: 1.185 ± 0.044
0.793MetLys: 0.793 ± 0.029
2.467MetLeu: 2.467 ± 0.062
0.652MetMet: 0.652 ± 0.032
0.736MetAsn: 0.736 ± 0.031
1.273MetPro: 1.273 ± 0.041
0.743MetGln: 0.743 ± 0.027
1.497MetArg: 1.497 ± 0.048
1.773MetSer: 1.773 ± 0.044
1.669MetThr: 1.669 ± 0.043
1.88MetVal: 1.88 ± 0.049
0.359MetTrp: 0.359 ± 0.023
0.426MetTyr: 0.426 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.195AsnAla: 3.195 ± 0.068
0.267AsnCys: 0.267 ± 0.018
1.804AsnAsp: 1.804 ± 0.048
1.496AsnGlu: 1.496 ± 0.046
0.977AsnPhe: 0.977 ± 0.034
2.476AsnGly: 2.476 ± 0.064
0.682AsnHis: 0.682 ± 0.033
1.704AsnIle: 1.704 ± 0.054
1.149AsnLys: 1.149 ± 0.04
2.794AsnLeu: 2.794 ± 0.058
0.634AsnMet: 0.634 ± 0.028
1.296AsnAsn: 1.296 ± 0.042
2.299AsnPro: 2.299 ± 0.051
0.976AsnGln: 0.976 ± 0.038
1.694AsnArg: 1.694 ± 0.046
2.019AsnSer: 2.019 ± 0.05
1.989AsnThr: 1.989 ± 0.053
2.341AsnVal: 2.341 ± 0.047
0.411AsnTrp: 0.411 ± 0.024
0.79AsnTyr: 0.79 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
5.369ProAla: 5.369 ± 0.101
0.32ProCys: 0.32 ± 0.019
3.503ProAsp: 3.503 ± 0.061
3.748ProGlu: 3.748 ± 0.073
1.617ProPhe: 1.617 ± 0.039
4.34ProGly: 4.34 ± 0.084
1.34ProHis: 1.34 ± 0.036
2.301ProIle: 2.301 ± 0.054
1.519ProLys: 1.519 ± 0.049
4.633ProLeu: 4.633 ± 0.085
1.101ProMet: 1.101 ± 0.035
1.574ProAsn: 1.574 ± 0.048
2.105ProPro: 2.105 ± 0.071
1.971ProGln: 1.971 ± 0.053
2.669ProArg: 2.669 ± 0.054
2.996ProSer: 2.996 ± 0.06
3.479ProThr: 3.479 ± 0.08
4.08ProVal: 4.08 ± 0.071
0.73ProTrp: 0.73 ± 0.034
1.093ProTyr: 1.093 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.879GlnAla: 3.879 ± 0.076
0.244GlnCys: 0.244 ± 0.017
1.67GlnAsp: 1.67 ± 0.053
2.016GlnGlu: 2.016 ± 0.053
1.084GlnPhe: 1.084 ± 0.04
2.409GlnGly: 2.409 ± 0.052
0.997GlnHis: 0.997 ± 0.033
1.528GlnIle: 1.528 ± 0.046
1.108GlnLys: 1.108 ± 0.045
3.92GlnLeu: 3.92 ± 0.076
0.803GlnMet: 0.803 ± 0.032
0.897GlnAsn: 0.897 ± 0.034
1.9GlnPro: 1.9 ± 0.057
1.849GlnGln: 1.849 ± 0.065
2.775GlnArg: 2.775 ± 0.06
1.738GlnSer: 1.738 ± 0.043
1.527GlnThr: 1.527 ± 0.046
2.692GlnVal: 2.692 ± 0.056
0.609GlnTrp: 0.609 ± 0.027
0.779GlnTyr: 0.779 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
5.942ArgAla: 5.942 ± 0.091
0.504ArgCys: 0.504 ± 0.022
3.599ArgAsp: 3.599 ± 0.068
3.654ArgGlu: 3.654 ± 0.075
2.199ArgPhe: 2.199 ± 0.05
4.286ArgGly: 4.286 ± 0.077
1.49ArgHis: 1.49 ± 0.047
3.472ArgIle: 3.472 ± 0.061
2.026ArgLys: 2.026 ± 0.057
5.574ArgLeu: 5.574 ± 0.079
1.677ArgMet: 1.677 ± 0.047
1.95ArgAsn: 1.95 ± 0.05
2.677ArgPro: 2.677 ± 0.061
2.098ArgGln: 2.098 ± 0.057
4.851ArgArg: 4.851 ± 0.097
3.504ArgSer: 3.504 ± 0.064
3.728ArgThr: 3.728 ± 0.066
4.571ArgVal: 4.571 ± 0.074
0.99ArgTrp: 0.99 ± 0.033
1.641ArgTyr: 1.641 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.455SerAla: 6.455 ± 0.091
0.482SerCys: 0.482 ± 0.027
3.666SerAsp: 3.666 ± 0.072
3.339SerGlu: 3.339 ± 0.069
2.073SerPhe: 2.073 ± 0.055
5.543SerGly: 5.543 ± 0.087
1.314SerHis: 1.314 ± 0.042
3.254SerIle: 3.254 ± 0.071
1.758SerLys: 1.758 ± 0.051
5.537SerLeu: 5.537 ± 0.093
1.597SerMet: 1.597 ± 0.046
1.756SerAsn: 1.756 ± 0.05
2.981SerPro: 2.981 ± 0.068
1.988SerGln: 1.988 ± 0.041
3.436SerArg: 3.436 ± 0.068
4.114SerSer: 4.114 ± 0.095
4.21SerThr: 4.21 ± 0.072
4.596SerVal: 4.596 ± 0.072
0.946SerTrp: 0.946 ± 0.036
1.443SerTyr: 1.443 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
6.774ThrAla: 6.774 ± 0.108
0.552ThrCys: 0.552 ± 0.026
3.568ThrAsp: 3.568 ± 0.069
3.114ThrGlu: 3.114 ± 0.064
2.129ThrPhe: 2.129 ± 0.063
5.067ThrGly: 5.067 ± 0.091
1.566ThrHis: 1.566 ± 0.046
3.44ThrIle: 3.44 ± 0.068
1.795ThrLys: 1.795 ± 0.05
6.109ThrLeu: 6.109 ± 0.086
1.5ThrMet: 1.5 ± 0.04
1.875ThrAsn: 1.875 ± 0.048
4.088ThrPro: 4.088 ± 0.094
2.063ThrGln: 2.063 ± 0.055
3.309ThrArg: 3.309 ± 0.058
3.922ThrSer: 3.922 ± 0.067
4.457ThrThr: 4.457 ± 0.097
5.595ThrVal: 5.595 ± 0.095
0.931ThrTrp: 0.931 ± 0.028
1.508ThrTyr: 1.508 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
9.417ValAla: 9.417 ± 0.125
0.78ValCys: 0.78 ± 0.034
5.71ValAsp: 5.71 ± 0.092
4.85ValGlu: 4.85 ± 0.079
2.821ValPhe: 2.821 ± 0.063
6.584ValGly: 6.584 ± 0.104
1.814ValHis: 1.814 ± 0.046
4.293ValIle: 4.293 ± 0.081
2.339ValLys: 2.339 ± 0.063
7.968ValLeu: 7.968 ± 0.139
1.798ValMet: 1.798 ± 0.054
2.44ValAsn: 2.44 ± 0.057
4.002ValPro: 4.002 ± 0.08
2.376ValGln: 2.376 ± 0.055
4.671ValArg: 4.671 ± 0.086
5.16ValSer: 5.16 ± 0.089
5.494ValThr: 5.494 ± 0.093
8.0ValVal: 8.0 ± 0.121
1.041ValTrp: 1.041 ± 0.042
1.654ValTyr: 1.654 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.398TrpAla: 1.398 ± 0.047
0.184TrpCys: 0.184 ± 0.015
0.746TrpAsp: 0.746 ± 0.031
0.744TrpGlu: 0.744 ± 0.032
0.526TrpPhe: 0.526 ± 0.025
1.011TrpGly: 1.011 ± 0.036
0.315TrpHis: 0.315 ± 0.02
0.707TrpIle: 0.707 ± 0.036
0.464TrpLys: 0.464 ± 0.024
1.618TrpLeu: 1.618 ± 0.046
0.373TrpMet: 0.373 ± 0.022
0.46TrpAsn: 0.46 ± 0.026
0.609TrpPro: 0.609 ± 0.028
0.588TrpGln: 0.588 ± 0.027
0.953TrpArg: 0.953 ± 0.038
0.852TrpSer: 0.852 ± 0.037
0.791TrpThr: 0.791 ± 0.03
1.138TrpVal: 1.138 ± 0.039
0.365TrpTrp: 0.365 ± 0.024
0.324TrpTyr: 0.324 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.309TyrAla: 2.309 ± 0.054
0.217TyrCys: 0.217 ± 0.017
1.381TyrAsp: 1.381 ± 0.048
1.249TyrGlu: 1.249 ± 0.04
0.894TyrPhe: 0.894 ± 0.03
2.053TyrGly: 2.053 ± 0.046
0.456TyrHis: 0.456 ± 0.022
1.094TyrIle: 1.094 ± 0.04
0.68TyrLys: 0.68 ± 0.034
2.245TyrLeu: 2.245 ± 0.053
0.441TyrMet: 0.441 ± 0.026
0.779TyrAsn: 0.779 ± 0.03
1.238TyrPro: 1.238 ± 0.037
0.854TyrGln: 0.854 ± 0.031
1.613TyrArg: 1.613 ± 0.044
1.523TyrSer: 1.523 ± 0.043
1.412TyrThr: 1.412 ± 0.045
1.84TyrVal: 1.84 ± 0.048
0.367TyrTrp: 0.367 ± 0.023
0.629TyrTyr: 0.629 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2823 proteins (843542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski