Amino acid dipepetide frequency for Cupriavidus sp. UYMMa02A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.051AlaAla: 17.051 ± 0.187	1.59AlaCys: 1.59 ± 0.041	6.465AlaAsp: 6.465 ± 0.079	6.474AlaGlu: 6.474 ± 0.088	4.208AlaPhe: 4.208 ± 0.069	10.872AlaGly: 10.872 ± 0.113	2.708AlaHis: 2.708 ± 0.058	5.696AlaIle: 5.696 ± 0.083	3.458AlaLys: 3.458 ± 0.076	13.389AlaLeu: 13.389 ± 0.129	3.826AlaMet: 3.826 ± 0.056	3.054AlaAsn: 3.054 ± 0.057	5.566AlaPro: 5.566 ± 0.093	5.03AlaGln: 5.03 ± 0.066	9.16AlaArg: 9.16 ± 0.115	7.077AlaSer: 7.077 ± 0.084	6.017AlaThr: 6.017 ± 0.082	8.87AlaVal: 8.87 ± 0.098	1.823AlaTrp: 1.823 ± 0.045	2.613AlaTyr: 2.613 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.399CysAla: 1.399 ± 0.038	0.161CysCys: 0.161 ± 0.013	0.568CysAsp: 0.568 ± 0.026	0.584CysGlu: 0.584 ± 0.022	0.38CysPhe: 0.38 ± 0.02	1.132CysGly: 1.132 ± 0.037	0.305CysHis: 0.305 ± 0.018	0.459CysIle: 0.459 ± 0.021	0.288CysLys: 0.288 ± 0.019	1.024CysLeu: 1.024 ± 0.033	0.248CysMet: 0.248 ± 0.017	0.278CysAsn: 0.278 ± 0.017	0.593CysPro: 0.593 ± 0.027	0.354CysGln: 0.354 ± 0.02	0.817CysArg: 0.817 ± 0.025	0.658CysSer: 0.658 ± 0.025	0.591CysThr: 0.591 ± 0.023	0.801CysVal: 0.801 ± 0.032	0.164CysTrp: 0.164 ± 0.014	0.293CysTyr: 0.293 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.865AspAla: 6.865 ± 0.093	0.554AspCys: 0.554 ± 0.025	2.712AspAsp: 2.712 ± 0.058	3.067AspGlu: 3.067 ± 0.062	1.977AspPhe: 1.977 ± 0.048	4.513AspGly: 4.513 ± 0.086	1.147AspHis: 1.147 ± 0.032	2.64AspIle: 2.64 ± 0.058	1.621AspLys: 1.621 ± 0.046	5.097AspLeu: 5.097 ± 0.073	1.37AspMet: 1.37 ± 0.038	1.322AspAsn: 1.322 ± 0.042	2.944AspPro: 2.944 ± 0.05	1.598AspGln: 1.598 ± 0.043	3.362AspArg: 3.362 ± 0.062	2.416AspSer: 2.416 ± 0.05	2.566AspThr: 2.566 ± 0.052	4.129AspVal: 4.129 ± 0.058	0.93AspTrp: 0.93 ± 0.027	1.524AspTyr: 1.524 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.824GluAla: 6.824 ± 0.087	0.496GluCys: 0.496 ± 0.022	2.413GluAsp: 2.413 ± 0.048	2.565GluGlu: 2.565 ± 0.055	1.693GluPhe: 1.693 ± 0.043	3.561GluGly: 3.561 ± 0.07	1.449GluHis: 1.449 ± 0.046	2.857GluIle: 2.857 ± 0.05	1.766GluLys: 1.766 ± 0.041	5.684GluLeu: 5.684 ± 0.091	1.373GluMet: 1.373 ± 0.038	1.375GluAsn: 1.375 ± 0.032	2.393GluPro: 2.393 ± 0.062	2.564GluGln: 2.564 ± 0.058	4.601GluArg: 4.601 ± 0.079	2.716GluSer: 2.716 ± 0.056	2.591GluThr: 2.591 ± 0.05	3.798GluVal: 3.798 ± 0.065	0.735GluTrp: 0.735 ± 0.029	1.189GluTyr: 1.189 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.386PheAla: 4.386 ± 0.072	0.467PheCys: 0.467 ± 0.023	2.299PheAsp: 2.299 ± 0.05	1.943PheGlu: 1.943 ± 0.046	1.33PhePhe: 1.33 ± 0.039	3.598PheGly: 3.598 ± 0.068	0.829PheHis: 0.829 ± 0.03	1.597PheIle: 1.597 ± 0.042	0.979PheLys: 0.979 ± 0.034	3.163PheLeu: 3.163 ± 0.063	0.817PheMet: 0.817 ± 0.028	1.072PheAsn: 1.072 ± 0.036	1.63PhePro: 1.63 ± 0.045	1.026PheGln: 1.026 ± 0.029	2.255PheArg: 2.255 ± 0.058	2.234PheSer: 2.234 ± 0.049	1.783PheThr: 1.783 ± 0.043	2.796PheVal: 2.796 ± 0.055	0.524PheTrp: 0.524 ± 0.022	0.943PheTyr: 0.943 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.832GlyAla: 8.832 ± 0.107	0.984GlyCys: 0.984 ± 0.031	3.883GlyAsp: 3.883 ± 0.063	4.231GlyGlu: 4.231 ± 0.07	3.266GlyPhe: 3.266 ± 0.057	6.789GlyGly: 6.789 ± 0.106	2.02GlyHis: 2.02 ± 0.047	4.393GlyIle: 4.393 ± 0.068	3.486GlyLys: 3.486 ± 0.066	8.123GlyLeu: 8.123 ± 0.103	2.664GlyMet: 2.664 ± 0.055	2.445GlyAsn: 2.445 ± 0.048	3.06GlyPro: 3.06 ± 0.058	3.114GlyGln: 3.114 ± 0.053	5.399GlyArg: 5.399 ± 0.083	4.628GlySer: 4.628 ± 0.079	4.701GlyThr: 4.701 ± 0.067	6.399GlyVal: 6.399 ± 0.08	1.396GlyTrp: 1.396 ± 0.039	2.449GlyTyr: 2.449 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	3.161HisAla: 3.161 ± 0.068	0.328HisCys: 0.328 ± 0.019	1.267HisAsp: 1.267 ± 0.039	1.161HisGlu: 1.161 ± 0.039	0.949HisPhe: 0.949 ± 0.034	2.324HisGly: 2.324 ± 0.053	0.731HisHis: 0.731 ± 0.029	1.005HisIle: 1.005 ± 0.029	0.542HisLys: 0.542 ± 0.025	2.165HisLeu: 2.165 ± 0.05	0.626HisMet: 0.626 ± 0.022	0.522HisAsn: 0.522 ± 0.022	1.492HisPro: 1.492 ± 0.043	0.71HisGln: 0.71 ± 0.026	1.631HisArg: 1.631 ± 0.04	1.101HisSer: 1.101 ± 0.04	1.085HisThr: 1.085 ± 0.031	1.821HisVal: 1.821 ± 0.047	0.466HisTrp: 0.466 ± 0.026	0.707HisTyr: 0.707 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.4IleAla: 6.4 ± 0.09	0.538IleCys: 0.538 ± 0.024	3.064IleAsp: 3.064 ± 0.053	3.054IleGlu: 3.054 ± 0.059	1.308IlePhe: 1.308 ± 0.042	4.599IleGly: 4.599 ± 0.071	0.997IleHis: 0.997 ± 0.038	1.679IleIle: 1.679 ± 0.041	1.362IleLys: 1.362 ± 0.045	3.707IleLeu: 3.707 ± 0.064	0.809IleMet: 0.809 ± 0.033	1.479IleAsn: 1.479 ± 0.044	2.231IlePro: 2.231 ± 0.051	1.346IleGln: 1.346 ± 0.033	3.25IleArg: 3.25 ± 0.055	2.645IleSer: 2.645 ± 0.061	2.369IleThr: 2.369 ± 0.044	3.82IleVal: 3.82 ± 0.07	0.467IleTrp: 0.467 ± 0.022	1.061IleTyr: 1.061 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.811LysAla: 3.811 ± 0.077	0.205LysCys: 0.205 ± 0.013	1.53LysAsp: 1.53 ± 0.039	1.572LysGlu: 1.572 ± 0.045	0.87LysPhe: 0.87 ± 0.028	2.322LysGly: 2.322 ± 0.053	0.663LysHis: 0.663 ± 0.029	1.459LysIle: 1.459 ± 0.046	1.192LysLys: 1.192 ± 0.049	3.354LysLeu: 3.354 ± 0.07	0.835LysMet: 0.835 ± 0.032	0.833LysAsn: 0.833 ± 0.033	1.885LysPro: 1.885 ± 0.051	1.246LysGln: 1.246 ± 0.039	2.312LysArg: 2.312 ± 0.055	1.733LysSer: 1.733 ± 0.046	1.871LysThr: 1.871 ± 0.047	2.436LysVal: 2.436 ± 0.065	0.381LysTrp: 0.381 ± 0.018	0.718LysTyr: 0.718 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	13.935LeuAla: 13.935 ± 0.135	1.17LeuCys: 1.17 ± 0.037	5.658LeuAsp: 5.658 ± 0.081	5.236LeuGlu: 5.236 ± 0.081	3.414LeuPhe: 3.414 ± 0.066	8.07LeuGly: 8.07 ± 0.108	2.351LeuHis: 2.351 ± 0.043	4.352LeuIle: 4.352 ± 0.071	3.177LeuLys: 3.177 ± 0.059	10.293LeuLeu: 10.293 ± 0.133	2.507LeuMet: 2.507 ± 0.058	2.688LeuAsn: 2.688 ± 0.052	5.781LeuPro: 5.781 ± 0.086	3.684LeuGln: 3.684 ± 0.064	7.459LeuArg: 7.459 ± 0.099	6.109LeuSer: 6.109 ± 0.081	5.278LeuThr: 5.278 ± 0.08	7.564LeuVal: 7.564 ± 0.095	1.17LeuTrp: 1.17 ± 0.032	2.155LeuTyr: 2.155 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.231MetAla: 3.231 ± 0.056	0.247MetCys: 0.247 ± 0.015	1.146MetAsp: 1.146 ± 0.036	1.25MetGlu: 1.25 ± 0.034	0.827MetPhe: 0.827 ± 0.029	1.768MetGly: 1.768 ± 0.047	0.615MetHis: 0.615 ± 0.024	1.143MetIle: 1.143 ± 0.036	1.057MetLys: 1.057 ± 0.033	2.93MetLeu: 2.93 ± 0.058	0.657MetMet: 0.657 ± 0.029	0.869MetAsn: 0.869 ± 0.033	1.674MetPro: 1.674 ± 0.043	1.151MetGln: 1.151 ± 0.038	2.068MetArg: 2.068 ± 0.05	1.814MetSer: 1.814 ± 0.041	1.862MetThr: 1.862 ± 0.042	1.856MetVal: 1.856 ± 0.047	0.243MetTrp: 0.243 ± 0.018	0.414MetTyr: 0.414 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.256AsnAla: 3.256 ± 0.057	0.307AsnCys: 0.307 ± 0.019	1.351AsnAsp: 1.351 ± 0.039	1.263AsnGlu: 1.263 ± 0.034	0.974AsnPhe: 0.974 ± 0.032	2.424AsnGly: 2.424 ± 0.048	0.615AsnHis: 0.615 ± 0.027	1.228AsnIle: 1.228 ± 0.035	0.812AsnLys: 0.812 ± 0.031	2.662AsnLeu: 2.662 ± 0.053	0.61AsnMet: 0.61 ± 0.027	0.755AsnAsn: 0.755 ± 0.031	1.78AsnPro: 1.78 ± 0.046	0.917AsnGln: 0.917 ± 0.03	1.874AsnArg: 1.874 ± 0.038	1.295AsnSer: 1.295 ± 0.04	1.48AsnThr: 1.48 ± 0.042	2.16AsnVal: 2.16 ± 0.053	0.469AsnTrp: 0.469 ± 0.021	0.743AsnTyr: 0.743 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.875ProAla: 6.875 ± 0.097	0.464ProCys: 0.464 ± 0.024	3.303ProAsp: 3.303 ± 0.058	3.174ProGlu: 3.174 ± 0.053	1.856ProPhe: 1.856 ± 0.041	4.491ProGly: 4.491 ± 0.079	1.174ProHis: 1.174 ± 0.032	2.003ProIle: 2.003 ± 0.049	1.406ProLys: 1.406 ± 0.04	4.863ProLeu: 4.863 ± 0.074	1.336ProMet: 1.336 ± 0.042	1.405ProAsn: 1.405 ± 0.039	2.502ProPro: 2.502 ± 0.065	1.946ProGln: 1.946 ± 0.045	3.021ProArg: 3.021 ± 0.055	2.723ProSer: 2.723 ± 0.06	2.523ProThr: 2.523 ± 0.043	4.391ProVal: 4.391 ± 0.066	0.664ProTrp: 0.664 ± 0.024	1.378ProTyr: 1.378 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	5.114GlnAla: 5.114 ± 0.086	0.351GlnCys: 0.351 ± 0.021	1.606GlnAsp: 1.606 ± 0.046	1.663GlnGlu: 1.663 ± 0.038	1.39GlnPhe: 1.39 ± 0.037	2.657GlnGly: 2.657 ± 0.052	1.027GlnHis: 1.027 ± 0.036	1.783GlnIle: 1.783 ± 0.044	1.065GlnLys: 1.065 ± 0.036	3.673GlnLeu: 3.673 ± 0.07	1.029GlnMet: 1.029 ± 0.03	0.893GlnAsn: 0.893 ± 0.034	2.008GlnPro: 2.008 ± 0.044	1.87GlnGln: 1.87 ± 0.059	3.137GlnArg: 3.137 ± 0.065	2.005GlnSer: 2.005 ± 0.045	1.919GlnThr: 1.919 ± 0.043	2.808GlnVal: 2.808 ± 0.057	0.572GlnTrp: 0.572 ± 0.025	0.897GlnTyr: 0.897 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	8.061ArgAla: 8.061 ± 0.095	0.806ArgCys: 0.806 ± 0.03	3.847ArgAsp: 3.847 ± 0.062	4.371ArgGlu: 4.371 ± 0.071	2.81ArgPhe: 2.81 ± 0.058	4.714ArgGly: 4.714 ± 0.068	2.041ArgHis: 2.041 ± 0.05	3.56ArgIle: 3.56 ± 0.069	2.425ArgLys: 2.425 ± 0.058	7.696ArgLeu: 7.696 ± 0.104	2.155ArgMet: 2.155 ± 0.046	2.002ArgAsn: 2.002 ± 0.05	3.382ArgPro: 3.382 ± 0.064	3.104ArgGln: 3.104 ± 0.06	5.718ArgArg: 5.718 ± 0.099	3.797ArgSer: 3.797 ± 0.058	3.577ArgThr: 3.577 ± 0.062	5.118ArgVal: 5.118 ± 0.091	1.145ArgTrp: 1.145 ± 0.033	2.016ArgTyr: 2.016 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.624SerAla: 6.624 ± 0.094	0.582SerCys: 0.582 ± 0.022	2.735SerAsp: 2.735 ± 0.058	2.612SerGlu: 2.612 ± 0.046	2.124SerPhe: 2.124 ± 0.05	5.336SerGly: 5.336 ± 0.088	1.315SerHis: 1.315 ± 0.041	2.54SerIle: 2.54 ± 0.056	1.707SerLys: 1.707 ± 0.037	5.636SerLeu: 5.636 ± 0.08	1.504SerMet: 1.504 ± 0.037	1.49SerAsn: 1.49 ± 0.038	2.942SerPro: 2.942 ± 0.048	1.921SerGln: 1.921 ± 0.048	3.957SerArg: 3.957 ± 0.068	3.281SerSer: 3.281 ± 0.067	3.003SerThr: 3.003 ± 0.057	4.202SerVal: 4.202 ± 0.067	0.786SerTrp: 0.786 ± 0.031	1.327SerTyr: 1.327 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.825ThrAla: 5.825 ± 0.08	0.501ThrCys: 0.501 ± 0.022	2.616ThrAsp: 2.616 ± 0.061	2.472ThrGlu: 2.472 ± 0.046	1.935ThrPhe: 1.935 ± 0.044	4.66ThrGly: 4.66 ± 0.078	1.215ThrHis: 1.215 ± 0.038	2.5ThrIle: 2.5 ± 0.047	1.306ThrLys: 1.306 ± 0.041	6.004ThrLeu: 6.004 ± 0.081	1.359ThrMet: 1.359 ± 0.039	1.211ThrAsn: 1.211 ± 0.033	3.41ThrPro: 3.41 ± 0.053	1.711ThrGln: 1.711 ± 0.042	3.531ThrArg: 3.531 ± 0.068	2.785ThrSer: 2.785 ± 0.061	2.833ThrThr: 2.833 ± 0.06	4.445ThrVal: 4.445 ± 0.071	0.706ThrTrp: 0.706 ± 0.031	1.173ThrTyr: 1.173 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.351ValAla: 9.351 ± 0.086	0.833ValCys: 0.833 ± 0.03	3.999ValAsp: 3.999 ± 0.059	4.161ValGlu: 4.161 ± 0.064	2.795ValPhe: 2.795 ± 0.054	5.317ValGly: 5.317 ± 0.074	1.599ValHis: 1.599 ± 0.041	3.684ValIle: 3.684 ± 0.063	2.405ValLys: 2.405 ± 0.062	8.087ValLeu: 8.087 ± 0.103	2.125ValMet: 2.125 ± 0.049	2.213ValAsn: 2.213 ± 0.052	4.248ValPro: 4.248 ± 0.083	2.566ValGln: 2.566 ± 0.059	5.581ValArg: 5.581 ± 0.074	4.508ValSer: 4.508 ± 0.063	4.24ValThr: 4.24 ± 0.077	6.302ValVal: 6.302 ± 0.104	0.896ValTrp: 0.896 ± 0.034	1.566ValTyr: 1.566 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.198TrpAla: 1.198 ± 0.04	0.178TrpCys: 0.178 ± 0.013	0.607TrpAsp: 0.607 ± 0.023	0.604TrpGlu: 0.604 ± 0.023	0.541TrpPhe: 0.541 ± 0.023	0.954TrpGly: 0.954 ± 0.031	0.42TrpHis: 0.42 ± 0.022	0.726TrpIle: 0.726 ± 0.027	0.451TrpLys: 0.451 ± 0.022	1.899TrpLeu: 1.899 ± 0.048	0.473TrpMet: 0.473 ± 0.025	0.468TrpAsn: 0.468 ± 0.022	0.71TrpPro: 0.71 ± 0.027	0.721TrpGln: 0.721 ± 0.027	1.238TrpArg: 1.238 ± 0.04	0.814TrpSer: 0.814 ± 0.033	0.71TrpThr: 0.71 ± 0.024	0.927TrpVal: 0.927 ± 0.032	0.226TrpTrp: 0.226 ± 0.015	0.308TrpTyr: 0.308 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.056	0.336TyrCys: 0.336 ± 0.019	1.283TyrAsp: 1.283 ± 0.038	1.188TyrGlu: 1.188 ± 0.038	1.025TyrPhe: 1.025 ± 0.035	2.16TyrGly: 2.16 ± 0.056	0.571TyrHis: 0.571 ± 0.027	0.882TyrIle: 0.882 ± 0.029	0.725TyrLys: 0.725 ± 0.027	2.601TyrLeu: 2.601 ± 0.049	0.5TyrMet: 0.5 ± 0.027	0.604TyrAsn: 0.604 ± 0.026	1.269TyrPro: 1.269 ± 0.039	0.888TyrGln: 0.888 ± 0.03	1.973TyrArg: 1.973 ± 0.045	1.284TyrSer: 1.284 ± 0.035	1.197TyrThr: 1.197 ± 0.036	1.831TyrVal: 1.831 ± 0.049	0.408TyrTrp: 0.408 ± 0.019	0.71TyrTyr: 0.71 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4000 proteins (957226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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