Amino acid dipepetide frequency for Proteus penneri ATCC 35198

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.935AlaAla: 5.935 ± 0.107
0.911AlaCys: 0.911 ± 0.03
4.065AlaAsp: 4.065 ± 0.066
4.66AlaGlu: 4.66 ± 0.077
3.317AlaPhe: 3.317 ± 0.057
5.816AlaGly: 5.816 ± 0.096
1.463AlaHis: 1.463 ± 0.037
6.351AlaIle: 6.351 ± 0.095
4.567AlaLys: 4.567 ± 0.067
9.344AlaLeu: 9.344 ± 0.093
2.395AlaMet: 2.395 ± 0.054
3.409AlaAsn: 3.409 ± 0.068
2.803AlaPro: 2.803 ± 0.067
3.849AlaGln: 3.849 ± 0.072
3.437AlaArg: 3.437 ± 0.058
4.823AlaSer: 4.823 ± 0.069
4.262AlaThr: 4.262 ± 0.067
5.213AlaVal: 5.213 ± 0.08
0.896AlaTrp: 0.896 ± 0.03
2.26AlaTyr: 2.26 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.816CysAla: 0.816 ± 0.031
0.223CysCys: 0.223 ± 0.017
0.614CysAsp: 0.614 ± 0.025
0.622CysGlu: 0.622 ± 0.022
0.54CysPhe: 0.54 ± 0.026
0.955CysGly: 0.955 ± 0.031
0.347CysHis: 0.347 ± 0.021
0.698CysIle: 0.698 ± 0.031
0.408CysLys: 0.408 ± 0.02
1.062CysLeu: 1.062 ± 0.031
0.319CysMet: 0.319 ± 0.016
0.38CysAsn: 0.38 ± 0.02
0.487CysPro: 0.487 ± 0.024
0.523CysGln: 0.523 ± 0.022
0.528CysArg: 0.528 ± 0.023
0.715CysSer: 0.715 ± 0.027
0.506CysThr: 0.506 ± 0.022
0.736CysVal: 0.736 ± 0.031
0.194CysTrp: 0.194 ± 0.012
0.386CysTyr: 0.386 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.047AspAla: 4.047 ± 0.066
0.53AspCys: 0.53 ± 0.021
2.816AspAsp: 2.816 ± 0.056
3.636AspGlu: 3.636 ± 0.056
2.246AspPhe: 2.246 ± 0.047
3.275AspGly: 3.275 ± 0.053
0.846AspHis: 0.846 ± 0.028
4.359AspIle: 4.359 ± 0.074
3.528AspLys: 3.528 ± 0.064
4.64AspLeu: 4.64 ± 0.069
1.346AspMet: 1.346 ± 0.036
2.911AspAsn: 2.911 ± 0.055
2.026AspPro: 2.026 ± 0.046
1.365AspGln: 1.365 ± 0.035
1.987AspArg: 1.987 ± 0.049
2.895AspSer: 2.895 ± 0.06
2.431AspThr: 2.431 ± 0.054
3.457AspVal: 3.457 ± 0.063
0.723AspTrp: 0.723 ± 0.027
2.002AspTyr: 2.002 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.4GluAla: 4.4 ± 0.077
0.521GluCys: 0.521 ± 0.026
2.67GluAsp: 2.67 ± 0.058
3.747GluGlu: 3.747 ± 0.07
2.04GluPhe: 2.04 ± 0.045
3.605GluGly: 3.605 ± 0.064
1.4GluHis: 1.4 ± 0.038
4.329GluIle: 4.329 ± 0.071
4.559GluLys: 4.559 ± 0.067
6.243GluLeu: 6.243 ± 0.09
1.795GluMet: 1.795 ± 0.041
3.394GluAsn: 3.394 ± 0.053
1.89GluPro: 1.89 ± 0.047
3.428GluGln: 3.428 ± 0.072
3.189GluArg: 3.189 ± 0.061
3.158GluSer: 3.158 ± 0.053
3.159GluThr: 3.159 ± 0.059
3.524GluVal: 3.524 ± 0.06
0.763GluTrp: 0.763 ± 0.031
1.768GluTyr: 1.768 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.194PheAla: 3.194 ± 0.062
0.569PheCys: 0.569 ± 0.028
2.422PheAsp: 2.422 ± 0.058
2.007PheGlu: 2.007 ± 0.044
2.239PhePhe: 2.239 ± 0.058
2.885PheGly: 2.885 ± 0.059
0.876PheHis: 0.876 ± 0.028
3.445PheIle: 3.445 ± 0.065
1.888PheLys: 1.888 ± 0.04
3.73PheLeu: 3.73 ± 0.077
1.233PheMet: 1.233 ± 0.032
2.21PheAsn: 2.21 ± 0.042
1.49PhePro: 1.49 ± 0.037
1.143PheGln: 1.143 ± 0.033
1.647PheArg: 1.647 ± 0.033
3.639PheSer: 3.639 ± 0.065
2.403PheThr: 2.403 ± 0.047
2.471PheVal: 2.471 ± 0.051
0.577PheTrp: 0.577 ± 0.026
1.577PheTyr: 1.577 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
5.141GlyAla: 5.141 ± 0.086
0.92GlyCys: 0.92 ± 0.029
3.362GlyAsp: 3.362 ± 0.059
4.068GlyGlu: 4.068 ± 0.061
3.145GlyPhe: 3.145 ± 0.055
4.665GlyGly: 4.665 ± 0.083
1.454GlyHis: 1.454 ± 0.038
5.342GlyIle: 5.342 ± 0.09
4.225GlyLys: 4.225 ± 0.071
6.663GlyLeu: 6.663 ± 0.093
2.053GlyMet: 2.053 ± 0.051
2.857GlyAsn: 2.857 ± 0.062
1.552GlyPro: 1.552 ± 0.043
2.537GlyGln: 2.537 ± 0.05
3.123GlyArg: 3.123 ± 0.057
3.934GlySer: 3.934 ± 0.067
3.402GlyThr: 3.402 ± 0.055
4.896GlyVal: 4.896 ± 0.075
0.962GlyTrp: 0.962 ± 0.038
2.542GlyTyr: 2.542 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.52HisAla: 1.52 ± 0.043
0.356HisCys: 0.356 ± 0.016
1.031HisAsp: 1.031 ± 0.031
1.09HisGlu: 1.09 ± 0.034
1.081HisPhe: 1.081 ± 0.03
1.369HisGly: 1.369 ± 0.038
0.733HisHis: 0.733 ± 0.033
1.474HisIle: 1.474 ± 0.039
0.973HisLys: 0.973 ± 0.03
2.2HisLeu: 2.2 ± 0.049
0.49HisMet: 0.49 ± 0.021
0.922HisAsn: 0.922 ± 0.031
1.087HisPro: 1.087 ± 0.034
1.245HisGln: 1.245 ± 0.039
1.027HisArg: 1.027 ± 0.033
1.316HisSer: 1.316 ± 0.037
1.053HisThr: 1.053 ± 0.032
1.156HisVal: 1.156 ± 0.033
0.369HisTrp: 0.369 ± 0.019
0.987HisTyr: 0.987 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.688IleAla: 6.688 ± 0.085
0.803IleCys: 0.803 ± 0.033
4.236IleAsp: 4.236 ± 0.067
4.679IleGlu: 4.679 ± 0.064
2.799IlePhe: 2.799 ± 0.051
5.129IleGly: 5.129 ± 0.085
1.369IleHis: 1.369 ± 0.037
5.226IleIle: 5.226 ± 0.084
4.142IleLys: 4.142 ± 0.064
6.331IleLeu: 6.331 ± 0.093
1.77IleMet: 1.77 ± 0.046
4.134IleAsn: 4.134 ± 0.075
3.199IlePro: 3.199 ± 0.057
2.411IleGln: 2.411 ± 0.053
3.151IleArg: 3.151 ± 0.06
5.216IleSer: 5.216 ± 0.074
4.552IleThr: 4.552 ± 0.07
4.373IleVal: 4.373 ± 0.071
0.754IleTrp: 0.754 ± 0.027
2.172IleTyr: 2.172 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.546LysAla: 4.546 ± 0.067
0.39LysCys: 0.39 ± 0.019
2.767LysAsp: 2.767 ± 0.054
3.984LysGlu: 3.984 ± 0.064
1.585LysPhe: 1.585 ± 0.036
3.607LysGly: 3.607 ± 0.063
1.077LysHis: 1.077 ± 0.031
3.74LysIle: 3.74 ± 0.07
4.271LysLys: 4.271 ± 0.067
5.48LysLeu: 5.48 ± 0.064
1.738LysMet: 1.738 ± 0.042
3.075LysAsn: 3.075 ± 0.058
2.373LysPro: 2.373 ± 0.05
2.911LysGln: 2.911 ± 0.06
2.88LysArg: 2.88 ± 0.053
3.319LysSer: 3.319 ± 0.064
3.317LysThr: 3.317 ± 0.056
3.599LysVal: 3.599 ± 0.063
0.631LysTrp: 0.631 ± 0.026
1.603LysTyr: 1.603 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
8.976LeuAla: 8.976 ± 0.101
1.191LeuCys: 1.191 ± 0.034
5.165LeuAsp: 5.165 ± 0.086
5.483LeuGlu: 5.483 ± 0.08
4.701LeuPhe: 4.701 ± 0.084
6.643LeuGly: 6.643 ± 0.095
1.941LeuHis: 1.941 ± 0.046
7.424LeuIle: 7.424 ± 0.1
5.695LeuLys: 5.695 ± 0.073
10.953LeuLeu: 10.953 ± 0.143
2.865LeuMet: 2.865 ± 0.058
5.025LeuAsn: 5.025 ± 0.07
5.056LeuPro: 5.056 ± 0.071
3.607LeuGln: 3.607 ± 0.062
4.805LeuArg: 4.805 ± 0.067
8.078LeuSer: 8.078 ± 0.091
6.228LeuThr: 6.228 ± 0.081
6.314LeuVal: 6.314 ± 0.087
1.149LeuTrp: 1.149 ± 0.039
2.967LeuTyr: 2.967 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.527MetAla: 2.527 ± 0.051
0.23MetCys: 0.23 ± 0.015
1.28MetAsp: 1.28 ± 0.034
1.337MetGlu: 1.337 ± 0.036
0.904MetPhe: 0.904 ± 0.034
1.894MetGly: 1.894 ± 0.044
0.477MetHis: 0.477 ± 0.023
1.863MetIle: 1.863 ± 0.044
1.773MetLys: 1.773 ± 0.043
2.971MetLeu: 2.971 ± 0.062
0.914MetMet: 0.914 ± 0.032
1.33MetAsn: 1.33 ± 0.037
1.248MetPro: 1.248 ± 0.036
1.166MetGln: 1.166 ± 0.032
1.278MetArg: 1.278 ± 0.039
2.011MetSer: 2.011 ± 0.046
1.735MetThr: 1.735 ± 0.041
1.876MetVal: 1.876 ± 0.044
0.252MetTrp: 0.252 ± 0.016
0.594MetTyr: 0.594 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.788AsnAla: 3.788 ± 0.061
0.441AsnCys: 0.441 ± 0.022
2.398AsnAsp: 2.398 ± 0.055
2.885AsnGlu: 2.885 ± 0.057
1.637AsnPhe: 1.637 ± 0.044
3.089AsnGly: 3.089 ± 0.067
1.053AsnHis: 1.053 ± 0.031
3.76AsnIle: 3.76 ± 0.064
3.132AsnLys: 3.132 ± 0.066
4.205AsnLeu: 4.205 ± 0.069
1.224AsnMet: 1.224 ± 0.036
2.937AsnAsn: 2.937 ± 0.062
2.075AsnPro: 2.075 ± 0.047
2.16AsnGln: 2.16 ± 0.053
2.073AsnArg: 2.073 ± 0.047
2.989AsnSer: 2.989 ± 0.059
2.675AsnThr: 2.675 ± 0.059
2.821AsnVal: 2.821 ± 0.055
0.594AsnTrp: 0.594 ± 0.024
1.683AsnTyr: 1.683 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.252ProAla: 3.252 ± 0.059
0.351ProCys: 0.351 ± 0.016
2.338ProAsp: 2.338 ± 0.049
3.291ProGlu: 3.291 ± 0.059
1.777ProPhe: 1.777 ± 0.043
2.137ProGly: 2.137 ± 0.042
0.89ProHis: 0.89 ± 0.028
2.843ProIle: 2.843 ± 0.056
2.001ProLys: 2.001 ± 0.041
4.328ProLeu: 4.328 ± 0.065
1.021ProMet: 1.021 ± 0.033
1.764ProAsn: 1.764 ± 0.041
1.238ProPro: 1.238 ± 0.041
1.685ProGln: 1.685 ± 0.044
1.414ProArg: 1.414 ± 0.044
2.347ProSer: 2.347 ± 0.045
2.246ProThr: 2.246 ± 0.052
3.094ProVal: 3.094 ± 0.056
0.52ProTrp: 0.52 ± 0.023
1.421ProTyr: 1.421 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.753GlnAla: 3.753 ± 0.069
0.427GlnCys: 0.427 ± 0.022
1.863GlnAsp: 1.863 ± 0.047
2.487GlnGlu: 2.487 ± 0.063
1.751GlnPhe: 1.751 ± 0.039
2.961GlnGly: 2.961 ± 0.062
1.077GlnHis: 1.077 ± 0.034
2.79GlnIle: 2.79 ± 0.055
2.455GlnLys: 2.455 ± 0.055
4.924GlnLeu: 4.924 ± 0.073
1.079GlnMet: 1.079 ± 0.031
1.773GlnAsn: 1.773 ± 0.044
1.714GlnPro: 1.714 ± 0.04
3.042GlnGln: 3.042 ± 0.08
2.554GlnArg: 2.554 ± 0.049
2.674GlnSer: 2.674 ± 0.055
2.136GlnThr: 2.136 ± 0.05
2.765GlnVal: 2.765 ± 0.053
0.734GlnTrp: 0.734 ± 0.026
1.457GlnTyr: 1.457 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.145ArgAla: 3.145 ± 0.053
0.524ArgCys: 0.524 ± 0.021
2.319ArgAsp: 2.319 ± 0.051
3.027ArgGlu: 3.027 ± 0.057
2.378ArgPhe: 2.378 ± 0.047
2.6ArgGly: 2.6 ± 0.049
1.258ArgHis: 1.258 ± 0.035
3.32ArgIle: 3.32 ± 0.068
2.526ArgLys: 2.526 ± 0.052
5.116ArgLeu: 5.116 ± 0.081
1.313ArgMet: 1.313 ± 0.04
2.026ArgAsn: 2.026 ± 0.044
1.678ArgPro: 1.678 ± 0.044
2.509ArgGln: 2.509 ± 0.051
2.598ArgArg: 2.598 ± 0.057
2.441ArgSer: 2.441 ± 0.053
2.109ArgThr: 2.109 ± 0.047
2.905ArgVal: 2.905 ± 0.059
0.704ArgTrp: 0.704 ± 0.027
2.08ArgTyr: 2.08 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.203SerAla: 5.203 ± 0.064
0.7SerCys: 0.7 ± 0.024
3.268SerAsp: 3.268 ± 0.06
3.625SerGlu: 3.625 ± 0.068
2.62SerPhe: 2.62 ± 0.049
4.84SerGly: 4.84 ± 0.07
1.593SerHis: 1.593 ± 0.038
4.466SerIle: 4.466 ± 0.068
2.902SerLys: 2.902 ± 0.051
7.363SerLeu: 7.363 ± 0.097
1.716SerMet: 1.716 ± 0.042
2.511SerAsn: 2.511 ± 0.048
2.632SerPro: 2.632 ± 0.054
3.08SerGln: 3.08 ± 0.061
3.055SerArg: 3.055 ± 0.055
4.082SerSer: 4.082 ± 0.071
3.33SerThr: 3.33 ± 0.062
4.184SerVal: 4.184 ± 0.067
0.919SerTrp: 0.919 ± 0.029
2.157SerTyr: 2.157 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.271ThrAla: 4.271 ± 0.063
0.526ThrCys: 0.526 ± 0.027
2.805ThrAsp: 2.805 ± 0.051
3.168ThrGlu: 3.168 ± 0.057
2.139ThrPhe: 2.139 ± 0.045
3.981ThrGly: 3.981 ± 0.065
1.275ThrHis: 1.275 ± 0.041
3.715ThrIle: 3.715 ± 0.065
2.455ThrLys: 2.455 ± 0.048
6.839ThrLeu: 6.839 ± 0.094
1.184ThrMet: 1.184 ± 0.037
2.073ThrAsn: 2.073 ± 0.043
3.043ThrPro: 3.043 ± 0.057
2.702ThrGln: 2.702 ± 0.056
2.372ThrArg: 2.372 ± 0.049
3.188ThrSer: 3.188 ± 0.052
3.068ThrThr: 3.068 ± 0.059
3.55ThrVal: 3.55 ± 0.064
0.603ThrTrp: 0.603 ± 0.022
1.554ThrTyr: 1.554 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.505ValAla: 5.505 ± 0.078
0.741ValCys: 0.741 ± 0.031
3.41ValAsp: 3.41 ± 0.064
3.714ValGlu: 3.714 ± 0.071
2.507ValPhe: 2.507 ± 0.054
4.316ValGly: 4.316 ± 0.07
1.066ValHis: 1.066 ± 0.032
5.204ValIle: 5.204 ± 0.082
3.467ValLys: 3.467 ± 0.062
6.36ValLeu: 6.36 ± 0.084
1.977ValMet: 1.977 ± 0.055
2.996ValAsn: 2.996 ± 0.057
2.492ValPro: 2.492 ± 0.052
1.986ValGln: 1.986 ± 0.048
2.799ValArg: 2.799 ± 0.06
4.454ValSer: 4.454 ± 0.068
3.871ValThr: 3.871 ± 0.057
4.548ValVal: 4.548 ± 0.086
0.733ValTrp: 0.733 ± 0.027
1.786ValTyr: 1.786 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.793TrpAla: 0.793 ± 0.031
0.175TrpCys: 0.175 ± 0.013
0.615TrpAsp: 0.615 ± 0.025
0.591TrpGlu: 0.591 ± 0.027
0.584TrpPhe: 0.584 ± 0.022
0.814TrpGly: 0.814 ± 0.032
0.372TrpHis: 0.372 ± 0.018
0.825TrpIle: 0.825 ± 0.03
0.622TrpLys: 0.622 ± 0.025
1.843TrpLeu: 1.843 ± 0.049
0.41TrpMet: 0.41 ± 0.022
0.492TrpAsn: 0.492 ± 0.024
0.422TrpPro: 0.422 ± 0.019
0.884TrpGln: 0.884 ± 0.031
0.771TrpArg: 0.771 ± 0.026
0.769TrpSer: 0.769 ± 0.025
0.429TrpThr: 0.429 ± 0.02
0.802TrpVal: 0.802 ± 0.026
0.202TrpTrp: 0.202 ± 0.016
0.379TrpTyr: 0.379 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.279TyrAla: 2.279 ± 0.048
0.529TyrCys: 0.529 ± 0.023
1.626TyrAsp: 1.626 ± 0.044
1.478TyrGlu: 1.478 ± 0.043
1.654TyrPhe: 1.654 ± 0.04
2.263TyrGly: 2.263 ± 0.056
0.911TyrHis: 0.911 ± 0.028
1.961TyrIle: 1.961 ± 0.044
1.303TyrLys: 1.303 ± 0.035
3.671TyrLeu: 3.671 ± 0.063
0.817TyrMet: 0.817 ± 0.028
1.398TyrAsn: 1.398 ± 0.041
1.452TyrPro: 1.452 ± 0.038
2.186TyrGln: 2.186 ± 0.051
1.886TyrArg: 1.886 ± 0.047
2.196TyrSer: 2.196 ± 0.054
1.604TyrThr: 1.604 ± 0.039
1.648TyrVal: 1.648 ± 0.04
0.513TyrTrp: 0.513 ± 0.024
1.174TyrTyr: 1.174 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4909 proteins (1040949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski