Amino acid dipepetide frequency for Mariniflexile fucanivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.886AlaAla: 3.886 ± 0.072	0.558AlaCys: 0.558 ± 0.02	3.149AlaAsp: 3.149 ± 0.05	3.789AlaGlu: 3.789 ± 0.066	3.323AlaPhe: 3.323 ± 0.052	3.834AlaGly: 3.834 ± 0.063	1.071AlaHis: 1.071 ± 0.031	5.412AlaIle: 5.412 ± 0.069	4.561AlaLys: 4.561 ± 0.06	5.983AlaLeu: 5.983 ± 0.07	1.458AlaMet: 1.458 ± 0.034	3.702AlaAsn: 3.702 ± 0.059	1.806AlaPro: 1.806 ± 0.049	2.201AlaGln: 2.201 ± 0.041	1.75AlaArg: 1.75 ± 0.037	4.35AlaSer: 4.35 ± 0.06	3.854AlaThr: 3.854 ± 0.074	3.784AlaVal: 3.784 ± 0.057	0.615AlaTrp: 0.615 ± 0.019	2.55AlaTyr: 2.55 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.021	0.102CysCys: 0.102 ± 0.009	0.443CysAsp: 0.443 ± 0.022	0.459CysGlu: 0.459 ± 0.019	0.481CysPhe: 0.481 ± 0.018	0.578CysGly: 0.578 ± 0.028	0.207CysHis: 0.207 ± 0.017	0.634CysIle: 0.634 ± 0.024	0.558CysLys: 0.558 ± 0.019	0.675CysLeu: 0.675 ± 0.023	0.179CysMet: 0.179 ± 0.01	0.459CysAsn: 0.459 ± 0.018	0.337CysPro: 0.337 ± 0.016	0.204CysGln: 0.204 ± 0.012	0.171CysArg: 0.171 ± 0.011	0.604CysSer: 0.604 ± 0.026	0.501CysThr: 0.501 ± 0.032	0.426CysVal: 0.426 ± 0.016	0.066CysTrp: 0.066 ± 0.007	0.333CysTyr: 0.333 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.028AspAla: 4.028 ± 0.064	0.452AspCys: 0.452 ± 0.023	3.074AspAsp: 3.074 ± 0.051	3.612AspGlu: 3.612 ± 0.047	3.593AspPhe: 3.593 ± 0.062	3.823AspGly: 3.823 ± 0.066	0.79AspHis: 0.79 ± 0.024	4.556AspIle: 4.556 ± 0.062	4.207AspLys: 4.207 ± 0.068	5.164AspLeu: 5.164 ± 0.058	1.187AspMet: 1.187 ± 0.032	3.273AspAsn: 3.273 ± 0.054	1.581AspPro: 1.581 ± 0.036	1.265AspGln: 1.265 ± 0.029	1.708AspArg: 1.708 ± 0.039	3.111AspSer: 3.111 ± 0.048	2.831AspThr: 2.831 ± 0.042	3.786AspVal: 3.786 ± 0.054	0.782AspTrp: 0.782 ± 0.023	2.965AspTyr: 2.965 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.457GluAla: 4.457 ± 0.074	0.328GluCys: 0.328 ± 0.015	3.577GluAsp: 3.577 ± 0.05	3.999GluGlu: 3.999 ± 0.071	2.894GluPhe: 2.894 ± 0.05	3.578GluGly: 3.578 ± 0.05	1.135GluHis: 1.135 ± 0.03	5.215GluIle: 5.215 ± 0.066	5.579GluLys: 5.579 ± 0.09	6.02GluLeu: 6.02 ± 0.075	1.394GluMet: 1.394 ± 0.035	4.906GluAsn: 4.906 ± 0.071	1.545GluPro: 1.545 ± 0.033	2.096GluGln: 2.096 ± 0.04	2.244GluArg: 2.244 ± 0.044	3.443GluSer: 3.443 ± 0.044	4.051GluThr: 4.051 ± 0.054	4.083GluVal: 4.083 ± 0.052	0.625GluTrp: 0.625 ± 0.021	2.184GluTyr: 2.184 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	2.74PheAla: 2.74 ± 0.047	0.483PheCys: 0.483 ± 0.023	3.258PheAsp: 3.258 ± 0.042	3.407PheGlu: 3.407 ± 0.052	2.662PhePhe: 2.662 ± 0.047	3.568PheGly: 3.568 ± 0.055	0.792PheHis: 0.792 ± 0.027	4.158PheIle: 4.158 ± 0.071	4.233PheLys: 4.233 ± 0.056	4.571PheLeu: 4.571 ± 0.068	1.113PheMet: 1.113 ± 0.033	3.77PheAsn: 3.77 ± 0.071	1.69PhePro: 1.69 ± 0.031	1.486PheGln: 1.486 ± 0.03	1.51PheArg: 1.51 ± 0.034	4.128PheSer: 4.128 ± 0.054	3.168PheThr: 3.168 ± 0.05	2.988PheVal: 2.988 ± 0.05	0.589PheTrp: 0.589 ± 0.022	2.187PheTyr: 2.187 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.016GlyAla: 4.016 ± 0.07	0.662GlyCys: 0.662 ± 0.035	3.458GlyAsp: 3.458 ± 0.057	3.446GlyGlu: 3.446 ± 0.048	3.695GlyPhe: 3.695 ± 0.056	4.408GlyGly: 4.408 ± 0.079	1.113GlyHis: 1.113 ± 0.028	5.327GlyIle: 5.327 ± 0.07	4.913GlyLys: 4.913 ± 0.07	5.63GlyLeu: 5.63 ± 0.072	1.495GlyMet: 1.495 ± 0.033	3.828GlyAsn: 3.828 ± 0.064	1.275GlyPro: 1.275 ± 0.036	1.645GlyGln: 1.645 ± 0.034	1.927GlyArg: 1.927 ± 0.04	3.982GlySer: 3.982 ± 0.066	4.107GlyThr: 4.107 ± 0.084	4.385GlyVal: 4.385 ± 0.06	0.813GlyTrp: 0.813 ± 0.026	2.905GlyTyr: 2.905 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.98HisAla: 0.98 ± 0.026	0.165HisCys: 0.165 ± 0.012	0.889HisAsp: 0.889 ± 0.024	0.924HisGlu: 0.924 ± 0.03	1.154HisPhe: 1.154 ± 0.033	1.104HisGly: 1.104 ± 0.031	0.47HisHis: 0.47 ± 0.019	1.518HisIle: 1.518 ± 0.034	1.22HisLys: 1.22 ± 0.03	1.719HisLeu: 1.719 ± 0.038	0.317HisMet: 0.317 ± 0.015	1.07HisAsn: 1.07 ± 0.024	0.85HisPro: 0.85 ± 0.028	0.661HisGln: 0.661 ± 0.024	0.583HisArg: 0.583 ± 0.022	1.008HisSer: 1.008 ± 0.026	0.937HisThr: 0.937 ± 0.026	1.019HisVal: 1.019 ± 0.026	0.233HisTrp: 0.233 ± 0.015	0.851HisTyr: 0.851 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.216IleAla: 5.216 ± 0.069	0.657IleCys: 0.657 ± 0.023	4.948IleAsp: 4.948 ± 0.065	5.646IleGlu: 5.646 ± 0.069	3.698IlePhe: 3.698 ± 0.052	5.128IleGly: 5.128 ± 0.066	1.359IleHis: 1.359 ± 0.037	6.601IleIle: 6.601 ± 0.084	6.485IleLys: 6.485 ± 0.075	7.031IleLeu: 7.031 ± 0.097	1.497IleMet: 1.497 ± 0.033	5.353IleAsn: 5.353 ± 0.064	3.264IlePro: 3.264 ± 0.048	2.526IleGln: 2.526 ± 0.045	2.351IleArg: 2.351 ± 0.044	5.956IleSer: 5.956 ± 0.071	5.13IleThr: 5.13 ± 0.073	4.722IleVal: 4.722 ± 0.074	0.715IleTrp: 0.715 ± 0.022	3.025IleTyr: 3.025 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.973LysAla: 4.973 ± 0.074	0.37LysCys: 0.37 ± 0.016	4.57LysAsp: 4.57 ± 0.064	5.988LysGlu: 5.988 ± 0.085	3.058LysPhe: 3.058 ± 0.049	4.605LysGly: 4.605 ± 0.058	1.596LysHis: 1.596 ± 0.034	6.258LysIle: 6.258 ± 0.075	6.739LysLys: 6.739 ± 0.094	6.982LysLeu: 6.982 ± 0.078	1.892LysMet: 1.892 ± 0.039	5.943LysAsn: 5.943 ± 0.081	2.679LysPro: 2.679 ± 0.047	2.994LysGln: 2.994 ± 0.05	2.728LysArg: 2.728 ± 0.051	4.746LysSer: 4.746 ± 0.069	5.271LysThr: 5.271 ± 0.078	4.48LysVal: 4.48 ± 0.061	0.811LysTrp: 0.811 ± 0.023	3.129LysTyr: 3.129 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	5.578LeuAla: 5.578 ± 0.066	0.682LeuCys: 0.682 ± 0.024	4.995LeuAsp: 4.995 ± 0.059	5.889LeuGlu: 5.889 ± 0.067	4.825LeuPhe: 4.825 ± 0.066	5.602LeuGly: 5.602 ± 0.072	1.462LeuHis: 1.462 ± 0.036	7.071LeuIle: 7.071 ± 0.091	8.269LeuLys: 8.269 ± 0.102	8.379LeuLeu: 8.379 ± 0.109	1.977LeuMet: 1.977 ± 0.039	6.322LeuAsn: 6.322 ± 0.087	3.425LeuPro: 3.425 ± 0.054	3.054LeuGln: 3.054 ± 0.047	2.865LeuArg: 2.865 ± 0.048	6.484LeuSer: 6.484 ± 0.073	5.199LeuThr: 5.199 ± 0.069	5.383LeuVal: 5.383 ± 0.069	0.817LeuTrp: 0.817 ± 0.026	3.249LeuTyr: 3.249 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.586MetAla: 1.586 ± 0.033	0.152MetCys: 0.152 ± 0.01	1.093MetAsp: 1.093 ± 0.03	1.28MetGlu: 1.28 ± 0.033	0.938MetPhe: 0.938 ± 0.031	1.343MetGly: 1.343 ± 0.036	0.409MetHis: 0.409 ± 0.016	1.388MetIle: 1.388 ± 0.032	2.122MetLys: 2.122 ± 0.039	1.958MetLeu: 1.958 ± 0.034	0.557MetMet: 0.557 ± 0.02	1.292MetAsn: 1.292 ± 0.031	0.863MetPro: 0.863 ± 0.024	0.79MetGln: 0.79 ± 0.026	0.783MetArg: 0.783 ± 0.024	1.339MetSer: 1.339 ± 0.032	1.096MetThr: 1.096 ± 0.029	1.402MetVal: 1.402 ± 0.034	0.175MetTrp: 0.175 ± 0.012	0.74MetTyr: 0.74 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.927AsnAla: 3.927 ± 0.057	0.546AsnCys: 0.546 ± 0.025	3.656AsnAsp: 3.656 ± 0.061	4.07AsnGlu: 4.07 ± 0.052	3.352AsnPhe: 3.352 ± 0.054	4.254AsnGly: 4.254 ± 0.075	1.213AsnHis: 1.213 ± 0.03	5.482AsnIle: 5.482 ± 0.077	5.003AsnLys: 5.003 ± 0.068	5.973AsnLeu: 5.973 ± 0.082	1.391AsnMet: 1.391 ± 0.033	4.763AsnAsn: 4.763 ± 0.079	2.848AsnPro: 2.848 ± 0.053	2.435AsnGln: 2.435 ± 0.054	2.115AsnArg: 2.115 ± 0.045	4.316AsnSer: 4.316 ± 0.064	4.335AsnThr: 4.335 ± 0.063	3.728AsnVal: 3.728 ± 0.057	0.836AsnTrp: 0.836 ± 0.026	3.187AsnTyr: 3.187 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.818ProAla: 1.818 ± 0.041	0.212ProCys: 0.212 ± 0.014	1.926ProAsp: 1.926 ± 0.037	2.772ProGlu: 2.772 ± 0.044	1.934ProPhe: 1.934 ± 0.035	1.745ProGly: 1.745 ± 0.046	0.628ProHis: 0.628 ± 0.022	2.872ProIle: 2.872 ± 0.049	2.613ProLys: 2.613 ± 0.053	2.99ProLeu: 2.99 ± 0.044	0.666ProMet: 0.666 ± 0.025	2.515ProAsn: 2.515 ± 0.049	0.759ProPro: 0.759 ± 0.024	1.051ProGln: 1.051 ± 0.027	0.86ProArg: 0.86 ± 0.025	2.212ProSer: 2.212 ± 0.042	2.063ProThr: 2.063 ± 0.052	2.137ProVal: 2.137 ± 0.043	0.388ProTrp: 0.388 ± 0.017	1.464ProTyr: 1.464 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.884GlnAla: 1.884 ± 0.037	0.18GlnCys: 0.18 ± 0.013	1.688GlnAsp: 1.688 ± 0.037	2.033GlnGlu: 2.033 ± 0.042	1.68GlnPhe: 1.68 ± 0.036	1.813GlnGly: 1.813 ± 0.038	0.569GlnHis: 0.569 ± 0.021	2.642GlnIle: 2.642 ± 0.042	2.657GlnLys: 2.657 ± 0.05	3.323GlnLeu: 3.323 ± 0.056	0.734GlnMet: 0.734 ± 0.023	2.23GlnAsn: 2.23 ± 0.037	1.08GlnPro: 1.08 ± 0.028	1.269GlnGln: 1.269 ± 0.034	1.076GlnArg: 1.076 ± 0.03	1.882GlnSer: 1.882 ± 0.039	1.941GlnThr: 1.941 ± 0.037	1.847GlnVal: 1.847 ± 0.039	0.319GlnTrp: 0.319 ± 0.016	1.309GlnTyr: 1.309 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.922ArgAla: 1.922 ± 0.036	0.199ArgCys: 0.199 ± 0.012	1.678ArgAsp: 1.678 ± 0.037	1.875ArgGlu: 1.875 ± 0.04	1.788ArgPhe: 1.788 ± 0.038	1.818ArgGly: 1.818 ± 0.04	0.568ArgHis: 0.568 ± 0.022	2.639ArgIle: 2.639 ± 0.049	2.387ArgLys: 2.387 ± 0.052	2.959ArgLeu: 2.959 ± 0.047	0.787ArgMet: 0.787 ± 0.022	2.002ArgAsn: 2.002 ± 0.036	1.004ArgPro: 1.004 ± 0.031	0.948ArgGln: 0.948 ± 0.026	1.086ArgArg: 1.086 ± 0.033	1.69ArgSer: 1.69 ± 0.034	1.827ArgThr: 1.827 ± 0.037	1.943ArgVal: 1.943 ± 0.037	0.399ArgTrp: 0.399 ± 0.018	1.41ArgTyr: 1.41 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.616SerAla: 3.616 ± 0.058	0.673SerCys: 0.673 ± 0.027	3.504SerAsp: 3.504 ± 0.049	4.023SerGlu: 4.023 ± 0.057	3.726SerPhe: 3.726 ± 0.052	4.629SerGly: 4.629 ± 0.075	1.15SerHis: 1.15 ± 0.031	5.659SerIle: 5.659 ± 0.076	5.342SerLys: 5.342 ± 0.069	5.929SerLeu: 5.929 ± 0.071	1.251SerMet: 1.251 ± 0.03	4.426SerAsn: 4.426 ± 0.065	2.115SerPro: 2.115 ± 0.043	2.078SerGln: 2.078 ± 0.045	1.96SerArg: 1.96 ± 0.04	4.292SerSer: 4.292 ± 0.073	3.832SerThr: 3.832 ± 0.058	4.042SerVal: 4.042 ± 0.058	0.706SerTrp: 0.706 ± 0.024	2.773SerTyr: 2.773 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.68ThrAla: 3.68 ± 0.068	0.459ThrCys: 0.459 ± 0.023	3.489ThrAsp: 3.489 ± 0.056	3.394ThrGlu: 3.394 ± 0.055	3.252ThrPhe: 3.252 ± 0.059	4.155ThrGly: 4.155 ± 0.074	1.057ThrHis: 1.057 ± 0.028	5.378ThrIle: 5.378 ± 0.065	4.184ThrLys: 4.184 ± 0.062	5.573ThrLeu: 5.573 ± 0.068	1.067ThrMet: 1.067 ± 0.027	4.01ThrAsn: 4.01 ± 0.063	2.507ThrPro: 2.507 ± 0.052	1.896ThrGln: 1.896 ± 0.033	1.545ThrArg: 1.545 ± 0.034	4.166ThrSer: 4.166 ± 0.072	3.773ThrThr: 3.773 ± 0.078	3.851ThrVal: 3.851 ± 0.088	0.671ThrTrp: 0.671 ± 0.028	2.648ThrTyr: 2.648 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	3.815ValAla: 3.815 ± 0.06	0.536ValCys: 0.536 ± 0.021	3.44ValAsp: 3.44 ± 0.055	3.84ValGlu: 3.84 ± 0.053	3.424ValPhe: 3.424 ± 0.056	3.736ValGly: 3.736 ± 0.06	0.977ValHis: 0.977 ± 0.026	4.803ValIle: 4.803 ± 0.073	4.537ValLys: 4.537 ± 0.056	5.866ValLeu: 5.866 ± 0.067	1.245ValMet: 1.245 ± 0.035	3.728ValAsn: 3.728 ± 0.051	2.152ValPro: 2.152 ± 0.041	1.592ValGln: 1.592 ± 0.034	1.853ValArg: 1.853 ± 0.04	4.62ValSer: 4.62 ± 0.065	3.755ValThr: 3.755 ± 0.086	4.136ValVal: 4.136 ± 0.072	0.613ValTrp: 0.613 ± 0.021	2.389ValTyr: 2.389 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.591TrpAla: 0.591 ± 0.023	0.104TrpCys: 0.104 ± 0.009	0.665TrpAsp: 0.665 ± 0.023	0.694TrpGlu: 0.694 ± 0.022	0.604TrpPhe: 0.604 ± 0.023	0.684TrpGly: 0.684 ± 0.029	0.292TrpHis: 0.292 ± 0.012	0.731TrpIle: 0.731 ± 0.023	0.865TrpLys: 0.865 ± 0.023	0.993TrpLeu: 0.993 ± 0.027	0.312TrpMet: 0.312 ± 0.015	0.779TrpAsn: 0.779 ± 0.026	0.283TrpPro: 0.283 ± 0.016	0.422TrpGln: 0.422 ± 0.019	0.363TrpArg: 0.363 ± 0.015	0.67TrpSer: 0.67 ± 0.022	0.565TrpThr: 0.565 ± 0.023	0.653TrpVal: 0.653 ± 0.024	0.164TrpTrp: 0.164 ± 0.012	0.438TrpTyr: 0.438 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.464TyrAla: 2.464 ± 0.047	0.356TyrCys: 0.356 ± 0.016	2.289TyrAsp: 2.289 ± 0.038	2.213TyrGlu: 2.213 ± 0.04	2.419TyrPhe: 2.419 ± 0.046	2.625TyrGly: 2.625 ± 0.048	0.812TyrHis: 0.812 ± 0.023	2.967TyrIle: 2.967 ± 0.047	3.334TyrLys: 3.334 ± 0.054	3.808TyrLeu: 3.808 ± 0.056	0.785TyrMet: 0.785 ± 0.023	3.058TyrAsn: 3.058 ± 0.055	1.563TyrPro: 1.563 ± 0.04	1.54TyrGln: 1.54 ± 0.036	1.451TyrArg: 1.451 ± 0.033	2.73TyrSer: 2.73 ± 0.054	2.521TyrThr: 2.521 ± 0.056	2.264TyrVal: 2.264 ± 0.037	0.535TyrTrp: 0.535 ± 0.018	1.914TyrTyr: 1.914 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3991 proteins (1414510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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