Amino acid dipepetide frequency for Lachnospiraceae bacterium 2_1_46FAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.462AlaAla: 4.462 ± 0.117	0.834AlaCys: 0.834 ± 0.036	3.973AlaAsp: 3.973 ± 0.095	5.339AlaGlu: 5.339 ± 0.114	2.789AlaPhe: 2.789 ± 0.069	5.59AlaGly: 5.59 ± 0.115	0.944AlaHis: 0.944 ± 0.037	4.984AlaIle: 4.984 ± 0.109	5.787AlaLys: 5.787 ± 0.107	5.938AlaLeu: 5.938 ± 0.117	2.095AlaMet: 2.095 ± 0.056	2.789AlaAsn: 2.789 ± 0.073	1.698AlaPro: 1.698 ± 0.056	1.895AlaGln: 1.895 ± 0.065	2.314AlaArg: 2.314 ± 0.062	3.205AlaSer: 3.205 ± 0.072	3.365AlaThr: 3.365 ± 0.08	5.588AlaVal: 5.588 ± 0.104	0.541AlaTrp: 0.541 ± 0.028	2.5AlaTyr: 2.5 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.831CysAla: 0.831 ± 0.036	0.244CysCys: 0.244 ± 0.02	0.759CysAsp: 0.759 ± 0.033	0.939CysGlu: 0.939 ± 0.04	0.56CysPhe: 0.56 ± 0.031	1.306CysGly: 1.306 ± 0.048	0.322CysHis: 0.322 ± 0.02	1.054CysIle: 1.054 ± 0.042	0.927CysLys: 0.927 ± 0.033	0.948CysLeu: 0.948 ± 0.039	0.4CysMet: 0.4 ± 0.025	0.529CysAsn: 0.529 ± 0.028	0.535CysPro: 0.535 ± 0.031	0.358CysGln: 0.358 ± 0.021	0.5CysArg: 0.5 ± 0.026	0.699CysSer: 0.699 ± 0.035	0.681CysThr: 0.681 ± 0.035	0.999CysVal: 0.999 ± 0.038	0.081CysTrp: 0.081 ± 0.011	0.526CysTyr: 0.526 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.708AspAla: 3.708 ± 0.103	0.659AspCys: 0.659 ± 0.031	2.587AspAsp: 2.587 ± 0.079	4.414AspGlu: 4.414 ± 0.093	2.444AspPhe: 2.444 ± 0.062	4.105AspGly: 4.105 ± 0.117	0.593AspHis: 0.593 ± 0.031	4.54AspIle: 4.54 ± 0.084	4.507AspLys: 4.507 ± 0.096	4.173AspLeu: 4.173 ± 0.075	1.739AspMet: 1.739 ± 0.054	2.387AspAsn: 2.387 ± 0.083	1.177AspPro: 1.177 ± 0.041	0.75AspGln: 0.75 ± 0.032	2.05AspArg: 2.05 ± 0.058	2.769AspSer: 2.769 ± 0.069	3.213AspThr: 3.213 ± 0.082	3.839AspVal: 3.839 ± 0.083	0.557AspTrp: 0.557 ± 0.033	2.564AspTyr: 2.564 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.966GluAla: 4.966 ± 0.103	0.813GluCys: 0.813 ± 0.033	4.128GluAsp: 4.128 ± 0.084	9.464GluGlu: 9.464 ± 0.192	2.829GluPhe: 2.829 ± 0.071	4.947GluGly: 4.947 ± 0.104	1.349GluHis: 1.349 ± 0.055	6.539GluIle: 6.539 ± 0.103	9.245GluLys: 9.245 ± 0.155	7.15GluLeu: 7.15 ± 0.126	2.834GluMet: 2.834 ± 0.072	4.914GluAsn: 4.914 ± 0.093	1.769GluPro: 1.769 ± 0.06	3.147GluGln: 3.147 ± 0.086	3.607GluArg: 3.607 ± 0.088	3.493GluSer: 3.493 ± 0.083	4.375GluThr: 4.375 ± 0.081	5.642GluVal: 5.642 ± 0.105	0.77GluTrp: 0.77 ± 0.043	3.412GluTyr: 3.412 ± 0.088	0.0GluXaa: 0.0 ± 0.0
Phe	2.804PheAla: 2.804 ± 0.081	0.641PheCys: 0.641 ± 0.031	2.486PheAsp: 2.486 ± 0.065	2.85PheGlu: 2.85 ± 0.071	1.875PhePhe: 1.875 ± 0.064	2.93PheGly: 2.93 ± 0.082	0.863PheHis: 0.863 ± 0.036	3.009PheIle: 3.009 ± 0.087	2.266PheLys: 2.266 ± 0.055	3.755PheLeu: 3.755 ± 0.097	1.158PheMet: 1.158 ± 0.041	1.486PheAsn: 1.486 ± 0.053	1.312PhePro: 1.312 ± 0.047	1.328PheGln: 1.328 ± 0.041	1.556PheArg: 1.556 ± 0.053	2.804PheSer: 2.804 ± 0.07	2.309PheThr: 2.309 ± 0.081	2.961PheVal: 2.961 ± 0.072	0.401PheTrp: 0.401 ± 0.027	1.784PheTyr: 1.784 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.54GlyAla: 4.54 ± 0.095	1.032GlyCys: 1.032 ± 0.042	3.253GlyAsp: 3.253 ± 0.095	5.485GlyGlu: 5.485 ± 0.111	2.948GlyPhe: 2.948 ± 0.07	4.535GlyGly: 4.535 ± 0.099	1.186GlyHis: 1.186 ± 0.044	6.163GlyIle: 6.163 ± 0.114	6.758GlyLys: 6.758 ± 0.115	5.308GlyLeu: 5.308 ± 0.106	2.268GlyMet: 2.268 ± 0.062	3.651GlyAsn: 3.651 ± 0.106	1.105GlyPro: 1.105 ± 0.045	1.967GlyGln: 1.967 ± 0.06	2.85GlyArg: 2.85 ± 0.079	3.475GlySer: 3.475 ± 0.083	4.189GlyThr: 4.189 ± 0.102	5.125GlyVal: 5.125 ± 0.1	0.596GlyTrp: 0.596 ± 0.04	3.115GlyTyr: 3.115 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	0.938HisAla: 0.938 ± 0.038	0.292HisCys: 0.292 ± 0.021	0.879HisAsp: 0.879 ± 0.033	0.999HisGlu: 0.999 ± 0.038	0.779HisPhe: 0.779 ± 0.038	1.198HisGly: 1.198 ± 0.044	0.409HisHis: 0.409 ± 0.03	1.534HisIle: 1.534 ± 0.054	1.096HisLys: 1.096 ± 0.044	1.477HisLeu: 1.477 ± 0.051	0.551HisMet: 0.551 ± 0.032	0.735HisAsn: 0.735 ± 0.038	0.619HisPro: 0.619 ± 0.032	0.547HisGln: 0.547 ± 0.029	0.761HisArg: 0.761 ± 0.034	0.974HisSer: 0.974 ± 0.039	0.99HisThr: 0.99 ± 0.038	0.93HisVal: 0.93 ± 0.034	0.142HisTrp: 0.142 ± 0.014	0.74HisTyr: 0.74 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.443IleAla: 5.443 ± 0.116	1.305IleCys: 1.305 ± 0.047	4.171IleAsp: 4.171 ± 0.091	5.654IleGlu: 5.654 ± 0.125	3.177IlePhe: 3.177 ± 0.088	5.392IleGly: 5.392 ± 0.109	1.382IleHis: 1.382 ± 0.05	5.468IleIle: 5.468 ± 0.125	4.835IleLys: 4.835 ± 0.078	7.233IleLeu: 7.233 ± 0.142	2.002IleMet: 2.002 ± 0.061	2.841IleAsn: 2.841 ± 0.063	3.093IlePro: 3.093 ± 0.073	2.672IleGln: 2.672 ± 0.063	3.335IleArg: 3.335 ± 0.082	4.984IleSer: 4.984 ± 0.094	4.337IleThr: 4.337 ± 0.089	5.622IleVal: 5.622 ± 0.1	0.581IleTrp: 0.581 ± 0.031	2.844IleTyr: 2.844 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	5.467LysAla: 5.467 ± 0.114	0.792LysCys: 0.792 ± 0.04	4.715LysAsp: 4.715 ± 0.108	9.334LysGlu: 9.334 ± 0.155	2.339LysPhe: 2.339 ± 0.064	4.889LysGly: 4.889 ± 0.086	1.201LysHis: 1.201 ± 0.046	5.909LysIle: 5.909 ± 0.1	7.984LysLys: 7.984 ± 0.131	5.964LysLeu: 5.964 ± 0.101	2.727LysMet: 2.727 ± 0.073	4.4LysAsn: 4.4 ± 0.092	2.387LysPro: 2.387 ± 0.071	2.933LysGln: 2.933 ± 0.074	3.608LysArg: 3.608 ± 0.089	3.732LysSer: 3.732 ± 0.08	4.632LysThr: 4.632 ± 0.096	5.585LysVal: 5.585 ± 0.095	0.72LysTrp: 0.72 ± 0.033	3.448LysTyr: 3.448 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	5.967LeuAla: 5.967 ± 0.118	1.291LeuCys: 1.291 ± 0.053	4.574LeuAsp: 4.574 ± 0.077	6.854LeuGlu: 6.854 ± 0.116	3.653LeuPhe: 3.653 ± 0.101	5.699LeuGly: 5.699 ± 0.116	1.535LeuHis: 1.535 ± 0.053	5.927LeuIle: 5.927 ± 0.137	6.852LeuLys: 6.852 ± 0.115	8.073LeuLeu: 8.073 ± 0.148	2.235LeuMet: 2.235 ± 0.062	3.855LeuAsn: 3.855 ± 0.079	3.19LeuPro: 3.19 ± 0.078	3.15LeuGln: 3.15 ± 0.074	3.326LeuArg: 3.326 ± 0.088	5.855LeuSer: 5.855 ± 0.118	4.889LeuThr: 4.889 ± 0.094	5.339LeuVal: 5.339 ± 0.108	0.677LeuTrp: 0.677 ± 0.036	3.216LeuTyr: 3.216 ± 0.083	0.0LeuXaa: 0.0 ± 0.0
Met	2.16MetAla: 2.16 ± 0.059	0.334MetCys: 0.334 ± 0.02	1.55MetAsp: 1.55 ± 0.05	2.654MetGlu: 2.654 ± 0.072	1.074MetPhe: 1.074 ± 0.044	1.971MetGly: 1.971 ± 0.059	0.355MetHis: 0.355 ± 0.027	2.103MetIle: 2.103 ± 0.057	2.909MetLys: 2.909 ± 0.073	2.67MetLeu: 2.67 ± 0.075	0.915MetMet: 0.915 ± 0.039	1.526MetAsn: 1.526 ± 0.044	0.975MetPro: 0.975 ± 0.038	1.075MetGln: 1.075 ± 0.038	1.171MetArg: 1.171 ± 0.042	1.691MetSer: 1.691 ± 0.041	1.688MetThr: 1.688 ± 0.056	1.742MetVal: 1.742 ± 0.05	0.235MetTrp: 0.235 ± 0.018	0.948MetTyr: 0.948 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.214AsnAla: 3.214 ± 0.082	0.672AsnCys: 0.672 ± 0.032	2.236AsnAsp: 2.236 ± 0.068	3.467AsnGlu: 3.467 ± 0.083	1.609AsnPhe: 1.609 ± 0.045	3.837AsnGly: 3.837 ± 0.103	0.828AsnHis: 0.828 ± 0.037	3.684AsnIle: 3.684 ± 0.082	3.25AsnLys: 3.25 ± 0.084	3.773AsnLeu: 3.773 ± 0.082	1.384AsnMet: 1.384 ± 0.046	2.107AsnAsn: 2.107 ± 0.075	2.107AsnPro: 2.107 ± 0.051	1.558AsnGln: 1.558 ± 0.05	2.098AsnArg: 2.098 ± 0.053	2.211AsnSer: 2.211 ± 0.063	2.524AsnThr: 2.524 ± 0.075	3.356AsnVal: 3.356 ± 0.072	0.443AsnTrp: 0.443 ± 0.032	1.941AsnTyr: 1.941 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.98ProAla: 1.98 ± 0.056	0.401ProCys: 0.401 ± 0.028	1.752ProAsp: 1.752 ± 0.055	3.045ProGlu: 3.045 ± 0.068	1.369ProPhe: 1.369 ± 0.048	1.728ProGly: 1.728 ± 0.061	0.569ProHis: 0.569 ± 0.03	2.369ProIle: 2.369 ± 0.059	2.298ProLys: 2.298 ± 0.055	2.417ProLeu: 2.417 ± 0.06	0.804ProMet: 0.804 ± 0.039	1.466ProAsn: 1.466 ± 0.054	0.623ProPro: 0.623 ± 0.031	0.944ProGln: 0.944 ± 0.042	0.83ProArg: 0.83 ± 0.034	1.739ProSer: 1.739 ± 0.053	1.659ProThr: 1.659 ± 0.054	2.495ProVal: 2.495 ± 0.064	0.246ProTrp: 0.246 ± 0.018	1.315ProTyr: 1.315 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.113GlnAla: 2.113 ± 0.062	0.331GlnCys: 0.331 ± 0.021	1.303GlnAsp: 1.303 ± 0.042	2.813GlnGlu: 2.813 ± 0.077	1.331GlnPhe: 1.331 ± 0.05	2.029GlnGly: 2.029 ± 0.057	0.412GlnHis: 0.412 ± 0.024	2.629GlnIle: 2.629 ± 0.058	3.144GlnLys: 3.144 ± 0.077	2.814GlnLeu: 2.814 ± 0.078	1.177GlnMet: 1.177 ± 0.042	1.692GlnAsn: 1.692 ± 0.055	0.857GlnPro: 0.857 ± 0.038	1.101GlnGln: 1.101 ± 0.046	1.234GlnArg: 1.234 ± 0.05	1.653GlnSer: 1.653 ± 0.049	1.724GlnThr: 1.724 ± 0.055	2.013GlnVal: 2.013 ± 0.056	0.271GlnTrp: 0.271 ± 0.021	1.363GlnTyr: 1.363 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	2.245ArgAla: 2.245 ± 0.064	0.47ArgCys: 0.47 ± 0.03	1.772ArgAsp: 1.772 ± 0.056	3.988ArgGlu: 3.988 ± 0.088	1.709ArgPhe: 1.709 ± 0.05	2.366ArgGly: 2.366 ± 0.056	0.66ArgHis: 0.66 ± 0.032	3.232ArgIle: 3.232 ± 0.078	3.795ArgLys: 3.795 ± 0.081	3.398ArgLeu: 3.398 ± 0.081	1.309ArgMet: 1.309 ± 0.046	1.984ArgAsn: 1.984 ± 0.059	1.059ArgPro: 1.059 ± 0.044	1.598ArgGln: 1.598 ± 0.046	2.058ArgArg: 2.058 ± 0.059	1.749ArgSer: 1.749 ± 0.053	2.121ArgThr: 2.121 ± 0.055	2.646ArgVal: 2.646 ± 0.054	0.318ArgTrp: 0.318 ± 0.025	1.754ArgTyr: 1.754 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.951SerAla: 3.951 ± 0.078	0.665SerCys: 0.665 ± 0.031	2.862SerAsp: 2.862 ± 0.071	4.149SerGlu: 4.149 ± 0.078	2.572SerPhe: 2.572 ± 0.062	4.597SerGly: 4.597 ± 0.107	0.983SerHis: 0.983 ± 0.036	4.033SerIle: 4.033 ± 0.089	3.794SerLys: 3.794 ± 0.078	4.754SerLeu: 4.754 ± 0.087	1.529SerMet: 1.529 ± 0.05	2.181SerAsn: 2.181 ± 0.061	1.61SerPro: 1.61 ± 0.054	1.622SerGln: 1.622 ± 0.048	2.151SerArg: 2.151 ± 0.066	3.093SerSer: 3.093 ± 0.083	2.739SerThr: 2.739 ± 0.067	4.351SerVal: 4.351 ± 0.084	0.487SerTrp: 0.487 ± 0.029	2.378SerTyr: 2.378 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	4.06ThrAla: 4.06 ± 0.091	0.503ThrCys: 0.503 ± 0.027	3.087ThrAsp: 3.087 ± 0.083	4.263ThrGlu: 4.263 ± 0.089	2.494ThrPhe: 2.494 ± 0.077	4.286ThrGly: 4.286 ± 0.097	0.881ThrHis: 0.881 ± 0.038	4.249ThrIle: 4.249 ± 0.077	4.146ThrLys: 4.146 ± 0.082	5.157ThrLeu: 5.157 ± 0.088	1.493ThrMet: 1.493 ± 0.052	2.262ThrAsn: 2.262 ± 0.062	2.115ThrPro: 2.115 ± 0.062	1.475ThrGln: 1.475 ± 0.045	1.817ThrArg: 1.817 ± 0.052	2.974ThrSer: 2.974 ± 0.067	3.114ThrThr: 3.114 ± 0.08	4.773ThrVal: 4.773 ± 0.111	0.514ThrTrp: 0.514 ± 0.031	2.326ThrTyr: 2.326 ± 0.084	0.0ThrXaa: 0.0 ± 0.0
Val	4.673ValAla: 4.673 ± 0.107	1.149ValCys: 1.149 ± 0.047	3.774ValAsp: 3.774 ± 0.092	5.664ValGlu: 5.664 ± 0.097	2.859ValPhe: 2.859 ± 0.074	4.591ValGly: 4.591 ± 0.091	1.11ValHis: 1.11 ± 0.044	5.329ValIle: 5.329 ± 0.106	5.536ValLys: 5.536 ± 0.119	6.803ValLeu: 6.803 ± 0.117	1.904ValMet: 1.904 ± 0.059	3.073ValAsn: 3.073 ± 0.08	2.305ValPro: 2.305 ± 0.056	2.077ValGln: 2.077 ± 0.062	2.702ValArg: 2.702 ± 0.074	4.779ValSer: 4.779 ± 0.084	4.57ValThr: 4.57 ± 0.122	5.089ValVal: 5.089 ± 0.114	0.619ValTrp: 0.619 ± 0.035	2.792ValTyr: 2.792 ± 0.074	0.0ValXaa: 0.0 ± 0.0
Trp	0.475TrpAla: 0.475 ± 0.028	0.148TrpCys: 0.148 ± 0.015	0.47TrpAsp: 0.47 ± 0.028	0.698TrpGlu: 0.698 ± 0.036	0.343TrpPhe: 0.343 ± 0.021	0.631TrpGly: 0.631 ± 0.039	0.139TrpHis: 0.139 ± 0.014	0.655TrpIle: 0.655 ± 0.035	0.878TrpLys: 0.878 ± 0.037	0.804TrpLeu: 0.804 ± 0.033	0.129TrpMet: 0.129 ± 0.014	0.514TrpAsn: 0.514 ± 0.029	0.171TrpPro: 0.171 ± 0.017	0.365TrpGln: 0.365 ± 0.03	0.332TrpArg: 0.332 ± 0.022	0.458TrpSer: 0.458 ± 0.03	0.433TrpThr: 0.433 ± 0.029	0.517TrpVal: 0.517 ± 0.028	0.087TrpTrp: 0.087 ± 0.011	0.374TrpTyr: 0.374 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.635TyrAla: 2.635 ± 0.077	0.623TyrCys: 0.623 ± 0.033	2.443TyrAsp: 2.443 ± 0.067	3.32TyrGlu: 3.32 ± 0.083	1.826TyrPhe: 1.826 ± 0.056	2.922TyrGly: 2.922 ± 0.071	0.867TyrHis: 0.867 ± 0.047	2.963TyrIle: 2.963 ± 0.075	2.762TyrLys: 2.762 ± 0.065	3.547TyrLeu: 3.547 ± 0.073	1.092TyrMet: 1.092 ± 0.039	1.907TyrAsn: 1.907 ± 0.071	1.343TyrPro: 1.343 ± 0.048	1.444TyrGln: 1.444 ± 0.052	1.932TyrArg: 1.932 ± 0.054	2.161TyrSer: 2.161 ± 0.064	2.435TyrThr: 2.435 ± 0.064	2.783TyrVal: 2.783 ± 0.064	0.335TyrTrp: 0.335 ± 0.021	1.811TyrTyr: 1.811 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2056 proteins (667679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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