Amino acid dipepetide frequency for Acidianus hospitalis (strain W1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.958AlaAla: 2.958 ± 0.101	0.435AlaCys: 0.435 ± 0.028	2.452AlaAsp: 2.452 ± 0.056	4.175AlaGlu: 4.175 ± 0.084	2.894AlaPhe: 2.894 ± 0.076	3.904AlaGly: 3.904 ± 0.084	0.8AlaHis: 0.8 ± 0.038	5.9AlaIle: 5.9 ± 0.09	4.628AlaLys: 4.628 ± 0.098	6.545AlaLeu: 6.545 ± 0.133	1.415AlaMet: 1.415 ± 0.045	2.063AlaAsn: 2.063 ± 0.071	1.593AlaPro: 1.593 ± 0.053	1.141AlaGln: 1.141 ± 0.042	2.426AlaArg: 2.426 ± 0.072	3.916AlaSer: 3.916 ± 0.088	2.782AlaThr: 2.782 ± 0.073	4.431AlaVal: 4.431 ± 0.105	0.592AlaTrp: 0.592 ± 0.035	2.85AlaTyr: 2.85 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.326CysAla: 0.326 ± 0.026	0.142CysCys: 0.142 ± 0.019	0.322CysAsp: 0.322 ± 0.025	0.532CysGlu: 0.532 ± 0.033	0.277CysPhe: 0.277 ± 0.022	0.804CysGly: 0.804 ± 0.04	0.153CysHis: 0.153 ± 0.015	0.619CysIle: 0.619 ± 0.037	0.701CysLys: 0.701 ± 0.039	0.526CysLeu: 0.526 ± 0.031	0.163CysMet: 0.163 ± 0.016	0.522CysAsn: 0.522 ± 0.035	0.571CysPro: 0.571 ± 0.034	0.179CysGln: 0.179 ± 0.018	0.258CysArg: 0.258 ± 0.024	0.521CysSer: 0.521 ± 0.032	0.34CysThr: 0.34 ± 0.027	0.508CysVal: 0.508 ± 0.036	0.077CysTrp: 0.077 ± 0.011	0.366CysTyr: 0.366 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	2.56AspAla: 2.56 ± 0.062	0.4AspCys: 0.4 ± 0.025	2.2AspAsp: 2.2 ± 0.066	4.459AspGlu: 4.459 ± 0.102	2.434AspPhe: 2.434 ± 0.064	2.684AspGly: 2.684 ± 0.071	0.503AspHis: 0.503 ± 0.029	4.572AspIle: 4.572 ± 0.086	4.259AspLys: 4.259 ± 0.095	5.01AspLeu: 5.01 ± 0.086	1.024AspMet: 1.024 ± 0.041	1.988AspAsn: 1.988 ± 0.051	2.186AspPro: 2.186 ± 0.07	0.725AspGln: 0.725 ± 0.034	1.738AspArg: 1.738 ± 0.054	2.574AspSer: 2.574 ± 0.075	1.717AspThr: 1.717 ± 0.046	3.933AspVal: 3.933 ± 0.097	0.506AspTrp: 0.506 ± 0.028	2.586AspTyr: 2.586 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.336GluAla: 4.336 ± 0.106	0.485GluCys: 0.485 ± 0.034	4.075GluAsp: 4.075 ± 0.09	7.397GluGlu: 7.397 ± 0.153	2.919GluPhe: 2.919 ± 0.065	4.713GluGly: 4.713 ± 0.1	0.69GluHis: 0.69 ± 0.036	8.124GluIle: 8.124 ± 0.13	7.407GluLys: 7.407 ± 0.135	6.977GluLeu: 6.977 ± 0.13	1.581GluMet: 1.581 ± 0.053	3.679GluAsn: 3.679 ± 0.074	1.672GluPro: 1.672 ± 0.049	1.086GluGln: 1.086 ± 0.038	3.011GluArg: 3.011 ± 0.064	3.261GluSer: 3.261 ± 0.076	2.387GluThr: 2.387 ± 0.055	5.671GluVal: 5.671 ± 0.1	0.651GluTrp: 0.651 ± 0.035	2.939GluTyr: 2.939 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.571PheAla: 2.571 ± 0.076	0.34PheCys: 0.34 ± 0.028	2.141PheAsp: 2.141 ± 0.057	2.387PheGlu: 2.387 ± 0.061	2.157PhePhe: 2.157 ± 0.072	2.623PheGly: 2.623 ± 0.072	0.769PheHis: 0.769 ± 0.034	4.169PheIle: 4.169 ± 0.108	2.982PheLys: 2.982 ± 0.059	4.899PheLeu: 4.899 ± 0.117	1.046PheMet: 1.046 ± 0.037	2.366PheAsn: 2.366 ± 0.058	1.946PhePro: 1.946 ± 0.06	0.89PheGln: 0.89 ± 0.037	1.58PheArg: 1.58 ± 0.047	3.995PheSer: 3.995 ± 0.09	2.491PheThr: 2.491 ± 0.069	2.763PheVal: 2.763 ± 0.064	0.467PheTrp: 0.467 ± 0.027	2.426PheTyr: 2.426 ± 0.072	0.0PheXaa: 0.0 ± 0.0
Gly	3.29GlyAla: 3.29 ± 0.089	0.447GlyCys: 0.447 ± 0.031	3.0GlyAsp: 3.0 ± 0.07	4.564GlyGlu: 4.564 ± 0.096	3.306GlyPhe: 3.306 ± 0.082	4.356GlyGly: 4.356 ± 0.107	0.899GlyHis: 0.899 ± 0.039	7.409GlyIle: 7.409 ± 0.106	6.308GlyLys: 6.308 ± 0.087	6.029GlyLeu: 6.029 ± 0.112	1.449GlyMet: 1.449 ± 0.055	2.969GlyAsn: 2.969 ± 0.077	1.596GlyPro: 1.596 ± 0.057	1.062GlyGln: 1.062 ± 0.052	2.665GlyArg: 2.665 ± 0.079	3.782GlySer: 3.782 ± 0.08	2.755GlyThr: 2.755 ± 0.088	4.85GlyVal: 4.85 ± 0.093	0.785GlyTrp: 0.785 ± 0.038	3.466GlyTyr: 3.466 ± 0.084	0.0GlyXaa: 0.0 ± 0.0
His	0.719HisAla: 0.719 ± 0.03	0.119HisCys: 0.119 ± 0.013	0.613HisAsp: 0.613 ± 0.038	0.895HisGlu: 0.895 ± 0.046	0.609HisPhe: 0.609 ± 0.032	1.072HisGly: 1.072 ± 0.041	0.285HisHis: 0.285 ± 0.02	0.993HisIle: 0.993 ± 0.042	0.764HisLys: 0.764 ± 0.038	1.151HisLeu: 1.151 ± 0.045	0.321HisMet: 0.321 ± 0.021	0.54HisAsn: 0.54 ± 0.031	0.7HisPro: 0.7 ± 0.032	0.235HisGln: 0.235 ± 0.019	0.484HisArg: 0.484 ± 0.028	0.808HisSer: 0.808 ± 0.042	0.535HisThr: 0.535 ± 0.026	1.115HisVal: 1.115 ± 0.039	0.134HisTrp: 0.134 ± 0.014	0.677HisTyr: 0.677 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.287IleAla: 6.287 ± 0.115	0.659IleCys: 0.659 ± 0.041	4.9IleAsp: 4.9 ± 0.108	6.338IleGlu: 6.338 ± 0.106	4.057IlePhe: 4.057 ± 0.1	5.942IleGly: 5.942 ± 0.093	1.217IleHis: 1.217 ± 0.048	10.08IleIle: 10.08 ± 0.17	7.91IleLys: 7.91 ± 0.135	9.388IleLeu: 9.388 ± 0.156	2.147IleMet: 2.147 ± 0.055	4.897IleAsn: 4.897 ± 0.09	4.288IlePro: 4.288 ± 0.091	1.875IleGln: 1.875 ± 0.051	3.811IleArg: 3.811 ± 0.081	7.925IleSer: 7.925 ± 0.144	4.725IleThr: 4.725 ± 0.096	6.408IleVal: 6.408 ± 0.116	0.682IleTrp: 0.682 ± 0.031	4.246IleTyr: 4.246 ± 0.088	0.0IleXaa: 0.0 ± 0.0
Lys	4.599LysAla: 4.599 ± 0.09	0.674LysCys: 0.674 ± 0.041	4.673LysAsp: 4.673 ± 0.101	8.182LysGlu: 8.182 ± 0.134	3.164LysPhe: 3.164 ± 0.076	5.719LysGly: 5.719 ± 0.102	0.667LysHis: 0.667 ± 0.033	9.024LysIle: 9.024 ± 0.134	6.564LysLys: 6.564 ± 0.135	7.792LysLeu: 7.792 ± 0.13	2.02LysMet: 2.02 ± 0.056	3.766LysAsn: 3.766 ± 0.083	2.682LysPro: 2.682 ± 0.061	1.42LysGln: 1.42 ± 0.06	3.472LysArg: 3.472 ± 0.091	4.012LysSer: 4.012 ± 0.079	3.022LysThr: 3.022 ± 0.076	6.696LysVal: 6.696 ± 0.103	0.751LysTrp: 0.751 ± 0.035	3.99LysTyr: 3.99 ± 0.08	0.0LysXaa: 0.0 ± 0.0
Leu	6.558LeuAla: 6.558 ± 0.113	0.656LeuCys: 0.656 ± 0.033	4.871LeuAsp: 4.871 ± 0.095	6.371LeuGlu: 6.371 ± 0.116	4.164LeuPhe: 4.164 ± 0.102	7.323LeuGly: 7.323 ± 0.125	1.412LeuHis: 1.412 ± 0.047	8.732LeuIle: 8.732 ± 0.162	8.052LeuLys: 8.052 ± 0.123	9.736LeuLeu: 9.736 ± 0.191	2.125LeuMet: 2.125 ± 0.06	4.912LeuAsn: 4.912 ± 0.103	4.231LeuPro: 4.231 ± 0.083	2.405LeuGln: 2.405 ± 0.069	4.283LeuArg: 4.283 ± 0.085	8.129LeuSer: 8.129 ± 0.111	4.844LeuThr: 4.844 ± 0.096	6.246LeuVal: 6.246 ± 0.1	0.832LeuTrp: 0.832 ± 0.037	4.057LeuTyr: 4.057 ± 0.082	0.0LeuXaa: 0.0 ± 0.0
Met	1.34MetAla: 1.34 ± 0.048	0.127MetCys: 0.127 ± 0.014	1.143MetAsp: 1.143 ± 0.043	1.63MetGlu: 1.63 ± 0.053	0.754MetPhe: 0.754 ± 0.036	1.417MetGly: 1.417 ± 0.049	0.289MetHis: 0.289 ± 0.021	2.128MetIle: 2.128 ± 0.064	2.171MetLys: 2.171 ± 0.061	2.202MetLeu: 2.202 ± 0.059	0.574MetMet: 0.574 ± 0.033	1.046MetAsn: 1.046 ± 0.038	0.899MetPro: 0.899 ± 0.039	0.585MetGln: 0.585 ± 0.034	1.177MetArg: 1.177 ± 0.044	1.617MetSer: 1.617 ± 0.051	1.08MetThr: 1.08 ± 0.043	1.256MetVal: 1.256 ± 0.047	0.226MetTrp: 0.226 ± 0.022	0.771MetTyr: 0.771 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.831AsnAla: 2.831 ± 0.074	0.508AsnCys: 0.508 ± 0.034	2.004AsnAsp: 2.004 ± 0.059	3.313AsnGlu: 3.313 ± 0.072	2.374AsnPhe: 2.374 ± 0.068	2.976AsnGly: 2.976 ± 0.099	0.44AsnHis: 0.44 ± 0.027	4.09AsnIle: 4.09 ± 0.098	3.708AsnLys: 3.708 ± 0.098	4.773AsnLeu: 4.773 ± 0.094	0.901AsnMet: 0.901 ± 0.034	2.262AsnAsn: 2.262 ± 0.068	2.445AsnPro: 2.445 ± 0.077	0.882AsnGln: 0.882 ± 0.041	1.543AsnArg: 1.543 ± 0.05	3.429AsnSer: 3.429 ± 0.075	1.931AsnThr: 1.931 ± 0.059	3.712AsnVal: 3.712 ± 0.084	0.471AsnTrp: 0.471 ± 0.035	2.487AsnTyr: 2.487 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	2.052ProAla: 2.052 ± 0.056	0.342ProCys: 0.342 ± 0.026	1.667ProAsp: 1.667 ± 0.057	2.898ProGlu: 2.898 ± 0.07	2.02ProPhe: 2.02 ± 0.051	2.289ProGly: 2.289 ± 0.071	0.627ProHis: 0.627 ± 0.032	3.393ProIle: 3.393 ± 0.079	2.718ProLys: 2.718 ± 0.071	3.854ProLeu: 3.854 ± 0.089	0.729ProMet: 0.729 ± 0.034	1.631ProAsn: 1.631 ± 0.057	1.833ProPro: 1.833 ± 0.065	1.156ProGln: 1.156 ± 0.047	1.459ProArg: 1.459 ± 0.053	3.018ProSer: 3.018 ± 0.068	1.967ProThr: 1.967 ± 0.055	2.607ProVal: 2.607 ± 0.065	0.459ProTrp: 0.459 ± 0.028	2.096ProTyr: 2.096 ± 0.059	0.0ProXaa: 0.0 ± 0.0
Gln	1.253GlnAla: 1.253 ± 0.045	0.163GlnCys: 0.163 ± 0.017	0.953GlnAsp: 0.953 ± 0.039	1.622GlnGlu: 1.622 ± 0.049	0.791GlnPhe: 0.791 ± 0.039	1.612GlnGly: 1.612 ± 0.055	0.266GlnHis: 0.266 ± 0.021	1.902GlnIle: 1.902 ± 0.061	1.643GlnLys: 1.643 ± 0.065	1.988GlnLeu: 1.988 ± 0.06	0.584GlnMet: 0.584 ± 0.028	0.938GlnAsn: 0.938 ± 0.042	0.771GlnPro: 0.771 ± 0.043	0.651GlnGln: 0.651 ± 0.041	0.814GlnArg: 0.814 ± 0.039	1.03GlnSer: 1.03 ± 0.041	0.79GlnThr: 0.79 ± 0.037	1.428GlnVal: 1.428 ± 0.045	0.197GlnTrp: 0.197 ± 0.018	0.919GlnTyr: 0.919 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.204ArgAla: 2.204 ± 0.061	0.308ArgCys: 0.308 ± 0.023	2.02ArgAsp: 2.02 ± 0.056	3.35ArgGlu: 3.35 ± 0.075	1.702ArgPhe: 1.702 ± 0.06	2.637ArgGly: 2.637 ± 0.058	0.484ArgHis: 0.484 ± 0.026	4.022ArgIle: 4.022 ± 0.073	4.281ArgLys: 4.281 ± 0.097	3.79ArgLeu: 3.79 ± 0.089	0.898ArgMet: 0.898 ± 0.041	1.923ArgAsn: 1.923 ± 0.059	1.235ArgPro: 1.235 ± 0.046	0.882ArgGln: 0.882 ± 0.038	2.27ArgArg: 2.27 ± 0.072	1.962ArgSer: 1.962 ± 0.043	1.549ArgThr: 1.549 ± 0.049	2.794ArgVal: 2.794 ± 0.08	0.414ArgTrp: 0.414 ± 0.029	1.596ArgTyr: 1.596 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.859SerAla: 3.859 ± 0.081	0.627SerCys: 0.627 ± 0.037	2.595SerAsp: 2.595 ± 0.061	3.825SerGlu: 3.825 ± 0.079	3.43SerPhe: 3.43 ± 0.074	4.077SerGly: 4.077 ± 0.089	0.911SerHis: 0.911 ± 0.032	6.272SerIle: 6.272 ± 0.117	5.295SerLys: 5.295 ± 0.093	7.989SerLeu: 7.989 ± 0.145	1.678SerMet: 1.678 ± 0.052	2.824SerAsn: 2.824 ± 0.087	2.911SerPro: 2.911 ± 0.069	1.694SerGln: 1.694 ± 0.057	2.637SerArg: 2.637 ± 0.066	5.666SerSer: 5.666 ± 0.121	3.616SerThr: 3.616 ± 0.077	4.115SerVal: 4.115 ± 0.085	0.746SerTrp: 0.746 ± 0.038	3.0SerTyr: 3.0 ± 0.078	0.0SerXaa: 0.0 ± 0.0
Thr	3.006ThrAla: 3.006 ± 0.082	0.34ThrCys: 0.34 ± 0.026	1.799ThrAsp: 1.799 ± 0.053	2.52ThrGlu: 2.52 ± 0.064	2.181ThrPhe: 2.181 ± 0.072	3.093ThrGly: 3.093 ± 0.072	0.664ThrHis: 0.664 ± 0.03	4.115ThrIle: 4.115 ± 0.094	2.818ThrLys: 2.818 ± 0.078	4.96ThrLeu: 4.96 ± 0.109	1.038ThrMet: 1.038 ± 0.043	1.794ThrAsn: 1.794 ± 0.057	2.339ThrPro: 2.339 ± 0.063	1.095ThrGln: 1.095 ± 0.043	1.755ThrArg: 1.755 ± 0.049	3.38ThrSer: 3.38 ± 0.081	2.676ThrThr: 2.676 ± 0.098	3.279ThrVal: 3.279 ± 0.084	0.466ThrTrp: 0.466 ± 0.032	2.044ThrTyr: 2.044 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.893ValAla: 3.893 ± 0.08	0.559ValCys: 0.559 ± 0.032	3.749ValAsp: 3.749 ± 0.09	4.97ValGlu: 4.97 ± 0.099	3.014ValPhe: 3.014 ± 0.079	4.175ValGly: 4.175 ± 0.089	0.888ValHis: 0.888 ± 0.038	7.341ValIle: 7.341 ± 0.098	6.651ValLys: 6.651 ± 0.105	6.409ValLeu: 6.409 ± 0.11	1.544ValMet: 1.544 ± 0.051	3.859ValAsn: 3.859 ± 0.089	2.565ValPro: 2.565 ± 0.07	1.261ValGln: 1.261 ± 0.049	2.892ValArg: 2.892 ± 0.073	4.639ValSer: 4.639 ± 0.084	3.635ValThr: 3.635 ± 0.085	4.954ValVal: 4.954 ± 0.104	0.558ValTrp: 0.558 ± 0.027	3.353ValTyr: 3.353 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.527TrpAla: 0.527 ± 0.029	0.073TrpCys: 0.073 ± 0.012	0.485TrpAsp: 0.485 ± 0.032	0.6TrpGlu: 0.6 ± 0.033	0.463TrpPhe: 0.463 ± 0.03	0.637TrpGly: 0.637 ± 0.03	0.131TrpHis: 0.131 ± 0.013	0.975TrpIle: 0.975 ± 0.039	0.919TrpLys: 0.919 ± 0.04	0.975TrpLeu: 0.975 ± 0.043	0.197TrpMet: 0.197 ± 0.017	0.545TrpAsn: 0.545 ± 0.029	0.255TrpPro: 0.255 ± 0.022	0.195TrpGln: 0.195 ± 0.015	0.495TrpArg: 0.495 ± 0.028	0.567TrpSer: 0.567 ± 0.029	0.358TrpThr: 0.358 ± 0.02	0.617TrpVal: 0.617 ± 0.031	0.132TrpTrp: 0.132 ± 0.015	0.488TrpTyr: 0.488 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.732TyrAla: 2.732 ± 0.06	0.503TyrCys: 0.503 ± 0.037	2.394TyrAsp: 2.394 ± 0.062	3.037TyrGlu: 3.037 ± 0.071	2.294TyrPhe: 2.294 ± 0.069	2.932TyrGly: 2.932 ± 0.069	0.674TyrHis: 0.674 ± 0.039	3.922TyrIle: 3.922 ± 0.088	3.113TyrLys: 3.113 ± 0.09	4.947TyrLeu: 4.947 ± 0.094	0.996TyrMet: 0.996 ± 0.036	2.553TyrAsn: 2.553 ± 0.092	2.097TyrPro: 2.097 ± 0.064	0.893TyrGln: 0.893 ± 0.041	1.551TyrArg: 1.551 ± 0.044	3.542TyrSer: 3.542 ± 0.085	2.163TyrThr: 2.163 ± 0.062	3.525TyrVal: 3.525 ± 0.08	0.487TyrTrp: 0.487 ± 0.028	2.713TyrTyr: 2.713 ± 0.085	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2329 proteins (620352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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