Amino acid dipepetide frequency for Desulfotomaculum ferrireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.55AlaAla: 8.55 ± 0.147	1.062AlaCys: 1.062 ± 0.045	3.662AlaAsp: 3.662 ± 0.069	5.922AlaGlu: 5.922 ± 0.094	2.739AlaPhe: 2.739 ± 0.064	6.752AlaGly: 6.752 ± 0.084	1.36AlaHis: 1.36 ± 0.04	5.833AlaIle: 5.833 ± 0.107	5.33AlaLys: 5.33 ± 0.091	8.919AlaLeu: 8.919 ± 0.115	2.328AlaMet: 2.328 ± 0.054	3.208AlaAsn: 3.208 ± 0.056	2.596AlaPro: 2.596 ± 0.06	3.271AlaGln: 3.271 ± 0.069	4.31AlaArg: 4.31 ± 0.069	3.764AlaSer: 3.764 ± 0.071	4.184AlaThr: 4.184 ± 0.063	6.759AlaVal: 6.759 ± 0.098	0.659AlaTrp: 0.659 ± 0.028	2.319AlaTyr: 2.319 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.79CysAla: 0.79 ± 0.033	0.286CysCys: 0.286 ± 0.022	0.522CysAsp: 0.522 ± 0.026	0.626CysGlu: 0.626 ± 0.031	0.398CysPhe: 0.398 ± 0.021	1.32CysGly: 1.32 ± 0.043	0.327CysHis: 0.327 ± 0.023	0.662CysIle: 0.662 ± 0.029	0.544CysLys: 0.544 ± 0.028	1.224CysLeu: 1.224 ± 0.041	0.276CysMet: 0.276 ± 0.018	0.468CysAsn: 0.468 ± 0.024	0.817CysPro: 0.817 ± 0.038	0.649CysGln: 0.649 ± 0.032	0.675CysArg: 0.675 ± 0.032	0.82CysSer: 0.82 ± 0.031	0.649CysThr: 0.649 ± 0.031	0.638CysVal: 0.638 ± 0.032	0.108CysTrp: 0.108 ± 0.012	0.424CysTyr: 0.424 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.147AspAla: 3.147 ± 0.063	0.596AspCys: 0.596 ± 0.022	1.866AspAsp: 1.866 ± 0.053	3.067AspGlu: 3.067 ± 0.063	2.159AspPhe: 2.159 ± 0.048	3.111AspGly: 3.111 ± 0.065	0.901AspHis: 0.901 ± 0.03	4.028AspIle: 4.028 ± 0.076	3.013AspLys: 3.013 ± 0.066	4.925AspLeu: 4.925 ± 0.08	1.243AspMet: 1.243 ± 0.037	1.841AspAsn: 1.841 ± 0.051	2.054AspPro: 2.054 ± 0.045	1.678AspGln: 1.678 ± 0.048	2.352AspArg: 2.352 ± 0.048	2.03AspSer: 2.03 ± 0.049	2.338AspThr: 2.338 ± 0.104	3.292AspVal: 3.292 ± 0.063	0.555AspTrp: 0.555 ± 0.029	1.889AspTyr: 1.889 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.714GluAla: 5.714 ± 0.092	0.564GluCys: 0.564 ± 0.028	3.062GluAsp: 3.062 ± 0.062	5.948GluGlu: 5.948 ± 0.105	2.175GluPhe: 2.175 ± 0.047	4.19GluGly: 4.19 ± 0.069	1.27GluHis: 1.27 ± 0.041	5.418GluIle: 5.418 ± 0.086	5.155GluLys: 5.155 ± 0.084	7.679GluLeu: 7.679 ± 0.121	2.007GluMet: 2.007 ± 0.039	2.77GluAsn: 2.77 ± 0.058	2.188GluPro: 2.188 ± 0.061	3.92GluGln: 3.92 ± 0.076	3.696GluArg: 3.696 ± 0.072	2.494GluSer: 2.494 ± 0.056	2.997GluThr: 2.997 ± 0.062	5.439GluVal: 5.439 ± 0.083	0.548GluTrp: 0.548 ± 0.028	2.025GluTyr: 2.025 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.062PheAla: 3.062 ± 0.065	0.549PheCys: 0.549 ± 0.028	1.788PheAsp: 1.788 ± 0.045	1.943PheGlu: 1.943 ± 0.048	1.73PhePhe: 1.73 ± 0.051	2.781PheGly: 2.781 ± 0.061	0.691PheHis: 0.691 ± 0.029	2.773PheIle: 2.773 ± 0.063	2.056PheLys: 2.056 ± 0.051	3.835PheLeu: 3.835 ± 0.087	0.976PheMet: 0.976 ± 0.038	1.555PheAsn: 1.555 ± 0.044	1.516PhePro: 1.516 ± 0.038	1.265PheGln: 1.265 ± 0.041	1.705PheArg: 1.705 ± 0.041	2.37PheSer: 2.37 ± 0.053	2.325PheThr: 2.325 ± 0.052	2.518PheVal: 2.518 ± 0.056	0.424PheTrp: 0.424 ± 0.02	1.333PheTyr: 1.333 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.669GlyAla: 5.669 ± 0.089	1.178GlyCys: 1.178 ± 0.039	3.362GlyAsp: 3.362 ± 0.113	4.705GlyGlu: 4.705 ± 0.073	3.1GlyPhe: 3.1 ± 0.06	5.305GlyGly: 5.305 ± 0.09	1.513GlyHis: 1.513 ± 0.045	5.701GlyIle: 5.701 ± 0.075	4.98GlyLys: 4.98 ± 0.081	8.21GlyLeu: 8.21 ± 0.12	2.144GlyMet: 2.144 ± 0.05	2.64GlyAsn: 2.64 ± 0.055	2.249GlyPro: 2.249 ± 0.109	3.186GlyGln: 3.186 ± 0.066	3.573GlyArg: 3.573 ± 0.06	3.929GlySer: 3.929 ± 0.061	3.983GlyThr: 3.983 ± 0.073	5.862GlyVal: 5.862 ± 0.094	0.783GlyTrp: 0.783 ± 0.031	2.886GlyTyr: 2.886 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.217HisAla: 1.217 ± 0.038	0.329HisCys: 0.329 ± 0.02	0.81HisAsp: 0.81 ± 0.034	0.916HisGlu: 0.916 ± 0.03	0.812HisPhe: 0.812 ± 0.031	1.397HisGly: 1.397 ± 0.039	0.538HisHis: 0.538 ± 0.031	1.373HisIle: 1.373 ± 0.035	0.966HisLys: 0.966 ± 0.029	2.064HisLeu: 2.064 ± 0.057	0.452HisMet: 0.452 ± 0.024	0.741HisAsn: 0.741 ± 0.031	1.105HisPro: 1.105 ± 0.036	0.848HisGln: 0.848 ± 0.031	1.112HisArg: 1.112 ± 0.034	1.062HisSer: 1.062 ± 0.033	0.99HisThr: 0.99 ± 0.034	1.043HisVal: 1.043 ± 0.04	0.238HisTrp: 0.238 ± 0.019	0.723HisTyr: 0.723 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.749IleAla: 5.749 ± 0.087	0.837IleCys: 0.837 ± 0.031	3.495IleAsp: 3.495 ± 0.067	4.434IleGlu: 4.434 ± 0.07	2.766IlePhe: 2.766 ± 0.069	5.048IleGly: 5.048 ± 0.097	1.191IleHis: 1.191 ± 0.035	5.545IleIle: 5.545 ± 0.097	4.77IleLys: 4.77 ± 0.081	7.061IleLeu: 7.061 ± 0.1	1.729IleMet: 1.729 ± 0.043	3.448IleAsn: 3.448 ± 0.062	3.326IlePro: 3.326 ± 0.055	2.265IleGln: 2.265 ± 0.048	3.209IleArg: 3.209 ± 0.055	4.255IleSer: 4.255 ± 0.083	4.279IleThr: 4.279 ± 0.073	4.548IleVal: 4.548 ± 0.068	0.528IleTrp: 0.528 ± 0.024	2.271IleTyr: 2.271 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.838LysAla: 4.838 ± 0.078	0.59LysCys: 0.59 ± 0.031	3.169LysAsp: 3.169 ± 0.058	5.475LysGlu: 5.475 ± 0.083	1.758LysPhe: 1.758 ± 0.038	4.165LysGly: 4.165 ± 0.074	1.047LysHis: 1.047 ± 0.035	4.429LysIle: 4.429 ± 0.078	4.145LysLys: 4.145 ± 0.085	6.043LysLeu: 6.043 ± 0.095	1.709LysMet: 1.709 ± 0.043	2.502LysAsn: 2.502 ± 0.056	2.512LysPro: 2.512 ± 0.057	2.625LysGln: 2.625 ± 0.059	2.878LysArg: 2.878 ± 0.067	2.808LysSer: 2.808 ± 0.065	3.018LysThr: 3.018 ± 0.057	4.811LysVal: 4.811 ± 0.081	0.547LysTrp: 0.547 ± 0.024	2.122LysTyr: 2.122 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	10.913LeuAla: 10.913 ± 0.12	1.157LeuCys: 1.157 ± 0.044	5.023LeuAsp: 5.023 ± 0.084	7.104LeuGlu: 7.104 ± 0.117	3.672LeuPhe: 3.672 ± 0.074	8.201LeuGly: 8.201 ± 0.11	1.762LeuHis: 1.762 ± 0.045	6.341LeuIle: 6.341 ± 0.1	6.323LeuLys: 6.323 ± 0.087	11.112LeuLeu: 11.112 ± 0.163	2.514LeuMet: 2.514 ± 0.065	3.96LeuAsn: 3.96 ± 0.075	5.06LeuPro: 5.06 ± 0.07	4.185LeuGln: 4.185 ± 0.078	5.063LeuArg: 5.063 ± 0.074	6.002LeuSer: 6.002 ± 0.1	5.909LeuThr: 5.909 ± 0.089	8.008LeuVal: 8.008 ± 0.102	0.951LeuTrp: 0.951 ± 0.033	2.932LeuTyr: 2.932 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.634MetAla: 2.634 ± 0.057	0.208MetCys: 0.208 ± 0.015	1.288MetAsp: 1.288 ± 0.039	1.805MetGlu: 1.805 ± 0.049	0.861MetPhe: 0.861 ± 0.031	2.093MetGly: 2.093 ± 0.05	0.412MetHis: 0.412 ± 0.021	1.577MetIle: 1.577 ± 0.039	1.569MetLys: 1.569 ± 0.041	2.705MetLeu: 2.705 ± 0.059	0.643MetMet: 0.643 ± 0.03	0.99MetAsn: 0.99 ± 0.028	1.078MetPro: 1.078 ± 0.034	0.991MetGln: 0.991 ± 0.04	1.125MetArg: 1.125 ± 0.038	1.512MetSer: 1.512 ± 0.041	1.35MetThr: 1.35 ± 0.038	2.112MetVal: 2.112 ± 0.051	0.182MetTrp: 0.182 ± 0.014	0.601MetTyr: 0.601 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.543AsnAla: 2.543 ± 0.055	0.64AsnCys: 0.64 ± 0.03	1.521AsnAsp: 1.521 ± 0.044	2.064AsnGlu: 2.064 ± 0.053	1.492AsnPhe: 1.492 ± 0.042	2.54AsnGly: 2.54 ± 0.065	0.878AsnHis: 0.878 ± 0.03	3.272AsnIle: 3.272 ± 0.064	2.617AsnLys: 2.617 ± 0.054	4.463AsnLeu: 4.463 ± 0.077	0.975AsnMet: 0.975 ± 0.034	1.923AsnAsn: 1.923 ± 0.06	2.247AsnPro: 2.247 ± 0.056	1.838AsnGln: 1.838 ± 0.046	2.023AsnArg: 2.023 ± 0.052	2.103AsnSer: 2.103 ± 0.056	2.075AsnThr: 2.075 ± 0.052	2.382AsnVal: 2.382 ± 0.054	0.49AsnTrp: 0.49 ± 0.024	1.48AsnTyr: 1.48 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.397ProAla: 3.397 ± 0.068	0.452ProCys: 0.452 ± 0.026	2.079ProAsp: 2.079 ± 0.05	3.74ProGlu: 3.74 ± 0.066	1.693ProPhe: 1.693 ± 0.042	3.608ProGly: 3.608 ± 0.065	0.867ProHis: 0.867 ± 0.034	2.428ProIle: 2.428 ± 0.051	2.142ProLys: 2.142 ± 0.049	4.182ProLeu: 4.182 ± 0.076	0.965ProMet: 0.965 ± 0.032	1.468ProAsn: 1.468 ± 0.043	1.553ProPro: 1.553 ± 0.048	1.837ProGln: 1.837 ± 0.051	1.771ProArg: 1.771 ± 0.045	2.009ProSer: 2.009 ± 0.045	2.244ProThr: 2.244 ± 0.097	3.794ProVal: 3.794 ± 0.065	0.499ProTrp: 0.499 ± 0.023	1.389ProTyr: 1.389 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.904GlnAla: 3.904 ± 0.076	0.441GlnCys: 0.441 ± 0.023	1.847GlnAsp: 1.847 ± 0.044	3.667GlnGlu: 3.667 ± 0.07	1.22GlnPhe: 1.22 ± 0.041	3.209GlnGly: 3.209 ± 0.064	0.73GlnHis: 0.73 ± 0.028	2.77GlnIle: 2.77 ± 0.061	2.361GlnLys: 2.361 ± 0.055	4.206GlnLeu: 4.206 ± 0.083	1.123GlnMet: 1.123 ± 0.038	1.512GlnAsn: 1.512 ± 0.043	1.738GlnPro: 1.738 ± 0.048	2.549GlnGln: 2.549 ± 0.066	2.538GlnArg: 2.538 ± 0.056	1.843GlnSer: 1.843 ± 0.044	1.876GlnThr: 1.876 ± 0.055	3.379GlnVal: 3.379 ± 0.061	0.441GlnTrp: 0.441 ± 0.023	1.282GlnTyr: 1.282 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.524ArgAla: 3.524 ± 0.078	0.567ArgCys: 0.567 ± 0.025	2.394ArgAsp: 2.394 ± 0.059	4.065ArgGlu: 4.065 ± 0.079	1.863ArgPhe: 1.863 ± 0.046	3.275ArgGly: 3.275 ± 0.068	0.987ArgHis: 0.987 ± 0.032	3.421ArgIle: 3.421 ± 0.07	2.916ArgLys: 2.916 ± 0.058	5.328ArgLeu: 5.328 ± 0.085	1.314ArgMet: 1.314 ± 0.043	1.873ArgAsn: 1.873 ± 0.047	1.986ArgPro: 1.986 ± 0.051	2.649ArgGln: 2.649 ± 0.059	2.721ArgArg: 2.721 ± 0.062	2.24ArgSer: 2.24 ± 0.051	2.231ArgThr: 2.231 ± 0.049	3.765ArgVal: 3.765 ± 0.069	0.525ArgTrp: 0.525 ± 0.028	1.773ArgTyr: 1.773 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.621SerAla: 3.621 ± 0.076	0.69SerCys: 0.69 ± 0.027	2.113SerAsp: 2.113 ± 0.05	2.976SerGlu: 2.976 ± 0.058	2.261SerPhe: 2.261 ± 0.049	4.294SerGly: 4.294 ± 0.074	1.013SerHis: 1.013 ± 0.034	3.447SerIle: 3.447 ± 0.066	2.763SerLys: 2.763 ± 0.062	5.992SerLeu: 5.992 ± 0.088	1.334SerMet: 1.334 ± 0.038	1.884SerAsn: 1.884 ± 0.042	2.319SerPro: 2.319 ± 0.053	2.229SerGln: 2.229 ± 0.052	2.662SerArg: 2.662 ± 0.058	2.888SerSer: 2.888 ± 0.074	2.662SerThr: 2.662 ± 0.057	3.517SerVal: 3.517 ± 0.068	0.549SerTrp: 0.549 ± 0.023	1.758SerTyr: 1.758 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.569ThrAla: 4.569 ± 0.081	0.563ThrCys: 0.563 ± 0.028	2.248ThrAsp: 2.248 ± 0.048	3.09ThrGlu: 3.09 ± 0.065	2.063ThrPhe: 2.063 ± 0.05	4.976ThrGly: 4.976 ± 0.185	0.957ThrHis: 0.957 ± 0.035	3.711ThrIle: 3.711 ± 0.066	2.893ThrLys: 2.893 ± 0.062	5.418ThrLeu: 5.418 ± 0.076	1.237ThrMet: 1.237 ± 0.039	2.042ThrAsn: 2.042 ± 0.052	2.717ThrPro: 2.717 ± 0.066	1.548ThrGln: 1.548 ± 0.044	2.23ThrArg: 2.23 ± 0.052	2.664ThrSer: 2.664 ± 0.064	3.03ThrThr: 3.03 ± 0.064	4.252ThrVal: 4.252 ± 0.075	0.49ThrTrp: 0.49 ± 0.028	1.607ThrTyr: 1.607 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	6.727ValAla: 6.727 ± 0.107	0.906ValCys: 0.906 ± 0.036	3.777ValAsp: 3.777 ± 0.073	5.192ValGlu: 5.192 ± 0.085	2.644ValPhe: 2.644 ± 0.054	5.491ValGly: 5.491 ± 0.088	1.243ValHis: 1.243 ± 0.038	5.487ValIle: 5.487 ± 0.087	4.589ValLys: 4.589 ± 0.083	7.7ValLeu: 7.7 ± 0.087	1.89ValMet: 1.89 ± 0.047	3.06ValAsn: 3.06 ± 0.062	3.147ValPro: 3.147 ± 0.057	2.549ValGln: 2.549 ± 0.049	3.368ValArg: 3.368 ± 0.069	4.054ValSer: 4.054 ± 0.069	4.162ValThr: 4.162 ± 0.066	6.287ValVal: 6.287 ± 0.095	0.611ValTrp: 0.611 ± 0.028	2.09ValTyr: 2.09 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.688TrpAla: 0.688 ± 0.031	0.139TrpCys: 0.139 ± 0.013	0.492TrpAsp: 0.492 ± 0.028	0.707TrpGlu: 0.707 ± 0.028	0.393TrpPhe: 0.393 ± 0.024	0.682TrpGly: 0.682 ± 0.031	0.235TrpHis: 0.235 ± 0.018	0.515TrpIle: 0.515 ± 0.026	0.364TrpLys: 0.364 ± 0.022	1.295TrpLeu: 1.295 ± 0.046	0.205TrpMet: 0.205 ± 0.013	0.349TrpAsn: 0.349 ± 0.022	0.371TrpPro: 0.371 ± 0.025	0.75TrpGln: 0.75 ± 0.032	0.498TrpArg: 0.498 ± 0.027	0.466TrpSer: 0.466 ± 0.023	0.358TrpThr: 0.358 ± 0.02	0.653TrpVal: 0.653 ± 0.028	0.124TrpTrp: 0.124 ± 0.013	0.307TrpTyr: 0.307 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.05	0.468TyrCys: 0.468 ± 0.024	1.567TyrAsp: 1.567 ± 0.048	1.813TyrGlu: 1.813 ± 0.046	1.394TyrPhe: 1.394 ± 0.042	2.52TyrGly: 2.52 ± 0.063	0.813TyrHis: 0.813 ± 0.034	2.023TyrIle: 2.023 ± 0.053	1.697TyrLys: 1.697 ± 0.046	3.833TyrLeu: 3.833 ± 0.072	0.673TyrMet: 0.673 ± 0.027	1.334TyrAsn: 1.334 ± 0.047	1.537TyrPro: 1.537 ± 0.042	1.802TyrGln: 1.802 ± 0.046	1.907TyrArg: 1.907 ± 0.046	1.66TyrSer: 1.66 ± 0.037	1.645TyrThr: 1.645 ± 0.045	1.915TyrVal: 1.915 ± 0.043	0.337TyrTrp: 0.337 ± 0.021	1.352TyrTyr: 1.352 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2924 proteins (873544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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