Amino acid dipepetide frequency for Nitrincola nitratireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.392AlaAla: 8.392 ± 0.119	1.095AlaCys: 1.095 ± 0.031	4.84AlaAsp: 4.84 ± 0.061	5.731AlaGlu: 5.731 ± 0.098	3.725AlaPhe: 3.725 ± 0.054	6.327AlaGly: 6.327 ± 0.089	1.916AlaHis: 1.916 ± 0.047	5.673AlaIle: 5.673 ± 0.08	3.892AlaLys: 3.892 ± 0.071	11.347AlaLeu: 11.347 ± 0.125	2.568AlaMet: 2.568 ± 0.052	3.039AlaAsn: 3.039 ± 0.057	3.116AlaPro: 3.116 ± 0.061	4.297AlaGln: 4.297 ± 0.066	4.784AlaArg: 4.784 ± 0.08	5.805AlaSer: 5.805 ± 0.072	4.237AlaThr: 4.237 ± 0.061	5.942AlaVal: 5.942 ± 0.078	1.183AlaTrp: 1.183 ± 0.035	2.479AlaTyr: 2.479 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.828CysAla: 0.828 ± 0.026	0.18CysCys: 0.18 ± 0.015	0.541CysAsp: 0.541 ± 0.021	0.565CysGlu: 0.565 ± 0.023	0.462CysPhe: 0.462 ± 0.019	0.836CysGly: 0.836 ± 0.027	0.356CysHis: 0.356 ± 0.019	0.647CysIle: 0.647 ± 0.024	0.373CysLys: 0.373 ± 0.017	1.179CysLeu: 1.179 ± 0.033	0.267CysMet: 0.267 ± 0.016	0.324CysAsn: 0.324 ± 0.018	0.489CysPro: 0.489 ± 0.023	0.479CysGln: 0.479 ± 0.02	0.566CysArg: 0.566 ± 0.022	0.686CysSer: 0.686 ± 0.024	0.459CysThr: 0.459 ± 0.021	0.782CysVal: 0.782 ± 0.028	0.153CysTrp: 0.153 ± 0.011	0.305CysTyr: 0.305 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.074AspAla: 5.074 ± 0.069	0.486AspCys: 0.486 ± 0.023	2.89AspAsp: 2.89 ± 0.062	3.837AspGlu: 3.837 ± 0.052	2.262AspPhe: 2.262 ± 0.053	3.319AspGly: 3.319 ± 0.06	1.256AspHis: 1.256 ± 0.034	3.613AspIle: 3.613 ± 0.058	2.21AspLys: 2.21 ± 0.042	5.945AspLeu: 5.945 ± 0.088	1.358AspMet: 1.358 ± 0.036	1.728AspAsn: 1.728 ± 0.04	2.487AspPro: 2.487 ± 0.046	2.556AspGln: 2.556 ± 0.049	2.875AspArg: 2.875 ± 0.05	2.882AspSer: 2.882 ± 0.054	2.705AspThr: 2.705 ± 0.048	3.888AspVal: 3.888 ± 0.064	0.876AspTrp: 0.876 ± 0.029	1.761AspTyr: 1.761 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.841GluAla: 5.841 ± 0.087	0.51GluCys: 0.51 ± 0.018	2.775GluAsp: 2.775 ± 0.052	3.406GluGlu: 3.406 ± 0.067	2.173GluPhe: 2.173 ± 0.044	3.946GluGly: 3.946 ± 0.063	1.688GluHis: 1.688 ± 0.037	3.659GluIle: 3.659 ± 0.063	3.041GluLys: 3.041 ± 0.058	6.943GluLeu: 6.943 ± 0.093	1.71GluMet: 1.71 ± 0.037	2.078GluAsn: 2.078 ± 0.045	2.191GluPro: 2.191 ± 0.042	3.676GluGln: 3.676 ± 0.064	4.124GluArg: 4.124 ± 0.062	3.696GluSer: 3.696 ± 0.061	3.154GluThr: 3.154 ± 0.057	4.248GluVal: 4.248 ± 0.06	0.815GluTrp: 0.815 ± 0.023	1.618GluTyr: 1.618 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.45PheAla: 3.45 ± 0.044	0.506PheCys: 0.506 ± 0.02	2.637PheAsp: 2.637 ± 0.051	2.489PheGlu: 2.489 ± 0.048	1.825PhePhe: 1.825 ± 0.048	2.952PheGly: 2.952 ± 0.062	0.8PheHis: 0.8 ± 0.024	2.606PheIle: 2.606 ± 0.05	1.771PheLys: 1.771 ± 0.038	3.623PheLeu: 3.623 ± 0.057	1.079PheMet: 1.079 ± 0.026	1.723PheAsn: 1.723 ± 0.043	1.507PhePro: 1.507 ± 0.046	1.358PheGln: 1.358 ± 0.036	1.801PheArg: 1.801 ± 0.041	3.215PheSer: 3.215 ± 0.054	2.144PheThr: 2.144 ± 0.05	2.723PheVal: 2.723 ± 0.047	0.56PheTrp: 0.56 ± 0.024	1.282PheTyr: 1.282 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.477GlyAla: 5.477 ± 0.089	0.88GlyCys: 0.88 ± 0.029	3.48GlyAsp: 3.48 ± 0.044	3.796GlyGlu: 3.796 ± 0.055	3.31GlyPhe: 3.31 ± 0.055	4.692GlyGly: 4.692 ± 0.08	1.779GlyHis: 1.779 ± 0.039	4.64GlyIle: 4.64 ± 0.068	3.073GlyLys: 3.073 ± 0.053	7.566GlyLeu: 7.566 ± 0.086	2.092GlyMet: 2.092 ± 0.044	2.206GlyAsn: 2.206 ± 0.052	1.891GlyPro: 1.891 ± 0.042	3.08GlyGln: 3.08 ± 0.062	3.967GlyArg: 3.967 ± 0.069	4.021GlySer: 4.021 ± 0.066	3.185GlyThr: 3.185 ± 0.05	5.478GlyVal: 5.478 ± 0.071	1.1GlyTrp: 1.1 ± 0.032	2.392GlyTyr: 2.392 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.041HisAla: 2.041 ± 0.042	0.299HisCys: 0.299 ± 0.016	1.141HisAsp: 1.141 ± 0.034	1.339HisGlu: 1.339 ± 0.035	1.17HisPhe: 1.17 ± 0.033	1.385HisGly: 1.385 ± 0.034	0.742HisHis: 0.742 ± 0.032	1.339HisIle: 1.339 ± 0.032	0.892HisLys: 0.892 ± 0.025	2.969HisLeu: 2.969 ± 0.058	0.558HisMet: 0.558 ± 0.023	0.792HisAsn: 0.792 ± 0.024	1.5HisPro: 1.5 ± 0.039	1.328HisGln: 1.328 ± 0.033	1.315HisArg: 1.315 ± 0.034	1.422HisSer: 1.422 ± 0.035	1.131HisThr: 1.131 ± 0.032	1.32HisVal: 1.32 ± 0.035	0.435HisTrp: 0.435 ± 0.019	0.896HisTyr: 0.896 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.047IleAla: 6.047 ± 0.082	0.692IleCys: 0.692 ± 0.021	3.959IleAsp: 3.959 ± 0.058	4.535IleGlu: 4.535 ± 0.065	2.104IlePhe: 2.104 ± 0.047	4.376IleGly: 4.376 ± 0.068	1.406IleHis: 1.406 ± 0.038	3.312IleIle: 3.312 ± 0.062	2.613IleLys: 2.613 ± 0.049	5.815IleLeu: 5.815 ± 0.081	1.272IleMet: 1.272 ± 0.033	2.626IleAsn: 2.626 ± 0.052	2.774IlePro: 2.774 ± 0.053	2.589IleGln: 2.589 ± 0.052	3.513IleArg: 3.513 ± 0.059	4.093IleSer: 4.093 ± 0.071	3.479IleThr: 3.479 ± 0.062	3.826IleVal: 3.826 ± 0.054	0.648IleTrp: 0.648 ± 0.022	1.471IleTyr: 1.471 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.205LysAla: 4.205 ± 0.073	0.301LysCys: 0.301 ± 0.016	2.292LysAsp: 2.292 ± 0.043	2.485LysGlu: 2.485 ± 0.053	0.998LysPhe: 0.998 ± 0.028	3.112LysGly: 3.112 ± 0.054	1.127LysHis: 1.127 ± 0.03	2.409LysIle: 2.409 ± 0.045	1.999LysLys: 1.999 ± 0.05	4.04LysLeu: 4.04 ± 0.059	1.152LysMet: 1.152 ± 0.033	1.553LysAsn: 1.553 ± 0.041	2.02LysPro: 2.02 ± 0.048	2.156LysGln: 2.156 ± 0.05	2.867LysArg: 2.867 ± 0.051	2.637LysSer: 2.637 ± 0.043	2.508LysThr: 2.508 ± 0.046	3.036LysVal: 3.036 ± 0.056	0.405LysTrp: 0.405 ± 0.02	0.874LysTyr: 0.874 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.709LeuAla: 10.709 ± 0.12	1.141LeuCys: 1.141 ± 0.033	6.133LeuAsp: 6.133 ± 0.082	6.65LeuGlu: 6.65 ± 0.093	4.236LeuPhe: 4.236 ± 0.077	7.432LeuGly: 7.432 ± 0.077	2.411LeuHis: 2.411 ± 0.049	6.97LeuIle: 6.97 ± 0.099	5.275LeuLys: 5.275 ± 0.077	12.413LeuLeu: 12.413 ± 0.164	3.153LeuMet: 3.153 ± 0.054	4.731LeuAsn: 4.731 ± 0.061	5.477LeuPro: 5.477 ± 0.082	4.443LeuGln: 4.443 ± 0.068	5.771LeuArg: 5.771 ± 0.076	8.726LeuSer: 8.726 ± 0.084	6.215LeuThr: 6.215 ± 0.07	7.404LeuVal: 7.404 ± 0.095	1.198LeuTrp: 1.198 ± 0.034	2.678LeuTyr: 2.678 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.508MetAla: 2.508 ± 0.044	0.209MetCys: 0.209 ± 0.013	1.259MetAsp: 1.259 ± 0.033	1.215MetGlu: 1.215 ± 0.035	0.858MetPhe: 0.858 ± 0.028	1.886MetGly: 1.886 ± 0.039	0.557MetHis: 0.557 ± 0.02	1.642MetIle: 1.642 ± 0.039	1.248MetLys: 1.248 ± 0.032	2.926MetLeu: 2.926 ± 0.049	0.808MetMet: 0.808 ± 0.029	1.097MetAsn: 1.097 ± 0.028	1.308MetPro: 1.308 ± 0.033	1.29MetGln: 1.29 ± 0.034	1.519MetArg: 1.519 ± 0.038	2.158MetSer: 2.158 ± 0.042	1.642MetThr: 1.642 ± 0.035	1.675MetVal: 1.675 ± 0.039	0.194MetTrp: 0.194 ± 0.013	0.476MetTyr: 0.476 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.367AsnAla: 3.367 ± 0.063	0.368AsnCys: 0.368 ± 0.02	1.874AsnAsp: 1.874 ± 0.047	2.218AsnGlu: 2.218 ± 0.049	1.311AsnPhe: 1.311 ± 0.038	2.195AsnGly: 2.195 ± 0.048	0.866AsnHis: 0.866 ± 0.027	2.267AsnIle: 2.267 ± 0.046	1.435AsnLys: 1.435 ± 0.035	3.87AsnLeu: 3.87 ± 0.051	0.847AsnMet: 0.847 ± 0.024	1.283AsnAsn: 1.283 ± 0.039	2.214AsnPro: 2.214 ± 0.04	1.917AsnGln: 1.917 ± 0.048	2.064AsnArg: 2.064 ± 0.04	2.105AsnSer: 2.105 ± 0.048	2.192AsnThr: 2.192 ± 0.046	2.206AsnVal: 2.206 ± 0.049	0.507AsnTrp: 0.507 ± 0.02	0.97AsnTyr: 0.97 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.599ProAla: 3.599 ± 0.064	0.366ProCys: 0.366 ± 0.017	2.863ProAsp: 2.863 ± 0.054	3.437ProGlu: 3.437 ± 0.06	1.839ProPhe: 1.839 ± 0.038	2.793ProGly: 2.793 ± 0.053	0.937ProHis: 0.937 ± 0.028	2.584ProIle: 2.584 ± 0.046	1.824ProLys: 1.824 ± 0.039	4.673ProLeu: 4.673 ± 0.065	1.139ProMet: 1.139 ± 0.032	1.641ProAsn: 1.641 ± 0.035	1.446ProPro: 1.446 ± 0.042	1.56ProGln: 1.56 ± 0.036	1.705ProArg: 1.705 ± 0.042	2.953ProSer: 2.953 ± 0.053	2.173ProThr: 2.173 ± 0.046	3.432ProVal: 3.432 ± 0.056	0.604ProTrp: 0.604 ± 0.024	1.214ProTyr: 1.214 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.8GlnAla: 4.8 ± 0.075	0.394GlnCys: 0.394 ± 0.017	2.078GlnAsp: 2.078 ± 0.039	2.482GlnGlu: 2.482 ± 0.053	1.542GlnPhe: 1.542 ± 0.038	3.334GlnGly: 3.334 ± 0.06	1.279GlnHis: 1.279 ± 0.034	2.586GlnIle: 2.586 ± 0.05	1.729GlnLys: 1.729 ± 0.032	5.424GlnLeu: 5.424 ± 0.085	1.177GlnMet: 1.177 ± 0.033	1.46GlnAsn: 1.46 ± 0.036	1.995GlnPro: 1.995 ± 0.044	2.787GlnGln: 2.787 ± 0.055	3.048GlnArg: 3.048 ± 0.055	2.959GlnSer: 2.959 ± 0.057	2.421GlnThr: 2.421 ± 0.047	3.471GlnVal: 3.471 ± 0.055	0.662GlnTrp: 0.662 ± 0.027	1.123GlnTyr: 1.123 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.197ArgAla: 4.197 ± 0.069	0.573ArgCys: 0.573 ± 0.022	2.823ArgAsp: 2.823 ± 0.052	3.399ArgGlu: 3.399 ± 0.06	2.684ArgPhe: 2.684 ± 0.052	3.045ArgGly: 3.045 ± 0.051	1.487ArgHis: 1.487 ± 0.039	3.817ArgIle: 3.817 ± 0.059	2.263ArgLys: 2.263 ± 0.051	6.891ArgLeu: 6.891 ± 0.085	1.597ArgMet: 1.597 ± 0.042	1.966ArgAsn: 1.966 ± 0.046	2.149ArgPro: 2.149 ± 0.047	2.875ArgGln: 2.875 ± 0.056	3.137ArgArg: 3.137 ± 0.067	3.376ArgSer: 3.376 ± 0.054	2.403ArgThr: 2.403 ± 0.044	4.054ArgVal: 4.054 ± 0.067	0.841ArgTrp: 0.841 ± 0.026	1.976ArgTyr: 1.976 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.953SerAla: 5.953 ± 0.085	0.595SerCys: 0.595 ± 0.024	3.641SerAsp: 3.641 ± 0.056	4.016SerGlu: 4.016 ± 0.064	2.672SerPhe: 2.672 ± 0.048	5.057SerGly: 5.057 ± 0.075	1.539SerHis: 1.539 ± 0.038	4.13SerIle: 4.13 ± 0.062	2.514SerLys: 2.514 ± 0.047	7.793SerLeu: 7.793 ± 0.097	1.784SerMet: 1.784 ± 0.041	2.286SerAsn: 2.286 ± 0.044	2.657SerPro: 2.657 ± 0.045	2.918SerGln: 2.918 ± 0.057	3.513SerArg: 3.513 ± 0.053	4.406SerSer: 4.406 ± 0.062	3.305SerThr: 3.305 ± 0.055	4.83SerVal: 4.83 ± 0.069	0.826SerTrp: 0.826 ± 0.027	1.693SerTyr: 1.693 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.396ThrAla: 4.396 ± 0.064	0.517ThrCys: 0.517 ± 0.019	2.85ThrAsp: 2.85 ± 0.044	3.172ThrGlu: 3.172 ± 0.049	2.08ThrPhe: 2.08 ± 0.046	4.145ThrGly: 4.145 ± 0.058	1.462ThrHis: 1.462 ± 0.035	2.514ThrIle: 2.514 ± 0.044	1.477ThrLys: 1.477 ± 0.041	7.293ThrLeu: 7.293 ± 0.096	0.94ThrMet: 0.94 ± 0.03	1.556ThrAsn: 1.556 ± 0.037	2.95ThrPro: 2.95 ± 0.057	2.573ThrGln: 2.573 ± 0.05	2.783ThrArg: 2.783 ± 0.052	3.238ThrSer: 3.238 ± 0.053	2.539ThrThr: 2.539 ± 0.051	3.085ThrVal: 3.085 ± 0.056	0.642ThrTrp: 0.642 ± 0.022	1.353ThrTyr: 1.353 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.285ValAla: 6.285 ± 0.084	0.86ValCys: 0.86 ± 0.032	3.888ValAsp: 3.888 ± 0.063	4.342ValGlu: 4.342 ± 0.063	2.997ValPhe: 2.997 ± 0.053	4.589ValGly: 4.589 ± 0.066	1.363ValHis: 1.363 ± 0.032	4.497ValIle: 4.497 ± 0.068	3.029ValLys: 3.029 ± 0.052	7.38ValLeu: 7.38 ± 0.086	1.981ValMet: 1.981 ± 0.043	2.669ValAsn: 2.669 ± 0.053	2.669ValPro: 2.669 ± 0.049	2.482ValGln: 2.482 ± 0.046	3.556ValArg: 3.556 ± 0.058	5.118ValSer: 5.118 ± 0.079	3.675ValThr: 3.675 ± 0.062	5.051ValVal: 5.051 ± 0.076	0.835ValTrp: 0.835 ± 0.026	1.86ValTyr: 1.86 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.836TrpAla: 0.836 ± 0.027	0.173TrpCys: 0.173 ± 0.011	0.553TrpAsp: 0.553 ± 0.021	0.564TrpGlu: 0.564 ± 0.025	0.57TrpPhe: 0.57 ± 0.023	0.781TrpGly: 0.781 ± 0.029	0.359TrpHis: 0.359 ± 0.018	0.837TrpIle: 0.837 ± 0.029	0.535TrpLys: 0.535 ± 0.023	1.874TrpLeu: 1.874 ± 0.047	0.436TrpMet: 0.436 ± 0.018	0.434TrpAsn: 0.434 ± 0.019	0.561TrpPro: 0.561 ± 0.021	0.851TrpGln: 0.851 ± 0.028	0.817TrpArg: 0.817 ± 0.027	0.837TrpSer: 0.837 ± 0.025	0.59TrpThr: 0.59 ± 0.023	0.98TrpVal: 0.98 ± 0.029	0.183TrpTrp: 0.183 ± 0.013	0.347TrpTyr: 0.347 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.381TyrAla: 2.381 ± 0.043	0.331TyrCys: 0.331 ± 0.016	1.489TyrAsp: 1.489 ± 0.036	1.615TyrGlu: 1.615 ± 0.035	1.233TyrPhe: 1.233 ± 0.035	1.902TyrGly: 1.902 ± 0.039	0.684TyrHis: 0.684 ± 0.025	1.409TyrIle: 1.409 ± 0.039	0.982TyrLys: 0.982 ± 0.03	3.201TyrLeu: 3.201 ± 0.054	0.557TyrMet: 0.557 ± 0.023	0.89TyrAsn: 0.89 ± 0.027	1.379TyrPro: 1.379 ± 0.036	1.538TyrGln: 1.538 ± 0.04	1.827TyrArg: 1.827 ± 0.037	1.795TyrSer: 1.795 ± 0.04	1.409TyrThr: 1.409 ± 0.04	1.694TyrVal: 1.694 ± 0.039	0.451TyrTrp: 0.451 ± 0.018	0.836TyrTyr: 0.836 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4019 proteins (1211048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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