Amino acid dipepetide frequency for Lacimicrobium alkaliphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.039AlaAla: 8.039 ± 0.115
1.0AlaCys: 1.0 ± 0.029
5.468AlaAsp: 5.468 ± 0.065
6.214AlaGlu: 6.214 ± 0.083
3.414AlaPhe: 3.414 ± 0.063
7.01AlaGly: 7.01 ± 0.089
1.643AlaHis: 1.643 ± 0.037
5.507AlaIle: 5.507 ± 0.094
3.688AlaLys: 3.688 ± 0.061
10.651AlaLeu: 10.651 ± 0.113
2.707AlaMet: 2.707 ± 0.047
3.187AlaAsn: 3.187 ± 0.059
3.107AlaPro: 3.107 ± 0.055
4.208AlaGln: 4.208 ± 0.061
5.027AlaArg: 5.027 ± 0.059
5.635AlaSer: 5.635 ± 0.068
4.196AlaThr: 4.196 ± 0.062
5.926AlaVal: 5.926 ± 0.083
1.089AlaTrp: 1.089 ± 0.033
2.463AlaTyr: 2.463 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.029
0.179CysCys: 0.179 ± 0.013
0.583CysAsp: 0.583 ± 0.022
0.572CysGlu: 0.572 ± 0.02
0.431CysPhe: 0.431 ± 0.018
0.87CysGly: 0.87 ± 0.032
0.339CysHis: 0.339 ± 0.018
0.552CysIle: 0.552 ± 0.021
0.362CysLys: 0.362 ± 0.018
1.058CysLeu: 1.058 ± 0.03
0.228CysMet: 0.228 ± 0.012
0.344CysAsn: 0.344 ± 0.018
0.443CysPro: 0.443 ± 0.018
0.531CysGln: 0.531 ± 0.019
0.547CysArg: 0.547 ± 0.021
0.654CysSer: 0.654 ± 0.022
0.43CysThr: 0.43 ± 0.018
0.566CysVal: 0.566 ± 0.02
0.146CysTrp: 0.146 ± 0.01
0.38CysTyr: 0.38 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.765AspAla: 4.765 ± 0.07
0.596AspCys: 0.596 ± 0.024
3.148AspAsp: 3.148 ± 0.055
3.771AspGlu: 3.771 ± 0.067
2.634AspPhe: 2.634 ± 0.046
4.033AspGly: 4.033 ± 0.075
1.074AspHis: 1.074 ± 0.034
3.944AspIle: 3.944 ± 0.062
3.595AspLys: 3.595 ± 0.055
5.298AspLeu: 5.298 ± 0.072
1.659AspMet: 1.659 ± 0.04
2.671AspAsn: 2.671 ± 0.046
2.352AspPro: 2.352 ± 0.047
2.123AspGln: 2.123 ± 0.04
2.491AspArg: 2.491 ± 0.053
3.587AspSer: 3.587 ± 0.061
2.74AspThr: 2.74 ± 0.052
3.431AspVal: 3.431 ± 0.056
1.076AspTrp: 1.076 ± 0.032
2.249AspTyr: 2.249 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.054GluAla: 5.054 ± 0.074
0.397GluCys: 0.397 ± 0.018
3.118GluAsp: 3.118 ± 0.058
3.526GluGlu: 3.526 ± 0.081
2.394GluPhe: 2.394 ± 0.044
3.575GluGly: 3.575 ± 0.054
1.672GluHis: 1.672 ± 0.042
3.397GluIle: 3.397 ± 0.056
3.387GluLys: 3.387 ± 0.053
7.194GluLeu: 7.194 ± 0.095
1.571GluMet: 1.571 ± 0.037
2.301GluAsn: 2.301 ± 0.049
2.394GluPro: 2.394 ± 0.054
5.136GluGln: 5.136 ± 0.08
3.368GluArg: 3.368 ± 0.06
3.302GluSer: 3.302 ± 0.057
2.686GluThr: 2.686 ± 0.045
4.16GluVal: 4.16 ± 0.064
0.653GluTrp: 0.653 ± 0.027
1.823GluTyr: 1.823 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.798PheAla: 3.798 ± 0.056
0.505PheCys: 0.505 ± 0.021
2.745PheAsp: 2.745 ± 0.051
2.552PheGlu: 2.552 ± 0.052
1.648PhePhe: 1.648 ± 0.041
3.118PheGly: 3.118 ± 0.052
0.765PheHis: 0.765 ± 0.025
2.352PheIle: 2.352 ± 0.047
1.571PheLys: 1.571 ± 0.037
3.234PheLeu: 3.234 ± 0.065
0.97PheMet: 0.97 ± 0.033
1.843PheAsn: 1.843 ± 0.036
1.408PhePro: 1.408 ± 0.033
1.125PheGln: 1.125 ± 0.029
1.882PheArg: 1.882 ± 0.042
3.406PheSer: 3.406 ± 0.056
2.167PheThr: 2.167 ± 0.044
2.749PheVal: 2.749 ± 0.056
0.591PheTrp: 0.591 ± 0.024
1.454PheTyr: 1.454 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.589GlyAla: 5.589 ± 0.08
0.876GlyCys: 0.876 ± 0.024
4.023GlyAsp: 4.023 ± 0.072
4.484GlyGlu: 4.484 ± 0.068
3.473GlyPhe: 3.473 ± 0.055
5.027GlyGly: 5.027 ± 0.081
1.713GlyHis: 1.713 ± 0.04
4.456GlyIle: 4.456 ± 0.068
3.854GlyLys: 3.854 ± 0.059
7.693GlyLeu: 7.693 ± 0.09
2.067GlyMet: 2.067 ± 0.045
2.784GlyAsn: 2.784 ± 0.061
2.111GlyPro: 2.111 ± 0.044
3.341GlyGln: 3.341 ± 0.058
3.513GlyArg: 3.513 ± 0.059
4.239GlySer: 4.239 ± 0.06
3.481GlyThr: 3.481 ± 0.06
4.877GlyVal: 4.877 ± 0.064
1.119GlyTrp: 1.119 ± 0.036
2.662GlyTyr: 2.662 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.578HisAla: 1.578 ± 0.035
0.349HisCys: 0.349 ± 0.016
1.037HisAsp: 1.037 ± 0.038
1.047HisGlu: 1.047 ± 0.032
1.098HisPhe: 1.098 ± 0.033
1.618HisGly: 1.618 ± 0.039
0.716HisHis: 0.716 ± 0.025
1.395HisIle: 1.395 ± 0.035
1.112HisLys: 1.112 ± 0.03
2.398HisLeu: 2.398 ± 0.048
0.461HisMet: 0.461 ± 0.021
0.859HisAsn: 0.859 ± 0.024
1.362HisPro: 1.362 ± 0.035
1.564HisGln: 1.564 ± 0.04
1.269HisArg: 1.269 ± 0.031
1.411HisSer: 1.411 ± 0.035
1.024HisThr: 1.024 ± 0.03
1.079HisVal: 1.079 ± 0.031
0.494HisTrp: 0.494 ± 0.02
0.954HisTyr: 0.954 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.608IleAla: 5.608 ± 0.079
0.695IleCys: 0.695 ± 0.025
3.536IleAsp: 3.536 ± 0.063
4.016IleGlu: 4.016 ± 0.053
1.884IlePhe: 1.884 ± 0.04
4.284IleGly: 4.284 ± 0.069
1.151IleHis: 1.151 ± 0.028
2.808IleIle: 2.808 ± 0.053
2.583IleLys: 2.583 ± 0.045
5.2IleLeu: 5.2 ± 0.07
1.114IleMet: 1.114 ± 0.03
2.634IleAsn: 2.634 ± 0.045
2.453IlePro: 2.453 ± 0.046
2.268IleGln: 2.268 ± 0.038
3.345IleArg: 3.345 ± 0.052
4.362IleSer: 4.362 ± 0.058
3.086IleThr: 3.086 ± 0.05
3.274IleVal: 3.274 ± 0.06
0.726IleTrp: 0.726 ± 0.029
1.596IleTyr: 1.596 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.511LysAla: 4.511 ± 0.07
0.252LysCys: 0.252 ± 0.017
2.561LysAsp: 2.561 ± 0.048
2.682LysGlu: 2.682 ± 0.056
1.202LysPhe: 1.202 ± 0.029
3.186LysGly: 3.186 ± 0.052
1.025LysHis: 1.025 ± 0.025
2.376LysIle: 2.376 ± 0.047
2.181LysLys: 2.181 ± 0.047
4.957LysLeu: 4.957 ± 0.071
1.149LysMet: 1.149 ± 0.031
1.603LysAsn: 1.603 ± 0.037
2.153LysPro: 2.153 ± 0.043
2.759LysGln: 2.759 ± 0.05
2.406LysArg: 2.406 ± 0.047
2.602LysSer: 2.602 ± 0.055
2.415LysThr: 2.415 ± 0.045
3.408LysVal: 3.408 ± 0.05
0.521LysTrp: 0.521 ± 0.022
1.134LysTyr: 1.134 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
10.775LeuAla: 10.775 ± 0.112
1.218LeuCys: 1.218 ± 0.028
6.172LeuAsp: 6.172 ± 0.083
6.282LeuGlu: 6.282 ± 0.082
4.302LeuPhe: 4.302 ± 0.065
7.255LeuGly: 7.255 ± 0.089
2.321LeuHis: 2.321 ± 0.045
6.142LeuIle: 6.142 ± 0.086
5.191LeuLys: 5.191 ± 0.064
12.216LeuLeu: 12.216 ± 0.162
2.903LeuMet: 2.903 ± 0.055
4.444LeuAsn: 4.444 ± 0.057
5.11LeuPro: 5.11 ± 0.068
4.963LeuGln: 4.963 ± 0.077
5.263LeuArg: 5.263 ± 0.073
8.175LeuSer: 8.175 ± 0.101
5.802LeuThr: 5.802 ± 0.078
7.081LeuVal: 7.081 ± 0.089
1.336LeuTrp: 1.336 ± 0.038
3.07LeuTyr: 3.07 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.766MetAla: 2.766 ± 0.047
0.173MetCys: 0.173 ± 0.01
1.355MetAsp: 1.355 ± 0.034
1.345MetGlu: 1.345 ± 0.038
0.764MetPhe: 0.764 ± 0.027
1.786MetGly: 1.786 ± 0.04
0.537MetHis: 0.537 ± 0.022
1.279MetIle: 1.279 ± 0.029
1.139MetLys: 1.139 ± 0.029
3.105MetLeu: 3.105 ± 0.055
0.701MetMet: 0.701 ± 0.027
0.92MetAsn: 0.92 ± 0.027
1.341MetPro: 1.341 ± 0.034
1.634MetGln: 1.634 ± 0.035
1.231MetArg: 1.231 ± 0.031
1.709MetSer: 1.709 ± 0.036
1.456MetThr: 1.456 ± 0.035
1.671MetVal: 1.671 ± 0.037
0.215MetTrp: 0.215 ± 0.015
0.497MetTyr: 0.497 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.15AsnAla: 3.15 ± 0.056
0.372AsnCys: 0.372 ± 0.018
1.931AsnAsp: 1.931 ± 0.042
1.875AsnGlu: 1.875 ± 0.037
1.426AsnPhe: 1.426 ± 0.04
2.726AsnGly: 2.726 ± 0.057
0.895AsnHis: 0.895 ± 0.026
2.359AsnIle: 2.359 ± 0.044
1.871AsnLys: 1.871 ± 0.044
4.113AsnLeu: 4.113 ± 0.069
0.958AsnMet: 0.958 ± 0.027
1.682AsnAsn: 1.682 ± 0.043
2.143AsnPro: 2.143 ± 0.043
2.242AsnGln: 2.242 ± 0.05
2.107AsnArg: 2.107 ± 0.045
2.243AsnSer: 2.243 ± 0.046
1.979AsnThr: 1.979 ± 0.042
2.062AsnVal: 2.062 ± 0.047
0.718AsnTrp: 0.718 ± 0.026
1.202AsnTyr: 1.202 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.93ProAla: 3.93 ± 0.064
0.35ProCys: 0.35 ± 0.017
3.171ProAsp: 3.171 ± 0.049
3.41ProGlu: 3.41 ± 0.053
1.787ProPhe: 1.787 ± 0.038
3.344ProGly: 3.344 ± 0.053
0.857ProHis: 0.857 ± 0.028
1.813ProIle: 1.813 ± 0.045
1.619ProLys: 1.619 ± 0.034
4.508ProLeu: 4.508 ± 0.069
1.069ProMet: 1.069 ± 0.032
1.269ProAsn: 1.269 ± 0.031
1.451ProPro: 1.451 ± 0.036
2.328ProGln: 2.328 ± 0.046
1.637ProArg: 1.637 ± 0.04
2.148ProSer: 2.148 ± 0.044
1.736ProThr: 1.736 ± 0.037
3.682ProVal: 3.682 ± 0.057
0.632ProTrp: 0.632 ± 0.023
1.273ProTyr: 1.273 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.573GlnAla: 5.573 ± 0.075
0.456GlnCys: 0.456 ± 0.02
2.54GlnAsp: 2.54 ± 0.047
2.547GlnGlu: 2.547 ± 0.051
1.724GlnPhe: 1.724 ± 0.034
3.859GlnGly: 3.859 ± 0.058
1.547GlnHis: 1.547 ± 0.04
2.822GlnIle: 2.822 ± 0.043
2.136GlnLys: 2.136 ± 0.044
6.072GlnLeu: 6.072 ± 0.085
1.293GlnMet: 1.293 ± 0.035
1.66GlnAsn: 1.66 ± 0.039
2.358GlnPro: 2.358 ± 0.048
5.249GlnGln: 5.249 ± 0.103
3.071GlnArg: 3.071 ± 0.054
3.38GlnSer: 3.38 ± 0.055
2.371GlnThr: 2.371 ± 0.044
3.535GlnVal: 3.535 ± 0.052
0.828GlnTrp: 0.828 ± 0.029
1.5GlnTyr: 1.5 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
4.197ArgAla: 4.197 ± 0.06
0.485ArgCys: 0.485 ± 0.021
2.786ArgAsp: 2.786 ± 0.054
3.248ArgGlu: 3.248 ± 0.051
2.466ArgPhe: 2.466 ± 0.044
2.883ArgGly: 2.883 ± 0.051
1.488ArgHis: 1.488 ± 0.039
3.414ArgIle: 3.414 ± 0.049
2.258ArgLys: 2.258 ± 0.045
6.255ArgLeu: 6.255 ± 0.081
1.334ArgMet: 1.334 ± 0.033
1.922ArgAsn: 1.922 ± 0.038
1.98ArgPro: 1.98 ± 0.044
3.369ArgGln: 3.369 ± 0.06
2.968ArgArg: 2.968 ± 0.056
2.753ArgSer: 2.753 ± 0.051
2.269ArgThr: 2.269 ± 0.046
3.355ArgVal: 3.355 ± 0.06
0.795ArgTrp: 0.795 ± 0.027
1.987ArgTyr: 1.987 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.113SerAla: 6.113 ± 0.074
0.614SerCys: 0.614 ± 0.028
3.761SerAsp: 3.761 ± 0.06
4.177SerGlu: 4.177 ± 0.066
2.692SerPhe: 2.692 ± 0.055
5.334SerGly: 5.334 ± 0.073
1.505SerHis: 1.505 ± 0.036
3.337SerIle: 3.337 ± 0.059
2.523SerLys: 2.523 ± 0.049
7.273SerLeu: 7.273 ± 0.089
1.623SerMet: 1.623 ± 0.039
2.116SerAsn: 2.116 ± 0.043
2.543SerPro: 2.543 ± 0.046
3.118SerGln: 3.118 ± 0.055
3.48SerArg: 3.48 ± 0.057
3.917SerSer: 3.917 ± 0.077
2.823SerThr: 2.823 ± 0.053
4.302SerVal: 4.302 ± 0.063
0.946SerTrp: 0.946 ± 0.03
1.943SerTyr: 1.943 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.397ThrAla: 4.397 ± 0.063
0.372ThrCys: 0.372 ± 0.017
3.217ThrAsp: 3.217 ± 0.059
3.307ThrGlu: 3.307 ± 0.057
1.84ThrPhe: 1.84 ± 0.043
4.313ThrGly: 4.313 ± 0.065
1.03ThrHis: 1.03 ± 0.032
2.432ThrIle: 2.432 ± 0.046
1.499ThrLys: 1.499 ± 0.034
6.1ThrLeu: 6.1 ± 0.082
0.996ThrMet: 0.996 ± 0.03
1.627ThrAsn: 1.627 ± 0.037
2.514ThrPro: 2.514 ± 0.045
2.255ThrGln: 2.255 ± 0.046
2.395ThrArg: 2.395 ± 0.049
2.992ThrSer: 2.992 ± 0.053
2.41ThrThr: 2.41 ± 0.055
3.15ThrVal: 3.15 ± 0.054
0.537ThrTrp: 0.537 ± 0.02
1.293ThrTyr: 1.293 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
6.03ValAla: 6.03 ± 0.082
0.695ValCys: 0.695 ± 0.022
3.795ValAsp: 3.795 ± 0.06
4.025ValGlu: 4.025 ± 0.058
2.673ValPhe: 2.673 ± 0.048
4.173ValGly: 4.173 ± 0.062
1.3ValHis: 1.3 ± 0.034
4.089ValIle: 4.089 ± 0.056
2.863ValLys: 2.863 ± 0.058
6.945ValLeu: 6.945 ± 0.079
1.834ValMet: 1.834 ± 0.042
2.714ValAsn: 2.714 ± 0.046
2.74ValPro: 2.74 ± 0.051
2.596ValGln: 2.596 ± 0.045
3.316ValArg: 3.316 ± 0.056
4.846ValSer: 4.846 ± 0.077
3.732ValThr: 3.732 ± 0.059
4.716ValVal: 4.716 ± 0.082
0.712ValTrp: 0.712 ± 0.024
1.763ValTyr: 1.763 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.944TrpAla: 0.944 ± 0.029
0.155TrpCys: 0.155 ± 0.011
0.631TrpAsp: 0.631 ± 0.022
0.502TrpGlu: 0.502 ± 0.022
0.618TrpPhe: 0.618 ± 0.024
0.832TrpGly: 0.832 ± 0.028
0.462TrpHis: 0.462 ± 0.019
0.679TrpIle: 0.679 ± 0.023
0.458TrpLys: 0.458 ± 0.019
2.117TrpLeu: 2.117 ± 0.048
0.359TrpMet: 0.359 ± 0.019
0.437TrpAsn: 0.437 ± 0.018
0.57TrpPro: 0.57 ± 0.025
1.403TrpGln: 1.403 ± 0.036
0.871TrpArg: 0.871 ± 0.029
0.801TrpSer: 0.801 ± 0.032
0.505TrpThr: 0.505 ± 0.017
0.837TrpVal: 0.837 ± 0.027
0.234TrpTrp: 0.234 ± 0.013
0.481TrpTyr: 0.481 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.465TyrAla: 2.465 ± 0.045
0.371TyrCys: 0.371 ± 0.02
1.661TyrAsp: 1.661 ± 0.041
1.528TyrGlu: 1.528 ± 0.033
1.412TyrPhe: 1.412 ± 0.032
2.154TyrGly: 2.154 ± 0.04
0.787TyrHis: 0.787 ± 0.025
1.47TyrIle: 1.47 ± 0.035
1.194TyrLys: 1.194 ± 0.032
3.632TyrLeu: 3.632 ± 0.067
0.628TyrMet: 0.628 ± 0.029
1.037TyrAsn: 1.037 ± 0.034
1.484TyrPro: 1.484 ± 0.035
2.311TyrGln: 2.311 ± 0.049
2.024TyrArg: 2.024 ± 0.04
1.978TyrSer: 1.978 ± 0.044
1.367TyrThr: 1.367 ± 0.035
1.696TyrVal: 1.696 ± 0.037
0.526TyrTrp: 0.526 ± 0.02
1.145TyrTyr: 1.145 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3754 proteins (1254132 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski