Amino acid dipepetide frequency for Jiulongibacter sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.217AlaAla: 5.217 ± 0.078	0.67AlaCys: 0.67 ± 0.025	3.994AlaAsp: 3.994 ± 0.054	5.042AlaGlu: 5.042 ± 0.085	3.556AlaPhe: 3.556 ± 0.056	5.338AlaGly: 5.338 ± 0.086	1.092AlaHis: 1.092 ± 0.034	4.802AlaIle: 4.802 ± 0.064	4.171AlaLys: 4.171 ± 0.068	6.51AlaLeu: 6.51 ± 0.077	1.802AlaMet: 1.802 ± 0.046	3.259AlaAsn: 3.259 ± 0.062	2.152AlaPro: 2.152 ± 0.049	2.565AlaGln: 2.565 ± 0.046	2.395AlaArg: 2.395 ± 0.041	4.363AlaSer: 4.363 ± 0.067	3.484AlaThr: 3.484 ± 0.091	4.512AlaVal: 4.512 ± 0.06	0.735AlaTrp: 0.735 ± 0.029	2.55AlaTyr: 2.55 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.42CysAla: 0.42 ± 0.022	0.095CysCys: 0.095 ± 0.009	0.451CysAsp: 0.451 ± 0.021	0.537CysGlu: 0.537 ± 0.022	0.397CysPhe: 0.397 ± 0.016	0.68CysGly: 0.68 ± 0.029	0.214CysHis: 0.214 ± 0.014	0.519CysIle: 0.519 ± 0.022	0.417CysLys: 0.417 ± 0.018	0.715CysLeu: 0.715 ± 0.024	0.161CysMet: 0.161 ± 0.012	0.414CysAsn: 0.414 ± 0.02	0.4CysPro: 0.4 ± 0.024	0.307CysGln: 0.307 ± 0.018	0.282CysArg: 0.282 ± 0.015	0.6CysSer: 0.6 ± 0.028	0.481CysThr: 0.481 ± 0.028	0.452CysVal: 0.452 ± 0.02	0.082CysTrp: 0.082 ± 0.007	0.264CysTyr: 0.264 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.492AspAla: 3.492 ± 0.054	0.417AspCys: 0.417 ± 0.021	2.723AspAsp: 2.723 ± 0.052	3.865AspGlu: 3.865 ± 0.06	3.667AspPhe: 3.667 ± 0.053	4.33AspGly: 4.33 ± 0.072	1.096AspHis: 1.096 ± 0.029	3.906AspIle: 3.906 ± 0.058	3.349AspLys: 3.349 ± 0.063	5.685AspLeu: 5.685 ± 0.065	1.252AspMet: 1.252 ± 0.03	2.548AspAsn: 2.548 ± 0.042	2.222AspPro: 2.222 ± 0.042	2.214AspGln: 2.214 ± 0.041	2.193AspArg: 2.193 ± 0.046	3.334AspSer: 3.334 ± 0.069	2.502AspThr: 2.502 ± 0.064	3.262AspVal: 3.262 ± 0.055	0.86AspTrp: 0.86 ± 0.025	2.538AspTyr: 2.538 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.959GluAla: 4.959 ± 0.067	0.392GluCys: 0.392 ± 0.019	3.635GluAsp: 3.635 ± 0.061	5.471GluGlu: 5.471 ± 0.085	2.969GluPhe: 2.969 ± 0.052	4.476GluGly: 4.476 ± 0.061	1.169GluHis: 1.169 ± 0.037	5.449GluIle: 5.449 ± 0.075	5.729GluLys: 5.729 ± 0.085	6.689GluLeu: 6.689 ± 0.086	1.891GluMet: 1.891 ± 0.039	4.514GluAsn: 4.514 ± 0.059	2.063GluPro: 2.063 ± 0.04	2.364GluGln: 2.364 ± 0.047	2.675GluArg: 2.675 ± 0.053	3.7GluSer: 3.7 ± 0.053	3.674GluThr: 3.674 ± 0.055	4.743GluVal: 4.743 ± 0.073	0.76GluTrp: 0.76 ± 0.029	2.426GluTyr: 2.426 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.053	0.417PheCys: 0.417 ± 0.019	3.381PheAsp: 3.381 ± 0.053	3.785PheGlu: 3.785 ± 0.057	2.633PhePhe: 2.633 ± 0.044	3.94PheGly: 3.94 ± 0.06	0.874PheHis: 0.874 ± 0.027	3.3PheIle: 3.3 ± 0.047	3.177PheLys: 3.177 ± 0.059	4.909PheLeu: 4.909 ± 0.075	1.182PheMet: 1.182 ± 0.034	2.755PheAsn: 2.755 ± 0.048	1.808PhePro: 1.808 ± 0.039	1.729PheGln: 1.729 ± 0.034	1.972PheArg: 1.972 ± 0.043	3.942PheSer: 3.942 ± 0.062	2.889PheThr: 2.889 ± 0.058	3.1PheVal: 3.1 ± 0.05	0.66PheTrp: 0.66 ± 0.023	2.04PheTyr: 2.04 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.42GlyAla: 4.42 ± 0.077	0.688GlyCys: 0.688 ± 0.032	3.831GlyAsp: 3.831 ± 0.055	4.492GlyGlu: 4.492 ± 0.064	4.126GlyPhe: 4.126 ± 0.061	5.646GlyGly: 5.646 ± 0.109	1.322GlyHis: 1.322 ± 0.039	5.394GlyIle: 5.394 ± 0.067	5.01GlyLys: 5.01 ± 0.07	7.067GlyLeu: 7.067 ± 0.085	1.789GlyMet: 1.789 ± 0.042	3.731GlyAsn: 3.731 ± 0.073	1.873GlyPro: 1.873 ± 0.041	2.614GlyGln: 2.614 ± 0.045	2.781GlyArg: 2.781 ± 0.055	4.805GlySer: 4.805 ± 0.087	4.183GlyThr: 4.183 ± 0.113	4.738GlyVal: 4.738 ± 0.069	0.946GlyTrp: 0.946 ± 0.026	2.925GlyTyr: 2.925 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.979HisAla: 0.979 ± 0.033	0.169HisCys: 0.169 ± 0.011	0.804HisAsp: 0.804 ± 0.026	1.139HisGlu: 1.139 ± 0.033	1.175HisPhe: 1.175 ± 0.033	1.274HisGly: 1.274 ± 0.039	0.515HisHis: 0.515 ± 0.025	1.187HisIle: 1.187 ± 0.033	0.957HisLys: 0.957 ± 0.03	1.889HisLeu: 1.889 ± 0.038	0.372HisMet: 0.372 ± 0.018	0.77HisAsn: 0.77 ± 0.022	0.975HisPro: 0.975 ± 0.032	0.759HisGln: 0.759 ± 0.024	0.753HisArg: 0.753 ± 0.028	1.16HisSer: 1.16 ± 0.033	0.906HisThr: 0.906 ± 0.029	1.003HisVal: 1.003 ± 0.031	0.296HisTrp: 0.296 ± 0.018	0.851HisTyr: 0.851 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	4.933IleAla: 4.933 ± 0.067	0.641IleCys: 0.641 ± 0.026	4.451IleAsp: 4.451 ± 0.067	5.167IleGlu: 5.167 ± 0.075	3.095IlePhe: 3.095 ± 0.058	4.974IleGly: 4.974 ± 0.063	1.297IleHis: 1.297 ± 0.034	4.402IleIle: 4.402 ± 0.067	4.309IleLys: 4.309 ± 0.067	6.383IleLeu: 6.383 ± 0.075	1.336IleMet: 1.336 ± 0.032	3.734IleAsn: 3.734 ± 0.067	3.053IlePro: 3.053 ± 0.056	2.481IleGln: 2.481 ± 0.044	2.797IleArg: 2.797 ± 0.047	5.236IleSer: 5.236 ± 0.065	3.843IleThr: 3.843 ± 0.083	3.758IleVal: 3.758 ± 0.062	0.723IleTrp: 0.723 ± 0.021	2.421IleTyr: 2.421 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.128LysAla: 5.128 ± 0.069	0.331LysCys: 0.331 ± 0.015	3.817LysAsp: 3.817 ± 0.07	5.496LysGlu: 5.496 ± 0.086	2.319LysPhe: 2.319 ± 0.045	4.435LysGly: 4.435 ± 0.069	1.106LysHis: 1.106 ± 0.035	4.646LysIle: 4.646 ± 0.068	5.21LysLys: 5.21 ± 0.101	5.932LysLeu: 5.932 ± 0.089	1.799LysMet: 1.799 ± 0.046	3.824LysAsn: 3.824 ± 0.055	2.741LysPro: 2.741 ± 0.05	1.953LysGln: 1.953 ± 0.042	2.685LysArg: 2.685 ± 0.052	4.151LysSer: 4.151 ± 0.07	3.857LysThr: 3.857 ± 0.058	4.604LysVal: 4.604 ± 0.067	0.772LysTrp: 0.772 ± 0.025	2.488LysTyr: 2.488 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.755LeuAla: 6.755 ± 0.083	0.753LeuCys: 0.753 ± 0.03	4.895LeuAsp: 4.895 ± 0.06	6.08LeuGlu: 6.08 ± 0.085	4.828LeuPhe: 4.828 ± 0.08	6.356LeuGly: 6.356 ± 0.083	1.558LeuHis: 1.558 ± 0.038	6.805LeuIle: 6.805 ± 0.091	7.353LeuLys: 7.353 ± 0.103	8.967LeuLeu: 8.967 ± 0.112	2.299LeuMet: 2.299 ± 0.045	5.41LeuAsn: 5.41 ± 0.075	4.043LeuPro: 4.043 ± 0.062	3.344LeuGln: 3.344 ± 0.053	3.723LeuArg: 3.723 ± 0.062	7.326LeuSer: 7.326 ± 0.083	5.4LeuThr: 5.4 ± 0.073	5.532LeuVal: 5.532 ± 0.068	0.983LeuTrp: 0.983 ± 0.027	3.059LeuTyr: 3.059 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.073MetAla: 2.073 ± 0.047	0.117MetCys: 0.117 ± 0.01	1.234MetAsp: 1.234 ± 0.033	1.593MetGlu: 1.593 ± 0.042	0.827MetPhe: 0.827 ± 0.027	1.69MetGly: 1.69 ± 0.043	0.431MetHis: 0.431 ± 0.019	1.524MetIle: 1.524 ± 0.034	2.099MetLys: 2.099 ± 0.036	2.035MetLeu: 2.035 ± 0.044	0.653MetMet: 0.653 ± 0.024	1.362MetAsn: 1.362 ± 0.036	1.079MetPro: 1.079 ± 0.033	0.788MetGln: 0.788 ± 0.029	0.963MetArg: 0.963 ± 0.029	1.471MetSer: 1.471 ± 0.033	1.288MetThr: 1.288 ± 0.031	1.468MetVal: 1.468 ± 0.034	0.178MetTrp: 0.178 ± 0.011	0.662MetTyr: 0.662 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.551AsnAla: 3.551 ± 0.063	0.441AsnCys: 0.441 ± 0.021	2.842AsnAsp: 2.842 ± 0.063	3.464AsnGlu: 3.464 ± 0.054	2.761AsnPhe: 2.761 ± 0.055	4.194AsnGly: 4.194 ± 0.078	1.017AsnHis: 1.017 ± 0.032	3.611AsnIle: 3.611 ± 0.063	2.932AsnLys: 2.932 ± 0.05	5.113AsnLeu: 5.113 ± 0.061	1.111AsnMet: 1.111 ± 0.03	2.675AsnAsn: 2.675 ± 0.068	2.806AsnPro: 2.806 ± 0.051	2.246AsnGln: 2.246 ± 0.048	2.245AsnArg: 2.245 ± 0.049	3.721AsnSer: 3.721 ± 0.074	2.99AsnThr: 2.99 ± 0.062	3.076AsnVal: 3.076 ± 0.055	0.792AsnTrp: 0.792 ± 0.027	2.363AsnTyr: 2.363 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.638ProAla: 2.638 ± 0.044	0.24ProCys: 0.24 ± 0.016	2.702ProAsp: 2.702 ± 0.051	3.761ProGlu: 3.761 ± 0.055	2.114ProPhe: 2.114 ± 0.036	2.689ProGly: 2.689 ± 0.053	0.736ProHis: 0.736 ± 0.026	2.278ProIle: 2.278 ± 0.045	2.242ProLys: 2.242 ± 0.051	3.355ProLeu: 3.355 ± 0.055	0.862ProMet: 0.862 ± 0.025	2.001ProAsn: 2.001 ± 0.042	1.149ProPro: 1.149 ± 0.04	1.325ProGln: 1.325 ± 0.034	1.186ProArg: 1.186 ± 0.035	2.501ProSer: 2.501 ± 0.053	1.989ProThr: 1.989 ± 0.045	2.918ProVal: 2.918 ± 0.051	0.438ProTrp: 0.438 ± 0.019	1.487ProTyr: 1.487 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.163GlnAla: 2.163 ± 0.039	0.196GlnCys: 0.196 ± 0.013	1.553GlnAsp: 1.553 ± 0.032	2.27GlnGlu: 2.27 ± 0.043	1.719GlnPhe: 1.719 ± 0.032	2.049GlnGly: 2.049 ± 0.04	0.598GlnHis: 0.598 ± 0.021	2.62GlnIle: 2.62 ± 0.043	3.111GlnLys: 3.111 ± 0.061	3.521GlnLeu: 3.521 ± 0.052	0.999GlnMet: 0.999 ± 0.03	2.479GlnAsn: 2.479 ± 0.051	1.327GlnPro: 1.327 ± 0.033	1.367GlnGln: 1.367 ± 0.038	1.381GlnArg: 1.381 ± 0.035	2.303GlnSer: 2.303 ± 0.046	2.019GlnThr: 2.019 ± 0.045	2.117GlnVal: 2.117 ± 0.044	0.516GlnTrp: 0.516 ± 0.021	1.38GlnTyr: 1.38 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.373ArgAla: 2.373 ± 0.053	0.249ArgCys: 0.249 ± 0.014	1.893ArgAsp: 1.893 ± 0.043	2.609ArgGlu: 2.609 ± 0.055	2.188ArgPhe: 2.188 ± 0.047	2.328ArgGly: 2.328 ± 0.048	0.676ArgHis: 0.676 ± 0.023	2.969ArgIle: 2.969 ± 0.045	2.99ArgLys: 2.99 ± 0.053	3.683ArgLeu: 3.683 ± 0.061	1.03ArgMet: 1.03 ± 0.026	2.28ArgAsn: 2.28 ± 0.05	1.439ArgPro: 1.439 ± 0.03	1.426ArgGln: 1.426 ± 0.034	1.676ArgArg: 1.676 ± 0.043	2.284ArgSer: 2.284 ± 0.048	1.922ArgThr: 1.922 ± 0.039	2.426ArgVal: 2.426 ± 0.04	0.499ArgTrp: 0.499 ± 0.02	1.538ArgTyr: 1.538 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.323SerAla: 4.323 ± 0.074	0.644SerCys: 0.644 ± 0.027	3.688SerAsp: 3.688 ± 0.055	4.349SerGlu: 4.349 ± 0.061	3.869SerPhe: 3.869 ± 0.062	5.655SerGly: 5.655 ± 0.108	1.127SerHis: 1.127 ± 0.033	4.515SerIle: 4.515 ± 0.062	4.246SerLys: 4.246 ± 0.066	6.735SerLeu: 6.735 ± 0.08	1.466SerMet: 1.466 ± 0.036	3.3SerAsn: 3.3 ± 0.073	2.598SerPro: 2.598 ± 0.052	2.388SerGln: 2.388 ± 0.043	2.422SerArg: 2.422 ± 0.046	4.742SerSer: 4.742 ± 0.092	3.645SerThr: 3.645 ± 0.076	4.283SerVal: 4.283 ± 0.062	0.863SerTrp: 0.863 ± 0.032	2.588SerTyr: 2.588 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.043ThrAla: 4.043 ± 0.09	0.417ThrCys: 0.417 ± 0.028	3.242ThrAsp: 3.242 ± 0.069	3.545ThrGlu: 3.545 ± 0.057	2.987ThrPhe: 2.987 ± 0.056	4.584ThrGly: 4.584 ± 0.08	0.934ThrHis: 0.934 ± 0.029	3.805ThrIle: 3.805 ± 0.084	2.758ThrLys: 2.758 ± 0.048	5.296ThrLeu: 5.296 ± 0.084	1.022ThrMet: 1.022 ± 0.024	2.602ThrAsn: 2.602 ± 0.065	2.48ThrPro: 2.48 ± 0.062	1.732ThrGln: 1.732 ± 0.04	1.723ThrArg: 1.723 ± 0.036	3.565ThrSer: 3.565 ± 0.073	2.902ThrThr: 2.902 ± 0.078	3.676ThrVal: 3.676 ± 0.086	0.615ThrTrp: 0.615 ± 0.026	2.23ThrTyr: 2.23 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.32ValAla: 4.32 ± 0.062	0.585ValCys: 0.585 ± 0.023	3.378ValAsp: 3.378 ± 0.063	4.03ValGlu: 4.03 ± 0.058	3.426ValPhe: 3.426 ± 0.06	4.114ValGly: 4.114 ± 0.063	1.005ValHis: 1.005 ± 0.033	4.417ValIle: 4.417 ± 0.063	4.367ValLys: 4.367 ± 0.063	5.92ValLeu: 5.92 ± 0.074	1.444ValMet: 1.444 ± 0.032	3.754ValAsn: 3.754 ± 0.058	2.439ValPro: 2.439 ± 0.042	1.822ValGln: 1.822 ± 0.035	2.303ValArg: 2.303 ± 0.044	4.647ValSer: 4.647 ± 0.071	3.404ValThr: 3.404 ± 0.094	4.099ValVal: 4.099 ± 0.068	0.736ValTrp: 0.736 ± 0.024	2.401ValTyr: 2.401 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.026	0.095TrpCys: 0.095 ± 0.007	0.678TrpAsp: 0.678 ± 0.023	0.763TrpGlu: 0.763 ± 0.028	0.62TrpPhe: 0.62 ± 0.027	0.862TrpGly: 0.862 ± 0.028	0.295TrpHis: 0.295 ± 0.016	0.739TrpIle: 0.739 ± 0.03	0.781TrpLys: 0.781 ± 0.026	1.214TrpLeu: 1.214 ± 0.039	0.313TrpMet: 0.313 ± 0.014	0.648TrpAsn: 0.648 ± 0.024	0.365TrpPro: 0.365 ± 0.019	0.52TrpGln: 0.52 ± 0.02	0.522TrpArg: 0.522 ± 0.025	0.852TrpSer: 0.852 ± 0.032	0.619TrpThr: 0.619 ± 0.025	0.764TrpVal: 0.764 ± 0.024	0.209TrpTrp: 0.209 ± 0.013	0.489TrpTyr: 0.489 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.501TyrAla: 2.501 ± 0.046	0.334TyrCys: 0.334 ± 0.016	2.265TyrAsp: 2.265 ± 0.042	2.291TyrGlu: 2.291 ± 0.043	2.335TyrPhe: 2.335 ± 0.046	2.765TyrGly: 2.765 ± 0.051	0.867TyrHis: 0.867 ± 0.027	2.149TyrIle: 2.149 ± 0.046	2.086TyrLys: 2.086 ± 0.044	3.851TyrLeu: 3.851 ± 0.061	0.752TyrMet: 0.752 ± 0.023	1.892TyrAsn: 1.892 ± 0.043	1.599TyrPro: 1.599 ± 0.039	1.745TyrGln: 1.745 ± 0.037	1.803TyrArg: 1.803 ± 0.04	2.741TyrSer: 2.741 ± 0.049	2.159TyrThr: 2.159 ± 0.05	2.079TyrVal: 2.079 ± 0.043	0.484TyrTrp: 0.484 ± 0.021	1.645TyrTyr: 1.645 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3642 proteins (1288792 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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