Amino acid dipepetide frequency for Candidatus Baumannia cicadellinicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.51AlaAla: 5.51 ± 0.197
0.918AlaCys: 0.918 ± 0.074
2.817AlaAsp: 2.817 ± 0.139
3.758AlaGlu: 3.758 ± 0.165
2.158AlaPhe: 2.158 ± 0.122
4.051AlaGly: 4.051 ± 0.171
1.155AlaHis: 1.155 ± 0.097
6.654AlaIle: 6.654 ± 0.21
4.315AlaLys: 4.315 ± 0.157
7.358AlaLeu: 7.358 ± 0.231
1.91AlaMet: 1.91 ± 0.105
3.797AlaAsn: 3.797 ± 0.143
1.775AlaPro: 1.775 ± 0.107
2.513AlaGln: 2.513 ± 0.123
3.33AlaArg: 3.33 ± 0.16
4.023AlaSer: 4.023 ± 0.155
3.425AlaThr: 3.425 ± 0.157
4.051AlaVal: 4.051 ± 0.157
0.597AlaTrp: 0.597 ± 0.062
2.158AlaTyr: 2.158 ± 0.11
0.0AlaXaa: 0.0 ± 0.0
Cys
0.862CysAla: 0.862 ± 0.074
0.265CysCys: 0.265 ± 0.041
0.687CysAsp: 0.687 ± 0.06
0.62CysGlu: 0.62 ± 0.067
0.575CysPhe: 0.575 ± 0.049
1.087CysGly: 1.087 ± 0.075
0.383CysHis: 0.383 ± 0.053
1.211CysIle: 1.211 ± 0.077
0.732CysLys: 0.732 ± 0.069
1.211CysLeu: 1.211 ± 0.094
0.27CysMet: 0.27 ± 0.037
0.89CysAsn: 0.89 ± 0.071
0.4CysPro: 0.4 ± 0.051
0.473CysGln: 0.473 ± 0.055
0.625CysArg: 0.625 ± 0.061
0.963CysSer: 0.963 ± 0.076
0.67CysThr: 0.67 ± 0.065
0.67CysVal: 0.67 ± 0.058
0.197CysTrp: 0.197 ± 0.034
0.569CysTyr: 0.569 ± 0.056
0.0CysXaa: 0.0 ± 0.0
Asp
2.603AspAla: 2.603 ± 0.125
0.518AspCys: 0.518 ± 0.057
1.899AspAsp: 1.899 ± 0.114
2.203AspGlu: 2.203 ± 0.101
1.735AspPhe: 1.735 ± 0.09
2.569AspGly: 2.569 ± 0.121
1.031AspHis: 1.031 ± 0.079
5.375AspIle: 5.375 ± 0.2
3.392AspLys: 3.392 ± 0.151
4.152AspLeu: 4.152 ± 0.146
1.132AspMet: 1.132 ± 0.088
3.172AspAsn: 3.172 ± 0.142
1.493AspPro: 1.493 ± 0.089
1.538AspGln: 1.538 ± 0.091
2.034AspArg: 2.034 ± 0.11
2.507AspSer: 2.507 ± 0.12
2.349AspThr: 2.349 ± 0.112
2.738AspVal: 2.738 ± 0.136
0.53AspTrp: 0.53 ± 0.056
1.983AspTyr: 1.983 ± 0.103
0.0AspXaa: 0.0 ± 0.0
Glu
3.769GluAla: 3.769 ± 0.158
0.535GluCys: 0.535 ± 0.053
1.921GluAsp: 1.921 ± 0.124
3.223GluGlu: 3.223 ± 0.177
1.718GluPhe: 1.718 ± 0.099
2.58GluGly: 2.58 ± 0.139
1.206GluHis: 1.206 ± 0.103
4.958GluIle: 4.958 ± 0.186
3.763GluLys: 3.763 ± 0.133
6.006GluLeu: 6.006 ± 0.189
1.234GluMet: 1.234 ± 0.088
2.479GluAsn: 2.479 ± 0.122
1.414GluPro: 1.414 ± 0.097
2.58GluGln: 2.58 ± 0.133
2.89GluArg: 2.89 ± 0.139
2.501GluSer: 2.501 ± 0.126
2.315GluThr: 2.315 ± 0.117
3.797GluVal: 3.797 ± 0.168
0.321GluTrp: 0.321 ± 0.042
1.752GluTyr: 1.752 ± 0.107
0.0GluXaa: 0.0 ± 0.0
Phe
2.299PheAla: 2.299 ± 0.116
0.721PheCys: 0.721 ± 0.059
2.056PheAsp: 2.056 ± 0.11
1.454PheGlu: 1.454 ± 0.096
1.994PhePhe: 1.994 ± 0.109
2.654PheGly: 2.654 ± 0.132
0.839PheHis: 0.839 ± 0.075
4.383PheIle: 4.383 ± 0.195
1.825PheLys: 1.825 ± 0.098
3.341PheLeu: 3.341 ± 0.149
1.003PheMet: 1.003 ± 0.085
2.654PheAsn: 2.654 ± 0.137
1.363PhePro: 1.363 ± 0.102
0.98PheGln: 0.98 ± 0.075
1.577PheArg: 1.577 ± 0.103
3.318PheSer: 3.318 ± 0.136
2.124PheThr: 2.124 ± 0.113
1.741PheVal: 1.741 ± 0.095
0.361PheTrp: 0.361 ± 0.046
1.752PheTyr: 1.752 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
3.651GlyAla: 3.651 ± 0.177
1.008GlyCys: 1.008 ± 0.081
2.721GlyAsp: 2.721 ± 0.135
3.155GlyGlu: 3.155 ± 0.126
2.439GlyPhe: 2.439 ± 0.137
3.882GlyGly: 3.882 ± 0.178
1.572GlyHis: 1.572 ± 0.09
7.093GlyIle: 7.093 ± 0.226
4.456GlyLys: 4.456 ± 0.146
5.786GlyLeu: 5.786 ± 0.195
1.577GlyMet: 1.577 ± 0.1
2.783GlyAsn: 2.783 ± 0.131
1.69GlyPro: 1.69 ± 0.111
2.068GlyGln: 2.068 ± 0.1
2.975GlyArg: 2.975 ± 0.146
3.408GlySer: 3.408 ± 0.145
3.273GlyThr: 3.273 ± 0.134
3.848GlyVal: 3.848 ± 0.16
0.755GlyTrp: 0.755 ± 0.062
2.287GlyTyr: 2.287 ± 0.113
0.0GlyXaa: 0.0 ± 0.0
His
1.279HisAla: 1.279 ± 0.091
0.372HisCys: 0.372 ± 0.046
0.862HisAsp: 0.862 ± 0.062
0.811HisGlu: 0.811 ± 0.075
0.794HisPhe: 0.794 ± 0.069
1.47HisGly: 1.47 ± 0.08
0.569HisHis: 0.569 ± 0.065
2.118HisIle: 2.118 ± 0.109
1.358HisLys: 1.358 ± 0.081
2.039HisLeu: 2.039 ± 0.109
0.592HisMet: 0.592 ± 0.055
1.69HisAsn: 1.69 ± 0.115
1.127HisPro: 1.127 ± 0.08
0.89HisGln: 0.89 ± 0.073
1.127HisArg: 1.127 ± 0.085
1.296HisSer: 1.296 ± 0.088
1.161HisThr: 1.161 ± 0.078
1.11HisVal: 1.11 ± 0.073
0.242HisTrp: 0.242 ± 0.031
0.873HisTyr: 0.873 ± 0.074
0.0HisXaa: 0.0 ± 0.0
Ile
7.51IleAla: 7.51 ± 0.221
1.363IleCys: 1.363 ± 0.091
5.746IleAsp: 5.746 ± 0.164
5.397IleGlu: 5.397 ± 0.202
4.18IlePhe: 4.18 ± 0.197
6.732IleGly: 6.732 ± 0.219
1.938IleHis: 1.938 ± 0.098
10.941IleIle: 10.941 ± 0.307
6.997IleLys: 6.997 ± 0.226
8.817IleLeu: 8.817 ± 0.247
2.315IleMet: 2.315 ± 0.122
8.13IleAsn: 8.13 ± 0.22
3.403IlePro: 3.403 ± 0.112
2.614IleGln: 2.614 ± 0.124
4.135IleArg: 4.135 ± 0.151
7.532IleSer: 7.532 ± 0.225
6.22IleThr: 6.22 ± 0.192
5.741IleVal: 5.741 ± 0.179
0.879IleTrp: 0.879 ± 0.078
3.194IleTyr: 3.194 ± 0.149
0.0IleXaa: 0.0 ± 0.0
Lys
3.662LysAla: 3.662 ± 0.169
0.659LysCys: 0.659 ± 0.078
2.496LysAsp: 2.496 ± 0.126
3.617LysGlu: 3.617 ± 0.15
2.344LysPhe: 2.344 ± 0.118
2.941LysGly: 2.941 ± 0.151
1.521LysHis: 1.521 ± 0.093
7.144LysIle: 7.144 ± 0.236
5.482LysLys: 5.482 ± 0.205
7.927LysLeu: 7.927 ± 0.222
1.707LysMet: 1.707 ± 0.105
5.2LysAsn: 5.2 ± 0.209
2.011LysPro: 2.011 ± 0.108
3.008LysGln: 3.008 ± 0.135
2.93LysArg: 2.93 ± 0.132
3.341LysSer: 3.341 ± 0.141
3.008LysThr: 3.008 ± 0.15
4.299LysVal: 4.299 ± 0.15
0.473LysTrp: 0.473 ± 0.056
2.71LysTyr: 2.71 ± 0.135
0.0LysXaa: 0.0 ± 0.0
Leu
7.966LeuAla: 7.966 ± 0.237
1.358LeuCys: 1.358 ± 0.082
4.946LeuAsp: 4.946 ± 0.174
5.33LeuGlu: 5.33 ± 0.186
3.842LeuPhe: 3.842 ± 0.151
6.186LeuGly: 6.186 ± 0.197
2.287LeuHis: 2.287 ± 0.1
9.206LeuIle: 9.206 ± 0.317
5.792LeuLys: 5.792 ± 0.173
11.285LeuLeu: 11.285 ± 0.32
2.383LeuMet: 2.383 ± 0.107
5.831LeuAsn: 5.831 ± 0.203
4.839LeuPro: 4.839 ± 0.159
3.769LeuGln: 3.769 ± 0.165
5.668LeuArg: 5.668 ± 0.201
7.172LeuSer: 7.172 ± 0.224
5.713LeuThr: 5.713 ± 0.163
6.946LeuVal: 6.946 ± 0.224
1.014LeuTrp: 1.014 ± 0.091
3.279LeuTyr: 3.279 ± 0.168
0.0LeuXaa: 0.0 ± 0.0
Met
1.685MetAla: 1.685 ± 0.1
0.208MetCys: 0.208 ± 0.034
0.89MetAsp: 0.89 ± 0.077
1.059MetGlu: 1.059 ± 0.07
0.862MetPhe: 0.862 ± 0.056
1.408MetGly: 1.408 ± 0.096
0.524MetHis: 0.524 ± 0.059
2.642MetIle: 2.642 ± 0.126
1.358MetLys: 1.358 ± 0.074
3.285MetLeu: 3.285 ± 0.141
0.913MetMet: 0.913 ± 0.091
1.431MetAsn: 1.431 ± 0.088
1.076MetPro: 1.076 ± 0.072
1.149MetGln: 1.149 ± 0.084
1.352MetArg: 1.352 ± 0.086
1.527MetSer: 1.527 ± 0.08
1.346MetThr: 1.346 ± 0.088
1.645MetVal: 1.645 ± 0.081
0.152MetTrp: 0.152 ± 0.031
0.642MetTyr: 0.642 ± 0.069
0.0MetXaa: 0.0 ± 0.0
Asn
3.369AsnAla: 3.369 ± 0.114
0.783AsnCys: 0.783 ± 0.062
2.366AsnAsp: 2.366 ± 0.135
2.992AsnGlu: 2.992 ± 0.136
3.025AsnPhe: 3.025 ± 0.149
3.099AsnGly: 3.099 ± 0.154
1.268AsnHis: 1.268 ± 0.083
8.101AsnIle: 8.101 ± 0.167
5.639AsnLys: 5.639 ± 0.221
5.887AsnLeu: 5.887 ± 0.186
1.538AsnMet: 1.538 ± 0.09
5.792AsnAsn: 5.792 ± 0.227
1.842AsnPro: 1.842 ± 0.096
2.254AsnGln: 2.254 ± 0.107
2.315AsnArg: 2.315 ± 0.11
3.904AsnSer: 3.904 ± 0.153
3.352AsnThr: 3.352 ± 0.16
2.907AsnVal: 2.907 ± 0.13
0.851AsnTrp: 0.851 ± 0.068
2.67AsnTyr: 2.67 ± 0.144
0.0AsnXaa: 0.0 ± 0.0
Pro
1.949ProAla: 1.949 ± 0.105
0.4ProCys: 0.4 ± 0.048
1.617ProAsp: 1.617 ± 0.096
2.175ProGlu: 2.175 ± 0.121
1.313ProPhe: 1.313 ± 0.08
2.27ProGly: 2.27 ± 0.121
0.715ProHis: 0.715 ± 0.062
3.656ProIle: 3.656 ± 0.151
2.034ProLys: 2.034 ± 0.104
3.639ProLeu: 3.639 ± 0.152
0.89ProMet: 0.89 ± 0.069
2.062ProAsn: 2.062 ± 0.116
1.048ProPro: 1.048 ± 0.084
1.121ProGln: 1.121 ± 0.073
1.127ProArg: 1.127 ± 0.09
2.079ProSer: 2.079 ± 0.113
1.792ProThr: 1.792 ± 0.087
2.473ProVal: 2.473 ± 0.121
0.428ProTrp: 0.428 ± 0.06
1.403ProTyr: 1.403 ± 0.091
0.0ProXaa: 0.0 ± 0.0
Gln
2.89GlnAla: 2.89 ± 0.126
0.518GlnCys: 0.518 ± 0.049
1.397GlnAsp: 1.397 ± 0.086
2.068GlnGlu: 2.068 ± 0.116
1.228GlnPhe: 1.228 ± 0.084
2.023GlnGly: 2.023 ± 0.096
1.025GlnHis: 1.025 ± 0.084
2.975GlnIle: 2.975 ± 0.115
2.383GlnLys: 2.383 ± 0.118
5.228GlnLeu: 5.228 ± 0.191
0.839GlnMet: 0.839 ± 0.063
1.42GlnAsn: 1.42 ± 0.087
1.335GlnPro: 1.335 ± 0.089
2.214GlnGln: 2.214 ± 0.121
1.859GlnArg: 1.859 ± 0.102
1.977GlnSer: 1.977 ± 0.101
1.583GlnThr: 1.583 ± 0.102
2.383GlnVal: 2.383 ± 0.106
0.451GlnTrp: 0.451 ± 0.054
1.566GlnTyr: 1.566 ± 0.106
0.0GlnXaa: 0.0 ± 0.0
Arg
2.901ArgAla: 2.901 ± 0.12
0.541ArgCys: 0.541 ± 0.058
2.079ArgAsp: 2.079 ± 0.121
2.524ArgGlu: 2.524 ± 0.13
1.989ArgPhe: 1.989 ± 0.105
2.552ArgGly: 2.552 ± 0.132
0.901ArgHis: 0.901 ± 0.065
4.856ArgIle: 4.856 ± 0.171
3.161ArgLys: 3.161 ± 0.148
4.924ArgLeu: 4.924 ± 0.177
1.335ArgMet: 1.335 ± 0.097
2.963ArgAsn: 2.963 ± 0.14
1.611ArgPro: 1.611 ± 0.088
2.039ArgGln: 2.039 ± 0.107
2.468ArgArg: 2.468 ± 0.145
2.552ArgSer: 2.552 ± 0.114
2.394ArgThr: 2.394 ± 0.118
2.637ArgVal: 2.637 ± 0.123
0.58ArgTrp: 0.58 ± 0.06
1.887ArgTyr: 1.887 ± 0.098
0.0ArgXaa: 0.0 ± 0.0
Ser
4.096SerAla: 4.096 ± 0.167
0.828SerCys: 0.828 ± 0.073
2.823SerAsp: 2.823 ± 0.118
2.986SerGlu: 2.986 ± 0.118
2.597SerPhe: 2.597 ± 0.134
4.372SerGly: 4.372 ± 0.162
1.206SerHis: 1.206 ± 0.087
6.423SerIle: 6.423 ± 0.194
4.107SerLys: 4.107 ± 0.17
6.411SerLeu: 6.411 ± 0.219
1.707SerMet: 1.707 ± 0.09
3.91SerAsn: 3.91 ± 0.161
1.831SerPro: 1.831 ± 0.111
2.158SerGln: 2.158 ± 0.126
2.614SerArg: 2.614 ± 0.142
4.237SerSer: 4.237 ± 0.163
3.206SerThr: 3.206 ± 0.15
3.38SerVal: 3.38 ± 0.14
0.687SerTrp: 0.687 ± 0.061
2.631SerTyr: 2.631 ± 0.112
0.0SerXaa: 0.0 ± 0.0
Thr
3.33ThrAla: 3.33 ± 0.148
0.732ThrCys: 0.732 ± 0.071
2.445ThrAsp: 2.445 ± 0.13
2.608ThrGlu: 2.608 ± 0.136
1.662ThrPhe: 1.662 ± 0.094
3.792ThrGly: 3.792 ± 0.145
0.986ThrHis: 0.986 ± 0.077
5.724ThrIle: 5.724 ± 0.232
3.465ThrLys: 3.465 ± 0.133
5.482ThrLeu: 5.482 ± 0.187
1.228ThrMet: 1.228 ± 0.078
3.437ThrAsn: 3.437 ± 0.137
1.932ThrPro: 1.932 ± 0.106
1.555ThrGln: 1.555 ± 0.09
2.293ThrArg: 2.293 ± 0.128
3.324ThrSer: 3.324 ± 0.135
3.268ThrThr: 3.268 ± 0.137
3.166ThrVal: 3.166 ± 0.143
0.473ThrTrp: 0.473 ± 0.049
1.634ThrTyr: 1.634 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
4.394ValAla: 4.394 ± 0.162
0.721ValCys: 0.721 ± 0.064
3.025ValAsp: 3.025 ± 0.149
3.025ValGlu: 3.025 ± 0.14
1.944ValPhe: 1.944 ± 0.108
3.69ValGly: 3.69 ± 0.167
1.228ValHis: 1.228 ± 0.078
6.101ValIle: 6.101 ± 0.189
3.673ValLys: 3.673 ± 0.155
6.304ValLeu: 6.304 ± 0.192
1.493ValMet: 1.493 ± 0.107
3.673ValAsn: 3.673 ± 0.154
2.225ValPro: 2.225 ± 0.132
1.854ValGln: 1.854 ± 0.114
3.166ValArg: 3.166 ± 0.16
3.803ValSer: 3.803 ± 0.133
3.38ValThr: 3.38 ± 0.157
4.051ValVal: 4.051 ± 0.172
0.496ValTrp: 0.496 ± 0.051
1.504ValTyr: 1.504 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.445TrpAla: 0.445 ± 0.051
0.22TrpCys: 0.22 ± 0.036
0.366TrpAsp: 0.366 ± 0.048
0.434TrpGlu: 0.434 ± 0.053
0.389TrpPhe: 0.389 ± 0.052
0.468TrpGly: 0.468 ± 0.053
0.366TrpHis: 0.366 ± 0.047
0.896TrpIle: 0.896 ± 0.078
0.473TrpLys: 0.473 ± 0.053
1.589TrpLeu: 1.589 ± 0.108
0.27TrpMet: 0.27 ± 0.041
0.468TrpAsn: 0.468 ± 0.05
0.366TrpPro: 0.366 ± 0.044
0.868TrpGln: 0.868 ± 0.082
0.58TrpArg: 0.58 ± 0.068
0.496TrpSer: 0.496 ± 0.051
0.389TrpThr: 0.389 ± 0.046
0.501TrpVal: 0.501 ± 0.049
0.113TrpTrp: 0.113 ± 0.025
0.377TrpTyr: 0.377 ± 0.054
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.101TyrAla: 2.101 ± 0.111
0.693TyrCys: 0.693 ± 0.064
1.792TyrAsp: 1.792 ± 0.115
1.527TyrGlu: 1.527 ± 0.109
1.651TyrPhe: 1.651 ± 0.095
2.603TyrGly: 2.603 ± 0.119
1.065TyrHis: 1.065 ± 0.074
3.33TyrIle: 3.33 ± 0.145
2.073TyrLys: 2.073 ± 0.107
4.141TyrLeu: 4.141 ± 0.166
0.811TyrMet: 0.811 ± 0.072
2.175TyrAsn: 2.175 ± 0.115
1.408TyrPro: 1.408 ± 0.095
1.718TyrGln: 1.718 ± 0.093
1.831TyrArg: 1.831 ± 0.102
2.248TyrSer: 2.248 ± 0.121
1.566TyrThr: 1.566 ± 0.091
1.668TyrVal: 1.668 ± 0.098
0.473TyrTrp: 0.473 ± 0.053
1.724TyrTyr: 1.724 ± 0.126
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 550 proteins (177501 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski