Amino acid dipepetide frequency for Rufibacter radiotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.579AlaAla: 7.579 ± 0.109
0.671AlaCys: 0.671 ± 0.024
3.83AlaAsp: 3.83 ± 0.061
4.679AlaGlu: 4.679 ± 0.069
3.873AlaPhe: 3.873 ± 0.059
6.46AlaGly: 6.46 ± 0.097
1.57AlaHis: 1.57 ± 0.038
4.737AlaIle: 4.737 ± 0.074
4.527AlaLys: 4.527 ± 0.074
8.682AlaLeu: 8.682 ± 0.092
2.01AlaMet: 2.01 ± 0.047
3.394AlaAsn: 3.394 ± 0.074
3.456AlaPro: 3.456 ± 0.075
4.263AlaGln: 4.263 ± 0.076
3.577AlaArg: 3.577 ± 0.06
4.972AlaSer: 4.972 ± 0.105
4.793AlaThr: 4.793 ± 0.105
5.511AlaVal: 5.511 ± 0.074
0.975AlaTrp: 0.975 ± 0.029
2.895AlaTyr: 2.895 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.549CysAla: 0.549 ± 0.027
0.103CysCys: 0.103 ± 0.009
0.347CysAsp: 0.347 ± 0.02
0.367CysGlu: 0.367 ± 0.018
0.367CysPhe: 0.367 ± 0.019
0.611CysGly: 0.611 ± 0.043
0.219CysHis: 0.219 ± 0.015
0.422CysIle: 0.422 ± 0.022
0.304CysLys: 0.304 ± 0.015
0.812CysLeu: 0.812 ± 0.029
0.128CysMet: 0.128 ± 0.01
0.292CysAsn: 0.292 ± 0.015
0.369CysPro: 0.369 ± 0.019
0.349CysGln: 0.349 ± 0.018
0.296CysArg: 0.296 ± 0.016
0.453CysSer: 0.453 ± 0.022
0.442CysThr: 0.442 ± 0.03
0.429CysVal: 0.429 ± 0.021
0.077CysTrp: 0.077 ± 0.008
0.209CysTyr: 0.209 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.853AspAla: 3.853 ± 0.066
0.33AspCys: 0.33 ± 0.019
1.972AspAsp: 1.972 ± 0.045
2.847AspGlu: 2.847 ± 0.058
2.838AspPhe: 2.838 ± 0.051
3.357AspGly: 3.357 ± 0.075
0.992AspHis: 0.992 ± 0.031
3.04AspIle: 3.04 ± 0.054
3.024AspLys: 3.024 ± 0.053
5.475AspLeu: 5.475 ± 0.067
1.095AspMet: 1.095 ± 0.031
2.022AspAsn: 2.022 ± 0.043
2.219AspPro: 2.219 ± 0.04
2.135AspGln: 2.135 ± 0.04
2.347AspArg: 2.347 ± 0.056
2.539AspSer: 2.539 ± 0.054
2.398AspThr: 2.398 ± 0.048
3.326AspVal: 3.326 ± 0.055
0.722AspTrp: 0.722 ± 0.023
2.198AspTyr: 2.198 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.295GluAla: 5.295 ± 0.074
0.295GluCys: 0.295 ± 0.02
2.929GluAsp: 2.929 ± 0.049
4.886GluGlu: 4.886 ± 0.086
2.451GluPhe: 2.451 ± 0.047
4.133GluGly: 4.133 ± 0.062
1.252GluHis: 1.252 ± 0.031
3.777GluIle: 3.777 ± 0.054
4.634GluLys: 4.634 ± 0.069
5.884GluLeu: 5.884 ± 0.076
1.601GluMet: 1.601 ± 0.038
2.975GluAsn: 2.975 ± 0.051
2.023GluPro: 2.023 ± 0.047
2.879GluGln: 2.879 ± 0.056
2.999GluArg: 2.999 ± 0.061
2.752GluSer: 2.752 ± 0.045
3.139GluThr: 3.139 ± 0.059
4.798GluVal: 4.798 ± 0.075
0.681GluTrp: 0.681 ± 0.023
2.039GluTyr: 2.039 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.352PheAla: 3.352 ± 0.058
0.42PheCys: 0.42 ± 0.018
2.505PheAsp: 2.505 ± 0.051
2.548PheGlu: 2.548 ± 0.055
2.402PhePhe: 2.402 ± 0.053
3.397PheGly: 3.397 ± 0.063
0.923PheHis: 0.923 ± 0.031
2.581PheIle: 2.581 ± 0.051
2.71PheLys: 2.71 ± 0.054
5.037PheLeu: 5.037 ± 0.083
1.112PheMet: 1.112 ± 0.03
2.172PheAsn: 2.172 ± 0.049
1.957PhePro: 1.957 ± 0.049
1.969PheGln: 1.969 ± 0.051
2.001PheArg: 2.001 ± 0.039
3.473PheSer: 3.473 ± 0.06
3.199PheThr: 3.199 ± 0.068
2.833PheVal: 2.833 ± 0.051
0.65PheTrp: 0.65 ± 0.027
1.882PheTyr: 1.882 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.423GlyAla: 5.423 ± 0.082
0.657GlyCys: 0.657 ± 0.049
3.098GlyAsp: 3.098 ± 0.058
3.757GlyGlu: 3.757 ± 0.059
3.618GlyPhe: 3.618 ± 0.059
5.507GlyGly: 5.507 ± 0.1
1.48GlyHis: 1.48 ± 0.042
4.631GlyIle: 4.631 ± 0.082
5.025GlyLys: 5.025 ± 0.068
7.122GlyLeu: 7.122 ± 0.094
1.857GlyMet: 1.857 ± 0.044
3.177GlyAsn: 3.177 ± 0.056
2.256GlyPro: 2.256 ± 0.06
3.124GlyGln: 3.124 ± 0.054
3.088GlyArg: 3.088 ± 0.056
4.293GlySer: 4.293 ± 0.079
4.644GlyThr: 4.644 ± 0.13
5.224GlyVal: 5.224 ± 0.075
0.96GlyTrp: 0.96 ± 0.033
2.956GlyTyr: 2.956 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.408HisAla: 1.408 ± 0.033
0.179HisCys: 0.179 ± 0.013
0.913HisAsp: 0.913 ± 0.033
1.113HisGlu: 1.113 ± 0.036
1.085HisPhe: 1.085 ± 0.035
1.38HisGly: 1.38 ± 0.038
0.641HisHis: 0.641 ± 0.025
1.131HisIle: 1.131 ± 0.037
0.947HisLys: 0.947 ± 0.028
2.519HisLeu: 2.519 ± 0.055
0.411HisMet: 0.411 ± 0.019
0.809HisAsn: 0.809 ± 0.027
1.264HisPro: 1.264 ± 0.034
1.007HisGln: 1.007 ± 0.029
0.969HisArg: 0.969 ± 0.028
1.102HisSer: 1.102 ± 0.032
1.152HisThr: 1.152 ± 0.031
1.227HisVal: 1.227 ± 0.034
0.267HisTrp: 0.267 ± 0.016
0.917HisTyr: 0.917 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
4.729IleAla: 4.729 ± 0.063
0.527IleCys: 0.527 ± 0.023
3.199IleAsp: 3.199 ± 0.063
3.339IleGlu: 3.339 ± 0.06
2.438IlePhe: 2.438 ± 0.053
4.476IleGly: 4.476 ± 0.079
1.09IleHis: 1.09 ± 0.034
3.507IleIle: 3.507 ± 0.07
3.601IleLys: 3.601 ± 0.064
5.362IleLeu: 5.362 ± 0.089
1.272IleMet: 1.272 ± 0.034
2.645IleAsn: 2.645 ± 0.046
2.597IlePro: 2.597 ± 0.05
2.247IleGln: 2.247 ± 0.047
2.579IleArg: 2.579 ± 0.047
3.907IleSer: 3.907 ± 0.063
3.878IleThr: 3.878 ± 0.078
3.36IleVal: 3.36 ± 0.059
0.581IleTrp: 0.581 ± 0.025
1.932IleTyr: 1.932 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
5.369LysAla: 5.369 ± 0.071
0.246LysCys: 0.246 ± 0.017
3.49LysAsp: 3.49 ± 0.08
4.597LysGlu: 4.597 ± 0.072
2.055LysPhe: 2.055 ± 0.041
4.304LysGly: 4.304 ± 0.059
1.132LysHis: 1.132 ± 0.031
3.51LysIle: 3.51 ± 0.071
4.249LysLys: 4.249 ± 0.079
5.491LysLeu: 5.491 ± 0.078
1.592LysMet: 1.592 ± 0.038
2.927LysAsn: 2.927 ± 0.056
2.769LysPro: 2.769 ± 0.053
2.48LysGln: 2.48 ± 0.051
2.708LysArg: 2.708 ± 0.054
3.159LysSer: 3.159 ± 0.057
3.59LysThr: 3.59 ± 0.053
4.382LysVal: 4.382 ± 0.059
0.699LysTrp: 0.699 ± 0.026
2.059LysTyr: 2.059 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
8.557LeuAla: 8.557 ± 0.099
0.798LeuCys: 0.798 ± 0.03
5.025LeuAsp: 5.025 ± 0.067
6.33LeuGlu: 6.33 ± 0.104
4.83LeuPhe: 4.83 ± 0.074
6.864LeuGly: 6.864 ± 0.096
2.19LeuHis: 2.19 ± 0.049
5.075LeuIle: 5.075 ± 0.086
6.22LeuLys: 6.22 ± 0.077
11.329LeuLeu: 11.329 ± 0.164
2.268LeuMet: 2.268 ± 0.051
4.515LeuAsn: 4.515 ± 0.07
5.148LeuPro: 5.148 ± 0.075
5.059LeuGln: 5.059 ± 0.084
4.798LeuArg: 4.798 ± 0.072
6.649LeuSer: 6.649 ± 0.089
5.876LeuThr: 5.876 ± 0.074
7.218LeuVal: 7.218 ± 0.096
1.09LeuTrp: 1.09 ± 0.038
3.415LeuTyr: 3.415 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.321MetAla: 2.321 ± 0.041
0.113MetCys: 0.113 ± 0.009
1.137MetAsp: 1.137 ± 0.031
1.489MetGlu: 1.489 ± 0.033
0.778MetPhe: 0.778 ± 0.028
1.727MetGly: 1.727 ± 0.045
0.448MetHis: 0.448 ± 0.021
1.183MetIle: 1.183 ± 0.033
1.719MetLys: 1.719 ± 0.037
2.3MetLeu: 2.3 ± 0.054
0.618MetMet: 0.618 ± 0.028
1.062MetAsn: 1.062 ± 0.032
1.173MetPro: 1.173 ± 0.032
1.033MetGln: 1.033 ± 0.031
1.142MetArg: 1.142 ± 0.027
1.218MetSer: 1.218 ± 0.035
1.199MetThr: 1.199 ± 0.032
1.76MetVal: 1.76 ± 0.043
0.19MetTrp: 0.19 ± 0.012
0.628MetTyr: 0.628 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.541AsnAla: 3.541 ± 0.056
0.3AsnCys: 0.3 ± 0.017
1.913AsnAsp: 1.913 ± 0.046
2.287AsnGlu: 2.287 ± 0.047
2.11AsnPhe: 2.11 ± 0.046
3.493AsnGly: 3.493 ± 0.105
0.857AsnHis: 0.857 ± 0.028
2.75AsnIle: 2.75 ± 0.048
2.433AsnLys: 2.433 ± 0.049
4.766AsnLeu: 4.766 ± 0.08
0.965AsnMet: 0.965 ± 0.03
2.149AsnAsn: 2.149 ± 0.05
2.695AsnPro: 2.695 ± 0.049
2.011AsnGln: 2.011 ± 0.043
2.204AsnArg: 2.204 ± 0.037
2.432AsnSer: 2.432 ± 0.055
2.694AsnThr: 2.694 ± 0.053
2.922AsnVal: 2.922 ± 0.054
0.657AsnTrp: 0.657 ± 0.027
1.894AsnTyr: 1.894 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
4.316ProAla: 4.316 ± 0.078
0.228ProCys: 0.228 ± 0.014
2.59ProAsp: 2.59 ± 0.05
3.688ProGlu: 3.688 ± 0.057
2.199ProPhe: 2.199 ± 0.047
3.099ProGly: 3.099 ± 0.059
0.902ProHis: 0.902 ± 0.03
2.205ProIle: 2.205 ± 0.037
2.353ProLys: 2.353 ± 0.048
4.081ProLeu: 4.081 ± 0.068
0.907ProMet: 0.907 ± 0.028
1.977ProAsn: 1.977 ± 0.045
1.286ProPro: 1.286 ± 0.045
1.913ProGln: 1.913 ± 0.04
1.568ProArg: 1.568 ± 0.039
2.593ProSer: 2.593 ± 0.047
2.528ProThr: 2.528 ± 0.051
3.531ProVal: 3.531 ± 0.06
0.499ProTrp: 0.499 ± 0.022
1.631ProTyr: 1.631 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.933GlnAla: 3.933 ± 0.069
0.205GlnCys: 0.205 ± 0.015
2.241GlnAsp: 2.241 ± 0.051
3.587GlnGlu: 3.587 ± 0.058
1.761GlnPhe: 1.761 ± 0.044
2.794GlnGly: 2.794 ± 0.052
0.974GlnHis: 0.974 ± 0.03
2.479GlnIle: 2.479 ± 0.05
3.038GlnLys: 3.038 ± 0.049
4.535GlnLeu: 4.535 ± 0.069
1.062GlnMet: 1.062 ± 0.03
2.172GlnAsn: 2.172 ± 0.049
1.995GlnPro: 1.995 ± 0.046
2.485GlnGln: 2.485 ± 0.066
2.072GlnArg: 2.072 ± 0.044
1.984GlnSer: 1.984 ± 0.044
2.555GlnThr: 2.555 ± 0.05
3.403GlnVal: 3.403 ± 0.051
0.536GlnTrp: 0.536 ± 0.022
1.587GlnTyr: 1.587 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.113ArgAla: 3.113 ± 0.059
0.258ArgCys: 0.258 ± 0.017
2.043ArgAsp: 2.043 ± 0.045
2.998ArgGlu: 2.998 ± 0.062
2.406ArgPhe: 2.406 ± 0.049
2.618ArgGly: 2.618 ± 0.054
1.025ArgHis: 1.025 ± 0.036
2.912ArgIle: 2.912 ± 0.054
2.943ArgLys: 2.943 ± 0.058
4.757ArgLeu: 4.757 ± 0.074
1.207ArgMet: 1.207 ± 0.029
2.208ArgAsn: 2.208 ± 0.047
1.784ArgPro: 1.784 ± 0.04
2.328ArgGln: 2.328 ± 0.044
2.218ArgArg: 2.218 ± 0.048
2.336ArgSer: 2.336 ± 0.047
2.517ArgThr: 2.517 ± 0.045
3.028ArgVal: 3.028 ± 0.059
0.583ArgTrp: 0.583 ± 0.023
1.831ArgTyr: 1.831 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.552SerAla: 4.552 ± 0.076
0.498SerCys: 0.498 ± 0.022
2.664SerAsp: 2.664 ± 0.044
3.097SerGlu: 3.097 ± 0.043
3.366SerPhe: 3.366 ± 0.049
4.613SerGly: 4.613 ± 0.06
1.101SerHis: 1.101 ± 0.035
3.542SerIle: 3.542 ± 0.066
3.244SerLys: 3.244 ± 0.06
6.216SerLeu: 6.216 ± 0.082
1.334SerMet: 1.334 ± 0.036
2.548SerAsn: 2.548 ± 0.056
2.66SerPro: 2.66 ± 0.047
2.196SerGln: 2.196 ± 0.047
2.633SerArg: 2.633 ± 0.047
3.911SerSer: 3.911 ± 0.072
3.491SerThr: 3.491 ± 0.078
3.996SerVal: 3.996 ± 0.062
0.653SerTrp: 0.653 ± 0.027
2.312SerTyr: 2.312 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.974ThrAla: 4.974 ± 0.125
0.392ThrCys: 0.392 ± 0.037
2.928ThrAsp: 2.928 ± 0.056
3.046ThrGlu: 3.046 ± 0.052
2.915ThrPhe: 2.915 ± 0.074
4.812ThrGly: 4.812 ± 0.081
1.188ThrHis: 1.188 ± 0.036
3.526ThrIle: 3.526 ± 0.075
2.882ThrLys: 2.882 ± 0.053
6.031ThrLeu: 6.031 ± 0.082
1.092ThrMet: 1.092 ± 0.029
2.502ThrAsn: 2.502 ± 0.06
3.178ThrPro: 3.178 ± 0.057
2.501ThrGln: 2.501 ± 0.05
2.29ThrArg: 2.29 ± 0.046
3.615ThrSer: 3.615 ± 0.073
3.609ThrThr: 3.609 ± 0.08
4.315ThrVal: 4.315 ± 0.113
0.755ThrTrp: 0.755 ± 0.029
2.404ThrTyr: 2.404 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
5.809ValAla: 5.809 ± 0.075
0.563ValCys: 0.563 ± 0.026
3.335ValAsp: 3.335 ± 0.058
4.128ValGlu: 4.128 ± 0.066
3.14ValPhe: 3.14 ± 0.056
4.671ValGly: 4.671 ± 0.079
1.279ValHis: 1.279 ± 0.034
3.914ValIle: 3.914 ± 0.068
4.191ValLys: 4.191 ± 0.065
7.368ValLeu: 7.368 ± 0.096
1.657ValMet: 1.657 ± 0.044
3.179ValAsn: 3.179 ± 0.053
3.217ValPro: 3.217 ± 0.06
2.892ValGln: 2.892 ± 0.054
3.11ValArg: 3.11 ± 0.058
4.251ValSer: 4.251 ± 0.069
4.324ValThr: 4.324 ± 0.114
5.286ValVal: 5.286 ± 0.08
0.802ValTrp: 0.802 ± 0.025
2.512ValTyr: 2.512 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.963TrpAla: 0.963 ± 0.026
0.095TrpCys: 0.095 ± 0.009
0.611TrpAsp: 0.611 ± 0.027
0.72TrpGlu: 0.72 ± 0.029
0.526TrpPhe: 0.526 ± 0.025
0.845TrpGly: 0.845 ± 0.029
0.315TrpHis: 0.315 ± 0.019
0.557TrpIle: 0.557 ± 0.022
0.725TrpLys: 0.725 ± 0.025
1.339TrpLeu: 1.339 ± 0.04
0.336TrpMet: 0.336 ± 0.014
0.572TrpAsn: 0.572 ± 0.024
0.394TrpPro: 0.394 ± 0.02
0.681TrpGln: 0.681 ± 0.028
0.592TrpArg: 0.592 ± 0.022
0.607TrpSer: 0.607 ± 0.027
0.613TrpThr: 0.613 ± 0.024
0.928TrpVal: 0.928 ± 0.03
0.207TrpTrp: 0.207 ± 0.014
0.425TrpTyr: 0.425 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.82TyrAla: 2.82 ± 0.048
0.267TyrCys: 0.267 ± 0.017
1.959TyrAsp: 1.959 ± 0.049
1.921TyrGlu: 1.921 ± 0.039
1.964TyrPhe: 1.964 ± 0.046
2.735TyrGly: 2.735 ± 0.053
0.864TyrHis: 0.864 ± 0.029
1.786TyrIle: 1.786 ± 0.042
2.036TyrLys: 2.036 ± 0.037
4.147TyrLeu: 4.147 ± 0.055
0.713TyrMet: 0.713 ± 0.021
1.777TyrAsn: 1.777 ± 0.044
1.655TyrPro: 1.655 ± 0.045
1.845TyrGln: 1.845 ± 0.04
1.919TyrArg: 1.919 ± 0.04
2.381TyrSer: 2.381 ± 0.06
2.314TyrThr: 2.314 ± 0.075
2.155TyrVal: 2.155 ± 0.045
0.466TyrTrp: 0.466 ± 0.022
1.553TyrTyr: 1.553 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3455 proteins (1172869 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski