Amino acid dipepetide frequency for Paenibacillus zeisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.836AlaAla: 8.836 ± 0.146
0.633AlaCys: 0.633 ± 0.025
4.087AlaAsp: 4.087 ± 0.068
5.756AlaGlu: 5.756 ± 0.072
3.179AlaPhe: 3.179 ± 0.066
6.928AlaGly: 6.928 ± 0.095
1.457AlaHis: 1.457 ± 0.035
5.151AlaIle: 5.151 ± 0.08
4.409AlaLys: 4.409 ± 0.066
7.98AlaLeu: 7.98 ± 0.101
2.161AlaMet: 2.161 ± 0.039
2.522AlaAsn: 2.522 ± 0.054
2.654AlaPro: 2.654 ± 0.057
2.676AlaGln: 2.676 ± 0.049
3.454AlaArg: 3.454 ± 0.053
5.214AlaSer: 5.214 ± 0.075
3.396AlaThr: 3.396 ± 0.158
6.401AlaVal: 6.401 ± 0.077
0.855AlaTrp: 0.855 ± 0.03
2.66AlaTyr: 2.66 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.455CysAla: 0.455 ± 0.02
0.097CysCys: 0.097 ± 0.009
0.349CysAsp: 0.349 ± 0.015
0.398CysGlu: 0.398 ± 0.019
0.261CysPhe: 0.261 ± 0.013
0.757CysGly: 0.757 ± 0.027
0.16CysHis: 0.16 ± 0.01
0.462CysIle: 0.462 ± 0.021
0.29CysLys: 0.29 ± 0.015
0.724CysLeu: 0.724 ± 0.03
0.18CysMet: 0.18 ± 0.013
0.237CysAsn: 0.237 ± 0.014
0.357CysPro: 0.357 ± 0.019
0.231CysGln: 0.231 ± 0.017
0.411CysArg: 0.411 ± 0.02
0.558CysSer: 0.558 ± 0.022
0.372CysThr: 0.372 ± 0.019
0.442CysVal: 0.442 ± 0.018
0.085CysTrp: 0.085 ± 0.008
0.249CysTyr: 0.249 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.549AspAla: 3.549 ± 0.056
0.311AspCys: 0.311 ± 0.016
2.101AspAsp: 2.101 ± 0.049
3.761AspGlu: 3.761 ± 0.066
2.055AspPhe: 2.055 ± 0.047
3.632AspGly: 3.632 ± 0.065
1.24AspHis: 1.24 ± 0.032
3.545AspIle: 3.545 ± 0.059
2.978AspLys: 2.978 ± 0.058
5.187AspLeu: 5.187 ± 0.065
1.333AspMet: 1.333 ± 0.03
1.841AspAsn: 1.841 ± 0.044
2.422AspPro: 2.422 ± 0.064
2.154AspGln: 2.154 ± 0.046
2.674AspArg: 2.674 ± 0.046
2.988AspSer: 2.988 ± 0.064
2.665AspThr: 2.665 ± 0.047
3.428AspVal: 3.428 ± 0.06
0.714AspTrp: 0.714 ± 0.028
2.054AspTyr: 2.054 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.96GluAla: 5.96 ± 0.076
0.357GluCys: 0.357 ± 0.021
3.361GluAsp: 3.361 ± 0.059
5.581GluGlu: 5.581 ± 0.083
2.24GluPhe: 2.24 ± 0.04
4.575GluGly: 4.575 ± 0.067
1.561GluHis: 1.561 ± 0.038
4.713GluIle: 4.713 ± 0.072
3.887GluLys: 3.887 ± 0.062
7.145GluLeu: 7.145 ± 0.089
1.972GluMet: 1.972 ± 0.045
2.48GluAsn: 2.48 ± 0.045
2.241GluPro: 2.241 ± 0.047
3.634GluGln: 3.634 ± 0.063
3.803GluArg: 3.803 ± 0.068
3.631GluSer: 3.631 ± 0.061
2.979GluThr: 2.979 ± 0.053
4.903GluVal: 4.903 ± 0.074
0.847GluTrp: 0.847 ± 0.028
2.053GluTyr: 2.053 ± 0.045
0.001GluXaa: 0.001 ± 0.001
Phe
3.075PheAla: 3.075 ± 0.053
0.319PheCys: 0.319 ± 0.017
2.125PheAsp: 2.125 ± 0.049
2.356PheGlu: 2.356 ± 0.047
1.684PhePhe: 1.684 ± 0.041
3.154PheGly: 3.154 ± 0.06
0.87PheHis: 0.87 ± 0.028
2.913PheIle: 2.913 ± 0.059
2.075PheLys: 2.075 ± 0.038
3.696PheLeu: 3.696 ± 0.061
1.113PheMet: 1.113 ± 0.032
1.607PheAsn: 1.607 ± 0.036
1.485PhePro: 1.485 ± 0.032
1.339PheGln: 1.339 ± 0.03
1.88PheArg: 1.88 ± 0.041
2.789PheSer: 2.789 ± 0.055
2.484PheThr: 2.484 ± 0.05
2.777PheVal: 2.777 ± 0.043
0.48PheTrp: 0.48 ± 0.022
1.33PheTyr: 1.33 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
5.69GlyAla: 5.69 ± 0.16
0.701GlyCys: 0.701 ± 0.025
3.533GlyAsp: 3.533 ± 0.065
4.652GlyGlu: 4.652 ± 0.075
3.263GlyPhe: 3.263 ± 0.05
5.754GlyGly: 5.754 ± 0.082
1.534GlyHis: 1.534 ± 0.042
5.876GlyIle: 5.876 ± 0.083
4.409GlyLys: 4.409 ± 0.071
7.382GlyLeu: 7.382 ± 0.092
2.215GlyMet: 2.215 ± 0.053
2.671GlyAsn: 2.671 ± 0.051
2.051GlyPro: 2.051 ± 0.046
2.895GlyGln: 2.895 ± 0.049
3.808GlyArg: 3.808 ± 0.065
5.173GlySer: 5.173 ± 0.089
4.853GlyThr: 4.853 ± 0.075
5.366GlyVal: 5.366 ± 0.081
0.961GlyTrp: 0.961 ± 0.035
2.946GlyTyr: 2.946 ± 0.056
0.001GlyXaa: 0.001 ± 0.001
His
1.541HisAla: 1.541 ± 0.038
0.181HisCys: 0.181 ± 0.012
0.978HisAsp: 0.978 ± 0.03
1.387HisGlu: 1.387 ± 0.034
0.99HisPhe: 0.99 ± 0.03
1.537HisGly: 1.537 ± 0.04
0.592HisHis: 0.592 ± 0.025
1.499HisIle: 1.499 ± 0.048
0.909HisLys: 0.909 ± 0.029
2.233HisLeu: 2.233 ± 0.056
0.6HisMet: 0.6 ± 0.027
0.715HisAsn: 0.715 ± 0.024
1.273HisPro: 1.273 ± 0.039
0.85HisGln: 0.85 ± 0.027
1.032HisArg: 1.032 ± 0.03
1.259HisSer: 1.259 ± 0.032
1.183HisThr: 1.183 ± 0.031
1.459HisVal: 1.459 ± 0.037
0.272HisTrp: 0.272 ± 0.017
0.828HisTyr: 0.828 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.775IleAla: 5.775 ± 0.079
0.616IleCys: 0.616 ± 0.025
3.591IleAsp: 3.591 ± 0.054
4.37IleGlu: 4.37 ± 0.07
2.452IlePhe: 2.452 ± 0.052
5.325IleGly: 5.325 ± 0.081
1.627IleHis: 1.627 ± 0.038
4.406IleIle: 4.406 ± 0.075
3.248IleLys: 3.248 ± 0.06
6.443IleLeu: 6.443 ± 0.086
1.737IleMet: 1.737 ± 0.038
2.46IleAsn: 2.46 ± 0.052
3.274IlePro: 3.274 ± 0.06
2.755IleGln: 2.755 ± 0.051
3.745IleArg: 3.745 ± 0.061
4.804IleSer: 4.804 ± 0.071
4.154IleThr: 4.154 ± 0.056
4.99IleVal: 4.99 ± 0.066
0.699IleTrp: 0.699 ± 0.028
2.192IleTyr: 2.192 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.348LysAla: 4.348 ± 0.06
0.26LysCys: 0.26 ± 0.016
3.207LysAsp: 3.207 ± 0.066
4.376LysGlu: 4.376 ± 0.074
1.719LysPhe: 1.719 ± 0.037
3.862LysGly: 3.862 ± 0.052
1.083LysHis: 1.083 ± 0.034
3.159LysIle: 3.159 ± 0.059
3.329LysLys: 3.329 ± 0.065
5.714LysLeu: 5.714 ± 0.072
1.612LysMet: 1.612 ± 0.035
2.12LysAsn: 2.12 ± 0.047
2.222LysPro: 2.222 ± 0.043
2.444LysGln: 2.444 ± 0.048
2.595LysArg: 2.595 ± 0.041
3.33LysSer: 3.33 ± 0.052
2.776LysThr: 2.776 ± 0.044
4.077LysVal: 4.077 ± 0.061
0.772LysTrp: 0.772 ± 0.026
1.883LysTyr: 1.883 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
8.35LeuAla: 8.35 ± 0.097
0.758LeuCys: 0.758 ± 0.026
5.14LeuAsp: 5.14 ± 0.073
6.21LeuGlu: 6.21 ± 0.079
4.189LeuPhe: 4.189 ± 0.063
7.447LeuGly: 7.447 ± 0.088
2.148LeuHis: 2.148 ± 0.043
7.047LeuIle: 7.047 ± 0.089
5.636LeuLys: 5.636 ± 0.072
10.654LeuLeu: 10.654 ± 0.15
2.603LeuMet: 2.603 ± 0.054
3.938LeuAsn: 3.938 ± 0.054
4.451LeuPro: 4.451 ± 0.071
3.911LeuGln: 3.911 ± 0.059
5.105LeuArg: 5.105 ± 0.068
7.449LeuSer: 7.449 ± 0.084
5.954LeuThr: 5.954 ± 0.074
6.487LeuVal: 6.487 ± 0.067
1.024LeuTrp: 1.024 ± 0.029
3.128LeuTyr: 3.128 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.101MetAla: 2.101 ± 0.041
0.164MetCys: 0.164 ± 0.011
1.551MetAsp: 1.551 ± 0.036
1.795MetGlu: 1.795 ± 0.036
0.948MetPhe: 0.948 ± 0.029
1.848MetGly: 1.848 ± 0.039
0.487MetHis: 0.487 ± 0.022
1.899MetIle: 1.899 ± 0.041
1.976MetLys: 1.976 ± 0.043
2.794MetLeu: 2.794 ± 0.054
0.805MetMet: 0.805 ± 0.031
1.553MetAsn: 1.553 ± 0.036
1.071MetPro: 1.071 ± 0.031
0.95MetGln: 0.95 ± 0.027
1.225MetArg: 1.225 ± 0.03
1.83MetSer: 1.83 ± 0.045
1.59MetThr: 1.59 ± 0.038
1.717MetVal: 1.717 ± 0.038
0.199MetTrp: 0.199 ± 0.014
0.721MetTyr: 0.721 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.651AsnAla: 2.651 ± 0.049
0.234AsnCys: 0.234 ± 0.014
1.762AsnAsp: 1.762 ± 0.04
2.446AsnGlu: 2.446 ± 0.046
1.445AsnPhe: 1.445 ± 0.034
3.024AsnGly: 3.024 ± 0.061
0.891AsnHis: 0.891 ± 0.027
2.43AsnIle: 2.43 ± 0.051
2.17AsnLys: 2.17 ± 0.045
3.68AsnLeu: 3.68 ± 0.053
1.068AsnMet: 1.068 ± 0.03
1.582AsnAsn: 1.582 ± 0.044
2.153AsnPro: 2.153 ± 0.045
1.597AsnGln: 1.597 ± 0.04
2.062AsnArg: 2.062 ± 0.037
2.182AsnSer: 2.182 ± 0.051
2.035AsnThr: 2.035 ± 0.049
2.576AsnVal: 2.576 ± 0.044
0.502AsnTrp: 0.502 ± 0.02
1.433AsnTyr: 1.433 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
3.398ProAla: 3.398 ± 0.057
0.218ProCys: 0.218 ± 0.016
2.545ProAsp: 2.545 ± 0.047
3.484ProGlu: 3.484 ± 0.05
1.776ProPhe: 1.776 ± 0.042
3.149ProGly: 3.149 ± 0.054
0.892ProHis: 0.892 ± 0.031
2.422ProIle: 2.422 ± 0.044
1.918ProLys: 1.918 ± 0.04
3.919ProLeu: 3.919 ± 0.07
0.882ProMet: 0.882 ± 0.027
1.566ProAsn: 1.566 ± 0.036
1.156ProPro: 1.156 ± 0.033
1.422ProGln: 1.422 ± 0.034
1.446ProArg: 1.446 ± 0.035
2.686ProSer: 2.686 ± 0.065
1.881ProThr: 1.881 ± 0.047
3.418ProVal: 3.418 ± 0.048
0.484ProTrp: 0.484 ± 0.022
1.506ProTyr: 1.506 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.366GlnAla: 3.366 ± 0.052
0.21GlnCys: 0.21 ± 0.013
1.877GlnAsp: 1.877 ± 0.037
2.94GlnGlu: 2.94 ± 0.053
1.416GlnPhe: 1.416 ± 0.035
2.881GlnGly: 2.881 ± 0.052
0.813GlnHis: 0.813 ± 0.027
2.818GlnIle: 2.818 ± 0.047
1.993GlnLys: 1.993 ± 0.043
4.221GlnLeu: 4.221 ± 0.064
1.175GlnMet: 1.175 ± 0.033
1.392GlnAsn: 1.392 ± 0.035
1.506GlnPro: 1.506 ± 0.035
1.885GlnGln: 1.885 ± 0.047
1.9GlnArg: 1.9 ± 0.047
2.403GlnSer: 2.403 ± 0.051
1.95GlnThr: 1.95 ± 0.039
2.786GlnVal: 2.786 ± 0.052
0.466GlnTrp: 0.466 ± 0.019
1.314GlnTyr: 1.314 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.298ArgAla: 3.298 ± 0.058
0.315ArgCys: 0.315 ± 0.019
2.429ArgAsp: 2.429 ± 0.047
3.743ArgGlu: 3.743 ± 0.066
1.964ArgPhe: 1.964 ± 0.04
3.07ArgGly: 3.07 ± 0.05
1.063ArgHis: 1.063 ± 0.037
3.784ArgIle: 3.784 ± 0.064
2.995ArgLys: 2.995 ± 0.051
5.084ArgLeu: 5.084 ± 0.079
1.529ArgMet: 1.529 ± 0.038
1.957ArgAsn: 1.957 ± 0.039
1.788ArgPro: 1.788 ± 0.044
2.091ArgGln: 2.091 ± 0.044
2.923ArgArg: 2.923 ± 0.054
3.273ArgSer: 3.273 ± 0.055
2.792ArgThr: 2.792 ± 0.049
3.187ArgVal: 3.187 ± 0.056
0.594ArgTrp: 0.594 ± 0.023
1.788ArgTyr: 1.788 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.167SerAla: 5.167 ± 0.076
0.408SerCys: 0.408 ± 0.022
3.147SerAsp: 3.147 ± 0.054
4.027SerGlu: 4.027 ± 0.059
2.902SerPhe: 2.902 ± 0.049
5.729SerGly: 5.729 ± 0.085
1.291SerHis: 1.291 ± 0.032
4.513SerIle: 4.513 ± 0.072
3.559SerLys: 3.559 ± 0.061
6.846SerLeu: 6.846 ± 0.082
1.827SerMet: 1.827 ± 0.039
2.326SerAsn: 2.326 ± 0.046
2.599SerPro: 2.599 ± 0.048
2.196SerGln: 2.196 ± 0.048
3.335SerArg: 3.335 ± 0.059
5.125SerSer: 5.125 ± 0.085
3.454SerThr: 3.454 ± 0.057
4.57SerVal: 4.57 ± 0.074
0.836SerTrp: 0.836 ± 0.032
2.273SerTyr: 2.273 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.675ThrAla: 4.675 ± 0.078
0.309ThrCys: 0.309 ± 0.021
2.859ThrAsp: 2.859 ± 0.052
3.397ThrGlu: 3.397 ± 0.055
2.251ThrPhe: 2.251 ± 0.043
5.069ThrGly: 5.069 ± 0.187
1.046ThrHis: 1.046 ± 0.026
3.558ThrIle: 3.558 ± 0.052
2.637ThrLys: 2.637 ± 0.049
5.714ThrLeu: 5.714 ± 0.067
1.217ThrMet: 1.217 ± 0.029
1.914ThrAsn: 1.914 ± 0.047
2.602ThrPro: 2.602 ± 0.059
1.7ThrGln: 1.7 ± 0.039
2.4ThrArg: 2.4 ± 0.039
3.576ThrSer: 3.576 ± 0.063
2.974ThrThr: 2.974 ± 0.061
4.345ThrVal: 4.345 ± 0.067
0.641ThrTrp: 0.641 ± 0.022
1.804ThrTyr: 1.804 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
4.949ValAla: 4.949 ± 0.064
0.59ValCys: 0.59 ± 0.021
3.581ValAsp: 3.581 ± 0.054
4.213ValGlu: 4.213 ± 0.066
2.802ValPhe: 2.802 ± 0.045
4.578ValGly: 4.578 ± 0.066
1.55ValHis: 1.55 ± 0.038
5.437ValIle: 5.437 ± 0.077
4.074ValLys: 4.074 ± 0.065
7.476ValLeu: 7.476 ± 0.084
1.969ValMet: 1.969 ± 0.043
3.01ValAsn: 3.01 ± 0.052
3.014ValPro: 3.014 ± 0.044
2.81ValGln: 2.81 ± 0.055
3.341ValArg: 3.341 ± 0.063
4.919ValSer: 4.919 ± 0.071
4.598ValThr: 4.598 ± 0.08
5.058ValVal: 5.058 ± 0.073
0.756ValTrp: 0.756 ± 0.025
2.32ValTyr: 2.32 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.806TrpAla: 0.806 ± 0.026
0.08TrpCys: 0.08 ± 0.008
0.621TrpAsp: 0.621 ± 0.027
0.755TrpGlu: 0.755 ± 0.028
0.504TrpPhe: 0.504 ± 0.023
0.766TrpGly: 0.766 ± 0.026
0.213TrpHis: 0.213 ± 0.013
0.959TrpIle: 0.959 ± 0.027
0.697TrpLys: 0.697 ± 0.028
1.302TrpLeu: 1.302 ± 0.041
0.388TrpMet: 0.388 ± 0.02
0.652TrpAsn: 0.652 ± 0.023
0.307TrpPro: 0.307 ± 0.019
0.421TrpGln: 0.421 ± 0.02
0.554TrpArg: 0.554 ± 0.022
0.767TrpSer: 0.767 ± 0.028
0.642TrpThr: 0.642 ± 0.024
0.794TrpVal: 0.794 ± 0.025
0.171TrpTrp: 0.171 ± 0.012
0.397TrpTyr: 0.397 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.42TyrAla: 2.42 ± 0.05
0.31TyrCys: 0.31 ± 0.015
1.786TyrAsp: 1.786 ± 0.043
2.274TyrGlu: 2.274 ± 0.051
1.515TyrPhe: 1.515 ± 0.038
2.648TyrGly: 2.648 ± 0.054
0.797TyrHis: 0.797 ± 0.027
2.067TyrIle: 2.067 ± 0.038
1.698TyrLys: 1.698 ± 0.041
3.437TyrLeu: 3.437 ± 0.058
0.837TyrMet: 0.837 ± 0.028
1.381TyrAsn: 1.381 ± 0.031
1.546TyrPro: 1.546 ± 0.039
1.354TyrGln: 1.354 ± 0.033
1.974TyrArg: 1.974 ± 0.044
2.175TyrSer: 2.175 ± 0.047
1.957TyrThr: 1.957 ± 0.041
2.265TyrVal: 2.265 ± 0.046
0.437TyrTrp: 0.437 ± 0.022
1.338TyrTyr: 1.338 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.001XaaCys: 0.001 ± 0.001
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.001
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4013 proteins (1259114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski