Amino acid dipepetide frequency for Coniella lustricola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.679AlaAla: 11.679 ± 0.076	1.226AlaCys: 1.226 ± 0.019	4.707AlaAsp: 4.707 ± 0.033	5.233AlaGlu: 5.233 ± 0.042	3.125AlaPhe: 3.125 ± 0.03	6.555AlaGly: 6.555 ± 0.045	2.045AlaHis: 2.045 ± 0.02	4.127AlaIle: 4.127 ± 0.028	4.154AlaLys: 4.154 ± 0.038	8.089AlaLeu: 8.089 ± 0.053	2.114AlaMet: 2.114 ± 0.021	3.126AlaAsn: 3.126 ± 0.025	5.116AlaPro: 5.116 ± 0.04	3.79AlaGln: 3.79 ± 0.034	5.494AlaArg: 5.494 ± 0.035	8.326AlaSer: 8.326 ± 0.051	6.058AlaThr: 6.058 ± 0.037	6.013AlaVal: 6.013 ± 0.041	1.303AlaTrp: 1.303 ± 0.017	2.219AlaTyr: 2.219 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.088CysAla: 1.088 ± 0.017	0.38CysCys: 0.38 ± 0.013	0.666CysAsp: 0.666 ± 0.013	0.597CysGlu: 0.597 ± 0.012	0.598CysPhe: 0.598 ± 0.013	1.008CysGly: 1.008 ± 0.017	0.358CysHis: 0.358 ± 0.008	0.689CysIle: 0.689 ± 0.013	0.493CysLys: 0.493 ± 0.011	1.411CysLeu: 1.411 ± 0.02	0.298CysMet: 0.298 ± 0.009	0.441CysAsn: 0.441 ± 0.01	0.711CysPro: 0.711 ± 0.015	0.49CysGln: 0.49 ± 0.011	0.834CysArg: 0.834 ± 0.015	1.07CysSer: 1.07 ± 0.017	0.78CysThr: 0.78 ± 0.014	0.909CysVal: 0.909 ± 0.015	0.25CysTrp: 0.25 ± 0.008	0.357CysTyr: 0.357 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.109AspAla: 5.109 ± 0.037	0.654AspCys: 0.654 ± 0.013	4.675AspAsp: 4.675 ± 0.052	4.427AspGlu: 4.427 ± 0.043	2.131AspPhe: 2.131 ± 0.023	4.269AspGly: 4.269 ± 0.034	1.258AspHis: 1.258 ± 0.018	2.731AspIle: 2.731 ± 0.026	2.437AspLys: 2.437 ± 0.025	4.854AspLeu: 4.854 ± 0.036	1.303AspMet: 1.303 ± 0.017	1.96AspAsn: 1.96 ± 0.021	3.055AspPro: 3.055 ± 0.025	1.871AspGln: 1.871 ± 0.018	2.975AspArg: 2.975 ± 0.03	4.036AspSer: 4.036 ± 0.033	2.924AspThr: 2.924 ± 0.023	3.654AspVal: 3.654 ± 0.031	0.881AspTrp: 0.881 ± 0.012	1.548AspTyr: 1.548 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.61GluAla: 5.61 ± 0.04	0.593GluCys: 0.593 ± 0.01	4.045GluAsp: 4.045 ± 0.038	4.849GluGlu: 4.849 ± 0.057	1.726GluPhe: 1.726 ± 0.02	3.447GluGly: 3.447 ± 0.03	1.368GluHis: 1.368 ± 0.018	2.612GluIle: 2.612 ± 0.025	3.113GluLys: 3.113 ± 0.035	4.789GluLeu: 4.789 ± 0.04	1.407GluMet: 1.407 ± 0.018	1.967GluAsn: 1.967 ± 0.022	2.683GluPro: 2.683 ± 0.028	2.521GluGln: 2.521 ± 0.028	3.691GluArg: 3.691 ± 0.034	3.794GluSer: 3.794 ± 0.031	3.276GluThr: 3.276 ± 0.028	3.325GluVal: 3.325 ± 0.027	0.827GluTrp: 0.827 ± 0.013	1.519GluTyr: 1.519 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.133PheAla: 3.133 ± 0.027	0.584PheCys: 0.584 ± 0.01	2.171PheAsp: 2.171 ± 0.022	1.992PheGlu: 1.992 ± 0.021	1.653PhePhe: 1.653 ± 0.024	2.811PheGly: 2.811 ± 0.033	0.856PheHis: 0.856 ± 0.014	1.599PheIle: 1.599 ± 0.018	1.35PheLys: 1.35 ± 0.021	3.371PheLeu: 3.371 ± 0.029	0.763PheMet: 0.763 ± 0.012	1.292PheAsn: 1.292 ± 0.017	1.865PhePro: 1.865 ± 0.019	1.298PheGln: 1.298 ± 0.018	1.85PheArg: 1.85 ± 0.019	2.924PheSer: 2.924 ± 0.027	2.034PheThr: 2.034 ± 0.021	2.384PheVal: 2.384 ± 0.025	0.648PheTrp: 0.648 ± 0.012	1.046PheTyr: 1.046 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.923GlyAla: 5.923 ± 0.043	0.94GlyCys: 0.94 ± 0.016	3.665GlyAsp: 3.665 ± 0.029	3.482GlyGlu: 3.482 ± 0.033	2.732GlyPhe: 2.732 ± 0.025	6.638GlyGly: 6.638 ± 0.071	1.798GlyHis: 1.798 ± 0.021	3.221GlyIle: 3.221 ± 0.03	3.151GlyLys: 3.151 ± 0.03	6.156GlyLeu: 6.156 ± 0.037	1.563GlyMet: 1.563 ± 0.019	2.508GlyAsn: 2.508 ± 0.028	3.517GlyPro: 3.517 ± 0.035	2.695GlyGln: 2.695 ± 0.025	4.243GlyArg: 4.243 ± 0.035	6.11GlySer: 6.11 ± 0.048	4.046GlyThr: 4.046 ± 0.031	4.294GlyVal: 4.294 ± 0.033	1.201GlyTrp: 1.201 ± 0.017	2.01GlyTyr: 2.01 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.05HisAla: 2.05 ± 0.024	0.389HisCys: 0.389 ± 0.009	1.415HisAsp: 1.415 ± 0.016	1.316HisGlu: 1.316 ± 0.016	0.897HisPhe: 0.897 ± 0.013	1.865HisGly: 1.865 ± 0.023	1.09HisHis: 1.09 ± 0.021	1.183HisIle: 1.183 ± 0.015	0.978HisLys: 0.978 ± 0.015	2.227HisLeu: 2.227 ± 0.023	0.538HisMet: 0.538 ± 0.01	0.947HisAsn: 0.947 ± 0.014	1.639HisPro: 1.639 ± 0.019	1.152HisGln: 1.152 ± 0.017	1.605HisArg: 1.605 ± 0.021	1.951HisSer: 1.951 ± 0.023	1.367HisThr: 1.367 ± 0.019	1.509HisVal: 1.509 ± 0.016	0.355HisTrp: 0.355 ± 0.008	0.702HisTyr: 0.702 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.024IleAla: 4.024 ± 0.027	0.742IleCys: 0.742 ± 0.012	2.631IleAsp: 2.631 ± 0.023	2.539IleGlu: 2.539 ± 0.024	1.766IlePhe: 1.766 ± 0.021	2.886IleGly: 2.886 ± 0.027	1.148IleHis: 1.148 ± 0.016	2.188IleIle: 2.188 ± 0.021	2.003IleLys: 2.003 ± 0.022	4.178IleLeu: 4.178 ± 0.036	1.011IleMet: 1.011 ± 0.014	1.642IleAsn: 1.642 ± 0.019	2.716IlePro: 2.716 ± 0.026	1.726IleGln: 1.726 ± 0.018	2.507IleArg: 2.507 ± 0.022	3.508IleSer: 3.508 ± 0.03	2.724IleThr: 2.724 ± 0.024	3.042IleVal: 3.042 ± 0.026	0.681IleTrp: 0.681 ± 0.013	1.306IleTyr: 1.306 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.223LysAla: 4.223 ± 0.039	0.462LysCys: 0.462 ± 0.011	2.583LysAsp: 2.583 ± 0.025	2.92LysGlu: 2.92 ± 0.034	1.287LysPhe: 1.287 ± 0.017	2.708LysGly: 2.708 ± 0.026	1.131LysHis: 1.131 ± 0.016	1.995LysIle: 1.995 ± 0.022	3.253LysLys: 3.253 ± 0.046	3.682LysLeu: 3.682 ± 0.03	1.011LysMet: 1.011 ± 0.016	1.562LysAsn: 1.562 ± 0.02	2.543LysPro: 2.543 ± 0.027	1.913LysGln: 1.913 ± 0.023	3.283LysArg: 3.283 ± 0.032	3.206LysSer: 3.206 ± 0.03	2.825LysThr: 2.825 ± 0.027	2.561LysVal: 2.561 ± 0.026	0.628LysTrp: 0.628 ± 0.012	1.21LysTyr: 1.21 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.567LeuAla: 8.567 ± 0.053	1.352LeuCys: 1.352 ± 0.018	5.129LeuAsp: 5.129 ± 0.039	4.966LeuGlu: 4.966 ± 0.039	3.322LeuPhe: 3.322 ± 0.033	5.993LeuGly: 5.993 ± 0.04	2.247LeuHis: 2.247 ± 0.022	3.584LeuIle: 3.584 ± 0.03	3.773LeuLys: 3.773 ± 0.038	8.533LeuLeu: 8.533 ± 0.068	1.765LeuMet: 1.765 ± 0.021	2.907LeuAsn: 2.907 ± 0.028	5.462LeuPro: 5.462 ± 0.034	3.808LeuGln: 3.808 ± 0.03	5.642LeuArg: 5.642 ± 0.039	7.25LeuSer: 7.25 ± 0.044	4.748LeuThr: 4.748 ± 0.031	5.706LeuVal: 5.706 ± 0.043	1.256LeuTrp: 1.256 ± 0.019	2.273LeuTyr: 2.273 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.419MetAla: 2.419 ± 0.021	0.273MetCys: 0.273 ± 0.007	1.25MetAsp: 1.25 ± 0.018	1.164MetGlu: 1.164 ± 0.016	0.736MetPhe: 0.736 ± 0.012	1.456MetGly: 1.456 ± 0.018	0.53MetHis: 0.53 ± 0.011	0.936MetIle: 0.936 ± 0.014	0.879MetLys: 0.879 ± 0.013	1.928MetLeu: 1.928 ± 0.024	0.598MetMet: 0.598 ± 0.012	0.728MetAsn: 0.728 ± 0.011	1.348MetPro: 1.348 ± 0.017	0.909MetGln: 0.909 ± 0.018	1.332MetArg: 1.332 ± 0.018	1.884MetSer: 1.884 ± 0.018	1.34MetThr: 1.34 ± 0.016	1.32MetVal: 1.32 ± 0.019	0.275MetTrp: 0.275 ± 0.009	0.547MetTyr: 0.547 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.153AsnAla: 3.153 ± 0.028	0.44AsnCys: 0.44 ± 0.011	1.957AsnAsp: 1.957 ± 0.024	1.891AsnGlu: 1.891 ± 0.021	1.239AsnPhe: 1.239 ± 0.015	2.936AsnGly: 2.936 ± 0.031	0.885AsnHis: 0.885 ± 0.014	1.817AsnIle: 1.817 ± 0.023	1.602AsnLys: 1.602 ± 0.02	3.006AsnLeu: 3.006 ± 0.024	0.827AsnMet: 0.827 ± 0.014	1.804AsnAsn: 1.804 ± 0.035	2.195AsnPro: 2.195 ± 0.019	1.238AsnGln: 1.238 ± 0.018	1.795AsnArg: 1.795 ± 0.021	2.72AsnSer: 2.72 ± 0.026	2.22AsnThr: 2.22 ± 0.023	2.171AsnVal: 2.171 ± 0.023	0.527AsnTrp: 0.527 ± 0.011	0.98AsnTyr: 0.98 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.81ProAla: 5.81 ± 0.04	0.629ProCys: 0.629 ± 0.013	3.011ProAsp: 3.011 ± 0.024	3.313ProGlu: 3.313 ± 0.028	2.005ProPhe: 2.005 ± 0.023	3.921ProGly: 3.921 ± 0.034	1.405ProHis: 1.405 ± 0.017	2.342ProIle: 2.342 ± 0.022	2.385ProLys: 2.385 ± 0.026	4.863ProLeu: 4.863 ± 0.034	1.09ProMet: 1.09 ± 0.019	1.944ProAsn: 1.944 ± 0.022	5.304ProPro: 5.304 ± 0.069	2.561ProGln: 2.561 ± 0.032	3.589ProArg: 3.589 ± 0.034	6.027ProSer: 6.027 ± 0.046	3.939ProThr: 3.939 ± 0.032	3.615ProVal: 3.615 ± 0.03	0.773ProTrp: 0.773 ± 0.013	1.444ProTyr: 1.444 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.815GlnAla: 3.815 ± 0.033	0.48GlnCys: 0.48 ± 0.011	2.235GlnAsp: 2.235 ± 0.02	2.355GlnGlu: 2.355 ± 0.024	1.173GlnPhe: 1.173 ± 0.015	2.515GlnGly: 2.515 ± 0.023	1.324GlnHis: 1.324 ± 0.02	1.739GlnIle: 1.739 ± 0.02	1.806GlnLys: 1.806 ± 0.02	3.455GlnLeu: 3.455 ± 0.03	0.898GlnMet: 0.898 ± 0.016	1.441GlnAsn: 1.441 ± 0.019	2.797GlnPro: 2.797 ± 0.036	3.534GlnGln: 3.534 ± 0.078	2.842GlnArg: 2.842 ± 0.026	3.181GlnSer: 3.181 ± 0.031	2.405GlnThr: 2.405 ± 0.024	2.235GlnVal: 2.235 ± 0.021	0.584GlnTrp: 0.584 ± 0.009	1.126GlnTyr: 1.126 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.07ArgAla: 5.07 ± 0.029	0.804ArgCys: 0.804 ± 0.014	3.375ArgAsp: 3.375 ± 0.034	3.573ArgGlu: 3.573 ± 0.035	2.079ArgPhe: 2.079 ± 0.019	3.888ArgGly: 3.888 ± 0.042	1.726ArgHis: 1.726 ± 0.02	2.729ArgIle: 2.729 ± 0.027	3.267ArgLys: 3.267 ± 0.03	5.587ArgLeu: 5.587 ± 0.038	1.329ArgMet: 1.329 ± 0.016	2.166ArgAsn: 2.166 ± 0.023	3.735ArgPro: 3.735 ± 0.034	2.797ArgGln: 2.797 ± 0.027	5.294ArgArg: 5.294 ± 0.047	4.824ArgSer: 4.824 ± 0.04	3.36ArgThr: 3.36 ± 0.03	3.331ArgVal: 3.331 ± 0.023	0.926ArgTrp: 0.926 ± 0.014	1.547ArgTyr: 1.547 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.417SerAla: 7.417 ± 0.045	1.054SerCys: 1.054 ± 0.016	4.085SerAsp: 4.085 ± 0.033	3.776SerGlu: 3.776 ± 0.031	2.961SerPhe: 2.961 ± 0.027	5.8SerGly: 5.8 ± 0.042	2.048SerHis: 2.048 ± 0.023	3.805SerIle: 3.805 ± 0.031	3.497SerLys: 3.497 ± 0.031	7.306SerLeu: 7.306 ± 0.045	1.768SerMet: 1.768 ± 0.022	3.001SerAsn: 3.001 ± 0.025	5.54SerPro: 5.54 ± 0.049	3.313SerGln: 3.313 ± 0.034	5.111SerArg: 5.111 ± 0.039	10.256SerSer: 10.256 ± 0.094	5.956SerThr: 5.956 ± 0.038	4.65SerVal: 4.65 ± 0.037	1.15SerTrp: 1.15 ± 0.016	1.988SerTyr: 1.988 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.171ThrAla: 6.171 ± 0.041	0.821ThrCys: 0.821 ± 0.013	2.891ThrAsp: 2.891 ± 0.025	2.91ThrGlu: 2.91 ± 0.026	2.102ThrPhe: 2.102 ± 0.023	4.282ThrGly: 4.282 ± 0.038	1.366ThrHis: 1.366 ± 0.018	2.969ThrIle: 2.969 ± 0.023	2.508ThrLys: 2.508 ± 0.027	5.139ThrLeu: 5.139 ± 0.039	1.26ThrMet: 1.26 ± 0.017	2.179ThrAsn: 2.179 ± 0.021	4.152ThrPro: 4.152 ± 0.036	2.176ThrGln: 2.176 ± 0.019	3.308ThrArg: 3.308 ± 0.025	5.675ThrSer: 5.675 ± 0.043	5.208ThrThr: 5.208 ± 0.061	3.82ThrVal: 3.82 ± 0.034	0.87ThrTrp: 0.87 ± 0.015	1.589ThrTyr: 1.589 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.819ValAla: 5.819 ± 0.039	0.948ValCys: 0.948 ± 0.018	3.757ValAsp: 3.757 ± 0.027	3.641ValGlu: 3.641 ± 0.034	2.431ValPhe: 2.431 ± 0.026	4.0ValGly: 4.0 ± 0.034	1.474ValHis: 1.474 ± 0.017	2.699ValIle: 2.699 ± 0.025	2.62ValLys: 2.62 ± 0.027	5.788ValLeu: 5.788 ± 0.046	1.304ValMet: 1.304 ± 0.015	2.095ValAsn: 2.095 ± 0.023	3.549ValPro: 3.549 ± 0.025	2.479ValGln: 2.479 ± 0.023	3.49ValArg: 3.49 ± 0.028	4.68ValSer: 4.68 ± 0.035	3.561ValThr: 3.561 ± 0.032	4.497ValVal: 4.497 ± 0.036	0.92ValTrp: 0.92 ± 0.016	1.728ValTyr: 1.728 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.233TrpAla: 1.233 ± 0.016	0.229TrpCys: 0.229 ± 0.008	0.904TrpAsp: 0.904 ± 0.013	0.777TrpGlu: 0.777 ± 0.013	0.543TrpPhe: 0.543 ± 0.013	0.912TrpGly: 0.912 ± 0.015	0.387TrpHis: 0.387 ± 0.009	0.702TrpIle: 0.702 ± 0.014	0.703TrpLys: 0.703 ± 0.012	1.445TrpLeu: 1.445 ± 0.019	0.382TrpMet: 0.382 ± 0.008	0.584TrpAsn: 0.584 ± 0.011	0.688TrpPro: 0.688 ± 0.011	0.617TrpGln: 0.617 ± 0.012	1.013TrpArg: 1.013 ± 0.015	1.081TrpSer: 1.081 ± 0.016	1.0TrpThr: 1.0 ± 0.016	0.862TrpVal: 0.862 ± 0.015	0.299TrpTrp: 0.299 ± 0.009	0.426TrpTyr: 0.426 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.185TyrAla: 2.185 ± 0.023	0.431TyrCys: 0.431 ± 0.007	1.601TyrAsp: 1.601 ± 0.018	1.441TyrGlu: 1.441 ± 0.018	1.119TyrPhe: 1.119 ± 0.015	2.003TyrGly: 2.003 ± 0.025	0.732TyrHis: 0.732 ± 0.015	1.302TyrIle: 1.302 ± 0.016	1.013TyrLys: 1.013 ± 0.014	2.473TyrLeu: 2.473 ± 0.025	0.623TyrMet: 0.623 ± 0.012	1.111TyrAsn: 1.111 ± 0.016	1.353TyrPro: 1.353 ± 0.017	1.051TyrGln: 1.051 ± 0.014	1.509TyrArg: 1.509 ± 0.018	1.978TyrSer: 1.978 ± 0.025	1.625TyrThr: 1.625 ± 0.019	1.582TyrVal: 1.582 ± 0.02	0.434TyrTrp: 0.434 ± 0.011	0.948TyrTyr: 0.948 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 11309 proteins (5000157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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