Amino acid dipepetide frequency for Succinatimonas hippei (strain DSM 22608 / JCM 16073 / KCTC 15190 / YIT 12066)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.305AlaAla: 8.305 ± 0.162
1.265AlaCys: 1.265 ± 0.049
4.687AlaAsp: 4.687 ± 0.08
4.326AlaGlu: 4.326 ± 0.097
3.893AlaPhe: 3.893 ± 0.072
5.723AlaGly: 5.723 ± 0.102
1.358AlaHis: 1.358 ± 0.049
5.716AlaIle: 5.716 ± 0.106
5.781AlaLys: 5.781 ± 0.1
9.892AlaLeu: 9.892 ± 0.147
2.267AlaMet: 2.267 ± 0.064
2.941AlaAsn: 2.941 ± 0.071
2.562AlaPro: 2.562 ± 0.068
2.864AlaGln: 2.864 ± 0.065
3.202AlaArg: 3.202 ± 0.068
4.737AlaSer: 4.737 ± 0.087
3.277AlaThr: 3.277 ± 0.079
6.844AlaVal: 6.844 ± 0.107
0.629AlaTrp: 0.629 ± 0.029
2.7AlaTyr: 2.7 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
1.438CysAla: 1.438 ± 0.048
0.283CysCys: 0.283 ± 0.02
0.859CysAsp: 0.859 ± 0.039
0.782CysGlu: 0.782 ± 0.031
0.74CysPhe: 0.74 ± 0.038
1.352CysGly: 1.352 ± 0.049
0.317CysHis: 0.317 ± 0.023
0.92CysIle: 0.92 ± 0.037
0.911CysLys: 0.911 ± 0.035
1.442CysLeu: 1.442 ± 0.047
0.342CysMet: 0.342 ± 0.021
0.563CysAsn: 0.563 ± 0.029
0.619CysPro: 0.619 ± 0.032
0.37CysGln: 0.37 ± 0.024
0.669CysArg: 0.669 ± 0.031
1.034CysSer: 1.034 ± 0.037
0.705CysThr: 0.705 ± 0.039
1.051CysVal: 1.051 ± 0.041
0.095CysTrp: 0.095 ± 0.012
0.49CysTyr: 0.49 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.517AspAla: 4.517 ± 0.093
0.78AspCys: 0.78 ± 0.036
3.138AspAsp: 3.138 ± 0.087
4.127AspGlu: 4.127 ± 0.093
3.255AspPhe: 3.255 ± 0.07
3.721AspGly: 3.721 ± 0.084
0.936AspHis: 0.936 ± 0.038
4.203AspIle: 4.203 ± 0.087
4.246AspLys: 4.246 ± 0.083
6.35AspLeu: 6.35 ± 0.103
1.334AspMet: 1.334 ± 0.041
2.76AspAsn: 2.76 ± 0.074
2.626AspPro: 2.626 ± 0.063
1.077AspGln: 1.077 ± 0.037
2.334AspArg: 2.334 ± 0.065
3.159AspSer: 3.159 ± 0.077
2.446AspThr: 2.446 ± 0.062
3.664AspVal: 3.664 ± 0.075
0.477AspTrp: 0.477 ± 0.028
2.264AspTyr: 2.264 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.714GluAla: 4.714 ± 0.108
0.677GluCys: 0.677 ± 0.034
3.325GluAsp: 3.325 ± 0.091
4.062GluGlu: 4.062 ± 0.095
2.667GluPhe: 2.667 ± 0.067
3.513GluGly: 3.513 ± 0.087
1.29GluHis: 1.29 ± 0.049
4.882GluIle: 4.882 ± 0.09
4.974GluLys: 4.974 ± 0.109
6.212GluLeu: 6.212 ± 0.105
1.429GluMet: 1.429 ± 0.049
3.588GluAsn: 3.588 ± 0.082
1.706GluPro: 1.706 ± 0.051
2.095GluGln: 2.095 ± 0.066
2.783GluArg: 2.783 ± 0.07
3.11GluSer: 3.11 ± 0.075
2.541GluThr: 2.541 ± 0.066
3.901GluVal: 3.901 ± 0.087
0.382GluTrp: 0.382 ± 0.027
1.838GluTyr: 1.838 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
4.009PheAla: 4.009 ± 0.075
0.838PheCys: 0.838 ± 0.037
3.025PheAsp: 3.025 ± 0.067
2.359PheGlu: 2.359 ± 0.062
2.358PhePhe: 2.358 ± 0.076
3.034PheGly: 3.034 ± 0.075
0.757PheHis: 0.757 ± 0.034
4.2PheIle: 4.2 ± 0.1
3.354PheLys: 3.354 ± 0.065
4.856PheLeu: 4.856 ± 0.104
1.231PheMet: 1.231 ± 0.046
2.677PheAsn: 2.677 ± 0.069
1.487PhePro: 1.487 ± 0.049
0.748PheGln: 0.748 ± 0.036
1.457PheArg: 1.457 ± 0.049
3.745PheSer: 3.745 ± 0.083
2.553PheThr: 2.553 ± 0.062
3.039PheVal: 3.039 ± 0.074
0.363PheTrp: 0.363 ± 0.024
1.749PheTyr: 1.749 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
5.306GlyAla: 5.306 ± 0.108
1.114GlyCys: 1.114 ± 0.048
3.388GlyAsp: 3.388 ± 0.084
3.376GlyGlu: 3.376 ± 0.076
3.498GlyPhe: 3.498 ± 0.072
4.48GlyGly: 4.48 ± 0.116
1.242GlyHis: 1.242 ± 0.047
5.815GlyIle: 5.815 ± 0.109
4.817GlyLys: 4.817 ± 0.102
6.123GlyLeu: 6.123 ± 0.101
1.915GlyMet: 1.915 ± 0.053
2.658GlyAsn: 2.658 ± 0.084
1.744GlyPro: 1.744 ± 0.056
2.014GlyGln: 2.014 ± 0.062
2.895GlyArg: 2.895 ± 0.079
4.346GlySer: 4.346 ± 0.107
3.683GlyThr: 3.683 ± 0.087
4.759GlyVal: 4.759 ± 0.096
0.561GlyTrp: 0.561 ± 0.03
2.421GlyTyr: 2.421 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.26HisAla: 1.26 ± 0.041
0.364HisCys: 0.364 ± 0.025
1.053HisAsp: 1.053 ± 0.044
1.117HisGlu: 1.117 ± 0.046
0.96HisPhe: 0.96 ± 0.039
1.393HisGly: 1.393 ± 0.045
0.492HisHis: 0.492 ± 0.035
1.315HisIle: 1.315 ± 0.046
1.093HisLys: 1.093 ± 0.033
1.776HisLeu: 1.776 ± 0.055
0.41HisMet: 0.41 ± 0.025
0.853HisAsn: 0.853 ± 0.038
1.034HisPro: 1.034 ± 0.04
0.615HisGln: 0.615 ± 0.029
0.78HisArg: 0.78 ± 0.033
1.057HisSer: 1.057 ± 0.031
0.843HisThr: 0.843 ± 0.035
1.127HisVal: 1.127 ± 0.044
0.16HisTrp: 0.16 ± 0.016
0.641HisTyr: 0.641 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.796IleAla: 6.796 ± 0.117
1.253IleCys: 1.253 ± 0.05
4.794IleAsp: 4.794 ± 0.076
4.542IleGlu: 4.542 ± 0.086
3.439IlePhe: 3.439 ± 0.079
5.079IleGly: 5.079 ± 0.099
1.125IleHis: 1.125 ± 0.044
5.402IleIle: 5.402 ± 0.102
5.601IleLys: 5.601 ± 0.096
6.926IleLeu: 6.926 ± 0.117
1.685IleMet: 1.685 ± 0.058
3.844IleAsn: 3.844 ± 0.074
3.208IlePro: 3.208 ± 0.066
1.488IleGln: 1.488 ± 0.051
2.962IleArg: 2.962 ± 0.068
5.331IleSer: 5.331 ± 0.093
3.924IleThr: 3.924 ± 0.078
4.853IleVal: 4.853 ± 0.099
0.481IleTrp: 0.481 ± 0.034
2.403IleTyr: 2.403 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
6.185LysAla: 6.185 ± 0.093
0.715LysCys: 0.715 ± 0.034
4.657LysAsp: 4.657 ± 0.113
5.755LysGlu: 5.755 ± 0.11
2.39LysPhe: 2.39 ± 0.062
3.827LysGly: 3.827 ± 0.07
1.199LysHis: 1.199 ± 0.044
5.389LysIle: 5.389 ± 0.084
4.913LysLys: 4.913 ± 0.103
6.566LysLeu: 6.566 ± 0.102
1.656LysMet: 1.656 ± 0.05
4.025LysAsn: 4.025 ± 0.093
2.155LysPro: 2.155 ± 0.056
2.31LysGln: 2.31 ± 0.064
3.299LysArg: 3.299 ± 0.073
3.988LysSer: 3.988 ± 0.074
3.507LysThr: 3.507 ± 0.072
4.742LysVal: 4.742 ± 0.092
0.523LysTrp: 0.523 ± 0.029
2.033LysTyr: 2.033 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
7.72LeuAla: 7.72 ± 0.111
1.925LeuCys: 1.925 ± 0.055
5.429LeuAsp: 5.429 ± 0.097
5.353LeuGlu: 5.353 ± 0.093
4.66LeuPhe: 4.66 ± 0.099
6.569LeuGly: 6.569 ± 0.122
1.777LeuHis: 1.777 ± 0.056
7.794LeuIle: 7.794 ± 0.127
8.01LeuLys: 8.01 ± 0.136
9.549LeuLeu: 9.549 ± 0.168
2.467LeuMet: 2.467 ± 0.064
5.984LeuAsn: 5.984 ± 0.125
4.219LeuPro: 4.219 ± 0.086
3.168LeuGln: 3.168 ± 0.082
4.333LeuArg: 4.333 ± 0.086
8.154LeuSer: 8.154 ± 0.129
5.506LeuThr: 5.506 ± 0.121
5.624LeuVal: 5.624 ± 0.099
0.8LeuTrp: 0.8 ± 0.036
3.218LeuTyr: 3.218 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.169MetAla: 2.169 ± 0.063
0.311MetCys: 0.311 ± 0.022
1.199MetAsp: 1.199 ± 0.042
1.254MetGlu: 1.254 ± 0.044
1.081MetPhe: 1.081 ± 0.047
1.589MetGly: 1.589 ± 0.056
0.576MetHis: 0.576 ± 0.029
1.666MetIle: 1.666 ± 0.053
1.42MetLys: 1.42 ± 0.042
2.704MetLeu: 2.704 ± 0.061
0.773MetMet: 0.773 ± 0.037
0.988MetAsn: 0.988 ± 0.036
1.253MetPro: 1.253 ± 0.046
1.146MetGln: 1.146 ± 0.04
1.349MetArg: 1.349 ± 0.041
1.749MetSer: 1.749 ± 0.056
1.337MetThr: 1.337 ± 0.048
1.653MetVal: 1.653 ± 0.053
0.193MetTrp: 0.193 ± 0.016
0.557MetTyr: 0.557 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.901AsnAla: 3.901 ± 0.085
0.712AsnCys: 0.712 ± 0.035
2.703AsnAsp: 2.703 ± 0.068
3.083AsnGlu: 3.083 ± 0.076
2.285AsnPhe: 2.285 ± 0.056
3.054AsnGly: 3.054 ± 0.079
0.844AsnHis: 0.844 ± 0.034
3.729AsnIle: 3.729 ± 0.09
3.299AsnLys: 3.299 ± 0.088
5.094AsnLeu: 5.094 ± 0.114
1.1AsnMet: 1.1 ± 0.04
2.523AsnAsn: 2.523 ± 0.086
2.164AsnPro: 2.164 ± 0.054
1.385AsnGln: 1.385 ± 0.045
1.968AsnArg: 1.968 ± 0.055
3.085AsnSer: 3.085 ± 0.084
2.331AsnThr: 2.331 ± 0.066
2.839AsnVal: 2.839 ± 0.065
0.37AsnTrp: 0.37 ± 0.024
1.741AsnTyr: 1.741 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.688ProAla: 2.688 ± 0.063
0.572ProCys: 0.572 ± 0.033
2.503ProAsp: 2.503 ± 0.06
2.781ProGlu: 2.781 ± 0.069
1.912ProPhe: 1.912 ± 0.06
2.212ProGly: 2.212 ± 0.063
0.832ProHis: 0.832 ± 0.035
2.42ProIle: 2.42 ± 0.066
2.221ProLys: 2.221 ± 0.06
3.886ProLeu: 3.886 ± 0.086
0.831ProMet: 0.831 ± 0.037
1.562ProAsn: 1.562 ± 0.054
1.038ProPro: 1.038 ± 0.041
1.404ProGln: 1.404 ± 0.046
1.383ProArg: 1.383 ± 0.045
2.3ProSer: 2.3 ± 0.061
1.653ProThr: 1.653 ± 0.051
2.7ProVal: 2.7 ± 0.073
0.367ProTrp: 0.367 ± 0.025
1.505ProTyr: 1.505 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.395GlnAla: 2.395 ± 0.064
0.351GlnCys: 0.351 ± 0.026
1.585GlnAsp: 1.585 ± 0.045
1.967GlnGlu: 1.967 ± 0.057
1.139GlnPhe: 1.139 ± 0.04
2.112GlnGly: 2.112 ± 0.056
0.52GlnHis: 0.52 ± 0.027
2.556GlnIle: 2.556 ± 0.066
2.525GlnLys: 2.525 ± 0.061
2.488GlnLeu: 2.488 ± 0.055
0.854GlnMet: 0.854 ± 0.032
1.804GlnAsn: 1.804 ± 0.05
0.755GlnPro: 0.755 ± 0.033
1.164GlnGln: 1.164 ± 0.05
1.401GlnArg: 1.401 ± 0.053
2.012GlnSer: 2.012 ± 0.06
1.488GlnThr: 1.488 ± 0.05
1.82GlnVal: 1.82 ± 0.055
0.252GlnTrp: 0.252 ± 0.019
1.066GlnTyr: 1.066 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.185ArgAla: 3.185 ± 0.069
0.492ArgCys: 0.492 ± 0.028
2.168ArgAsp: 2.168 ± 0.064
2.757ArgGlu: 2.757 ± 0.067
2.328ArgPhe: 2.328 ± 0.062
2.606ArgGly: 2.606 ± 0.07
0.991ArgHis: 0.991 ± 0.039
3.182ArgIle: 3.182 ± 0.076
2.843ArgLys: 2.843 ± 0.064
4.34ArgLeu: 4.34 ± 0.09
1.149ArgMet: 1.149 ± 0.037
1.882ArgAsn: 1.882 ± 0.059
1.549ArgPro: 1.549 ± 0.047
1.635ArgGln: 1.635 ± 0.049
2.266ArgArg: 2.266 ± 0.071
2.606ArgSer: 2.606 ± 0.07
1.962ArgThr: 1.962 ± 0.055
2.637ArgVal: 2.637 ± 0.069
0.327ArgTrp: 0.327 ± 0.023
1.707ArgTyr: 1.707 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.331SerAla: 5.331 ± 0.092
0.983SerCys: 0.983 ± 0.038
3.788SerAsp: 3.788 ± 0.079
3.521SerGlu: 3.521 ± 0.073
3.724SerPhe: 3.724 ± 0.097
5.139SerGly: 5.139 ± 0.092
1.189SerHis: 1.189 ± 0.048
4.434SerIle: 4.434 ± 0.094
3.547SerLys: 3.547 ± 0.075
7.361SerLeu: 7.361 ± 0.117
1.528SerMet: 1.528 ± 0.049
2.593SerAsn: 2.593 ± 0.075
2.178SerPro: 2.178 ± 0.063
1.965SerGln: 1.965 ± 0.06
2.784SerArg: 2.784 ± 0.063
4.677SerSer: 4.677 ± 0.114
2.86SerThr: 2.86 ± 0.069
4.561SerVal: 4.561 ± 0.089
0.545SerTrp: 0.545 ± 0.026
2.454SerTyr: 2.454 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.622ThrAla: 4.622 ± 0.083
0.573ThrCys: 0.573 ± 0.03
2.953ThrAsp: 2.953 ± 0.065
2.626ThrGlu: 2.626 ± 0.076
2.232ThrPhe: 2.232 ± 0.055
3.613ThrGly: 3.613 ± 0.09
0.926ThrHis: 0.926 ± 0.041
3.196ThrIle: 3.196 ± 0.067
2.753ThrLys: 2.753 ± 0.059
5.495ThrLeu: 5.495 ± 0.097
1.136ThrMet: 1.136 ± 0.044
1.741ThrAsn: 1.741 ± 0.058
2.281ThrPro: 2.281 ± 0.06
1.43ThrGln: 1.43 ± 0.041
1.823ThrArg: 1.823 ± 0.048
2.768ThrSer: 2.768 ± 0.064
2.368ThrThr: 2.368 ± 0.07
4.249ThrVal: 4.249 ± 0.084
0.389ThrTrp: 0.389 ± 0.026
1.586ThrTyr: 1.586 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
5.161ValAla: 5.161 ± 0.106
1.143ValCys: 1.143 ± 0.047
3.533ValAsp: 3.533 ± 0.076
3.459ValGlu: 3.459 ± 0.083
3.154ValPhe: 3.154 ± 0.077
4.324ValGly: 4.324 ± 0.09
1.1ValHis: 1.1 ± 0.04
5.447ValIle: 5.447 ± 0.1
4.894ValLys: 4.894 ± 0.096
6.871ValLeu: 6.871 ± 0.105
1.854ValMet: 1.854 ± 0.059
3.393ValAsn: 3.393 ± 0.082
2.612ValPro: 2.612 ± 0.07
1.798ValGln: 1.798 ± 0.057
2.861ValArg: 2.861 ± 0.077
4.696ValSer: 4.696 ± 0.088
3.652ValThr: 3.652 ± 0.08
4.4ValVal: 4.4 ± 0.105
0.509ValTrp: 0.509 ± 0.027
2.076ValTyr: 2.076 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.486TrpAla: 0.486 ± 0.031
0.154TrpCys: 0.154 ± 0.015
0.464TrpAsp: 0.464 ± 0.031
0.394TrpGlu: 0.394 ± 0.026
0.429TrpPhe: 0.429 ± 0.025
0.52TrpGly: 0.52 ± 0.025
0.222TrpHis: 0.222 ± 0.02
0.517TrpIle: 0.517 ± 0.028
0.407TrpLys: 0.407 ± 0.025
0.774TrpLeu: 0.774 ± 0.034
0.222TrpMet: 0.222 ± 0.022
0.392TrpAsn: 0.392 ± 0.023
0.258TrpPro: 0.258 ± 0.019
0.455TrpGln: 0.455 ± 0.025
0.418TrpArg: 0.418 ± 0.024
0.493TrpSer: 0.493 ± 0.026
0.385TrpThr: 0.385 ± 0.025
0.434TrpVal: 0.434 ± 0.031
0.098TrpTrp: 0.098 ± 0.011
0.286TrpTyr: 0.286 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.784TyrAla: 2.784 ± 0.064
0.477TyrCys: 0.477 ± 0.025
2.164TyrAsp: 2.164 ± 0.052
2.047TyrGlu: 2.047 ± 0.057
1.694TyrPhe: 1.694 ± 0.058
2.297TyrGly: 2.297 ± 0.067
0.649TyrHis: 0.649 ± 0.03
2.356TyrIle: 2.356 ± 0.059
2.224TyrLys: 2.224 ± 0.064
3.551TyrLeu: 3.551 ± 0.078
0.782TyrMet: 0.782 ± 0.033
1.436TyrAsn: 1.436 ± 0.052
1.322TyrPro: 1.322 ± 0.048
1.122TyrGln: 1.122 ± 0.04
1.648TyrArg: 1.648 ± 0.051
2.116TyrSer: 2.116 ± 0.07
1.739TyrThr: 1.739 ± 0.054
2.042TyrVal: 2.042 ± 0.06
0.286TyrTrp: 0.286 ± 0.022
1.177TyrTyr: 1.177 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2169 proteins (675290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski