Amino acid dipepetide frequency for Staphylococcus phage vB_SauS-phiIPLA88

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.243AlaAla: 1.243 ± 0.365
0.233AlaCys: 0.233 ± 0.141
3.029AlaAsp: 3.029 ± 0.451
4.039AlaGlu: 4.039 ± 0.657
2.641AlaPhe: 2.641 ± 0.535
3.262AlaGly: 3.262 ± 0.535
1.398AlaHis: 1.398 ± 0.356
4.737AlaIle: 4.737 ± 0.914
5.359AlaLys: 5.359 ± 0.665
4.039AlaLeu: 4.039 ± 0.61
1.786AlaMet: 1.786 ± 0.449
4.427AlaAsn: 4.427 ± 0.546
1.709AlaPro: 1.709 ± 0.358
2.33AlaGln: 2.33 ± 0.393
2.874AlaArg: 2.874 ± 0.461
3.573AlaSer: 3.573 ± 0.697
4.737AlaThr: 4.737 ± 0.65
3.34AlaVal: 3.34 ± 0.708
1.01AlaTrp: 1.01 ± 0.343
2.718AlaTyr: 2.718 ± 0.363
0.0AlaXaa: 0.0 ± 0.0
Cys
0.155CysAla: 0.155 ± 0.102
0.0CysCys: 0.0 ± 0.0
0.388CysAsp: 0.388 ± 0.143
0.233CysGlu: 0.233 ± 0.137
0.311CysPhe: 0.311 ± 0.14
0.233CysGly: 0.233 ± 0.148
0.0CysHis: 0.0 ± 0.0
0.078CysIle: 0.078 ± 0.077
0.621CysLys: 0.621 ± 0.221
0.388CysLeu: 0.388 ± 0.175
0.078CysMet: 0.078 ± 0.085
0.233CysAsn: 0.233 ± 0.103
0.233CysPro: 0.233 ± 0.149
0.155CysGln: 0.155 ± 0.099
0.233CysArg: 0.233 ± 0.131
0.233CysSer: 0.233 ± 0.189
0.311CysThr: 0.311 ± 0.181
0.155CysVal: 0.155 ± 0.11
0.233CysTrp: 0.233 ± 0.139
0.233CysTyr: 0.233 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
4.116AspAla: 4.116 ± 0.65
0.233AspCys: 0.233 ± 0.139
4.427AspAsp: 4.427 ± 0.845
5.203AspGlu: 5.203 ± 0.822
3.495AspPhe: 3.495 ± 0.458
3.806AspGly: 3.806 ± 0.586
0.311AspHis: 0.311 ± 0.13
4.427AspIle: 4.427 ± 0.58
5.359AspLys: 5.359 ± 0.77
5.203AspLeu: 5.203 ± 0.843
2.019AspMet: 2.019 ± 0.398
4.427AspAsn: 4.427 ± 0.644
1.476AspPro: 1.476 ± 0.319
1.087AspGln: 1.087 ± 0.28
2.563AspArg: 2.563 ± 0.428
3.806AspSer: 3.806 ± 0.528
3.495AspThr: 3.495 ± 0.537
4.039AspVal: 4.039 ± 0.472
0.777AspTrp: 0.777 ± 0.286
3.184AspTyr: 3.184 ± 0.578
0.0AspXaa: 0.0 ± 0.0
Glu
5.747GluAla: 5.747 ± 0.804
0.621GluCys: 0.621 ± 0.224
2.874GluAsp: 2.874 ± 0.412
5.592GluGlu: 5.592 ± 0.877
2.874GluPhe: 2.874 ± 0.469
3.029GluGly: 3.029 ± 0.626
1.631GluHis: 1.631 ± 0.379
4.97GluIle: 4.97 ± 0.791
5.203GluLys: 5.203 ± 0.832
6.524GluLeu: 6.524 ± 0.723
1.864GluMet: 1.864 ± 0.445
4.039GluAsn: 4.039 ± 0.778
1.32GluPro: 1.32 ± 0.294
3.728GluGln: 3.728 ± 0.548
2.563GluArg: 2.563 ± 0.458
3.65GluSer: 3.65 ± 0.537
4.505GluThr: 4.505 ± 0.642
5.126GluVal: 5.126 ± 0.705
1.087GluTrp: 1.087 ± 0.272
4.349GluTyr: 4.349 ± 0.775
0.0GluXaa: 0.0 ± 0.0
Phe
2.33PheAla: 2.33 ± 0.319
0.155PheCys: 0.155 ± 0.119
3.495PheAsp: 3.495 ± 0.636
3.184PheGlu: 3.184 ± 0.513
1.553PhePhe: 1.553 ± 0.404
2.33PheGly: 2.33 ± 0.352
0.544PheHis: 0.544 ± 0.248
3.573PheIle: 3.573 ± 0.448
5.048PheLys: 5.048 ± 0.557
2.718PheLeu: 2.718 ± 0.404
1.087PheMet: 1.087 ± 0.343
3.495PheAsn: 3.495 ± 0.549
0.621PhePro: 0.621 ± 0.212
1.165PheGln: 1.165 ± 0.391
1.243PheArg: 1.243 ± 0.289
2.796PheSer: 2.796 ± 0.402
3.184PheThr: 3.184 ± 0.398
3.029PheVal: 3.029 ± 0.443
0.311PheTrp: 0.311 ± 0.133
1.398PheTyr: 1.398 ± 0.324
0.0PheXaa: 0.0 ± 0.0
Gly
2.874GlyAla: 2.874 ± 0.562
0.155GlyCys: 0.155 ± 0.107
3.495GlyAsp: 3.495 ± 0.608
3.417GlyGlu: 3.417 ± 0.624
2.874GlyPhe: 2.874 ± 0.474
3.495GlyGly: 3.495 ± 0.495
1.398GlyHis: 1.398 ± 0.35
4.427GlyIle: 4.427 ± 0.548
4.349GlyLys: 4.349 ± 0.616
5.203GlyLeu: 5.203 ± 0.884
1.398GlyMet: 1.398 ± 0.343
2.874GlyAsn: 2.874 ± 0.488
0.621GlyPro: 0.621 ± 0.257
2.097GlyGln: 2.097 ± 0.359
1.709GlyArg: 1.709 ± 0.38
3.184GlySer: 3.184 ± 0.456
4.039GlyThr: 4.039 ± 0.645
4.427GlyVal: 4.427 ± 0.577
1.087GlyTrp: 1.087 ± 0.378
2.718GlyTyr: 2.718 ± 0.487
0.0GlyXaa: 0.0 ± 0.0
His
1.243HisAla: 1.243 ± 0.353
0.078HisCys: 0.078 ± 0.073
0.932HisAsp: 0.932 ± 0.237
0.777HisGlu: 0.777 ± 0.202
0.621HisPhe: 0.621 ± 0.272
0.777HisGly: 0.777 ± 0.241
0.388HisHis: 0.388 ± 0.168
1.01HisIle: 1.01 ± 0.303
0.699HisLys: 0.699 ± 0.244
0.854HisLeu: 0.854 ± 0.283
0.388HisMet: 0.388 ± 0.189
1.087HisAsn: 1.087 ± 0.273
0.621HisPro: 0.621 ± 0.227
0.699HisGln: 0.699 ± 0.27
0.466HisArg: 0.466 ± 0.139
1.32HisSer: 1.32 ± 0.283
1.32HisThr: 1.32 ± 0.263
1.476HisVal: 1.476 ± 0.395
0.078HisTrp: 0.078 ± 0.071
0.777HisTyr: 0.777 ± 0.309
0.0HisXaa: 0.0 ± 0.0
Ile
5.436IleAla: 5.436 ± 0.676
0.155IleCys: 0.155 ± 0.127
5.592IleAsp: 5.592 ± 0.632
5.359IleGlu: 5.359 ± 0.658
2.097IlePhe: 2.097 ± 0.375
4.272IleGly: 4.272 ± 0.496
1.01IleHis: 1.01 ± 0.256
4.893IleIle: 4.893 ± 0.782
6.912IleLys: 6.912 ± 0.597
3.806IleLeu: 3.806 ± 0.561
2.019IleMet: 2.019 ± 0.366
4.893IleAsn: 4.893 ± 0.612
2.175IlePro: 2.175 ± 0.412
2.175IleGln: 2.175 ± 0.452
2.718IleArg: 2.718 ± 0.506
3.806IleSer: 3.806 ± 0.4
5.203IleThr: 5.203 ± 0.733
4.349IleVal: 4.349 ± 0.748
1.398IleTrp: 1.398 ± 0.713
2.485IleTyr: 2.485 ± 0.486
0.0IleXaa: 0.0 ± 0.0
Lys
4.893LysAla: 4.893 ± 0.618
0.078LysCys: 0.078 ± 0.066
5.359LysAsp: 5.359 ± 0.741
7.611LysGlu: 7.611 ± 0.937
3.262LysPhe: 3.262 ± 0.517
5.747LysGly: 5.747 ± 0.709
1.087LysHis: 1.087 ± 0.331
5.592LysIle: 5.592 ± 0.579
7.922LysLys: 7.922 ± 0.941
6.601LysLeu: 6.601 ± 0.651
2.408LysMet: 2.408 ± 0.454
5.669LysAsn: 5.669 ± 0.717
2.485LysPro: 2.485 ± 0.479
5.747LysGln: 5.747 ± 0.667
4.893LysArg: 4.893 ± 0.704
5.281LysSer: 5.281 ± 0.701
6.058LysThr: 6.058 ± 0.572
5.747LysVal: 5.747 ± 0.603
0.777LysTrp: 0.777 ± 0.184
3.495LysTyr: 3.495 ± 0.613
0.0LysXaa: 0.0 ± 0.0
Leu
3.262LeuAla: 3.262 ± 0.646
0.311LeuCys: 0.311 ± 0.159
5.048LeuAsp: 5.048 ± 0.538
5.669LeuGlu: 5.669 ± 0.837
3.495LeuPhe: 3.495 ± 0.593
3.883LeuGly: 3.883 ± 0.38
1.01LeuHis: 1.01 ± 0.288
4.349LeuIle: 4.349 ± 0.52
7.999LeuLys: 7.999 ± 0.651
5.592LeuLeu: 5.592 ± 0.773
1.398LeuMet: 1.398 ± 0.351
5.048LeuAsn: 5.048 ± 0.555
2.641LeuPro: 2.641 ± 0.337
3.029LeuGln: 3.029 ± 0.525
2.641LeuArg: 2.641 ± 0.379
4.582LeuSer: 4.582 ± 0.505
5.514LeuThr: 5.514 ± 0.657
4.427LeuVal: 4.427 ± 0.692
0.777LeuTrp: 0.777 ± 0.221
2.718LeuTyr: 2.718 ± 0.495
0.0LeuXaa: 0.0 ± 0.0
Met
0.932MetAla: 0.932 ± 0.28
0.078MetCys: 0.078 ± 0.071
1.553MetAsp: 1.553 ± 0.354
1.476MetGlu: 1.476 ± 0.304
1.01MetPhe: 1.01 ± 0.249
0.932MetGly: 0.932 ± 0.305
0.466MetHis: 0.466 ± 0.193
1.631MetIle: 1.631 ± 0.275
2.175MetLys: 2.175 ± 0.427
2.408MetLeu: 2.408 ± 0.421
0.777MetMet: 0.777 ± 0.241
1.864MetAsn: 1.864 ± 0.437
1.087MetPro: 1.087 ± 0.287
1.786MetGln: 1.786 ± 0.342
1.165MetArg: 1.165 ± 0.319
2.097MetSer: 2.097 ± 0.444
2.408MetThr: 2.408 ± 0.466
1.165MetVal: 1.165 ± 0.324
0.388MetTrp: 0.388 ± 0.157
1.01MetTyr: 1.01 ± 0.294
0.0MetXaa: 0.0 ± 0.0
Asn
5.436AsnAla: 5.436 ± 0.834
0.466AsnCys: 0.466 ± 0.24
4.349AsnAsp: 4.349 ± 0.659
4.505AsnGlu: 4.505 ± 0.665
3.262AsnPhe: 3.262 ± 0.643
5.048AsnGly: 5.048 ± 0.735
0.854AsnHis: 0.854 ± 0.23
4.039AsnIle: 4.039 ± 0.454
7.3AsnLys: 7.3 ± 0.632
4.737AsnLeu: 4.737 ± 0.507
1.864AsnMet: 1.864 ± 0.349
5.359AsnAsn: 5.359 ± 0.873
2.563AsnPro: 2.563 ± 0.558
2.563AsnGln: 2.563 ± 0.335
3.107AsnArg: 3.107 ± 0.527
2.718AsnSer: 2.718 ± 0.461
4.66AsnThr: 4.66 ± 0.561
4.349AsnVal: 4.349 ± 0.627
1.01AsnTrp: 1.01 ± 0.327
3.107AsnTyr: 3.107 ± 0.569
0.0AsnXaa: 0.0 ± 0.0
Pro
1.087ProAla: 1.087 ± 0.324
0.078ProCys: 0.078 ± 0.074
1.32ProAsp: 1.32 ± 0.243
1.942ProGlu: 1.942 ± 0.294
1.476ProPhe: 1.476 ± 0.338
1.553ProGly: 1.553 ± 0.391
0.466ProHis: 0.466 ± 0.172
2.33ProIle: 2.33 ± 0.387
3.262ProLys: 3.262 ± 0.721
1.243ProLeu: 1.243 ± 0.263
1.087ProMet: 1.087 ± 0.292
2.252ProAsn: 2.252 ± 0.428
0.621ProPro: 0.621 ± 0.288
1.243ProGln: 1.243 ± 0.266
1.01ProArg: 1.01 ± 0.286
1.631ProSer: 1.631 ± 0.35
1.864ProThr: 1.864 ± 0.355
2.408ProVal: 2.408 ± 0.45
0.155ProTrp: 0.155 ± 0.104
1.243ProTyr: 1.243 ± 0.375
0.0ProXaa: 0.0 ± 0.0
Gln
3.029GlnAla: 3.029 ± 0.448
0.388GlnCys: 0.388 ± 0.195
2.641GlnAsp: 2.641 ± 0.402
2.408GlnGlu: 2.408 ± 0.539
2.019GlnPhe: 2.019 ± 0.361
1.942GlnGly: 1.942 ± 0.326
0.621GlnHis: 0.621 ± 0.183
2.252GlnIle: 2.252 ± 0.318
2.796GlnLys: 2.796 ± 0.491
3.65GlnLeu: 3.65 ± 0.589
1.32GlnMet: 1.32 ± 0.328
3.107GlnAsn: 3.107 ± 0.677
2.097GlnPro: 2.097 ± 0.407
2.019GlnGln: 2.019 ± 0.471
2.408GlnArg: 2.408 ± 0.471
1.942GlnSer: 1.942 ± 0.382
2.252GlnThr: 2.252 ± 0.453
2.252GlnVal: 2.252 ± 0.407
0.311GlnTrp: 0.311 ± 0.137
1.398GlnTyr: 1.398 ± 0.399
0.0GlnXaa: 0.0 ± 0.0
Arg
1.709ArgAla: 1.709 ± 0.299
0.233ArgCys: 0.233 ± 0.117
2.563ArgAsp: 2.563 ± 0.565
2.951ArgGlu: 2.951 ± 0.471
1.631ArgPhe: 1.631 ± 0.419
2.641ArgGly: 2.641 ± 0.624
0.854ArgHis: 0.854 ± 0.214
3.262ArgIle: 3.262 ± 0.511
4.039ArgLys: 4.039 ± 0.622
3.262ArgLeu: 3.262 ± 0.47
0.621ArgMet: 0.621 ± 0.207
3.417ArgAsn: 3.417 ± 0.6
0.932ArgPro: 0.932 ± 0.231
1.476ArgGln: 1.476 ± 0.346
2.097ArgArg: 2.097 ± 0.476
1.709ArgSer: 1.709 ± 0.283
2.097ArgThr: 2.097 ± 0.415
2.563ArgVal: 2.563 ± 0.535
0.233ArgTrp: 0.233 ± 0.131
2.252ArgTyr: 2.252 ± 0.482
0.0ArgXaa: 0.0 ± 0.0
Ser
3.961SerAla: 3.961 ± 0.694
0.311SerCys: 0.311 ± 0.141
4.427SerAsp: 4.427 ± 0.834
3.107SerGlu: 3.107 ± 0.546
2.408SerPhe: 2.408 ± 0.425
2.874SerGly: 2.874 ± 0.579
0.777SerHis: 0.777 ± 0.317
4.737SerIle: 4.737 ± 0.567
4.815SerLys: 4.815 ± 0.592
4.039SerLeu: 4.039 ± 0.481
1.476SerMet: 1.476 ± 0.363
4.737SerAsn: 4.737 ± 0.509
1.476SerPro: 1.476 ± 0.4
2.097SerGln: 2.097 ± 0.395
2.641SerArg: 2.641 ± 0.365
3.34SerSer: 3.34 ± 0.677
3.65SerThr: 3.65 ± 0.459
3.728SerVal: 3.728 ± 0.516
0.388SerTrp: 0.388 ± 0.193
2.563SerTyr: 2.563 ± 0.451
0.0SerXaa: 0.0 ± 0.0
Thr
4.272ThrAla: 4.272 ± 0.728
0.155ThrCys: 0.155 ± 0.106
4.039ThrAsp: 4.039 ± 0.704
4.505ThrGlu: 4.505 ± 0.73
3.34ThrPhe: 3.34 ± 0.605
4.039ThrGly: 4.039 ± 0.744
0.854ThrHis: 0.854 ± 0.276
5.514ThrIle: 5.514 ± 1.098
6.135ThrLys: 6.135 ± 0.672
4.505ThrLeu: 4.505 ± 0.615
1.398ThrMet: 1.398 ± 0.325
4.116ThrAsn: 4.116 ± 0.635
1.864ThrPro: 1.864 ± 0.349
3.184ThrGln: 3.184 ± 0.468
1.631ThrArg: 1.631 ± 0.311
4.737ThrSer: 4.737 ± 0.767
4.66ThrThr: 4.66 ± 0.776
4.582ThrVal: 4.582 ± 0.66
0.932ThrTrp: 0.932 ± 0.269
2.641ThrTyr: 2.641 ± 0.496
0.0ThrXaa: 0.0 ± 0.0
Val
3.883ValAla: 3.883 ± 0.877
0.311ValCys: 0.311 ± 0.139
5.203ValAsp: 5.203 ± 0.685
5.126ValGlu: 5.126 ± 0.638
2.485ValPhe: 2.485 ± 0.48
2.718ValGly: 2.718 ± 0.539
0.777ValHis: 0.777 ± 0.303
4.97ValIle: 4.97 ± 0.554
5.203ValLys: 5.203 ± 0.53
4.815ValLeu: 4.815 ± 0.723
1.942ValMet: 1.942 ± 0.403
5.436ValAsn: 5.436 ± 0.555
2.252ValPro: 2.252 ± 0.551
1.864ValGln: 1.864 ± 0.333
2.252ValArg: 2.252 ± 0.448
3.728ValSer: 3.728 ± 0.712
3.806ValThr: 3.806 ± 0.438
3.883ValVal: 3.883 ± 0.624
0.854ValTrp: 0.854 ± 0.289
2.874ValTyr: 2.874 ± 0.523
0.0ValXaa: 0.0 ± 0.0
Trp
1.165TrpAla: 1.165 ± 0.495
0.078TrpCys: 0.078 ± 0.086
0.155TrpAsp: 0.155 ± 0.115
0.699TrpGlu: 0.699 ± 0.216
0.388TrpPhe: 0.388 ± 0.151
0.544TrpGly: 0.544 ± 0.272
0.311TrpHis: 0.311 ± 0.122
0.932TrpIle: 0.932 ± 0.216
0.854TrpLys: 0.854 ± 0.289
1.01TrpLeu: 1.01 ± 0.265
0.155TrpMet: 0.155 ± 0.119
1.709TrpAsn: 1.709 ± 0.934
0.155TrpPro: 0.155 ± 0.107
0.621TrpGln: 0.621 ± 0.226
0.311TrpArg: 0.311 ± 0.158
1.243TrpSer: 1.243 ± 0.3
0.854TrpThr: 0.854 ± 0.298
0.621TrpVal: 0.621 ± 0.228
0.078TrpTrp: 0.078 ± 0.088
0.699TrpTyr: 0.699 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.709TyrAla: 1.709 ± 0.395
0.388TyrCys: 0.388 ± 0.139
2.563TyrAsp: 2.563 ± 0.52
3.495TyrGlu: 3.495 ± 0.529
2.019TyrPhe: 2.019 ± 0.424
2.718TyrGly: 2.718 ± 0.489
0.854TyrHis: 0.854 ± 0.302
3.029TyrIle: 3.029 ± 0.458
4.66TyrLys: 4.66 ± 0.695
2.796TyrLeu: 2.796 ± 0.548
1.243TyrMet: 1.243 ± 0.258
3.107TyrAsn: 3.107 ± 0.407
1.32TyrPro: 1.32 ± 0.357
1.786TyrGln: 1.786 ± 0.351
2.019TyrArg: 2.019 ± 0.426
2.252TyrSer: 2.252 ± 0.411
2.485TyrThr: 2.485 ± 0.366
2.718TyrVal: 2.718 ± 0.522
0.699TyrTrp: 0.699 ± 0.204
1.864TyrTyr: 1.864 ± 0.364
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (12877 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski