Amino acid dipepetide frequency for Lactococcus phage P1046

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.871AlaAla: 5.871 ± 1.205
0.237AlaCys: 0.237 ± 0.131
3.973AlaAsp: 3.973 ± 0.44
4.092AlaGlu: 4.092 ± 0.701
2.965AlaPhe: 2.965 ± 0.503
5.219AlaGly: 5.219 ± 1.155
1.127AlaHis: 1.127 ± 0.296
5.634AlaIle: 5.634 ± 0.806
5.515AlaLys: 5.515 ± 0.623
5.93AlaLeu: 5.93 ± 1.508
2.55AlaMet: 2.55 ± 0.665
4.507AlaAsn: 4.507 ± 0.555
1.957AlaPro: 1.957 ± 0.333
2.194AlaGln: 2.194 ± 0.388
2.016AlaArg: 2.016 ± 0.391
5.871AlaSer: 5.871 ± 1.117
4.744AlaThr: 4.744 ± 0.512
5.397AlaVal: 5.397 ± 0.944
0.949AlaTrp: 0.949 ± 0.308
2.906AlaTyr: 2.906 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.356CysAla: 0.356 ± 0.162
0.0CysCys: 0.0 ± 0.0
0.119CysAsp: 0.119 ± 0.099
0.415CysGlu: 0.415 ± 0.137
0.178CysPhe: 0.178 ± 0.108
0.119CysGly: 0.119 ± 0.103
0.059CysHis: 0.059 ± 0.06
0.474CysIle: 0.474 ± 0.204
0.297CysLys: 0.297 ± 0.158
0.356CysLeu: 0.356 ± 0.147
0.119CysMet: 0.119 ± 0.09
0.059CysAsn: 0.059 ± 0.056
0.059CysPro: 0.059 ± 0.074
0.237CysGln: 0.237 ± 0.127
0.297CysArg: 0.297 ± 0.129
0.297CysSer: 0.297 ± 0.157
0.415CysThr: 0.415 ± 0.157
0.178CysVal: 0.178 ± 0.092
0.059CysTrp: 0.059 ± 0.052
0.119CysTyr: 0.119 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
4.507AspAla: 4.507 ± 0.79
0.119AspCys: 0.119 ± 0.093
3.677AspAsp: 3.677 ± 0.721
3.736AspGlu: 3.736 ± 0.628
3.262AspPhe: 3.262 ± 0.467
6.049AspGly: 6.049 ± 1.052
0.771AspHis: 0.771 ± 0.244
5.397AspIle: 5.397 ± 0.888
3.855AspLys: 3.855 ± 0.544
5.278AspLeu: 5.278 ± 0.611
2.016AspMet: 2.016 ± 0.296
4.033AspAsn: 4.033 ± 0.563
2.609AspPro: 2.609 ± 0.54
1.779AspGln: 1.779 ± 0.318
1.779AspArg: 1.779 ± 0.395
3.796AspSer: 3.796 ± 0.448
3.499AspThr: 3.499 ± 0.518
3.499AspVal: 3.499 ± 0.475
1.245AspTrp: 1.245 ± 0.301
3.025AspTyr: 3.025 ± 0.49
0.0AspXaa: 0.0 ± 0.0
Glu
4.389GluAla: 4.389 ± 0.659
0.297GluCys: 0.297 ± 0.142
3.558GluAsp: 3.558 ± 0.741
5.1GluGlu: 5.1 ± 0.739
2.491GluPhe: 2.491 ± 0.394
2.906GluGly: 2.906 ± 0.397
0.89GluHis: 0.89 ± 0.258
4.448GluIle: 4.448 ± 0.604
4.389GluLys: 4.389 ± 0.666
5.99GluLeu: 5.99 ± 0.837
1.779GluMet: 1.779 ± 0.32
3.973GluAsn: 3.973 ± 0.589
1.245GluPro: 1.245 ± 0.281
3.025GluGln: 3.025 ± 0.686
2.728GluArg: 2.728 ± 0.566
2.728GluSer: 2.728 ± 0.31
3.855GluThr: 3.855 ± 0.679
3.499GluVal: 3.499 ± 0.609
0.771GluTrp: 0.771 ± 0.255
2.787GluTyr: 2.787 ± 0.516
0.0GluXaa: 0.0 ± 0.0
Phe
2.787PheAla: 2.787 ± 0.487
0.297PheCys: 0.297 ± 0.144
3.202PheAsp: 3.202 ± 0.621
2.313PheGlu: 2.313 ± 0.497
1.423PhePhe: 1.423 ± 0.31
3.499PheGly: 3.499 ± 0.603
0.297PheHis: 0.297 ± 0.16
2.787PheIle: 2.787 ± 0.48
3.736PheLys: 3.736 ± 0.41
1.779PheLeu: 1.779 ± 0.266
0.771PheMet: 0.771 ± 0.226
2.254PheAsn: 2.254 ± 0.371
1.305PhePro: 1.305 ± 0.256
1.067PheGln: 1.067 ± 0.276
1.127PheArg: 1.127 ± 0.298
2.135PheSer: 2.135 ± 0.404
2.313PheThr: 2.313 ± 0.53
1.779PheVal: 1.779 ± 0.326
0.356PheTrp: 0.356 ± 0.176
1.364PheTyr: 1.364 ± 0.341
0.0PheXaa: 0.0 ± 0.0
Gly
6.049GlyAla: 6.049 ± 1.556
0.297GlyCys: 0.297 ± 0.151
3.796GlyAsp: 3.796 ± 0.514
3.914GlyGlu: 3.914 ± 0.586
2.55GlyPhe: 2.55 ± 0.506
4.566GlyGly: 4.566 ± 0.898
1.186GlyHis: 1.186 ± 0.284
5.337GlyIle: 5.337 ± 0.722
5.337GlyLys: 5.337 ± 0.592
5.278GlyLeu: 5.278 ± 1.173
2.254GlyMet: 2.254 ± 0.436
4.626GlyAsn: 4.626 ± 0.715
1.483GlyPro: 1.483 ± 0.353
2.491GlyGln: 2.491 ± 0.482
1.838GlyArg: 1.838 ± 0.339
4.566GlySer: 4.566 ± 0.876
4.863GlyThr: 4.863 ± 0.77
6.82GlyVal: 6.82 ± 0.929
1.305GlyTrp: 1.305 ± 0.294
2.372GlyTyr: 2.372 ± 0.464
0.0GlyXaa: 0.0 ± 0.0
His
0.771HisAla: 0.771 ± 0.267
0.059HisCys: 0.059 ± 0.07
1.186HisAsp: 1.186 ± 0.23
1.067HisGlu: 1.067 ± 0.315
0.712HisPhe: 0.712 ± 0.227
0.83HisGly: 0.83 ± 0.278
0.534HisHis: 0.534 ± 0.203
1.305HisIle: 1.305 ± 0.269
1.305HisLys: 1.305 ± 0.328
0.83HisLeu: 0.83 ± 0.214
0.534HisMet: 0.534 ± 0.209
1.127HisAsn: 1.127 ± 0.28
0.297HisPro: 0.297 ± 0.109
0.534HisGln: 0.534 ± 0.148
0.237HisArg: 0.237 ± 0.131
1.483HisSer: 1.483 ± 0.283
0.652HisThr: 0.652 ± 0.283
1.008HisVal: 1.008 ± 0.234
0.297HisTrp: 0.297 ± 0.144
0.949HisTyr: 0.949 ± 0.265
0.0HisXaa: 0.0 ± 0.0
Ile
4.804IleAla: 4.804 ± 0.543
0.356IleCys: 0.356 ± 0.168
5.575IleAsp: 5.575 ± 0.507
4.685IleGlu: 4.685 ± 0.814
1.601IlePhe: 1.601 ± 0.336
4.566IleGly: 4.566 ± 0.801
1.245IleHis: 1.245 ± 0.236
5.397IleIle: 5.397 ± 0.597
5.93IleLys: 5.93 ± 0.515
6.108IleLeu: 6.108 ± 0.677
1.364IleMet: 1.364 ± 0.293
5.575IleAsn: 5.575 ± 0.596
3.025IlePro: 3.025 ± 0.417
2.432IleGln: 2.432 ± 0.407
1.898IleArg: 1.898 ± 0.365
4.804IleSer: 4.804 ± 0.583
6.939IleThr: 6.939 ± 0.557
4.092IleVal: 4.092 ± 0.644
0.771IleTrp: 0.771 ± 0.277
2.076IleTyr: 2.076 ± 0.464
0.0IleXaa: 0.0 ± 0.0
Lys
4.744LysAla: 4.744 ± 0.58
0.237LysCys: 0.237 ± 0.137
4.982LysAsp: 4.982 ± 0.82
5.693LysGlu: 5.693 ± 0.792
2.313LysPhe: 2.313 ± 0.385
4.804LysGly: 4.804 ± 0.687
1.957LysHis: 1.957 ± 0.337
4.863LysIle: 4.863 ± 0.484
5.99LysLys: 5.99 ± 1.095
6.761LysLeu: 6.761 ± 0.747
2.491LysMet: 2.491 ± 0.406
3.618LysAsn: 3.618 ± 0.587
2.016LysPro: 2.016 ± 0.362
2.965LysGln: 2.965 ± 0.477
3.025LysArg: 3.025 ± 0.638
5.16LysSer: 5.16 ± 0.622
5.041LysThr: 5.041 ± 0.559
4.626LysVal: 4.626 ± 0.605
1.067LysTrp: 1.067 ± 0.294
3.855LysTyr: 3.855 ± 0.618
0.0LysXaa: 0.0 ± 0.0
Leu
6.049LeuAla: 6.049 ± 1.128
0.297LeuCys: 0.297 ± 0.138
5.278LeuAsp: 5.278 ± 0.491
4.151LeuGlu: 4.151 ± 0.666
2.787LeuPhe: 2.787 ± 0.431
6.049LeuGly: 6.049 ± 1.489
1.661LeuHis: 1.661 ± 0.368
5.871LeuIle: 5.871 ± 0.633
6.761LeuLys: 6.761 ± 0.904
5.397LeuLeu: 5.397 ± 0.599
1.661LeuMet: 1.661 ± 0.345
5.219LeuAsn: 5.219 ± 0.741
2.016LeuPro: 2.016 ± 0.33
3.143LeuGln: 3.143 ± 0.404
2.728LeuArg: 2.728 ± 0.387
5.634LeuSer: 5.634 ± 0.847
5.456LeuThr: 5.456 ± 0.721
5.041LeuVal: 5.041 ± 0.646
1.067LeuTrp: 1.067 ± 0.285
2.669LeuTyr: 2.669 ± 0.515
0.0LeuXaa: 0.0 ± 0.0
Met
2.135MetAla: 2.135 ± 0.421
0.059MetCys: 0.059 ± 0.065
1.779MetAsp: 1.779 ± 0.352
1.542MetGlu: 1.542 ± 0.282
0.89MetPhe: 0.89 ± 0.244
1.898MetGly: 1.898 ± 0.36
0.415MetHis: 0.415 ± 0.153
1.661MetIle: 1.661 ± 0.366
2.491MetLys: 2.491 ± 0.461
2.432MetLeu: 2.432 ± 0.438
0.83MetMet: 0.83 ± 0.241
1.542MetAsn: 1.542 ± 0.322
0.652MetPro: 0.652 ± 0.182
1.305MetGln: 1.305 ± 0.325
1.186MetArg: 1.186 ± 0.246
2.076MetSer: 2.076 ± 0.352
1.423MetThr: 1.423 ± 0.208
1.483MetVal: 1.483 ± 0.374
0.237MetTrp: 0.237 ± 0.111
0.712MetTyr: 0.712 ± 0.216
0.0MetXaa: 0.0 ± 0.0
Asn
5.041AsnAla: 5.041 ± 0.648
0.237AsnCys: 0.237 ± 0.134
4.626AsnAsp: 4.626 ± 0.749
4.507AsnGlu: 4.507 ± 0.524
2.194AsnPhe: 2.194 ± 0.349
5.693AsnGly: 5.693 ± 0.809
0.89AsnHis: 0.89 ± 0.255
5.456AsnIle: 5.456 ± 0.776
4.566AsnLys: 4.566 ± 0.633
4.626AsnLeu: 4.626 ± 0.539
1.601AsnMet: 1.601 ± 0.324
3.973AsnAsn: 3.973 ± 0.706
2.669AsnPro: 2.669 ± 0.38
3.143AsnGln: 3.143 ± 0.839
2.194AsnArg: 2.194 ± 0.386
4.033AsnSer: 4.033 ± 0.535
4.566AsnThr: 4.566 ± 0.625
3.855AsnVal: 3.855 ± 0.503
0.474AsnTrp: 0.474 ± 0.163
2.254AsnTyr: 2.254 ± 0.413
0.0AsnXaa: 0.0 ± 0.0
Pro
2.372ProAla: 2.372 ± 0.352
0.356ProCys: 0.356 ± 0.205
1.72ProAsp: 1.72 ± 0.357
2.55ProGlu: 2.55 ± 0.445
1.838ProPhe: 1.838 ± 0.266
2.787ProGly: 2.787 ± 0.557
0.474ProHis: 0.474 ± 0.12
2.432ProIle: 2.432 ± 0.363
2.432ProLys: 2.432 ± 0.538
1.601ProLeu: 1.601 ± 0.305
0.593ProMet: 0.593 ± 0.196
2.847ProAsn: 2.847 ± 0.434
0.712ProPro: 0.712 ± 0.18
1.008ProGln: 1.008 ± 0.212
1.008ProArg: 1.008 ± 0.242
1.957ProSer: 1.957 ± 0.327
2.135ProThr: 2.135 ± 0.452
1.601ProVal: 1.601 ± 0.289
0.593ProTrp: 0.593 ± 0.171
1.364ProTyr: 1.364 ± 0.331
0.0ProXaa: 0.0 ± 0.0
Gln
2.669GlnAla: 2.669 ± 0.458
0.119GlnCys: 0.119 ± 0.092
1.957GlnAsp: 1.957 ± 0.418
1.957GlnGlu: 1.957 ± 0.373
1.72GlnPhe: 1.72 ± 0.258
2.491GlnGly: 2.491 ± 0.502
0.593GlnHis: 0.593 ± 0.212
2.965GlnIle: 2.965 ± 0.553
2.135GlnLys: 2.135 ± 0.329
3.38GlnLeu: 3.38 ± 0.595
1.186GlnMet: 1.186 ± 0.256
2.847GlnAsn: 2.847 ± 0.403
1.542GlnPro: 1.542 ± 0.258
1.898GlnGln: 1.898 ± 0.497
1.305GlnArg: 1.305 ± 0.293
2.016GlnSer: 2.016 ± 0.297
1.957GlnThr: 1.957 ± 0.488
2.313GlnVal: 2.313 ± 0.397
0.474GlnTrp: 0.474 ± 0.19
1.779GlnTyr: 1.779 ± 0.384
0.0GlnXaa: 0.0 ± 0.0
Arg
2.254ArgAla: 2.254 ± 0.411
0.178ArgCys: 0.178 ± 0.102
1.779ArgAsp: 1.779 ± 0.389
2.076ArgGlu: 2.076 ± 0.444
1.186ArgPhe: 1.186 ± 0.314
2.076ArgGly: 2.076 ± 0.409
0.83ArgHis: 0.83 ± 0.31
1.838ArgIle: 1.838 ± 0.399
2.016ArgLys: 2.016 ± 0.48
3.025ArgLeu: 3.025 ± 0.592
0.949ArgMet: 0.949 ± 0.243
2.313ArgAsn: 2.313 ± 0.443
1.305ArgPro: 1.305 ± 0.269
1.601ArgGln: 1.601 ± 0.344
1.601ArgArg: 1.601 ± 0.433
1.957ArgSer: 1.957 ± 0.464
2.609ArgThr: 2.609 ± 0.464
1.957ArgVal: 1.957 ± 0.336
0.237ArgTrp: 0.237 ± 0.142
1.305ArgTyr: 1.305 ± 0.334
0.0ArgXaa: 0.0 ± 0.0
Ser
4.27SerAla: 4.27 ± 0.553
0.178SerCys: 0.178 ± 0.107
3.321SerAsp: 3.321 ± 0.46
3.025SerGlu: 3.025 ± 0.485
2.609SerPhe: 2.609 ± 0.449
5.871SerGly: 5.871 ± 1.071
0.415SerHis: 0.415 ± 0.148
4.329SerIle: 4.329 ± 0.573
5.99SerLys: 5.99 ± 0.925
5.16SerLeu: 5.16 ± 0.766
1.483SerMet: 1.483 ± 0.228
4.448SerAsn: 4.448 ± 0.522
1.661SerPro: 1.661 ± 0.342
2.847SerGln: 2.847 ± 0.53
2.609SerArg: 2.609 ± 0.398
4.389SerSer: 4.389 ± 0.577
4.092SerThr: 4.092 ± 0.654
4.389SerVal: 4.389 ± 0.573
0.652SerTrp: 0.652 ± 0.198
2.313SerTyr: 2.313 ± 0.376
0.0SerXaa: 0.0 ± 0.0
Thr
6.049ThrAla: 6.049 ± 0.81
0.297ThrCys: 0.297 ± 0.205
4.507ThrAsp: 4.507 ± 0.491
3.321ThrGlu: 3.321 ± 0.688
2.55ThrPhe: 2.55 ± 0.462
4.507ThrGly: 4.507 ± 0.739
0.712ThrHis: 0.712 ± 0.251
4.982ThrIle: 4.982 ± 0.769
4.389ThrLys: 4.389 ± 0.414
5.93ThrLeu: 5.93 ± 0.741
1.483ThrMet: 1.483 ± 0.371
4.27ThrAsn: 4.27 ± 0.656
3.558ThrPro: 3.558 ± 0.446
2.076ThrGln: 2.076 ± 0.333
2.076ThrArg: 2.076 ± 0.367
4.151ThrSer: 4.151 ± 0.659
6.108ThrThr: 6.108 ± 1.18
4.566ThrVal: 4.566 ± 0.609
1.008ThrTrp: 1.008 ± 0.297
2.669ThrTyr: 2.669 ± 0.482
0.0ThrXaa: 0.0 ± 0.0
Val
4.626ValAla: 4.626 ± 0.667
0.059ValCys: 0.059 ± 0.056
4.744ValAsp: 4.744 ± 0.661
3.558ValGlu: 3.558 ± 0.506
1.72ValPhe: 1.72 ± 0.296
3.499ValGly: 3.499 ± 0.502
0.652ValHis: 0.652 ± 0.183
4.448ValIle: 4.448 ± 0.574
5.397ValLys: 5.397 ± 0.679
4.863ValLeu: 4.863 ± 0.701
1.483ValMet: 1.483 ± 0.344
5.278ValAsn: 5.278 ± 0.775
2.669ValPro: 2.669 ± 0.387
1.542ValGln: 1.542 ± 0.319
1.898ValArg: 1.898 ± 0.384
3.736ValSer: 3.736 ± 0.431
4.626ValThr: 4.626 ± 0.586
4.27ValVal: 4.27 ± 0.694
0.89ValTrp: 0.89 ± 0.291
3.084ValTyr: 3.084 ± 0.497
0.0ValXaa: 0.0 ± 0.0
Trp
1.127TrpAla: 1.127 ± 0.268
0.059TrpCys: 0.059 ± 0.07
1.067TrpAsp: 1.067 ± 0.309
0.89TrpGlu: 0.89 ± 0.234
0.356TrpPhe: 0.356 ± 0.145
0.712TrpGly: 0.712 ± 0.172
0.237TrpHis: 0.237 ± 0.112
0.949TrpIle: 0.949 ± 0.291
0.593TrpLys: 0.593 ± 0.2
1.067TrpLeu: 1.067 ± 0.243
0.356TrpMet: 0.356 ± 0.167
1.067TrpAsn: 1.067 ± 0.254
0.297TrpPro: 0.297 ± 0.125
0.356TrpGln: 0.356 ± 0.137
0.356TrpArg: 0.356 ± 0.147
0.89TrpSer: 0.89 ± 0.24
1.127TrpThr: 1.127 ± 0.328
0.83TrpVal: 0.83 ± 0.256
0.178TrpTrp: 0.178 ± 0.114
0.593TrpTyr: 0.593 ± 0.213
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.787TyrAla: 2.787 ± 0.408
0.474TyrCys: 0.474 ± 0.233
3.084TyrAsp: 3.084 ± 0.583
2.313TyrGlu: 2.313 ± 0.489
1.245TyrPhe: 1.245 ± 0.388
2.787TyrGly: 2.787 ± 0.502
0.771TyrHis: 0.771 ± 0.234
2.669TyrIle: 2.669 ± 0.515
3.084TyrLys: 3.084 ± 0.505
3.143TyrLeu: 3.143 ± 0.549
1.186TyrMet: 1.186 ± 0.277
3.025TyrAsn: 3.025 ± 0.654
1.305TyrPro: 1.305 ± 0.376
1.661TyrGln: 1.661 ± 0.304
1.186TyrArg: 1.186 ± 0.239
2.372TyrSer: 2.372 ± 0.483
2.787TyrThr: 2.787 ± 0.557
1.838TyrVal: 1.838 ± 0.361
0.474TyrTrp: 0.474 ± 0.164
2.016TyrTyr: 2.016 ± 0.371
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (16863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski