Amino acid dipepetide frequency for Kushneria marisflavi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.702AlaAla: 10.702 ± 0.114	1.166AlaCys: 1.166 ± 0.033	5.191AlaAsp: 5.191 ± 0.076	5.534AlaGlu: 5.534 ± 0.093	3.78AlaPhe: 3.78 ± 0.067	8.775AlaGly: 8.775 ± 0.093	2.552AlaHis: 2.552 ± 0.052	5.49AlaIle: 5.49 ± 0.083	1.824AlaLys: 1.824 ± 0.054	14.342AlaLeu: 14.342 ± 0.15	3.516AlaMet: 3.516 ± 0.06	2.533AlaAsn: 2.533 ± 0.055	4.75AlaPro: 4.75 ± 0.076	3.942AlaGln: 3.942 ± 0.065	8.534AlaArg: 8.534 ± 0.117	6.244AlaSer: 6.244 ± 0.088	5.29AlaThr: 5.29 ± 0.07	6.715AlaVal: 6.715 ± 0.083	1.678AlaTrp: 1.678 ± 0.046	1.9AlaTyr: 1.9 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.037	0.156CysCys: 0.156 ± 0.015	0.649CysAsp: 0.649 ± 0.032	0.583CysGlu: 0.583 ± 0.025	0.366CysPhe: 0.366 ± 0.019	0.902CysGly: 0.902 ± 0.029	0.332CysHis: 0.332 ± 0.016	0.412CysIle: 0.412 ± 0.022	0.162CysLys: 0.162 ± 0.012	1.003CysLeu: 1.003 ± 0.032	0.203CysMet: 0.203 ± 0.014	0.234CysAsn: 0.234 ± 0.016	0.502CysPro: 0.502 ± 0.023	0.43CysGln: 0.43 ± 0.021	0.727CysArg: 0.727 ± 0.026	0.528CysSer: 0.528 ± 0.021	0.417CysThr: 0.417 ± 0.02	0.643CysVal: 0.643 ± 0.025	0.151CysTrp: 0.151 ± 0.015	0.273CysTyr: 0.273 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.918AspAla: 5.918 ± 0.073	0.479AspCys: 0.479 ± 0.023	3.998AspAsp: 3.998 ± 0.073	3.925AspGlu: 3.925 ± 0.061	2.099AspPhe: 2.099 ± 0.041	4.389AspGly: 4.389 ± 0.078	1.816AspHis: 1.816 ± 0.042	3.534AspIle: 3.534 ± 0.06	1.424AspLys: 1.424 ± 0.04	4.953AspLeu: 4.953 ± 0.076	1.536AspMet: 1.536 ± 0.037	2.052AspAsn: 2.052 ± 0.052	2.853AspPro: 2.853 ± 0.053	2.676AspGln: 2.676 ± 0.061	4.157AspArg: 4.157 ± 0.073	3.237AspSer: 3.237 ± 0.058	3.201AspThr: 3.201 ± 0.062	4.041AspVal: 4.041 ± 0.064	0.982AspTrp: 0.982 ± 0.032	1.726AspTyr: 1.726 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.071GluAla: 7.071 ± 0.11	0.505GluCys: 0.505 ± 0.023	2.898GluAsp: 2.898 ± 0.055	3.458GluGlu: 3.458 ± 0.072	1.603GluPhe: 1.603 ± 0.04	4.623GluGly: 4.623 ± 0.066	1.944GluHis: 1.944 ± 0.037	2.974GluIle: 2.974 ± 0.059	2.063GluLys: 2.063 ± 0.054	5.804GluLeu: 5.804 ± 0.085	1.559GluMet: 1.559 ± 0.042	1.572GluAsn: 1.572 ± 0.047	2.364GluPro: 2.364 ± 0.062	3.599GluGln: 3.599 ± 0.066	5.692GluArg: 5.692 ± 0.081	3.366GluSer: 3.366 ± 0.063	3.38GluThr: 3.38 ± 0.063	3.999GluVal: 3.999 ± 0.073	0.744GluTrp: 0.744 ± 0.029	1.247GluTyr: 1.247 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.277PheAla: 3.277 ± 0.062	0.389PheCys: 0.389 ± 0.02	2.679PheAsp: 2.679 ± 0.052	2.364PheGlu: 2.364 ± 0.047	1.399PhePhe: 1.399 ± 0.041	3.184PheGly: 3.184 ± 0.064	0.863PheHis: 0.863 ± 0.031	1.908PheIle: 1.908 ± 0.047	0.902PheLys: 0.902 ± 0.032	3.067PheLeu: 3.067 ± 0.067	1.061PheMet: 1.061 ± 0.032	1.318PheAsn: 1.318 ± 0.042	1.313PhePro: 1.313 ± 0.038	1.144PheGln: 1.144 ± 0.033	1.929PheArg: 1.929 ± 0.04	2.379PheSer: 2.379 ± 0.057	1.909PheThr: 1.909 ± 0.048	2.38PheVal: 2.38 ± 0.058	0.556PheTrp: 0.556 ± 0.024	1.038PheTyr: 1.038 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.484GlyAla: 7.484 ± 0.1	0.885GlyCys: 0.885 ± 0.033	4.484GlyAsp: 4.484 ± 0.069	5.022GlyGlu: 5.022 ± 0.079	3.273GlyPhe: 3.273 ± 0.061	6.3GlyGly: 6.3 ± 0.106	2.293GlyHis: 2.293 ± 0.055	4.786GlyIle: 4.786 ± 0.074	2.402GlyLys: 2.402 ± 0.049	8.73GlyLeu: 8.73 ± 0.11	2.548GlyMet: 2.548 ± 0.049	2.334GlyAsn: 2.334 ± 0.05	2.685GlyPro: 2.685 ± 0.054	3.421GlyGln: 3.421 ± 0.05	5.596GlyArg: 5.596 ± 0.067	4.563GlySer: 4.563 ± 0.071	3.827GlyThr: 3.827 ± 0.065	6.296GlyVal: 6.296 ± 0.09	1.425GlyTrp: 1.425 ± 0.039	2.366GlyTyr: 2.366 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.545HisAla: 2.545 ± 0.05	0.325HisCys: 0.325 ± 0.02	1.922HisAsp: 1.922 ± 0.056	1.562HisGlu: 1.562 ± 0.039	1.146HisPhe: 1.146 ± 0.035	2.346HisGly: 2.346 ± 0.047	1.027HisHis: 1.027 ± 0.036	1.129HisIle: 1.129 ± 0.031	0.498HisLys: 0.498 ± 0.021	2.758HisLeu: 2.758 ± 0.056	0.608HisMet: 0.608 ± 0.027	0.62HisAsn: 0.62 ± 0.021	1.488HisPro: 1.488 ± 0.042	1.251HisGln: 1.251 ± 0.033	1.9HisArg: 1.9 ± 0.05	1.114HisSer: 1.114 ± 0.032	1.148HisThr: 1.148 ± 0.029	1.767HisVal: 1.767 ± 0.044	0.515HisTrp: 0.515 ± 0.024	0.886HisTyr: 0.886 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.782IleAla: 5.782 ± 0.078	0.521IleCys: 0.521 ± 0.023	4.19IleAsp: 4.19 ± 0.067	4.187IleGlu: 4.187 ± 0.071	1.603IlePhe: 1.603 ± 0.049	4.576IleGly: 4.576 ± 0.078	1.138IleHis: 1.138 ± 0.036	2.448IleIle: 2.448 ± 0.058	1.447IleLys: 1.447 ± 0.042	4.2IleLeu: 4.2 ± 0.085	1.265IleMet: 1.265 ± 0.038	1.998IleAsn: 1.998 ± 0.053	2.237IlePro: 2.237 ± 0.052	1.416IleGln: 1.416 ± 0.035	3.145IleArg: 3.145 ± 0.054	3.186IleSer: 3.186 ± 0.064	3.018IleThr: 3.018 ± 0.052	3.782IleVal: 3.782 ± 0.068	0.531IleTrp: 0.531 ± 0.022	1.111IleTyr: 1.111 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.847LysAla: 2.847 ± 0.066	0.165LysCys: 0.165 ± 0.013	1.289LysAsp: 1.289 ± 0.042	1.324LysGlu: 1.324 ± 0.044	0.575LysPhe: 0.575 ± 0.026	2.304LysGly: 2.304 ± 0.053	0.58LysHis: 0.58 ± 0.024	1.068LysIle: 1.068 ± 0.039	1.138LysLys: 1.138 ± 0.046	2.441LysLeu: 2.441 ± 0.054	0.637LysMet: 0.637 ± 0.022	0.787LysAsn: 0.787 ± 0.03	1.315LysPro: 1.315 ± 0.038	1.038LysGln: 1.038 ± 0.032	2.38LysArg: 2.38 ± 0.052	1.654LysSer: 1.654 ± 0.048	1.537LysThr: 1.537 ± 0.04	1.703LysVal: 1.703 ± 0.043	0.283LysTrp: 0.283 ± 0.018	0.498LysTyr: 0.498 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.599LeuAla: 12.599 ± 0.141	1.141LeuCys: 1.141 ± 0.033	6.691LeuAsp: 6.691 ± 0.099	7.448LeuGlu: 7.448 ± 0.105	3.785LeuPhe: 3.785 ± 0.077	8.831LeuGly: 8.831 ± 0.114	2.31LeuHis: 2.31 ± 0.053	6.154LeuIle: 6.154 ± 0.095	3.534LeuLys: 3.534 ± 0.069	11.332LeuLeu: 11.332 ± 0.158	3.283LeuMet: 3.283 ± 0.064	3.085LeuAsn: 3.085 ± 0.053	5.653LeuPro: 5.653 ± 0.076	3.019LeuGln: 3.019 ± 0.054	6.31LeuArg: 6.31 ± 0.083	7.67LeuSer: 7.67 ± 0.091	5.886LeuThr: 5.886 ± 0.073	7.411LeuVal: 7.411 ± 0.091	1.458LeuTrp: 1.458 ± 0.038	2.592LeuTyr: 2.592 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.792MetAla: 3.792 ± 0.06	0.167MetCys: 0.167 ± 0.012	1.285MetAsp: 1.285 ± 0.032	1.155MetGlu: 1.155 ± 0.029	0.775MetPhe: 0.775 ± 0.029	2.16MetGly: 2.16 ± 0.05	0.596MetHis: 0.596 ± 0.025	1.474MetIle: 1.474 ± 0.039	0.905MetLys: 0.905 ± 0.029	3.111MetLeu: 3.111 ± 0.063	0.846MetMet: 0.846 ± 0.033	0.835MetAsn: 0.835 ± 0.027	1.594MetPro: 1.594 ± 0.042	1.1MetGln: 1.1 ± 0.033	1.705MetArg: 1.705 ± 0.04	2.128MetSer: 2.128 ± 0.046	2.216MetThr: 2.216 ± 0.048	2.035MetVal: 2.035 ± 0.044	0.19MetTrp: 0.19 ± 0.014	0.371MetTyr: 0.371 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.269AsnAla: 3.269 ± 0.064	0.207AsnCys: 0.207 ± 0.013	1.976AsnAsp: 1.976 ± 0.048	1.545AsnGlu: 1.545 ± 0.04	0.964AsnPhe: 0.964 ± 0.034	2.301AsnGly: 2.301 ± 0.053	0.685AsnHis: 0.685 ± 0.026	1.531AsnIle: 1.531 ± 0.043	0.606AsnLys: 0.606 ± 0.027	2.645AsnLeu: 2.645 ± 0.055	0.735AsnMet: 0.735 ± 0.025	0.896AsnAsn: 0.896 ± 0.031	1.603AsnPro: 1.603 ± 0.039	1.094AsnGln: 1.094 ± 0.033	1.861AsnArg: 1.861 ± 0.045	1.309AsnSer: 1.309 ± 0.043	1.577AsnThr: 1.577 ± 0.036	2.075AsnVal: 2.075 ± 0.048	0.393AsnTrp: 0.393 ± 0.019	0.73AsnTyr: 0.73 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.845ProAla: 4.845 ± 0.071	0.389ProCys: 0.389 ± 0.018	3.348ProAsp: 3.348 ± 0.056	3.776ProGlu: 3.776 ± 0.069	1.766ProPhe: 1.766 ± 0.04	4.198ProGly: 4.198 ± 0.065	1.064ProHis: 1.064 ± 0.031	2.211ProIle: 2.211 ± 0.049	1.0ProLys: 1.0 ± 0.031	5.103ProLeu: 5.103 ± 0.074	1.321ProMet: 1.321 ± 0.034	1.153ProAsn: 1.153 ± 0.031	1.914ProPro: 1.914 ± 0.047	1.728ProGln: 1.728 ± 0.044	2.778ProArg: 2.778 ± 0.062	2.621ProSer: 2.621 ± 0.046	2.168ProThr: 2.168 ± 0.047	3.712ProVal: 3.712 ± 0.067	0.834ProTrp: 0.834 ± 0.03	0.977ProTyr: 0.977 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.939GlnAla: 4.939 ± 0.074	0.372GlnCys: 0.372 ± 0.019	1.709GlnAsp: 1.709 ± 0.042	1.98GlnGlu: 1.98 ± 0.05	1.087GlnPhe: 1.087 ± 0.03	3.395GlnGly: 3.395 ± 0.067	1.154GlnHis: 1.154 ± 0.035	1.773GlnIle: 1.773 ± 0.043	1.31GlnLys: 1.31 ± 0.039	4.18GlnLeu: 4.18 ± 0.081	1.042GlnMet: 1.042 ± 0.028	1.015GlnAsn: 1.015 ± 0.033	1.892GlnPro: 1.892 ± 0.046	2.448GlnGln: 2.448 ± 0.065	3.549GlnArg: 3.549 ± 0.067	2.315GlnSer: 2.315 ± 0.048	2.075GlnThr: 2.075 ± 0.044	2.684GlnVal: 2.684 ± 0.06	0.862GlnTrp: 0.862 ± 0.028	0.898GlnTyr: 0.898 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.886ArgAla: 6.886 ± 0.088	0.666ArgCys: 0.666 ± 0.027	4.423ArgAsp: 4.423 ± 0.086	5.087ArgGlu: 5.087 ± 0.086	3.03ArgPhe: 3.03 ± 0.055	4.505ArgGly: 4.505 ± 0.068	2.551ArgHis: 2.551 ± 0.046	3.72ArgIle: 3.72 ± 0.071	1.601ArgLys: 1.601 ± 0.042	9.185ArgLeu: 9.185 ± 0.114	1.867ArgMet: 1.867 ± 0.042	1.688ArgAsn: 1.688 ± 0.043	2.985ArgPro: 2.985 ± 0.05	3.637ArgGln: 3.637 ± 0.06	5.729ArgArg: 5.729 ± 0.092	3.412ArgSer: 3.412 ± 0.051	3.169ArgThr: 3.169 ± 0.06	4.898ArgVal: 4.898 ± 0.074	1.158ArgTrp: 1.158 ± 0.034	2.205ArgTyr: 2.205 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.966SerAla: 5.966 ± 0.077	0.457SerCys: 0.457 ± 0.022	3.616SerAsp: 3.616 ± 0.075	3.416SerGlu: 3.416 ± 0.061	2.032SerPhe: 2.032 ± 0.043	5.46SerGly: 5.46 ± 0.074	1.504SerHis: 1.504 ± 0.039	2.844SerIle: 2.844 ± 0.051	1.356SerLys: 1.356 ± 0.038	6.743SerLeu: 6.743 ± 0.08	1.752SerMet: 1.752 ± 0.04	1.628SerAsn: 1.628 ± 0.041	2.9SerPro: 2.9 ± 0.049	2.318SerGln: 2.318 ± 0.057	4.434SerArg: 4.434 ± 0.066	3.877SerSer: 3.877 ± 0.089	2.98SerThr: 2.98 ± 0.052	4.125SerVal: 4.125 ± 0.073	0.84SerTrp: 0.84 ± 0.032	1.192SerTyr: 1.192 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.9ThrAla: 4.9 ± 0.061	0.474ThrCys: 0.474 ± 0.021	2.704ThrAsp: 2.704 ± 0.049	2.191ThrGlu: 2.191 ± 0.051	1.874ThrPhe: 1.874 ± 0.044	4.657ThrGly: 4.657 ± 0.064	1.44ThrHis: 1.44 ± 0.038	2.441ThrIle: 2.441 ± 0.048	0.813ThrLys: 0.813 ± 0.032	7.862ThrLeu: 7.862 ± 0.1	1.298ThrMet: 1.298 ± 0.036	1.167ThrAsn: 1.167 ± 0.04	3.822ThrPro: 3.822 ± 0.066	1.881ThrGln: 1.881 ± 0.044	4.066ThrArg: 4.066 ± 0.07	3.125ThrSer: 3.125 ± 0.061	2.86ThrThr: 2.86 ± 0.053	3.459ThrVal: 3.459 ± 0.058	0.725ThrTrp: 0.725 ± 0.029	0.942ThrTyr: 0.942 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.414ValAla: 7.414 ± 0.089	0.703ValCys: 0.703 ± 0.026	4.124ValAsp: 4.124 ± 0.071	4.223ValGlu: 4.223 ± 0.063	2.437ValPhe: 2.437 ± 0.052	4.891ValGly: 4.891 ± 0.08	1.521ValHis: 1.521 ± 0.041	4.213ValIle: 4.213 ± 0.067	1.655ValLys: 1.655 ± 0.044	7.657ValLeu: 7.657 ± 0.102	2.369ValMet: 2.369 ± 0.044	2.041ValAsn: 2.041 ± 0.054	3.078ValPro: 3.078 ± 0.062	2.087ValGln: 2.087 ± 0.05	4.562ValArg: 4.562 ± 0.065	4.516ValSer: 4.516 ± 0.065	4.265ValThr: 4.265 ± 0.069	5.58ValVal: 5.58 ± 0.093	0.816ValTrp: 0.816 ± 0.031	1.494ValTyr: 1.494 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.111TrpAla: 1.111 ± 0.036	0.217TrpCys: 0.217 ± 0.014	0.521TrpAsp: 0.521 ± 0.023	0.576TrpGlu: 0.576 ± 0.024	0.547TrpPhe: 0.547 ± 0.023	0.922TrpGly: 0.922 ± 0.032	0.507TrpHis: 0.507 ± 0.02	0.683TrpIle: 0.683 ± 0.026	0.368TrpLys: 0.368 ± 0.021	2.361TrpLeu: 2.361 ± 0.058	0.434TrpMet: 0.434 ± 0.018	0.368TrpAsn: 0.368 ± 0.019	0.725TrpPro: 0.725 ± 0.029	1.195TrpGln: 1.195 ± 0.033	1.23TrpArg: 1.23 ± 0.04	0.859TrpSer: 0.859 ± 0.027	0.622TrpThr: 0.622 ± 0.026	0.886TrpVal: 0.886 ± 0.034	0.291TrpTrp: 0.291 ± 0.019	0.389TrpTyr: 0.389 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.145TyrAla: 2.145 ± 0.045	0.258TyrCys: 0.258 ± 0.014	1.299TyrAsp: 1.299 ± 0.033	1.108TyrGlu: 1.108 ± 0.035	0.919TyrPhe: 0.919 ± 0.031	1.998TyrGly: 1.998 ± 0.051	0.677TyrHis: 0.677 ± 0.026	0.989TyrIle: 0.989 ± 0.03	0.552TyrLys: 0.552 ± 0.023	2.716TyrLeu: 2.716 ± 0.057	0.561TyrMet: 0.561 ± 0.019	0.681TyrAsn: 0.681 ± 0.029	1.235TyrPro: 1.235 ± 0.03	1.256TyrGln: 1.256 ± 0.035	2.12TyrArg: 2.12 ± 0.05	1.335TyrSer: 1.335 ± 0.034	1.158TyrThr: 1.158 ± 0.032	1.45TyrVal: 1.45 ± 0.035	0.377TyrTrp: 0.377 ± 0.02	0.703TyrTyr: 0.703 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3205 proteins (1071555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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