Amino acid dipepetide frequency for Lucheng Rn rat coronavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.582AlaAla: 5.582 ± 1.374
2.093AlaCys: 2.093 ± 0.386
3.721AlaAsp: 3.721 ± 0.37
1.977AlaGlu: 1.977 ± 0.591
3.024AlaPhe: 3.024 ± 1.001
3.838AlaGly: 3.838 ± 0.588
1.279AlaHis: 1.279 ± 0.652
5.117AlaIle: 5.117 ± 0.909
4.187AlaLys: 4.187 ± 1.613
6.047AlaLeu: 6.047 ± 0.714
1.744AlaMet: 1.744 ± 0.704
3.838AlaAsn: 3.838 ± 0.589
2.21AlaPro: 2.21 ± 0.938
2.791AlaGln: 2.791 ± 1.628
3.372AlaArg: 3.372 ± 1.112
4.768AlaSer: 4.768 ± 1.794
4.07AlaThr: 4.07 ± 0.926
6.28AlaVal: 6.28 ± 1.285
0.349AlaTrp: 0.349 ± 0.175
2.326AlaTyr: 2.326 ± 0.741
0.0AlaXaa: 0.0 ± 0.0
Cys
2.326CysAla: 2.326 ± 0.777
2.093CysCys: 2.093 ± 0.951
2.675CysAsp: 2.675 ± 0.832
0.814CysGlu: 0.814 ± 0.278
1.396CysPhe: 1.396 ± 0.262
2.558CysGly: 2.558 ± 0.897
0.465CysHis: 0.465 ± 0.163
1.512CysIle: 1.512 ± 0.437
2.093CysLys: 2.093 ± 0.826
2.558CysLeu: 2.558 ± 0.886
0.465CysMet: 0.465 ± 0.237
2.21CysAsn: 2.21 ± 0.673
0.814CysPro: 0.814 ± 0.239
0.581CysGln: 0.581 ± 0.296
1.279CysArg: 1.279 ± 0.443
2.791CysSer: 2.791 ± 0.845
2.791CysThr: 2.791 ± 0.916
4.187CysVal: 4.187 ± 0.773
0.93CysTrp: 0.93 ± 0.285
2.21CysTyr: 2.21 ± 1.126
0.0CysXaa: 0.0 ± 0.0
Asp
4.187AspAla: 4.187 ± 0.847
2.558AspCys: 2.558 ± 0.822
4.187AspAsp: 4.187 ± 1.345
2.326AspGlu: 2.326 ± 0.808
3.721AspPhe: 3.721 ± 1.073
6.396AspGly: 6.396 ± 1.13
1.047AspHis: 1.047 ± 0.331
2.791AspIle: 2.791 ± 0.845
2.093AspLys: 2.093 ± 0.843
5.117AspLeu: 5.117 ± 1.397
1.047AspMet: 1.047 ± 0.331
2.907AspAsn: 2.907 ± 0.698
1.861AspPro: 1.861 ± 1.379
1.628AspGln: 1.628 ± 0.531
1.861AspArg: 1.861 ± 0.279
3.372AspSer: 3.372 ± 0.569
2.558AspThr: 2.558 ± 0.822
5.582AspVal: 5.582 ± 1.806
0.465AspTrp: 0.465 ± 0.163
4.768AspTyr: 4.768 ± 0.871
0.0AspXaa: 0.0 ± 0.0
Glu
1.977GluAla: 1.977 ± 0.62
1.628GluCys: 1.628 ± 0.501
1.396GluAsp: 1.396 ± 0.262
1.861GluGlu: 1.861 ± 0.45
2.558GluPhe: 2.558 ± 0.139
2.907GluGly: 2.907 ± 0.925
1.744GluHis: 1.744 ± 0.669
1.744GluIle: 1.744 ± 0.653
1.977GluLys: 1.977 ± 0.785
4.187GluLeu: 4.187 ± 1.653
0.581GluMet: 0.581 ± 0.829
1.396GluAsn: 1.396 ± 0.282
1.861GluPro: 1.861 ± 0.683
1.396GluGln: 1.396 ± 0.269
1.861GluArg: 1.861 ± 0.362
2.21GluSer: 2.21 ± 0.398
1.744GluThr: 1.744 ± 1.896
3.256GluVal: 3.256 ± 0.602
0.698GluTrp: 0.698 ± 0.2
1.396GluTyr: 1.396 ± 0.509
0.0GluXaa: 0.0 ± 0.0
Phe
2.558PheAla: 2.558 ± 0.988
2.442PheCys: 2.442 ± 0.42
4.884PheAsp: 4.884 ± 0.667
3.256PheGlu: 3.256 ± 0.761
2.675PhePhe: 2.675 ± 0.942
3.605PheGly: 3.605 ± 0.305
0.581PheHis: 0.581 ± 0.569
2.791PheIle: 2.791 ± 0.748
4.303PheLys: 4.303 ± 0.63
3.372PheLeu: 3.372 ± 1.627
1.512PheMet: 1.512 ± 0.437
4.187PheAsn: 4.187 ± 0.929
1.628PhePro: 1.628 ± 0.83
0.93PheGln: 0.93 ± 0.415
1.279PheArg: 1.279 ± 0.493
5.001PheSer: 5.001 ± 0.978
3.489PheThr: 3.489 ± 0.8
5.698PheVal: 5.698 ± 1.13
1.396PheTrp: 1.396 ± 1.051
3.372PheTyr: 3.372 ± 0.94
0.0PheXaa: 0.0 ± 0.0
Gly
4.652GlyAla: 4.652 ± 0.536
2.326GlyCys: 2.326 ± 1.113
3.954GlyAsp: 3.954 ± 0.677
1.512GlyGlu: 1.512 ± 0.437
5.001GlyPhe: 5.001 ± 0.719
4.07GlyGly: 4.07 ± 0.735
1.047GlyHis: 1.047 ± 0.534
3.372GlyIle: 3.372 ± 0.381
3.489GlyLys: 3.489 ± 1.195
5.698GlyLeu: 5.698 ± 1.336
1.163GlyMet: 1.163 ± 0.245
3.256GlyAsn: 3.256 ± 0.941
2.326GlyPro: 2.326 ± 0.902
1.279GlyGln: 1.279 ± 0.5
1.977GlyArg: 1.977 ± 0.368
5.117GlySer: 5.117 ± 0.666
4.07GlyThr: 4.07 ± 1.507
6.164GlyVal: 6.164 ± 2.607
0.581GlyTrp: 0.581 ± 0.33
4.419GlyTyr: 4.419 ± 1.068
0.0GlyXaa: 0.0 ± 0.0
His
1.512HisAla: 1.512 ± 0.555
0.465HisCys: 0.465 ± 0.237
0.93HisAsp: 0.93 ± 0.285
0.465HisGlu: 0.465 ± 0.237
0.93HisPhe: 0.93 ± 0.285
1.279HisGly: 1.279 ± 0.443
0.465HisHis: 0.465 ± 0.237
0.698HisIle: 0.698 ± 0.2
1.047HisLys: 1.047 ± 0.534
1.977HisLeu: 1.977 ± 0.846
0.233HisMet: 0.233 ± 0.377
0.93HisAsn: 0.93 ± 0.285
0.465HisPro: 0.465 ± 0.35
0.465HisGln: 0.465 ± 0.163
0.698HisArg: 0.698 ± 0.335
0.93HisSer: 0.93 ± 0.263
1.512HisThr: 1.512 ± 0.245
2.442HisVal: 2.442 ± 0.717
0.349HisTrp: 0.349 ± 0.178
1.047HisTyr: 1.047 ± 0.331
0.0HisXaa: 0.0 ± 0.0
Ile
3.256IleAla: 3.256 ± 1.0
1.628IleCys: 1.628 ± 0.403
3.838IleAsp: 3.838 ± 1.305
2.442IleGlu: 2.442 ± 1.438
2.21IlePhe: 2.21 ± 0.506
2.326IleGly: 2.326 ± 0.69
0.465IleHis: 0.465 ± 0.237
2.442IleIle: 2.442 ± 1.258
3.024IleLys: 3.024 ± 0.956
4.535IleLeu: 4.535 ± 1.317
1.744IleMet: 1.744 ± 0.533
2.675IleAsn: 2.675 ± 0.808
0.93IlePro: 0.93 ± 0.263
1.861IleGln: 1.861 ± 1.265
1.512IleArg: 1.512 ± 0.338
3.605IleSer: 3.605 ± 0.939
4.187IleThr: 4.187 ± 0.732
4.07IleVal: 4.07 ± 1.793
0.233IleTrp: 0.233 ± 0.119
1.628IleTyr: 1.628 ± 0.478
0.0IleXaa: 0.0 ± 0.0
Lys
3.721LysAla: 3.721 ± 0.937
2.791LysCys: 2.791 ± 0.8
3.024LysAsp: 3.024 ± 1.312
2.21LysGlu: 2.21 ± 0.609
3.605LysPhe: 3.605 ± 1.093
3.14LysGly: 3.14 ± 0.688
1.279LysHis: 1.279 ± 0.652
2.326LysIle: 2.326 ± 0.705
3.024LysLys: 3.024 ± 1.61
6.978LysLeu: 6.978 ± 2.678
1.047LysMet: 1.047 ± 0.251
1.628LysAsn: 1.628 ± 1.147
3.954LysPro: 3.954 ± 1.152
1.744LysGln: 1.744 ± 0.702
1.512LysArg: 1.512 ± 0.684
2.791LysSer: 2.791 ± 0.441
2.558LysThr: 2.558 ± 0.892
3.489LysVal: 3.489 ± 1.081
0.465LysTrp: 0.465 ± 0.163
2.907LysTyr: 2.907 ± 0.748
0.0LysXaa: 0.0 ± 0.0
Leu
5.815LeuAla: 5.815 ± 1.005
3.256LeuCys: 3.256 ± 1.224
3.256LeuAsp: 3.256 ± 0.655
3.721LeuGlu: 3.721 ± 1.142
5.117LeuPhe: 5.117 ± 2.17
4.419LeuGly: 4.419 ± 0.734
1.744LeuHis: 1.744 ± 0.281
3.372LeuIle: 3.372 ± 0.669
4.07LeuLys: 4.07 ± 0.872
6.512LeuLeu: 6.512 ± 2.011
1.512LeuMet: 1.512 ± 0.245
4.07LeuAsn: 4.07 ± 0.949
3.256LeuPro: 3.256 ± 2.577
3.489LeuGln: 3.489 ± 0.711
4.884LeuArg: 4.884 ± 0.89
8.257LeuSer: 8.257 ± 0.975
5.001LeuThr: 5.001 ± 1.209
5.466LeuVal: 5.466 ± 1.352
1.861LeuTrp: 1.861 ± 0.571
5.815LeuTyr: 5.815 ± 1.171
0.0LeuXaa: 0.0 ± 0.0
Met
1.279MetAla: 1.279 ± 0.443
0.698MetCys: 0.698 ± 0.356
1.163MetAsp: 1.163 ± 0.566
0.93MetGlu: 0.93 ± 0.285
1.396MetPhe: 1.396 ± 0.962
1.396MetGly: 1.396 ± 0.816
0.349MetHis: 0.349 ± 0.178
0.93MetIle: 0.93 ± 0.673
0.349MetLys: 0.349 ± 0.178
2.558MetLeu: 2.558 ± 1.382
0.465MetMet: 0.465 ± 0.237
1.163MetAsn: 1.163 ± 0.345
0.93MetPro: 0.93 ± 0.263
0.698MetGln: 0.698 ± 0.61
0.581MetArg: 0.581 ± 0.296
1.396MetSer: 1.396 ± 0.282
1.163MetThr: 1.163 ± 0.326
2.675MetVal: 2.675 ± 0.615
0.233MetTrp: 0.233 ± 0.377
1.396MetTyr: 1.396 ± 0.619
0.0MetXaa: 0.0 ± 0.0
Asn
4.187AsnAla: 4.187 ± 0.635
2.326AsnCys: 2.326 ± 0.96
3.256AsnAsp: 3.256 ± 0.824
1.861AsnGlu: 1.861 ± 0.571
3.838AsnPhe: 3.838 ± 1.146
6.396AsnGly: 6.396 ± 2.009
0.93AsnHis: 0.93 ± 0.474
2.558AsnIle: 2.558 ± 0.684
3.256AsnLys: 3.256 ± 0.761
4.187AsnLeu: 4.187 ± 0.609
0.93AsnMet: 0.93 ± 0.377
2.791AsnAsn: 2.791 ± 0.841
2.21AsnPro: 2.21 ± 0.26
1.047AsnGln: 1.047 ± 1.111
2.093AsnArg: 2.093 ± 0.556
4.07AsnSer: 4.07 ± 0.735
2.442AsnThr: 2.442 ± 0.169
5.815AsnVal: 5.815 ± 1.236
0.465AsnTrp: 0.465 ± 0.337
1.396AsnTyr: 1.396 ± 0.471
0.0AsnXaa: 0.0 ± 0.0
Pro
2.326ProAla: 2.326 ± 0.498
1.163ProCys: 1.163 ± 0.593
1.977ProAsp: 1.977 ± 0.805
1.977ProGlu: 1.977 ± 0.368
0.814ProPhe: 0.814 ± 0.239
2.907ProGly: 2.907 ± 0.973
1.047ProHis: 1.047 ± 1.111
2.21ProIle: 2.21 ± 0.738
1.628ProLys: 1.628 ± 0.243
3.256ProLeu: 3.256 ± 0.905
0.814ProMet: 0.814 ± 0.764
1.977ProAsn: 1.977 ± 1.54
1.977ProPro: 1.977 ± 0.312
1.163ProGln: 1.163 ± 0.326
0.93ProArg: 0.93 ± 1.137
1.861ProSer: 1.861 ± 0.918
2.326ProThr: 2.326 ± 1.278
2.442ProVal: 2.442 ± 1.145
0.581ProTrp: 0.581 ± 0.374
1.047ProTyr: 1.047 ± 0.534
0.0ProXaa: 0.0 ± 0.0
Gln
2.21GlnAla: 2.21 ± 0.734
0.93GlnCys: 0.93 ± 0.7
1.744GlnAsp: 1.744 ± 0.789
0.814GlnGlu: 0.814 ± 0.687
1.512GlnPhe: 1.512 ± 0.555
2.21GlnGly: 2.21 ± 0.37
0.465GlnHis: 0.465 ± 0.163
1.512GlnIle: 1.512 ± 0.979
1.047GlnLys: 1.047 ± 0.687
3.489GlnLeu: 3.489 ± 0.919
1.163GlnMet: 1.163 ± 0.363
2.21GlnAsn: 2.21 ± 1.749
1.047GlnPro: 1.047 ± 0.78
1.163GlnGln: 1.163 ± 1.137
1.279GlnArg: 1.279 ± 0.403
2.093GlnSer: 2.093 ± 0.556
1.396GlnThr: 1.396 ± 1.24
2.093GlnVal: 2.093 ± 0.736
0.465GlnTrp: 0.465 ± 0.163
1.628GlnTyr: 1.628 ± 0.651
0.0GlnXaa: 0.0 ± 0.0
Arg
2.907ArgAla: 2.907 ± 1.763
0.581ArgCys: 0.581 ± 0.296
1.396ArgAsp: 1.396 ± 0.282
0.698ArgGlu: 0.698 ± 0.2
3.256ArgPhe: 3.256 ± 1.116
2.558ArgGly: 2.558 ± 0.902
1.163ArgHis: 1.163 ± 0.389
2.093ArgIle: 2.093 ± 0.672
2.093ArgLys: 2.093 ± 1.067
2.791ArgLeu: 2.791 ± 0.548
0.349ArgMet: 0.349 ± 0.175
2.675ArgAsn: 2.675 ± 0.131
1.047ArgPro: 1.047 ± 0.247
0.93ArgGln: 0.93 ± 0.367
1.396ArgArg: 1.396 ± 1.256
2.675ArgSer: 2.675 ± 1.658
2.326ArgThr: 2.326 ± 0.552
2.791ArgVal: 2.791 ± 1.737
0.349ArgTrp: 0.349 ± 0.178
1.977ArgTyr: 1.977 ± 0.55
0.0ArgXaa: 0.0 ± 0.0
Ser
5.001SerAla: 5.001 ± 1.021
2.21SerCys: 2.21 ± 0.724
4.768SerAsp: 4.768 ± 1.102
2.558SerGlu: 2.558 ± 0.653
4.07SerPhe: 4.07 ± 1.35
4.419SerGly: 4.419 ± 0.396
0.814SerHis: 0.814 ± 0.415
3.489SerIle: 3.489 ± 1.498
4.419SerLys: 4.419 ± 0.679
4.535SerLeu: 4.535 ± 0.767
2.093SerMet: 2.093 ± 0.313
4.652SerAsn: 4.652 ± 1.04
1.396SerPro: 1.396 ± 0.269
2.558SerGln: 2.558 ± 1.936
2.558SerArg: 2.558 ± 2.57
5.698SerSer: 5.698 ± 0.52
4.187SerThr: 4.187 ± 0.635
6.861SerVal: 6.861 ± 1.261
1.628SerTrp: 1.628 ± 1.269
3.954SerTyr: 3.954 ± 0.923
0.0SerXaa: 0.0 ± 0.0
Thr
3.721ThrAla: 3.721 ± 0.692
1.512ThrCys: 1.512 ± 0.679
4.303ThrAsp: 4.303 ± 1.008
1.861ThrGlu: 1.861 ± 0.949
4.303ThrPhe: 4.303 ± 0.736
3.489ThrGly: 3.489 ± 1.975
0.698ThrHis: 0.698 ± 0.61
3.256ThrIle: 3.256 ± 1.182
3.838ThrLys: 3.838 ± 1.048
4.652ThrLeu: 4.652 ± 1.112
1.744ThrMet: 1.744 ± 0.889
3.838ThrAsn: 3.838 ± 0.806
2.442ThrPro: 2.442 ± 1.468
2.558ThrGln: 2.558 ± 0.821
1.744ThrArg: 1.744 ± 0.401
3.605ThrSer: 3.605 ± 0.548
5.233ThrThr: 5.233 ± 0.918
5.117ThrVal: 5.117 ± 0.994
0.465ThrTrp: 0.465 ± 0.603
1.977ThrTyr: 1.977 ± 0.62
0.0ThrXaa: 0.0 ± 0.0
Val
6.28ValAla: 6.28 ± 1.854
3.256ValCys: 3.256 ± 0.824
5.001ValAsp: 5.001 ± 0.736
4.419ValGlu: 4.419 ± 0.313
5.582ValPhe: 5.582 ± 0.548
4.419ValGly: 4.419 ± 1.559
1.628ValHis: 1.628 ± 0.612
3.605ValIle: 3.605 ± 1.128
5.582ValLys: 5.582 ± 1.518
8.14ValLeu: 8.14 ± 3.013
1.628ValMet: 1.628 ± 1.42
5.582ValAsn: 5.582 ± 1.095
2.442ValPro: 2.442 ± 0.835
2.558ValGln: 2.558 ± 0.988
3.605ValArg: 3.605 ± 0.53
7.326ValSer: 7.326 ± 1.993
5.466ValThr: 5.466 ± 1.18
7.792ValVal: 7.792 ± 1.794
1.279ValTrp: 1.279 ± 0.619
3.372ValTyr: 3.372 ± 0.673
0.0ValXaa: 0.0 ± 0.0
Trp
1.047TrpAla: 1.047 ± 0.247
0.698TrpCys: 0.698 ± 0.2
1.396TrpAsp: 1.396 ± 0.711
0.465TrpGlu: 0.465 ± 0.35
0.93TrpPhe: 0.93 ± 0.874
0.233TrpGly: 0.233 ± 0.119
0.465TrpHis: 0.465 ± 0.603
0.233TrpIle: 0.233 ± 0.49
0.581TrpLys: 0.581 ± 0.367
1.047TrpLeu: 1.047 ± 0.358
0.465TrpMet: 0.465 ± 0.337
0.814TrpAsn: 0.814 ± 0.35
0.349TrpPro: 0.349 ± 0.44
0.233TrpGln: 0.233 ± 0.119
0.349TrpArg: 0.349 ± 0.178
1.396TrpSer: 1.396 ± 0.619
0.465TrpThr: 0.465 ± 0.163
1.047TrpVal: 1.047 ± 0.247
0.233TrpTrp: 0.233 ± 0.377
1.163TrpTyr: 1.163 ± 0.735
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.07TyrAla: 4.07 ± 0.824
2.093TyrCys: 2.093 ± 0.843
3.605TyrAsp: 3.605 ± 1.606
2.21TyrGlu: 2.21 ± 1.126
3.024TyrPhe: 3.024 ± 0.848
2.907TyrGly: 2.907 ± 0.184
1.163TyrHis: 1.163 ± 1.0
2.558TyrIle: 2.558 ± 0.49
2.093TyrLys: 2.093 ± 0.764
3.256TyrLeu: 3.256 ± 1.429
0.93TyrMet: 0.93 ± 0.326
3.256TyrAsn: 3.256 ± 0.957
1.279TyrPro: 1.279 ± 0.369
1.512TyrGln: 1.512 ± 0.882
1.279TyrArg: 1.279 ± 0.493
2.907TyrSer: 2.907 ± 1.644
3.372TyrThr: 3.372 ± 0.967
5.698TyrVal: 5.698 ± 1.06
0.581TyrTrp: 0.581 ± 0.339
3.489TyrTyr: 3.489 ± 1.144
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (8600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski