Amino acid dipepetide frequency for Alfalfa virus S

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.248AlaAla: 6.248 ± 1.289
1.47AlaCys: 1.47 ± 0.585
4.043AlaAsp: 4.043 ± 1.278
4.41AlaGlu: 4.41 ± 1.775
2.573AlaPhe: 2.573 ± 0.82
6.248AlaGly: 6.248 ± 0.881
2.205AlaHis: 2.205 ± 0.681
4.41AlaIle: 4.41 ± 0.713
4.043AlaLys: 4.043 ± 1.432
9.188AlaLeu: 9.188 ± 2.935
1.47AlaMet: 1.47 ± 0.477
5.88AlaAsn: 5.88 ± 1.845
4.043AlaPro: 4.043 ± 1.119
3.308AlaGln: 3.308 ± 0.775
3.308AlaArg: 3.308 ± 0.764
4.043AlaSer: 4.043 ± 1.228
9.188AlaThr: 9.188 ± 1.586
4.41AlaVal: 4.41 ± 1.07
1.103AlaTrp: 1.103 ± 1.063
4.043AlaTyr: 4.043 ± 1.329
0.0AlaXaa: 0.0 ± 0.0
Cys
0.368CysAla: 0.368 ± 0.442
0.0CysCys: 0.0 ± 0.0
0.368CysAsp: 0.368 ± 0.194
1.47CysGlu: 1.47 ± 0.655
0.735CysPhe: 0.735 ± 0.389
1.47CysGly: 1.47 ± 0.585
0.368CysHis: 0.368 ± 0.194
0.0CysIle: 0.0 ± 0.0
1.103CysLys: 1.103 ± 0.583
2.94CysLeu: 2.94 ± 0.768
1.103CysMet: 1.103 ± 1.004
0.368CysAsn: 0.368 ± 0.194
1.47CysPro: 1.47 ± 0.576
1.103CysGln: 1.103 ± 0.637
0.735CysArg: 0.735 ± 0.714
1.103CysSer: 1.103 ± 0.494
1.103CysThr: 1.103 ± 1.175
0.368CysVal: 0.368 ± 0.633
0.0CysTrp: 0.0 ± 0.0
1.47CysTyr: 1.47 ± 1.045
0.0CysXaa: 0.0 ± 0.0
Asp
4.778AspAla: 4.778 ± 1.799
1.103AspCys: 1.103 ± 0.583
3.308AspAsp: 3.308 ± 0.786
3.675AspGlu: 3.675 ± 1.586
2.205AspPhe: 2.205 ± 0.719
1.838AspGly: 1.838 ± 0.768
1.838AspHis: 1.838 ± 0.585
1.838AspIle: 1.838 ± 1.666
2.205AspLys: 2.205 ± 0.874
5.145AspLeu: 5.145 ± 1.537
1.47AspMet: 1.47 ± 0.618
2.94AspAsn: 2.94 ± 0.6
2.573AspPro: 2.573 ± 0.526
2.205AspGln: 2.205 ± 0.874
3.675AspArg: 3.675 ± 0.73
2.205AspSer: 2.205 ± 1.26
3.308AspThr: 3.308 ± 1.358
2.94AspVal: 2.94 ± 0.751
0.368AspTrp: 0.368 ± 0.194
2.94AspTyr: 2.94 ± 0.932
0.0AspXaa: 0.0 ± 0.0
Glu
4.778GluAla: 4.778 ± 1.963
1.47GluCys: 1.47 ± 0.496
2.205GluAsp: 2.205 ± 1.166
3.308GluGlu: 3.308 ± 0.775
1.103GluPhe: 1.103 ± 0.977
1.47GluGly: 1.47 ± 0.576
1.103GluHis: 1.103 ± 0.791
3.675GluIle: 3.675 ± 2.613
2.94GluLys: 2.94 ± 1.555
5.513GluLeu: 5.513 ± 1.935
2.205GluMet: 2.205 ± 0.851
2.94GluAsn: 2.94 ± 0.65
2.94GluPro: 2.94 ± 0.993
2.205GluGln: 2.205 ± 0.812
4.043GluArg: 4.043 ± 1.09
4.043GluSer: 4.043 ± 1.008
3.675GluThr: 3.675 ± 0.855
3.308GluVal: 3.308 ± 0.632
0.368GluTrp: 0.368 ± 0.194
2.205GluTyr: 2.205 ± 0.874
0.0GluXaa: 0.0 ± 0.0
Phe
3.308PheAla: 3.308 ± 1.262
1.47PheCys: 1.47 ± 1.173
3.675PheAsp: 3.675 ± 0.96
3.308PheGlu: 3.308 ± 0.775
1.103PhePhe: 1.103 ± 0.613
2.205PheGly: 2.205 ± 0.425
1.47PheHis: 1.47 ± 0.941
2.573PheIle: 2.573 ± 1.065
2.573PheLys: 2.573 ± 1.097
3.308PheLeu: 3.308 ± 0.974
1.103PheMet: 1.103 ± 0.583
2.94PheAsn: 2.94 ± 1.57
1.838PhePro: 1.838 ± 0.718
1.838PheGln: 1.838 ± 1.159
1.47PheArg: 1.47 ± 0.585
2.94PheSer: 2.94 ± 0.783
2.94PheThr: 2.94 ± 1.172
1.103PheVal: 1.103 ± 0.583
0.0PheTrp: 0.0 ± 0.0
1.103PheTyr: 1.103 ± 0.494
0.0PheXaa: 0.0 ± 0.0
Gly
4.41GlyAla: 4.41 ± 1.199
1.838GlyCys: 1.838 ± 0.741
4.043GlyAsp: 4.043 ± 0.654
2.94GlyGlu: 2.94 ± 0.759
1.47GlyPhe: 1.47 ± 0.941
2.94GlyGly: 2.94 ± 0.88
1.838GlyHis: 1.838 ± 1.348
1.47GlyIle: 1.47 ± 0.629
3.308GlyLys: 3.308 ± 0.818
3.308GlyLeu: 3.308 ± 0.78
1.47GlyMet: 1.47 ± 1.045
1.838GlyAsn: 1.838 ± 1.244
2.205GlyPro: 2.205 ± 0.681
2.205GlyGln: 2.205 ± 0.812
1.47GlyArg: 1.47 ± 0.778
1.838GlySer: 1.838 ± 1.669
1.838GlyThr: 1.838 ± 0.601
2.94GlyVal: 2.94 ± 1.612
0.735GlyTrp: 0.735 ± 0.389
0.735GlyTyr: 0.735 ± 0.523
0.0GlyXaa: 0.0 ± 0.0
His
4.41HisAla: 4.41 ± 2.008
1.103HisCys: 1.103 ± 0.583
1.47HisAsp: 1.47 ± 0.655
0.368HisGlu: 0.368 ± 0.194
2.573HisPhe: 2.573 ± 0.802
2.573HisGly: 2.573 ± 0.911
2.205HisHis: 2.205 ± 0.833
1.103HisIle: 1.103 ± 0.392
0.368HisLys: 0.368 ± 0.194
3.308HisLeu: 3.308 ± 0.804
0.368HisMet: 0.368 ± 0.194
0.735HisAsn: 0.735 ± 0.523
1.838HisPro: 1.838 ± 1.182
2.94HisGln: 2.94 ± 0.281
3.675HisArg: 3.675 ± 1.232
3.308HisSer: 3.308 ± 2.561
1.838HisThr: 1.838 ± 0.741
2.205HisVal: 2.205 ± 0.668
0.368HisTrp: 0.368 ± 0.194
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.513IleAla: 5.513 ± 1.31
0.0IleCys: 0.0 ± 0.0
2.573IleAsp: 2.573 ± 0.484
2.573IleGlu: 2.573 ± 0.873
1.103IlePhe: 1.103 ± 0.583
1.103IleGly: 1.103 ± 0.527
2.573IleHis: 2.573 ± 1.203
3.308IleIle: 3.308 ± 1.275
4.41IleLys: 4.41 ± 0.85
4.778IleLeu: 4.778 ± 0.777
1.47IleMet: 1.47 ± 0.778
1.838IleAsn: 1.838 ± 1.666
2.94IlePro: 2.94 ± 1.431
4.41IleGln: 4.41 ± 1.263
2.205IleArg: 2.205 ± 0.784
1.838IleSer: 1.838 ± 0.768
4.043IleThr: 4.043 ± 1.153
1.47IleVal: 1.47 ± 0.496
0.0IleTrp: 0.0 ± 0.0
1.103IleTyr: 1.103 ± 0.392
0.0IleXaa: 0.0 ± 0.0
Lys
5.88LysAla: 5.88 ± 1.628
1.103LysCys: 1.103 ± 0.613
1.838LysAsp: 1.838 ± 0.972
1.47LysGlu: 1.47 ± 0.778
1.838LysPhe: 1.838 ± 0.975
0.735LysGly: 0.735 ± 0.389
1.47LysHis: 1.47 ± 0.496
2.573LysIle: 2.573 ± 0.876
1.47LysLys: 1.47 ± 0.778
5.88LysLeu: 5.88 ± 2.693
1.103LysMet: 1.103 ± 0.47
1.47LysAsn: 1.47 ± 0.503
2.205LysPro: 2.205 ± 1.166
2.94LysGln: 2.94 ± 0.66
3.308LysArg: 3.308 ± 1.39
3.308LysSer: 3.308 ± 0.688
4.41LysThr: 4.41 ± 1.145
1.838LysVal: 1.838 ± 0.768
0.368LysTrp: 0.368 ± 0.442
0.735LysTyr: 0.735 ± 0.471
0.0LysXaa: 0.0 ± 0.0
Leu
9.188LeuAla: 9.188 ± 1.126
1.47LeuCys: 1.47 ± 0.941
4.043LeuAsp: 4.043 ± 0.529
7.35LeuGlu: 7.35 ± 0.841
5.145LeuPhe: 5.145 ± 0.815
3.308LeuGly: 3.308 ± 1.363
3.675LeuHis: 3.675 ± 1.849
4.043LeuIle: 4.043 ± 0.852
3.675LeuLys: 3.675 ± 0.808
10.29LeuLeu: 10.29 ± 2.935
0.735LeuMet: 0.735 ± 0.523
3.675LeuAsn: 3.675 ± 0.73
8.453LeuPro: 8.453 ± 1.654
4.778LeuGln: 4.778 ± 1.857
5.88LeuArg: 5.88 ± 0.836
5.88LeuSer: 5.88 ± 1.559
8.453LeuThr: 8.453 ± 1.128
7.35LeuVal: 7.35 ± 1.782
0.735LeuTrp: 0.735 ± 0.389
2.205LeuTyr: 2.205 ± 0.927
0.0LeuXaa: 0.0 ± 0.0
Met
1.838MetAla: 1.838 ± 0.585
0.735MetCys: 0.735 ± 0.523
0.735MetAsp: 0.735 ± 0.37
1.47MetGlu: 1.47 ± 0.778
0.368MetPhe: 0.368 ± 0.633
0.368MetGly: 0.368 ± 0.633
0.368MetHis: 0.368 ± 0.194
1.838MetIle: 1.838 ± 1.05
0.368MetLys: 0.368 ± 0.194
1.103MetLeu: 1.103 ± 0.392
0.368MetMet: 0.368 ± 0.633
0.368MetAsn: 0.368 ± 0.524
1.838MetPro: 1.838 ± 1.664
1.47MetGln: 1.47 ± 0.955
1.103MetArg: 1.103 ± 0.583
1.838MetSer: 1.838 ± 0.681
1.47MetThr: 1.47 ± 0.778
0.368MetVal: 0.368 ± 0.194
0.0MetTrp: 0.0 ± 0.0
0.735MetTyr: 0.735 ± 0.523
0.0MetXaa: 0.0 ± 0.0
Asn
4.043AsnAla: 4.043 ± 1.278
0.735AsnCys: 0.735 ± 0.37
1.103AsnAsp: 1.103 ± 0.583
2.205AsnGlu: 2.205 ± 0.823
2.205AsnPhe: 2.205 ± 1.296
1.838AsnGly: 1.838 ± 0.585
0.368AsnHis: 0.368 ± 0.765
2.573AsnIle: 2.573 ± 0.787
1.838AsnLys: 1.838 ± 0.601
4.043AsnLeu: 4.043 ± 1.48
0.368AsnMet: 0.368 ± 0.633
1.838AsnAsn: 1.838 ± 1.384
4.778AsnPro: 4.778 ± 1.031
2.94AsnGln: 2.94 ± 2.039
1.838AsnArg: 1.838 ± 0.887
3.675AsnSer: 3.675 ± 2.092
4.41AsnThr: 4.41 ± 1.938
2.573AsnVal: 2.573 ± 0.6
0.0AsnTrp: 0.0 ± 0.0
1.47AsnTyr: 1.47 ± 0.655
0.0AsnXaa: 0.0 ± 0.0
Pro
4.41ProAla: 4.41 ± 1.729
0.0ProCys: 0.0 ± 0.0
4.043ProAsp: 4.043 ± 0.9
4.41ProGlu: 4.41 ± 0.965
3.308ProPhe: 3.308 ± 0.808
4.043ProGly: 4.043 ± 1.496
4.043ProHis: 4.043 ± 0.846
2.205ProIle: 2.205 ± 0.812
3.308ProLys: 3.308 ± 1.75
2.94ProLeu: 2.94 ± 1.593
0.735ProMet: 0.735 ± 0.775
5.145ProAsn: 5.145 ± 0.994
6.615ProPro: 6.615 ± 3.229
2.205ProGln: 2.205 ± 0.395
2.573ProArg: 2.573 ± 0.554
4.043ProSer: 4.043 ± 0.852
4.043ProThr: 4.043 ± 0.939
3.308ProVal: 3.308 ± 1.075
0.735ProTrp: 0.735 ± 1.529
1.838ProTyr: 1.838 ± 0.945
0.0ProXaa: 0.0 ± 0.0
Gln
4.043GlnAla: 4.043 ± 1.318
0.368GlnCys: 0.368 ± 0.194
3.675GlnAsp: 3.675 ± 1.262
0.368GlnGlu: 0.368 ± 0.194
2.205GlnPhe: 2.205 ± 0.425
1.838GlnGly: 1.838 ± 0.431
1.47GlnHis: 1.47 ± 0.715
4.41GlnIle: 4.41 ± 2.327
1.103GlnLys: 1.103 ± 0.392
8.453GlnLeu: 8.453 ± 0.798
0.368GlnMet: 0.368 ± 0.55
1.838GlnAsn: 1.838 ± 0.644
3.308GlnPro: 3.308 ± 1.295
3.308GlnGln: 3.308 ± 0.919
4.778GlnArg: 4.778 ± 1.421
4.043GlnSer: 4.043 ± 1.769
2.94GlnThr: 2.94 ± 1.431
2.94GlnVal: 2.94 ± 0.618
0.368GlnTrp: 0.368 ± 0.194
0.735GlnTyr: 0.735 ± 0.523
0.0GlnXaa: 0.0 ± 0.0
Arg
5.145ArgAla: 5.145 ± 1.349
0.368ArgCys: 0.368 ± 0.518
2.94ArgAsp: 2.94 ± 1.045
4.778ArgGlu: 4.778 ± 0.862
2.573ArgPhe: 2.573 ± 0.772
2.94ArgGly: 2.94 ± 1.399
1.838ArgHis: 1.838 ± 0.577
2.94ArgIle: 2.94 ± 0.503
2.205ArgLys: 2.205 ± 1.166
6.248ArgLeu: 6.248 ± 2.159
0.368ArgMet: 0.368 ± 0.194
0.735ArgAsn: 0.735 ± 0.714
2.573ArgPro: 2.573 ± 1.085
2.573ArgGln: 2.573 ± 0.973
2.205ArgArg: 2.205 ± 0.812
3.675ArgSer: 3.675 ± 0.726
4.41ArgThr: 4.41 ± 2.44
3.308ArgVal: 3.308 ± 0.976
1.103ArgTrp: 1.103 ± 0.583
2.573ArgTyr: 2.573 ± 1.361
0.0ArgXaa: 0.0 ± 0.0
Ser
4.778SerAla: 4.778 ± 0.737
1.47SerCys: 1.47 ± 2.058
5.145SerAsp: 5.145 ± 1.134
4.043SerGlu: 4.043 ± 1.837
2.573SerPhe: 2.573 ± 1.138
2.94SerGly: 2.94 ± 2.284
2.205SerHis: 2.205 ± 1.328
2.205SerIle: 2.205 ± 1.583
2.94SerLys: 2.94 ± 1.169
5.145SerLeu: 5.145 ± 1.38
0.735SerMet: 0.735 ± 0.389
2.573SerAsn: 2.573 ± 0.837
3.675SerPro: 3.675 ± 1.283
4.043SerGln: 4.043 ± 1.278
3.675SerArg: 3.675 ± 0.542
4.778SerSer: 4.778 ± 1.719
6.983SerThr: 6.983 ± 2.024
2.573SerVal: 2.573 ± 1.766
1.103SerTrp: 1.103 ± 0.47
2.573SerTyr: 2.573 ± 0.526
0.0SerXaa: 0.0 ± 0.0
Thr
4.778ThrAla: 4.778 ± 1.584
0.368ThrCys: 0.368 ± 0.633
3.675ThrAsp: 3.675 ± 0.488
3.675ThrGlu: 3.675 ± 1.311
5.145ThrPhe: 5.145 ± 1.458
4.043ThrGly: 4.043 ± 1.074
4.41ThrHis: 4.41 ± 0.861
2.94ThrIle: 2.94 ± 0.682
4.41ThrLys: 4.41 ± 1.281
9.188ThrLeu: 9.188 ± 1.076
1.103ThrMet: 1.103 ± 0.492
3.675ThrAsn: 3.675 ± 2.115
4.043ThrPro: 4.043 ± 0.852
2.94ThrGln: 2.94 ± 1.973
5.513ThrArg: 5.513 ± 2.149
6.248ThrSer: 6.248 ± 1.453
7.35ThrThr: 7.35 ± 2.126
2.573ThrVal: 2.573 ± 0.911
0.0ThrTrp: 0.0 ± 0.0
1.838ThrTyr: 1.838 ± 0.644
0.0ThrXaa: 0.0 ± 0.0
Val
4.043ValAla: 4.043 ± 1.728
1.103ValCys: 1.103 ± 0.392
2.205ValAsp: 2.205 ± 0.812
1.47ValGlu: 1.47 ± 0.477
2.573ValPhe: 2.573 ± 0.833
1.47ValGly: 1.47 ± 0.629
2.205ValHis: 2.205 ± 0.839
2.94ValIle: 2.94 ± 0.768
1.838ValLys: 1.838 ± 0.585
5.88ValLeu: 5.88 ± 1.091
0.735ValMet: 0.735 ± 0.523
2.94ValAsn: 2.94 ± 0.89
3.308ValPro: 3.308 ± 1.431
2.205ValGln: 2.205 ± 0.812
2.94ValArg: 2.94 ± 0.281
4.41ValSer: 4.41 ± 2.177
3.675ValThr: 3.675 ± 1.58
1.838ValVal: 1.838 ± 0.713
0.0ValTrp: 0.0 ± 0.0
1.838ValTyr: 1.838 ± 0.718
0.0ValXaa: 0.0 ± 0.0
Trp
0.368TrpAla: 0.368 ± 0.765
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.368TrpGlu: 0.368 ± 0.194
0.735TrpPhe: 0.735 ± 0.523
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.368TrpLys: 0.368 ± 0.194
1.103TrpLeu: 1.103 ± 0.583
0.368TrpMet: 0.368 ± 0.194
0.368TrpAsn: 0.368 ± 0.194
0.368TrpPro: 0.368 ± 0.194
0.0TrpGln: 0.0 ± 0.0
0.368TrpArg: 0.368 ± 0.194
1.103TrpSer: 1.103 ± 1.063
0.0TrpThr: 0.0 ± 0.0
1.103TrpVal: 1.103 ± 0.583
0.0TrpTrp: 0.0 ± 0.0
0.735TrpTyr: 0.735 ± 0.879
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.308TyrAla: 3.308 ± 1.015
1.47TyrCys: 1.47 ± 0.585
1.47TyrAsp: 1.47 ± 0.496
1.838TyrGlu: 1.838 ± 0.972
0.735TyrPhe: 0.735 ± 0.676
1.47TyrGly: 1.47 ± 0.585
1.103TyrHis: 1.103 ± 0.63
2.205TyrIle: 2.205 ± 1.166
1.47TyrLys: 1.47 ± 0.74
2.573TyrLeu: 2.573 ± 1.361
0.735TyrMet: 0.735 ± 0.389
0.735TyrAsn: 0.735 ± 0.785
2.94TyrPro: 2.94 ± 0.988
3.308TyrGln: 3.308 ± 0.952
0.735TyrArg: 0.735 ± 0.389
1.838TyrSer: 1.838 ± 0.877
1.838TyrThr: 1.838 ± 0.681
1.103TyrVal: 1.103 ± 0.494
0.0TyrTrp: 0.0 ± 0.0
1.838TyrTyr: 1.838 ± 0.975
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski