Amino acid dipepetide frequency for Oceanobacillus oncorhynchi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.794AlaAla: 6.794 ± 0.098	0.622AlaCys: 0.622 ± 0.021	4.065AlaAsp: 4.065 ± 0.071	5.279AlaGlu: 5.279 ± 0.086	3.634AlaPhe: 3.634 ± 0.061	5.723AlaGly: 5.723 ± 0.082	1.267AlaHis: 1.267 ± 0.036	6.208AlaIle: 6.208 ± 0.078	4.307AlaLys: 4.307 ± 0.071	7.4AlaLeu: 7.4 ± 0.077	2.212AlaMet: 2.212 ± 0.041	2.864AlaAsn: 2.864 ± 0.052	2.091AlaPro: 2.091 ± 0.049	2.134AlaGln: 2.134 ± 0.045	2.46AlaArg: 2.46 ± 0.049	4.536AlaSer: 4.536 ± 0.062	3.344AlaThr: 3.344 ± 0.053	5.874AlaVal: 5.874 ± 0.069	0.685AlaTrp: 0.685 ± 0.024	2.676AlaTyr: 2.676 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.43CysAla: 0.43 ± 0.019	0.089CysCys: 0.089 ± 0.009	0.337CysAsp: 0.337 ± 0.015	0.392CysGlu: 0.392 ± 0.016	0.284CysPhe: 0.284 ± 0.016	0.591CysGly: 0.591 ± 0.028	0.195CysHis: 0.195 ± 0.013	0.52CysIle: 0.52 ± 0.019	0.31CysLys: 0.31 ± 0.015	0.59CysLeu: 0.59 ± 0.02	0.191CysMet: 0.191 ± 0.012	0.249CysAsn: 0.249 ± 0.013	0.304CysPro: 0.304 ± 0.017	0.258CysGln: 0.258 ± 0.015	0.239CysArg: 0.239 ± 0.014	0.444CysSer: 0.444 ± 0.018	0.357CysThr: 0.357 ± 0.018	0.372CysVal: 0.372 ± 0.017	0.065CysTrp: 0.065 ± 0.008	0.251CysTyr: 0.251 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.734AspAla: 3.734 ± 0.065	0.311AspCys: 0.311 ± 0.019	2.644AspAsp: 2.644 ± 0.053	4.527AspGlu: 4.527 ± 0.07	2.521AspPhe: 2.521 ± 0.045	3.479AspGly: 3.479 ± 0.064	1.033AspHis: 1.033 ± 0.035	4.492AspIle: 4.492 ± 0.058	3.323AspLys: 3.323 ± 0.051	4.923AspLeu: 4.923 ± 0.065	1.544AspMet: 1.544 ± 0.035	2.201AspAsn: 2.201 ± 0.044	1.858AspPro: 1.858 ± 0.038	1.851AspGln: 1.851 ± 0.036	2.178AspArg: 2.178 ± 0.045	2.878AspSer: 2.878 ± 0.048	2.842AspThr: 2.842 ± 0.05	3.822AspVal: 3.822 ± 0.067	0.679AspTrp: 0.679 ± 0.026	2.424AspTyr: 2.424 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.463GluAla: 6.463 ± 0.1	0.311GluCys: 0.311 ± 0.015	4.426GluAsp: 4.426 ± 0.072	8.709GluGlu: 8.709 ± 0.148	2.346GluPhe: 2.346 ± 0.042	4.573GluGly: 4.573 ± 0.069	1.478GluHis: 1.478 ± 0.03	5.847GluIle: 5.847 ± 0.084	6.614GluLys: 6.614 ± 0.088	6.986GluLeu: 6.986 ± 0.074	2.47GluMet: 2.47 ± 0.042	4.205GluAsn: 4.205 ± 0.071	2.028GluPro: 2.028 ± 0.047	3.855GluGln: 3.855 ± 0.066	3.381GluArg: 3.381 ± 0.054	3.647GluSer: 3.647 ± 0.06	4.1GluThr: 4.1 ± 0.061	5.174GluVal: 5.174 ± 0.083	0.782GluTrp: 0.782 ± 0.026	2.123GluTyr: 2.123 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.168PheAla: 3.168 ± 0.053	0.3PheCys: 0.3 ± 0.016	2.372PheAsp: 2.372 ± 0.045	2.802PheGlu: 2.802 ± 0.05	2.465PhePhe: 2.465 ± 0.055	3.275PheGly: 3.275 ± 0.064	1.034PheHis: 1.034 ± 0.03	4.267PheIle: 4.267 ± 0.072	2.078PheLys: 2.078 ± 0.04	4.606PheLeu: 4.606 ± 0.068	1.251PheMet: 1.251 ± 0.029	1.777PheAsn: 1.777 ± 0.036	1.702PhePro: 1.702 ± 0.035	1.874PheGln: 1.874 ± 0.043	1.497PheArg: 1.497 ± 0.03	3.175PheSer: 3.175 ± 0.054	2.587PheThr: 2.587 ± 0.051	3.058PheVal: 3.058 ± 0.051	0.467PheTrp: 0.467 ± 0.02	1.716PheTyr: 1.716 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.079GlyAla: 5.079 ± 0.073	0.564GlyCys: 0.564 ± 0.023	3.226GlyAsp: 3.226 ± 0.065	4.798GlyGlu: 4.798 ± 0.08	3.451GlyPhe: 3.451 ± 0.055	4.821GlyGly: 4.821 ± 0.074	1.246GlyHis: 1.246 ± 0.038	6.197GlyIle: 6.197 ± 0.079	4.633GlyLys: 4.633 ± 0.069	6.589GlyLeu: 6.589 ± 0.074	2.298GlyMet: 2.298 ± 0.04	2.763GlyAsn: 2.763 ± 0.048	1.698GlyPro: 1.698 ± 0.039	1.99GlyGln: 1.99 ± 0.041	2.378GlyArg: 2.378 ± 0.05	4.008GlySer: 4.008 ± 0.06	3.99GlyThr: 3.99 ± 0.063	4.97GlyVal: 4.97 ± 0.071	0.833GlyTrp: 0.833 ± 0.029	2.822GlyTyr: 2.822 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.483HisAla: 1.483 ± 0.036	0.185HisCys: 0.185 ± 0.013	1.038HisAsp: 1.038 ± 0.029	1.287HisGlu: 1.287 ± 0.034	1.104HisPhe: 1.104 ± 0.031	1.371HisGly: 1.371 ± 0.038	0.687HisHis: 0.687 ± 0.029	1.557HisIle: 1.557 ± 0.037	0.968HisLys: 0.968 ± 0.03	2.166HisLeu: 2.166 ± 0.048	0.526HisMet: 0.526 ± 0.019	0.68HisAsn: 0.68 ± 0.02	1.156HisPro: 1.156 ± 0.03	0.991HisGln: 0.991 ± 0.029	0.9HisArg: 0.9 ± 0.027	1.12HisSer: 1.12 ± 0.029	1.014HisThr: 1.014 ± 0.029	1.423HisVal: 1.423 ± 0.038	0.226HisTrp: 0.226 ± 0.013	0.805HisTyr: 0.805 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.653IleAla: 6.653 ± 0.076	0.615IleCys: 0.615 ± 0.024	4.511IleAsp: 4.511 ± 0.064	5.613IleGlu: 5.613 ± 0.071	3.558IlePhe: 3.558 ± 0.06	6.278IleGly: 6.278 ± 0.081	1.78IleHis: 1.78 ± 0.04	6.679IleIle: 6.679 ± 0.09	4.064IleLys: 4.064 ± 0.067	7.583IleLeu: 7.583 ± 0.087	1.903IleMet: 1.903 ± 0.044	3.193IleAsn: 3.193 ± 0.054	3.5IlePro: 3.5 ± 0.051	3.183IleGln: 3.183 ± 0.052	3.124IleArg: 3.124 ± 0.05	5.342IleSer: 5.342 ± 0.076	4.627IleThr: 4.627 ± 0.063	5.466IleVal: 5.466 ± 0.066	0.746IleTrp: 0.746 ± 0.028	2.654IleTyr: 2.654 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.352LysAla: 4.352 ± 0.068	0.25LysCys: 0.25 ± 0.015	3.608LysAsp: 3.608 ± 0.057	6.923LysGlu: 6.923 ± 0.087	1.628LysPhe: 1.628 ± 0.037	3.861LysGly: 3.861 ± 0.052	1.391LysHis: 1.391 ± 0.034	4.183LysIle: 4.183 ± 0.06	5.659LysLys: 5.659 ± 0.078	5.309LysLeu: 5.309 ± 0.061	1.977LysMet: 1.977 ± 0.044	3.299LysAsn: 3.299 ± 0.046	1.898LysPro: 1.898 ± 0.045	3.386LysGln: 3.386 ± 0.067	2.985LysArg: 2.985 ± 0.052	3.179LysSer: 3.179 ± 0.055	3.224LysThr: 3.224 ± 0.051	3.882LysVal: 3.882 ± 0.049	0.681LysTrp: 0.681 ± 0.024	2.058LysTyr: 2.058 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	7.197LeuAla: 7.197 ± 0.083	0.605LeuCys: 0.605 ± 0.019	4.953LeuAsp: 4.953 ± 0.076	7.239LeuGlu: 7.239 ± 0.08	5.062LeuPhe: 5.062 ± 0.088	6.475LeuGly: 6.475 ± 0.085	1.954LeuHis: 1.954 ± 0.04	7.46LeuIle: 7.46 ± 0.091	5.84LeuLys: 5.84 ± 0.086	9.667LeuLeu: 9.667 ± 0.106	2.584LeuMet: 2.584 ± 0.047	3.955LeuAsn: 3.955 ± 0.056	3.882LeuPro: 3.882 ± 0.07	3.776LeuGln: 3.776 ± 0.061	3.425LeuArg: 3.425 ± 0.052	6.429LeuSer: 6.429 ± 0.065	5.528LeuThr: 5.528 ± 0.064	5.803LeuVal: 5.803 ± 0.071	0.761LeuTrp: 0.761 ± 0.025	3.021LeuTyr: 3.021 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.062MetAla: 2.062 ± 0.043	0.137MetCys: 0.137 ± 0.012	1.677MetAsp: 1.677 ± 0.037	2.431MetGlu: 2.431 ± 0.041	1.031MetPhe: 1.031 ± 0.03	1.758MetGly: 1.758 ± 0.035	0.545MetHis: 0.545 ± 0.023	2.329MetIle: 2.329 ± 0.048	2.375MetLys: 2.375 ± 0.039	2.684MetLeu: 2.684 ± 0.045	0.907MetMet: 0.907 ± 0.03	1.513MetAsn: 1.513 ± 0.036	1.039MetPro: 1.039 ± 0.033	1.146MetGln: 1.146 ± 0.031	1.067MetArg: 1.067 ± 0.029	1.611MetSer: 1.611 ± 0.033	1.697MetThr: 1.697 ± 0.037	1.816MetVal: 1.816 ± 0.032	0.193MetTrp: 0.193 ± 0.012	0.779MetTyr: 0.779 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.845AsnAla: 2.845 ± 0.051	0.262AsnCys: 0.262 ± 0.014	2.283AsnAsp: 2.283 ± 0.042	3.456AsnGlu: 3.456 ± 0.05	1.548AsnPhe: 1.548 ± 0.036	3.062AsnGly: 3.062 ± 0.056	1.154AsnHis: 1.154 ± 0.032	3.361AsnIle: 3.361 ± 0.061	2.815AsnLys: 2.815 ± 0.05	3.724AsnLeu: 3.724 ± 0.049	1.213AsnMet: 1.213 ± 0.029	2.027AsnAsn: 2.027 ± 0.047	2.034AsnPro: 2.034 ± 0.037	2.385AsnGln: 2.385 ± 0.052	1.965AsnArg: 1.965 ± 0.044	2.08AsnSer: 2.08 ± 0.047	2.227AsnThr: 2.227 ± 0.039	2.847AsnVal: 2.847 ± 0.048	0.54AsnTrp: 0.54 ± 0.022	1.615AsnTyr: 1.615 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.631ProAla: 2.631 ± 0.05	0.18ProCys: 0.18 ± 0.013	2.145ProAsp: 2.145 ± 0.039	3.301ProGlu: 3.301 ± 0.052	1.944ProPhe: 1.944 ± 0.047	2.298ProGly: 2.298 ± 0.046	0.744ProHis: 0.744 ± 0.025	2.805ProIle: 2.805 ± 0.052	1.938ProLys: 1.938 ± 0.038	3.388ProLeu: 3.388 ± 0.053	0.857ProMet: 0.857 ± 0.027	1.492ProAsn: 1.492 ± 0.034	0.923ProPro: 0.923 ± 0.029	0.974ProGln: 0.974 ± 0.027	0.992ProArg: 0.992 ± 0.03	2.163ProSer: 2.163 ± 0.046	1.72ProThr: 1.72 ± 0.037	2.93ProVal: 2.93 ± 0.05	0.381ProTrp: 0.381 ± 0.018	1.35ProTyr: 1.35 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.157GlnAla: 3.157 ± 0.058	0.185GlnCys: 0.185 ± 0.012	1.901GlnAsp: 1.901 ± 0.044	3.407GlnGlu: 3.407 ± 0.056	1.635GlnPhe: 1.635 ± 0.033	2.354GlnGly: 2.354 ± 0.044	0.802GlnHis: 0.802 ± 0.026	2.865GlnIle: 2.865 ± 0.053	2.759GlnLys: 2.759 ± 0.052	4.237GlnLeu: 4.237 ± 0.067	1.23GlnMet: 1.23 ± 0.033	1.586GlnAsn: 1.586 ± 0.037	1.242GlnPro: 1.242 ± 0.035	1.976GlnGln: 1.976 ± 0.047	1.61GlnArg: 1.61 ± 0.039	2.208GlnSer: 2.208 ± 0.046	2.231GlnThr: 2.231 ± 0.04	2.481GlnVal: 2.481 ± 0.043	0.423GlnTrp: 0.423 ± 0.021	1.212GlnTyr: 1.212 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.313ArgAla: 2.313 ± 0.04	0.237ArgCys: 0.237 ± 0.012	1.98ArgAsp: 1.98 ± 0.04	3.13ArgGlu: 3.13 ± 0.05	1.854ArgPhe: 1.854 ± 0.036	2.158ArgGly: 2.158 ± 0.042	0.761ArgHis: 0.761 ± 0.026	3.147ArgIle: 3.147 ± 0.047	3.072ArgLys: 3.072 ± 0.049	3.616ArgLeu: 3.616 ± 0.059	1.27ArgMet: 1.27 ± 0.03	1.858ArgAsn: 1.858 ± 0.042	1.185ArgPro: 1.185 ± 0.033	1.527ArgGln: 1.527 ± 0.038	1.726ArgArg: 1.726 ± 0.043	2.103ArgSer: 2.103 ± 0.044	2.058ArgThr: 2.058 ± 0.043	2.33ArgVal: 2.33 ± 0.048	0.363ArgTrp: 0.363 ± 0.018	1.52ArgTyr: 1.52 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.852SerAla: 3.852 ± 0.063	0.373SerCys: 0.373 ± 0.018	2.991SerAsp: 2.991 ± 0.045	4.141SerGlu: 4.141 ± 0.067	3.239SerPhe: 3.239 ± 0.054	4.501SerGly: 4.501 ± 0.065	1.152SerHis: 1.152 ± 0.031	5.194SerIle: 5.194 ± 0.073	3.464SerLys: 3.464 ± 0.056	5.765SerLeu: 5.765 ± 0.08	1.81SerMet: 1.81 ± 0.04	2.547SerAsn: 2.547 ± 0.052	2.078SerPro: 2.078 ± 0.044	1.903SerGln: 1.903 ± 0.042	2.25SerArg: 2.25 ± 0.045	3.892SerSer: 3.892 ± 0.084	3.003SerThr: 3.003 ± 0.05	3.991SerVal: 3.991 ± 0.057	0.689SerTrp: 0.689 ± 0.027	2.338SerTyr: 2.338 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.363ThrAla: 4.363 ± 0.06	0.353ThrCys: 0.353 ± 0.018	2.953ThrAsp: 2.953 ± 0.046	3.896ThrGlu: 3.896 ± 0.065	2.615ThrPhe: 2.615 ± 0.049	4.29ThrGly: 4.29 ± 0.064	0.981ThrHis: 0.981 ± 0.027	4.555ThrIle: 4.555 ± 0.066	3.003ThrLys: 3.003 ± 0.057	5.04ThrLeu: 5.04 ± 0.066	1.431ThrMet: 1.431 ± 0.035	2.355ThrAsn: 2.355 ± 0.05	2.245ThrPro: 2.245 ± 0.045	1.449ThrGln: 1.449 ± 0.031	1.699ThrArg: 1.699 ± 0.037	3.229ThrSer: 3.229 ± 0.054	2.816ThrThr: 2.816 ± 0.052	4.091ThrVal: 4.091 ± 0.068	0.539ThrTrp: 0.539 ± 0.019	1.92ThrTyr: 1.92 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.714ValAla: 4.714 ± 0.072	0.538ValCys: 0.538 ± 0.021	3.7ValAsp: 3.7 ± 0.056	4.908ValGlu: 4.908 ± 0.076	3.217ValPhe: 3.217 ± 0.051	4.434ValGly: 4.434 ± 0.069	1.372ValHis: 1.372 ± 0.033	5.927ValIle: 5.927 ± 0.073	3.899ValLys: 3.899 ± 0.053	6.598ValLeu: 6.598 ± 0.081	1.872ValMet: 1.872 ± 0.042	3.016ValAsn: 3.016 ± 0.051	2.577ValPro: 2.577 ± 0.044	2.491ValGln: 2.491 ± 0.051	2.409ValArg: 2.409 ± 0.039	4.553ValSer: 4.553 ± 0.067	3.99ValThr: 3.99 ± 0.06	4.653ValVal: 4.653 ± 0.071	0.645ValTrp: 0.645 ± 0.026	2.346ValTyr: 2.346 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.624TrpAla: 0.624 ± 0.025	0.07TrpCys: 0.07 ± 0.007	0.521TrpAsp: 0.521 ± 0.022	0.754TrpGlu: 0.754 ± 0.027	0.524TrpPhe: 0.524 ± 0.021	0.683TrpGly: 0.683 ± 0.023	0.192TrpHis: 0.192 ± 0.013	0.862TrpIle: 0.862 ± 0.027	0.749TrpLys: 0.749 ± 0.026	1.137TrpLeu: 1.137 ± 0.032	0.359TrpMet: 0.359 ± 0.018	0.509TrpAsn: 0.509 ± 0.024	0.238TrpPro: 0.238 ± 0.014	0.401TrpGln: 0.401 ± 0.018	0.388TrpArg: 0.388 ± 0.019	0.599TrpSer: 0.599 ± 0.023	0.538TrpThr: 0.538 ± 0.022	0.648TrpVal: 0.648 ± 0.022	0.138TrpTrp: 0.138 ± 0.01	0.332TrpTyr: 0.332 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.261TyrAla: 2.261 ± 0.048	0.279TyrCys: 0.279 ± 0.018	1.933TyrAsp: 1.933 ± 0.034	2.528TyrGlu: 2.528 ± 0.044	1.812TyrPhe: 1.812 ± 0.041	2.368TyrGly: 2.368 ± 0.046	0.919TyrHis: 0.919 ± 0.03	2.615TyrIle: 2.615 ± 0.046	1.862TyrLys: 1.862 ± 0.041	3.607TyrLeu: 3.607 ± 0.059	0.893TyrMet: 0.893 ± 0.03	1.353TyrAsn: 1.353 ± 0.034	1.48TyrPro: 1.48 ± 0.035	1.952TyrGln: 1.952 ± 0.043	1.535TyrArg: 1.535 ± 0.041	1.976TyrSer: 1.976 ± 0.037	1.933TyrThr: 1.933 ± 0.039	2.228TyrVal: 2.228 ± 0.039	0.426TyrTrp: 0.426 ± 0.019	1.463TyrTyr: 1.463 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4386 proteins (1268742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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