Amino acid dipepetide frequency for Gordonia phage BaxterFox

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.344AlaAla: 18.344 ± 1.947
0.92AlaCys: 0.92 ± 0.251
9.316AlaAsp: 9.316 ± 0.565
8.453AlaGlu: 8.453 ± 0.751
2.76AlaPhe: 2.76 ± 0.454
9.316AlaGly: 9.316 ± 0.671
2.588AlaHis: 2.588 ± 0.44
5.463AlaIle: 5.463 ± 0.469
4.888AlaLys: 4.888 ± 0.629
8.511AlaLeu: 8.511 ± 0.607
3.623AlaMet: 3.623 ± 0.554
3.335AlaAsn: 3.335 ± 0.444
5.578AlaPro: 5.578 ± 0.656
4.14AlaGln: 4.14 ± 0.762
7.763AlaArg: 7.763 ± 0.583
6.843AlaSer: 6.843 ± 0.996
8.281AlaThr: 8.281 ± 1.123
8.741AlaVal: 8.741 ± 0.785
1.898AlaTrp: 1.898 ± 0.367
2.013AlaTyr: 2.013 ± 0.285
0.0AlaXaa: 0.0 ± 0.0
Cys
0.92CysAla: 0.92 ± 0.318
0.23CysCys: 0.23 ± 0.141
0.69CysAsp: 0.69 ± 0.253
0.633CysGlu: 0.633 ± 0.193
0.23CysPhe: 0.23 ± 0.115
0.863CysGly: 0.863 ± 0.264
0.058CysHis: 0.058 ± 0.062
0.173CysIle: 0.173 ± 0.086
0.173CysLys: 0.173 ± 0.107
0.46CysLeu: 0.46 ± 0.164
0.115CysMet: 0.115 ± 0.067
0.518CysAsn: 0.518 ± 0.186
0.46CysPro: 0.46 ± 0.225
0.23CysGln: 0.23 ± 0.156
0.748CysArg: 0.748 ± 0.206
0.345CysSer: 0.345 ± 0.173
0.46CysThr: 0.46 ± 0.169
0.575CysVal: 0.575 ± 0.182
0.403CysTrp: 0.403 ± 0.164
0.173CysTyr: 0.173 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
7.706AspAla: 7.706 ± 0.808
0.633AspCys: 0.633 ± 0.271
5.923AspAsp: 5.923 ± 0.862
5.233AspGlu: 5.233 ± 0.675
1.955AspPhe: 1.955 ± 0.427
5.52AspGly: 5.52 ± 0.722
1.84AspHis: 1.84 ± 0.382
2.473AspIle: 2.473 ± 0.427
1.725AspLys: 1.725 ± 0.287
7.418AspLeu: 7.418 ± 0.634
1.208AspMet: 1.208 ± 0.33
2.415AspAsn: 2.415 ± 0.405
4.945AspPro: 4.945 ± 0.569
2.07AspGln: 2.07 ± 0.331
5.348AspArg: 5.348 ± 0.715
2.933AspSer: 2.933 ± 0.549
3.853AspThr: 3.853 ± 0.572
4.888AspVal: 4.888 ± 0.486
1.38AspTrp: 1.38 ± 0.295
1.265AspTyr: 1.265 ± 0.285
0.0AspXaa: 0.0 ± 0.0
Glu
7.476GluAla: 7.476 ± 0.723
0.92GluCys: 0.92 ± 0.286
3.45GluAsp: 3.45 ± 0.466
2.99GluGlu: 2.99 ± 0.505
2.53GluPhe: 2.53 ± 0.384
3.22GluGly: 3.22 ± 0.41
1.323GluHis: 1.323 ± 0.256
3.68GluIle: 3.68 ± 0.455
2.185GluLys: 2.185 ± 0.386
5.463GluLeu: 5.463 ± 0.707
0.863GluMet: 0.863 ± 0.242
1.438GluAsn: 1.438 ± 0.312
3.105GluPro: 3.105 ± 0.445
2.76GluGln: 2.76 ± 0.415
4.773GluArg: 4.773 ± 0.672
3.335GluSer: 3.335 ± 0.426
3.68GluThr: 3.68 ± 0.556
4.313GluVal: 4.313 ± 0.564
1.495GluTrp: 1.495 ± 0.271
1.15GluTyr: 1.15 ± 0.232
0.0GluXaa: 0.0 ± 0.0
Phe
2.53PheAla: 2.53 ± 0.423
0.173PheCys: 0.173 ± 0.105
2.473PheAsp: 2.473 ± 0.451
1.84PheGlu: 1.84 ± 0.286
0.46PhePhe: 0.46 ± 0.145
2.473PheGly: 2.473 ± 0.352
0.518PheHis: 0.518 ± 0.184
1.035PheIle: 1.035 ± 0.289
0.805PheLys: 0.805 ± 0.236
1.265PheLeu: 1.265 ± 0.323
0.518PheMet: 0.518 ± 0.154
1.035PheAsn: 1.035 ± 0.21
1.208PhePro: 1.208 ± 0.252
0.518PheGln: 0.518 ± 0.166
1.725PheArg: 1.725 ± 0.362
1.725PheSer: 1.725 ± 0.292
1.84PheThr: 1.84 ± 0.324
1.955PheVal: 1.955 ± 0.357
1.035PheTrp: 1.035 ± 0.202
0.518PheTyr: 0.518 ± 0.179
0.0PheXaa: 0.0 ± 0.0
Gly
7.476GlyAla: 7.476 ± 0.735
0.518GlyCys: 0.518 ± 0.259
6.153GlyAsp: 6.153 ± 0.52
4.428GlyGlu: 4.428 ± 0.513
2.3GlyPhe: 2.3 ± 0.288
8.108GlyGly: 8.108 ± 1.151
1.323GlyHis: 1.323 ± 0.344
3.278GlyIle: 3.278 ± 0.419
3.68GlyLys: 3.68 ± 0.508
6.095GlyLeu: 6.095 ± 0.646
1.898GlyMet: 1.898 ± 0.307
3.393GlyAsn: 3.393 ± 0.462
3.795GlyPro: 3.795 ± 0.518
3.048GlyGln: 3.048 ± 0.452
6.555GlyArg: 6.555 ± 0.746
5.175GlySer: 5.175 ± 0.782
6.44GlyThr: 6.44 ± 1.012
5.693GlyVal: 5.693 ± 0.577
1.438GlyTrp: 1.438 ± 0.367
1.783GlyTyr: 1.783 ± 0.31
0.0GlyXaa: 0.0 ± 0.0
His
2.185HisAla: 2.185 ± 0.301
0.115HisCys: 0.115 ± 0.089
1.725HisAsp: 1.725 ± 0.377
1.323HisGlu: 1.323 ± 0.313
0.633HisPhe: 0.633 ± 0.168
1.38HisGly: 1.38 ± 0.283
0.748HisHis: 0.748 ± 0.202
0.863HisIle: 0.863 ± 0.261
0.345HisLys: 0.345 ± 0.2
1.898HisLeu: 1.898 ± 0.412
0.288HisMet: 0.288 ± 0.141
0.518HisAsn: 0.518 ± 0.166
1.553HisPro: 1.553 ± 0.382
1.035HisGln: 1.035 ± 0.235
1.725HisArg: 1.725 ± 0.353
1.265HisSer: 1.265 ± 0.265
1.38HisThr: 1.38 ± 0.279
0.978HisVal: 0.978 ± 0.272
0.575HisTrp: 0.575 ± 0.196
0.575HisTyr: 0.575 ± 0.192
0.0HisXaa: 0.0 ± 0.0
Ile
5.578IleAla: 5.578 ± 0.481
0.23IleCys: 0.23 ± 0.117
4.6IleAsp: 4.6 ± 0.558
3.91IleGlu: 3.91 ± 0.467
0.69IlePhe: 0.69 ± 0.156
4.025IleGly: 4.025 ± 0.533
1.093IleHis: 1.093 ± 0.252
1.035IleIle: 1.035 ± 0.265
1.15IleLys: 1.15 ± 0.228
2.185IleLeu: 2.185 ± 0.434
0.518IleMet: 0.518 ± 0.17
1.15IleAsn: 1.15 ± 0.23
2.818IlePro: 2.818 ± 0.366
1.84IleGln: 1.84 ± 0.306
3.623IleArg: 3.623 ± 0.46
2.3IleSer: 2.3 ± 0.329
3.105IleThr: 3.105 ± 0.539
3.048IleVal: 3.048 ± 0.469
0.288IleTrp: 0.288 ± 0.134
1.265IleTyr: 1.265 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
4.6LysAla: 4.6 ± 0.9
0.173LysCys: 0.173 ± 0.112
1.323LysAsp: 1.323 ± 0.315
1.38LysGlu: 1.38 ± 0.357
1.035LysPhe: 1.035 ± 0.259
2.76LysGly: 2.76 ± 0.415
0.633LysHis: 0.633 ± 0.175
2.013LysIle: 2.013 ± 0.349
1.38LysLys: 1.38 ± 0.34
2.645LysLeu: 2.645 ± 0.489
0.575LysMet: 0.575 ± 0.22
0.978LysAsn: 0.978 ± 0.208
2.07LysPro: 2.07 ± 0.365
1.265LysGln: 1.265 ± 0.338
2.703LysArg: 2.703 ± 0.44
2.128LysSer: 2.128 ± 0.386
2.07LysThr: 2.07 ± 0.337
2.358LysVal: 2.358 ± 0.347
0.748LysTrp: 0.748 ± 0.213
0.748LysTyr: 0.748 ± 0.209
0.0LysXaa: 0.0 ± 0.0
Leu
10.236LeuAla: 10.236 ± 0.803
0.863LeuCys: 0.863 ± 0.298
5.578LeuAsp: 5.578 ± 0.526
4.083LeuGlu: 4.083 ± 0.545
2.358LeuPhe: 2.358 ± 0.493
5.808LeuGly: 5.808 ± 0.505
1.15LeuHis: 1.15 ± 0.329
3.45LeuIle: 3.45 ± 0.48
2.128LeuLys: 2.128 ± 0.35
5.06LeuLeu: 5.06 ± 0.643
1.61LeuMet: 1.61 ± 0.303
2.473LeuAsn: 2.473 ± 0.428
3.565LeuPro: 3.565 ± 0.432
2.588LeuGln: 2.588 ± 0.331
5.75LeuArg: 5.75 ± 0.667
4.14LeuSer: 4.14 ± 0.464
4.428LeuThr: 4.428 ± 0.543
5.923LeuVal: 5.923 ± 0.85
1.38LeuTrp: 1.38 ± 0.279
1.208LeuTyr: 1.208 ± 0.314
0.0LeuXaa: 0.0 ± 0.0
Met
2.99MetAla: 2.99 ± 0.493
0.288MetCys: 0.288 ± 0.132
0.403MetAsp: 0.403 ± 0.17
0.575MetGlu: 0.575 ± 0.186
0.173MetPhe: 0.173 ± 0.109
1.438MetGly: 1.438 ± 0.364
0.575MetHis: 0.575 ± 0.179
0.633MetIle: 0.633 ± 0.175
1.093MetLys: 1.093 ± 0.263
1.035MetLeu: 1.035 ± 0.27
0.69MetMet: 0.69 ± 0.227
0.748MetAsn: 0.748 ± 0.26
1.093MetPro: 1.093 ± 0.25
0.69MetGln: 0.69 ± 0.185
1.955MetArg: 1.955 ± 0.433
1.668MetSer: 1.668 ± 0.356
2.76MetThr: 2.76 ± 0.408
1.265MetVal: 1.265 ± 0.28
0.403MetTrp: 0.403 ± 0.211
0.288MetTyr: 0.288 ± 0.132
0.0MetXaa: 0.0 ± 0.0
Asn
2.99AsnAla: 2.99 ± 0.367
0.23AsnCys: 0.23 ± 0.118
1.725AsnAsp: 1.725 ± 0.326
1.38AsnGlu: 1.38 ± 0.313
0.345AsnPhe: 0.345 ± 0.163
3.278AsnGly: 3.278 ± 0.446
0.978AsnHis: 0.978 ± 0.305
1.265AsnIle: 1.265 ± 0.264
1.035AsnLys: 1.035 ± 0.251
1.898AsnLeu: 1.898 ± 0.367
0.518AsnMet: 0.518 ± 0.133
0.69AsnAsn: 0.69 ± 0.21
2.3AsnPro: 2.3 ± 0.325
1.15AsnGln: 1.15 ± 0.234
2.703AsnArg: 2.703 ± 0.444
2.013AsnSer: 2.013 ± 0.301
2.473AsnThr: 2.473 ± 0.491
2.185AsnVal: 2.185 ± 0.34
0.69AsnTrp: 0.69 ± 0.176
0.575AsnTyr: 0.575 ± 0.186
0.0AsnXaa: 0.0 ± 0.0
Pro
6.44ProAla: 6.44 ± 0.572
0.518ProCys: 0.518 ± 0.192
4.773ProAsp: 4.773 ± 0.852
4.485ProGlu: 4.485 ± 0.63
1.15ProPhe: 1.15 ± 0.311
5.405ProGly: 5.405 ± 0.564
0.748ProHis: 0.748 ± 0.245
1.898ProIle: 1.898 ± 0.324
1.725ProLys: 1.725 ± 0.367
2.818ProLeu: 2.818 ± 0.339
1.265ProMet: 1.265 ± 0.263
1.898ProAsn: 1.898 ± 0.294
2.875ProPro: 2.875 ± 0.5
1.668ProGln: 1.668 ± 0.376
3.91ProArg: 3.91 ± 0.62
2.99ProSer: 2.99 ± 0.33
4.083ProThr: 4.083 ± 0.518
4.37ProVal: 4.37 ± 0.418
1.668ProTrp: 1.668 ± 0.331
0.978ProTyr: 0.978 ± 0.243
0.0ProXaa: 0.0 ± 0.0
Gln
4.485GlnAla: 4.485 ± 0.506
0.23GlnCys: 0.23 ± 0.117
1.208GlnAsp: 1.208 ± 0.259
1.495GlnGlu: 1.495 ± 0.348
1.093GlnPhe: 1.093 ± 0.243
2.818GlnGly: 2.818 ± 0.648
1.035GlnHis: 1.035 ± 0.21
2.473GlnIle: 2.473 ± 0.406
0.92GlnLys: 0.92 ± 0.336
3.508GlnLeu: 3.508 ± 0.555
0.978GlnMet: 0.978 ± 0.235
0.92GlnAsn: 0.92 ± 0.228
1.725GlnPro: 1.725 ± 0.273
1.438GlnGln: 1.438 ± 0.314
3.278GlnArg: 3.278 ± 0.602
1.61GlnSer: 1.61 ± 0.427
2.128GlnThr: 2.128 ± 0.356
2.588GlnVal: 2.588 ± 0.344
1.093GlnTrp: 1.093 ± 0.222
0.92GlnTyr: 0.92 ± 0.206
0.0GlnXaa: 0.0 ± 0.0
Arg
8.453ArgAla: 8.453 ± 0.718
0.69ArgCys: 0.69 ± 0.237
4.37ArgAsp: 4.37 ± 0.518
4.888ArgGlu: 4.888 ± 0.623
2.013ArgPhe: 2.013 ± 0.311
5.06ArgGly: 5.06 ± 0.654
1.495ArgHis: 1.495 ± 0.358
3.968ArgIle: 3.968 ± 0.568
2.933ArgLys: 2.933 ± 0.416
6.325ArgLeu: 6.325 ± 0.725
2.07ArgMet: 2.07 ± 0.422
2.3ArgAsn: 2.3 ± 0.384
4.428ArgPro: 4.428 ± 0.722
2.933ArgGln: 2.933 ± 0.449
5.923ArgArg: 5.923 ± 0.809
3.738ArgSer: 3.738 ± 0.413
5.52ArgThr: 5.52 ± 0.542
5.348ArgVal: 5.348 ± 0.587
1.553ArgTrp: 1.553 ± 0.341
2.128ArgTyr: 2.128 ± 0.375
0.0ArgXaa: 0.0 ± 0.0
Ser
6.843SerAla: 6.843 ± 0.855
0.173SerCys: 0.173 ± 0.1
3.565SerAsp: 3.565 ± 0.532
3.105SerGlu: 3.105 ± 0.359
1.323SerPhe: 1.323 ± 0.267
6.153SerGly: 6.153 ± 0.658
0.92SerHis: 0.92 ± 0.211
2.473SerIle: 2.473 ± 0.39
1.495SerLys: 1.495 ± 0.259
3.45SerLeu: 3.45 ± 0.47
1.323SerMet: 1.323 ± 0.442
2.07SerAsn: 2.07 ± 0.346
2.53SerPro: 2.53 ± 0.413
2.473SerGln: 2.473 ± 0.455
3.335SerArg: 3.335 ± 0.426
2.3SerSer: 2.3 ± 0.366
3.853SerThr: 3.853 ± 0.529
4.715SerVal: 4.715 ± 0.489
1.323SerTrp: 1.323 ± 0.317
1.323SerTyr: 1.323 ± 0.308
0.0SerXaa: 0.0 ± 0.0
Thr
11.041ThrAla: 11.041 ± 1.316
0.345ThrCys: 0.345 ± 0.127
4.888ThrAsp: 4.888 ± 0.576
3.278ThrGlu: 3.278 ± 0.484
1.438ThrPhe: 1.438 ± 0.26
6.153ThrGly: 6.153 ± 0.768
1.438ThrHis: 1.438 ± 0.266
3.623ThrIle: 3.623 ± 0.446
2.013ThrLys: 2.013 ± 0.31
4.715ThrLeu: 4.715 ± 0.555
1.265ThrMet: 1.265 ± 0.328
1.553ThrAsn: 1.553 ± 0.282
4.37ThrPro: 4.37 ± 0.463
1.61ThrGln: 1.61 ± 0.296
4.773ThrArg: 4.773 ± 0.52
4.255ThrSer: 4.255 ± 0.689
5.865ThrThr: 5.865 ± 0.702
5.923ThrVal: 5.923 ± 0.519
1.38ThrTrp: 1.38 ± 0.313
0.978ThrTyr: 0.978 ± 0.27
0.0ThrXaa: 0.0 ± 0.0
Val
8.166ValAla: 8.166 ± 0.905
0.518ValCys: 0.518 ± 0.182
6.153ValAsp: 6.153 ± 0.678
5.003ValGlu: 5.003 ± 0.511
2.07ValPhe: 2.07 ± 0.31
5.118ValGly: 5.118 ± 0.633
1.668ValHis: 1.668 ± 0.329
3.68ValIle: 3.68 ± 0.45
2.358ValLys: 2.358 ± 0.404
5.808ValLeu: 5.808 ± 0.747
0.92ValMet: 0.92 ± 0.216
2.243ValAsn: 2.243 ± 0.396
4.83ValPro: 4.83 ± 0.518
2.76ValGln: 2.76 ± 0.632
4.945ValArg: 4.945 ± 0.538
3.508ValSer: 3.508 ± 0.503
5.865ValThr: 5.865 ± 0.618
4.485ValVal: 4.485 ± 0.622
0.633ValTrp: 0.633 ± 0.18
1.15ValTyr: 1.15 ± 0.224
0.0ValXaa: 0.0 ± 0.0
Trp
1.668TrpAla: 1.668 ± 0.288
0.345TrpCys: 0.345 ± 0.184
1.265TrpAsp: 1.265 ± 0.285
1.093TrpGlu: 1.093 ± 0.266
0.575TrpPhe: 0.575 ± 0.226
1.553TrpGly: 1.553 ± 0.286
0.403TrpHis: 0.403 ± 0.182
0.46TrpIle: 0.46 ± 0.176
0.748TrpLys: 0.748 ± 0.219
1.61TrpLeu: 1.61 ± 0.303
0.288TrpMet: 0.288 ± 0.148
0.345TrpAsn: 0.345 ± 0.138
1.208TrpPro: 1.208 ± 0.258
0.863TrpGln: 0.863 ± 0.258
2.703TrpArg: 2.703 ± 0.501
0.863TrpSer: 0.863 ± 0.239
1.783TrpThr: 1.783 ± 0.351
1.15TrpVal: 1.15 ± 0.239
0.575TrpTrp: 0.575 ± 0.19
0.69TrpTyr: 0.69 ± 0.186
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.645TyrAla: 2.645 ± 0.411
0.345TyrCys: 0.345 ± 0.146
1.15TyrAsp: 1.15 ± 0.269
0.575TyrGlu: 0.575 ± 0.246
0.518TyrPhe: 0.518 ± 0.159
2.128TyrGly: 2.128 ± 0.334
0.575TyrHis: 0.575 ± 0.236
0.518TyrIle: 0.518 ± 0.159
0.805TyrLys: 0.805 ± 0.22
1.61TyrLeu: 1.61 ± 0.431
0.173TyrMet: 0.173 ± 0.106
0.403TyrAsn: 0.403 ± 0.129
1.208TyrPro: 1.208 ± 0.319
0.92TyrGln: 0.92 ± 0.209
1.898TyrArg: 1.898 ± 0.423
1.61TyrSer: 1.61 ± 0.281
1.035TyrThr: 1.035 ± 0.231
1.38TyrVal: 1.38 ± 0.321
0.23TyrTrp: 0.23 ± 0.102
0.403TyrTyr: 0.403 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 86 proteins (17391 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski