Amino acid dipepetide frequency for Flavobacterium psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.272AlaAla: 4.272 ± 0.101	0.549AlaCys: 0.549 ± 0.028	3.084AlaAsp: 3.084 ± 0.063	3.569AlaGlu: 3.569 ± 0.078	3.246AlaPhe: 3.246 ± 0.067	4.367AlaGly: 4.367 ± 0.096	0.977AlaHis: 0.977 ± 0.031	5.817AlaIle: 5.817 ± 0.091	4.846AlaLys: 4.846 ± 0.084	6.129AlaLeu: 6.129 ± 0.092	1.536AlaMet: 1.536 ± 0.046	3.826AlaAsn: 3.826 ± 0.083	1.95AlaPro: 1.95 ± 0.063	2.374AlaGln: 2.374 ± 0.056	1.776AlaArg: 1.776 ± 0.047	4.421AlaSer: 4.421 ± 0.093	4.652AlaThr: 4.652 ± 0.146	4.214AlaVal: 4.214 ± 0.079	0.589AlaTrp: 0.589 ± 0.027	2.139AlaTyr: 2.139 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.505CysAla: 0.505 ± 0.024	0.104CysCys: 0.104 ± 0.009	0.441CysAsp: 0.441 ± 0.024	0.467CysGlu: 0.467 ± 0.025	0.478CysPhe: 0.478 ± 0.024	0.688CysGly: 0.688 ± 0.027	0.227CysHis: 0.227 ± 0.016	0.628CysIle: 0.628 ± 0.027	0.51CysLys: 0.51 ± 0.025	0.663CysLeu: 0.663 ± 0.027	0.152CysMet: 0.152 ± 0.014	0.474CysAsn: 0.474 ± 0.026	0.38CysPro: 0.38 ± 0.025	0.236CysGln: 0.236 ± 0.02	0.212CysArg: 0.212 ± 0.015	0.701CysSer: 0.701 ± 0.043	0.499CysThr: 0.499 ± 0.029	0.485CysVal: 0.485 ± 0.021	0.076CysTrp: 0.076 ± 0.009	0.319CysTyr: 0.319 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.582AspAla: 3.582 ± 0.064	0.443AspCys: 0.443 ± 0.023	2.367AspAsp: 2.367 ± 0.067	3.23AspGlu: 3.23 ± 0.07	3.61AspPhe: 3.61 ± 0.074	3.579AspGly: 3.579 ± 0.086	0.76AspHis: 0.76 ± 0.032	4.029AspIle: 4.029 ± 0.065	4.207AspLys: 4.207 ± 0.084	5.021AspLeu: 5.021 ± 0.073	0.99AspMet: 0.99 ± 0.03	2.948AspAsn: 2.948 ± 0.064	1.421AspPro: 1.421 ± 0.045	1.253AspGln: 1.253 ± 0.038	1.563AspArg: 1.563 ± 0.04	2.803AspSer: 2.803 ± 0.055	2.568AspThr: 2.568 ± 0.054	3.459AspVal: 3.459 ± 0.06	0.721AspTrp: 0.721 ± 0.035	2.689AspTyr: 2.689 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.911GluAla: 3.911 ± 0.078	0.361GluCys: 0.361 ± 0.019	2.866GluAsp: 2.866 ± 0.066	4.089GluGlu: 4.089 ± 0.1	2.718GluPhe: 2.718 ± 0.054	3.306GluGly: 3.306 ± 0.072	1.011GluHis: 1.011 ± 0.038	5.731GluIle: 5.731 ± 0.094	5.9GluLys: 5.9 ± 0.099	5.64GluLeu: 5.64 ± 0.094	1.583GluMet: 1.583 ± 0.042	4.782GluAsn: 4.782 ± 0.09	1.43GluPro: 1.43 ± 0.045	2.115GluGln: 2.115 ± 0.052	2.138GluArg: 2.138 ± 0.064	3.044GluSer: 3.044 ± 0.061	3.511GluThr: 3.511 ± 0.062	3.831GluVal: 3.831 ± 0.071	0.542GluTrp: 0.542 ± 0.024	2.168GluTyr: 2.168 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.244PheAla: 3.244 ± 0.065	0.494PheCys: 0.494 ± 0.025	3.218PheAsp: 3.218 ± 0.062	3.355PheGlu: 3.355 ± 0.068	2.981PhePhe: 2.981 ± 0.084	3.889PheGly: 3.889 ± 0.077	0.927PheHis: 0.927 ± 0.032	4.095PheIle: 4.095 ± 0.081	3.727PheLys: 3.727 ± 0.071	4.887PheLeu: 4.887 ± 0.103	1.185PheMet: 1.185 ± 0.035	3.267PheAsn: 3.267 ± 0.068	1.813PhePro: 1.813 ± 0.044	1.716PheGln: 1.716 ± 0.043	1.565PheArg: 1.565 ± 0.048	4.305PheSer: 4.305 ± 0.086	3.262PheThr: 3.262 ± 0.069	3.244PheVal: 3.244 ± 0.064	0.589PheTrp: 0.589 ± 0.028	2.09PheTyr: 2.09 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.214GlyAla: 4.214 ± 0.105	0.696GlyCys: 0.696 ± 0.035	3.102GlyAsp: 3.102 ± 0.056	3.18GlyGlu: 3.18 ± 0.061	3.708GlyPhe: 3.708 ± 0.065	4.7GlyGly: 4.7 ± 0.099	1.061GlyHis: 1.061 ± 0.031	6.032GlyIle: 6.032 ± 0.089	5.159GlyLys: 5.159 ± 0.09	5.607GlyLeu: 5.607 ± 0.082	1.676GlyMet: 1.676 ± 0.051	4.008GlyAsn: 4.008 ± 0.087	1.245GlyPro: 1.245 ± 0.035	1.929GlyGln: 1.929 ± 0.055	1.882GlyArg: 1.882 ± 0.046	4.363GlySer: 4.363 ± 0.099	5.071GlyThr: 5.071 ± 0.193	4.135GlyVal: 4.135 ± 0.084	0.67GlyTrp: 0.67 ± 0.026	2.77GlyTyr: 2.77 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.932HisAla: 0.932 ± 0.033	0.195HisCys: 0.195 ± 0.015	0.835HisAsp: 0.835 ± 0.031	0.927HisGlu: 0.927 ± 0.032	1.199HisPhe: 1.199 ± 0.033	1.011HisGly: 1.011 ± 0.033	0.458HisHis: 0.458 ± 0.026	1.345HisIle: 1.345 ± 0.042	1.122HisLys: 1.122 ± 0.035	1.744HisLeu: 1.744 ± 0.051	0.294HisMet: 0.294 ± 0.017	0.919HisAsn: 0.919 ± 0.03	0.839HisPro: 0.839 ± 0.031	0.681HisGln: 0.681 ± 0.025	0.577HisArg: 0.577 ± 0.026	1.067HisSer: 1.067 ± 0.032	0.845HisThr: 0.845 ± 0.032	0.88HisVal: 0.88 ± 0.036	0.201HisTrp: 0.201 ± 0.015	0.822HisTyr: 0.822 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.082IleAla: 6.082 ± 0.093	0.762IleCys: 0.762 ± 0.035	4.837IleAsp: 4.837 ± 0.08	5.406IleGlu: 5.406 ± 0.111	3.89IlePhe: 3.89 ± 0.075	5.403IleGly: 5.403 ± 0.087	1.476IleHis: 1.476 ± 0.041	6.785IleIle: 6.785 ± 0.113	6.215IleLys: 6.215 ± 0.094	7.534IleLeu: 7.534 ± 0.113	1.509IleMet: 1.509 ± 0.044	5.077IleAsn: 5.077 ± 0.095	3.471IlePro: 3.471 ± 0.057	2.888IleGln: 2.888 ± 0.049	2.654IleArg: 2.654 ± 0.055	5.89IleSer: 5.89 ± 0.085	5.35IleThr: 5.35 ± 0.112	5.232IleVal: 5.232 ± 0.079	0.681IleTrp: 0.681 ± 0.029	2.995IleTyr: 2.995 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.782LysAla: 4.782 ± 0.078	0.427LysCys: 0.427 ± 0.02	4.055LysAsp: 4.055 ± 0.079	5.594LysGlu: 5.594 ± 0.108	3.177LysPhe: 3.177 ± 0.071	4.647LysGly: 4.647 ± 0.067	1.202LysHis: 1.202 ± 0.038	7.444LysIle: 7.444 ± 0.108	6.981LysLys: 6.981 ± 0.111	6.428LysLeu: 6.428 ± 0.09	2.335LysMet: 2.335 ± 0.054	5.702LysAsn: 5.702 ± 0.097	2.565LysPro: 2.565 ± 0.052	2.608LysGln: 2.608 ± 0.062	2.531LysArg: 2.531 ± 0.056	4.904LysSer: 4.904 ± 0.083	4.98LysThr: 4.98 ± 0.075	4.702LysVal: 4.702 ± 0.07	0.763LysTrp: 0.763 ± 0.029	3.031LysTyr: 3.031 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.702LeuAla: 5.702 ± 0.094	0.707LeuCys: 0.707 ± 0.027	4.786LeuAsp: 4.786 ± 0.08	5.674LeuGlu: 5.674 ± 0.095	5.259LeuPhe: 5.259 ± 0.103	5.843LeuGly: 5.843 ± 0.084	1.595LeuHis: 1.595 ± 0.046	6.906LeuIle: 6.906 ± 0.095	7.63LeuLys: 7.63 ± 0.107	8.693LeuLeu: 8.693 ± 0.141	2.129LeuMet: 2.129 ± 0.05	5.649LeuAsn: 5.649 ± 0.094	3.493LeuPro: 3.493 ± 0.063	3.154LeuGln: 3.154 ± 0.057	2.835LeuArg: 2.835 ± 0.062	6.655LeuSer: 6.655 ± 0.096	5.329LeuThr: 5.329 ± 0.099	5.356LeuVal: 5.356 ± 0.077	0.795LeuTrp: 0.795 ± 0.032	3.105LeuTyr: 3.105 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.519MetAla: 1.519 ± 0.042	0.145MetCys: 0.145 ± 0.013	1.101MetAsp: 1.101 ± 0.035	1.414MetGlu: 1.414 ± 0.044	0.856MetPhe: 0.856 ± 0.032	1.454MetGly: 1.454 ± 0.05	0.4MetHis: 0.4 ± 0.022	1.631MetIle: 1.631 ± 0.043	2.3MetLys: 2.3 ± 0.057	1.805MetLeu: 1.805 ± 0.048	0.633MetMet: 0.633 ± 0.027	1.454MetAsn: 1.454 ± 0.039	0.867MetPro: 0.867 ± 0.032	0.82MetGln: 0.82 ± 0.028	0.774MetArg: 0.774 ± 0.029	1.448MetSer: 1.448 ± 0.037	1.284MetThr: 1.284 ± 0.041	1.477MetVal: 1.477 ± 0.045	0.159MetTrp: 0.159 ± 0.012	0.69MetTyr: 0.69 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	4.108AsnAla: 4.108 ± 0.08	0.59AsnCys: 0.59 ± 0.033	3.157AsnAsp: 3.157 ± 0.063	3.799AsnGlu: 3.799 ± 0.067	3.248AsnPhe: 3.248 ± 0.074	4.344AsnGly: 4.344 ± 0.097	1.133AsnHis: 1.133 ± 0.036	4.845AsnIle: 4.845 ± 0.075	4.548AsnLys: 4.548 ± 0.08	5.756AsnLeu: 5.756 ± 0.094	1.26AsnMet: 1.26 ± 0.042	4.046AsnAsn: 4.046 ± 0.1	3.076AsnPro: 3.076 ± 0.064	2.432AsnGln: 2.432 ± 0.056	2.02AsnArg: 2.02 ± 0.049	4.321AsnSer: 4.321 ± 0.09	3.777AsnThr: 3.777 ± 0.094	3.79AsnVal: 3.79 ± 0.073	0.827AsnTrp: 0.827 ± 0.033	2.901AsnTyr: 2.901 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	2.006ProAla: 2.006 ± 0.057	0.236ProCys: 0.236 ± 0.018	1.759ProAsp: 1.759 ± 0.047	2.601ProGlu: 2.601 ± 0.062	1.958ProPhe: 1.958 ± 0.051	1.796ProGly: 1.796 ± 0.05	0.545ProHis: 0.545 ± 0.027	3.01ProIle: 3.01 ± 0.066	2.62ProLys: 2.62 ± 0.053	2.967ProLeu: 2.967 ± 0.059	0.718ProMet: 0.718 ± 0.03	2.487ProAsn: 2.487 ± 0.054	0.789ProPro: 0.789 ± 0.038	1.03ProGln: 1.03 ± 0.035	0.812ProArg: 0.812 ± 0.034	2.34ProSer: 2.34 ± 0.064	2.351ProThr: 2.351 ± 0.077	2.39ProVal: 2.39 ± 0.063	0.282ProTrp: 0.282 ± 0.017	1.3ProTyr: 1.3 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.884GlnAla: 1.884 ± 0.043	0.207GlnCys: 0.207 ± 0.015	1.507GlnAsp: 1.507 ± 0.042	2.215GlnGlu: 2.215 ± 0.058	1.785GlnPhe: 1.785 ± 0.045	1.693GlnGly: 1.693 ± 0.05	0.56GlnHis: 0.56 ± 0.025	2.939GlnIle: 2.939 ± 0.053	3.046GlnLys: 3.046 ± 0.059	3.371GlnLeu: 3.371 ± 0.067	0.836GlnMet: 0.836 ± 0.032	2.424GlnAsn: 2.424 ± 0.061	0.98GlnPro: 0.98 ± 0.038	1.285GlnGln: 1.285 ± 0.039	1.074GlnArg: 1.074 ± 0.033	1.992GlnSer: 1.992 ± 0.052	2.059GlnThr: 2.059 ± 0.062	1.896GlnVal: 1.896 ± 0.045	0.362GlnTrp: 0.362 ± 0.022	1.343GlnTyr: 1.343 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.827ArgAla: 1.827 ± 0.053	0.237ArgCys: 0.237 ± 0.018	1.584ArgAsp: 1.584 ± 0.04	1.963ArgGlu: 1.963 ± 0.057	1.714ArgPhe: 1.714 ± 0.046	1.718ArgGly: 1.718 ± 0.051	0.518ArgHis: 0.518 ± 0.022	2.767ArgIle: 2.767 ± 0.063	2.67ArgLys: 2.67 ± 0.062	2.906ArgLeu: 2.906 ± 0.063	0.824ArgMet: 0.824 ± 0.029	1.966ArgAsn: 1.966 ± 0.053	0.953ArgPro: 0.953 ± 0.034	0.952ArgGln: 0.952 ± 0.035	1.079ArgArg: 1.079 ± 0.037	1.664ArgSer: 1.664 ± 0.043	1.776ArgThr: 1.776 ± 0.05	1.831ArgVal: 1.831 ± 0.044	0.335ArgTrp: 0.335 ± 0.021	1.328ArgTyr: 1.328 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.991SerAla: 3.991 ± 0.1	0.681SerCys: 0.681 ± 0.028	3.442SerAsp: 3.442 ± 0.06	3.753SerGlu: 3.753 ± 0.073	3.94SerPhe: 3.94 ± 0.071	5.172SerGly: 5.172 ± 0.116	1.136SerHis: 1.136 ± 0.04	5.549SerIle: 5.549 ± 0.09	5.027SerLys: 5.027 ± 0.078	5.909SerLeu: 5.909 ± 0.091	1.264SerMet: 1.264 ± 0.038	4.153SerAsn: 4.153 ± 0.088	2.22SerPro: 2.22 ± 0.061	2.306SerGln: 2.306 ± 0.049	2.03SerArg: 2.03 ± 0.053	4.649SerSer: 4.649 ± 0.114	3.916SerThr: 3.916 ± 0.112	4.323SerVal: 4.323 ± 0.068	0.655SerTrp: 0.655 ± 0.03	2.676SerTyr: 2.676 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.365ThrAla: 4.365 ± 0.146	0.413ThrCys: 0.413 ± 0.032	3.186ThrAsp: 3.186 ± 0.074	3.172ThrGlu: 3.172 ± 0.058	3.437ThrPhe: 3.437 ± 0.08	4.552ThrGly: 4.552 ± 0.136	1.015ThrHis: 1.015 ± 0.034	5.836ThrIle: 5.836 ± 0.112	4.052ThrLys: 4.052 ± 0.072	5.728ThrLeu: 5.728 ± 0.103	1.008ThrMet: 1.008 ± 0.033	3.823ThrAsn: 3.823 ± 0.094	2.693ThrPro: 2.693 ± 0.081	1.961ThrGln: 1.961 ± 0.052	1.542ThrArg: 1.542 ± 0.045	4.215ThrSer: 4.215 ± 0.118	4.314ThrThr: 4.314 ± 0.151	4.331ThrVal: 4.331 ± 0.125	0.588ThrTrp: 0.588 ± 0.03	2.275ThrTyr: 2.275 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	4.509ValAla: 4.509 ± 0.091	0.542ValCys: 0.542 ± 0.024	3.311ValAsp: 3.311 ± 0.066	3.491ValGlu: 3.491 ± 0.071	3.54ValPhe: 3.54 ± 0.064	3.853ValGly: 3.853 ± 0.068	0.954ValHis: 0.954 ± 0.035	5.16ValIle: 5.16 ± 0.08	4.593ValLys: 4.593 ± 0.084	5.979ValLeu: 5.979 ± 0.088	1.322ValMet: 1.322 ± 0.039	3.723ValAsn: 3.723 ± 0.076	2.159ValPro: 2.159 ± 0.049	1.837ValGln: 1.837 ± 0.049	1.831ValArg: 1.831 ± 0.048	4.627ValSer: 4.627 ± 0.081	4.012ValThr: 4.012 ± 0.103	4.244ValVal: 4.244 ± 0.077	0.583ValTrp: 0.583 ± 0.028	2.266ValTyr: 2.266 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.63TrpAla: 0.63 ± 0.037	0.1TrpCys: 0.1 ± 0.011	0.509TrpAsp: 0.509 ± 0.023	0.611TrpGlu: 0.611 ± 0.031	0.534TrpPhe: 0.534 ± 0.025	0.645TrpGly: 0.645 ± 0.031	0.209TrpHis: 0.209 ± 0.016	0.806TrpIle: 0.806 ± 0.033	0.789TrpLys: 0.789 ± 0.033	0.851TrpLeu: 0.851 ± 0.031	0.273TrpMet: 0.273 ± 0.017	0.729TrpAsn: 0.729 ± 0.032	0.199TrpPro: 0.199 ± 0.016	0.397TrpGln: 0.397 ± 0.024	0.337TrpArg: 0.337 ± 0.019	0.678TrpSer: 0.678 ± 0.033	0.638TrpThr: 0.638 ± 0.033	0.58TrpVal: 0.58 ± 0.025	0.111TrpTrp: 0.111 ± 0.012	0.41TrpTyr: 0.41 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.269TyrAla: 2.269 ± 0.05	0.357TyrCys: 0.357 ± 0.019	2.096TyrAsp: 2.096 ± 0.048	2.167TyrGlu: 2.167 ± 0.044	2.575TyrPhe: 2.575 ± 0.053	2.545TyrGly: 2.545 ± 0.063	0.73TyrHis: 0.73 ± 0.027	2.787TyrIle: 2.787 ± 0.062	2.92TyrLys: 2.92 ± 0.061	3.674TyrLeu: 3.674 ± 0.071	0.705TyrMet: 0.705 ± 0.026	2.519TyrAsn: 2.519 ± 0.058	1.453TyrPro: 1.453 ± 0.043	1.481TyrGln: 1.481 ± 0.045	1.378TyrArg: 1.378 ± 0.04	2.707TyrSer: 2.707 ± 0.063	2.311TyrThr: 2.311 ± 0.075	2.137TyrVal: 2.137 ± 0.049	0.506TyrTrp: 0.506 ± 0.022	1.79TyrTyr: 1.79 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2753 proteins (953119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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