Amino acid dipepetide frequency for Gemella asaccharolytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.627AlaAla: 2.627 ± 0.111
0.453AlaCys: 0.453 ± 0.038
2.442AlaAsp: 2.442 ± 0.097
2.961AlaGlu: 2.961 ± 0.152
2.205AlaPhe: 2.205 ± 0.083
3.187AlaGly: 3.187 ± 0.115
0.742AlaHis: 0.742 ± 0.046
5.327AlaIle: 5.327 ± 0.134
5.945AlaLys: 5.945 ± 0.242
4.833AlaLeu: 4.833 ± 0.145
1.237AlaMet: 1.237 ± 0.064
2.859AlaAsn: 2.859 ± 0.092
1.25AlaPro: 1.25 ± 0.059
1.109AlaGln: 1.109 ± 0.066
1.713AlaArg: 1.713 ± 0.069
3.138AlaSer: 3.138 ± 0.089
2.903AlaThr: 2.903 ± 0.097
3.177AlaVal: 3.177 ± 0.102
0.263AlaTrp: 0.263 ± 0.03
1.919AlaTyr: 1.919 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.417CysAla: 0.417 ± 0.032
0.133CysCys: 0.133 ± 0.019
0.547CysAsp: 0.547 ± 0.04
0.594CysGlu: 0.594 ± 0.043
0.367CysPhe: 0.367 ± 0.032
0.786CysGly: 0.786 ± 0.048
0.164CysHis: 0.164 ± 0.023
0.667CysIle: 0.667 ± 0.042
0.815CysLys: 0.815 ± 0.055
0.693CysLeu: 0.693 ± 0.047
0.187CysMet: 0.187 ± 0.021
0.482CysAsn: 0.482 ± 0.037
0.286CysPro: 0.286 ± 0.028
0.208CysGln: 0.208 ± 0.025
0.276CysArg: 0.276 ± 0.027
0.615CysSer: 0.615 ± 0.041
0.331CysThr: 0.331 ± 0.035
0.492CysVal: 0.492 ± 0.034
0.052CysTrp: 0.052 ± 0.012
0.354CysTyr: 0.354 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.265AspAla: 2.265 ± 0.089
0.388AspCys: 0.388 ± 0.037
2.726AspAsp: 2.726 ± 0.112
4.203AspGlu: 4.203 ± 0.116
3.039AspPhe: 3.039 ± 0.098
2.945AspGly: 2.945 ± 0.13
0.516AspHis: 0.516 ± 0.038
6.249AspIle: 6.249 ± 0.163
6.265AspLys: 6.265 ± 0.198
4.52AspLeu: 4.52 ± 0.115
1.068AspMet: 1.068 ± 0.06
3.679AspAsn: 3.679 ± 0.105
1.167AspPro: 1.167 ± 0.063
0.758AspGln: 0.758 ± 0.053
1.531AspArg: 1.531 ± 0.066
2.963AspSer: 2.963 ± 0.092
2.476AspThr: 2.476 ± 0.106
3.278AspVal: 3.278 ± 0.108
0.276AspTrp: 0.276 ± 0.029
2.63AspTyr: 2.63 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
3.52GluAla: 3.52 ± 0.172
0.461GluCys: 0.461 ± 0.041
3.71GluAsp: 3.71 ± 0.11
7.197GluGlu: 7.197 ± 0.206
2.911GluPhe: 2.911 ± 0.103
3.346GluGly: 3.346 ± 0.104
0.849GluHis: 0.849 ± 0.042
8.418GluIle: 8.418 ± 0.166
11.514GluLys: 11.514 ± 0.29
6.208GluLeu: 6.208 ± 0.156
1.62GluMet: 1.62 ± 0.073
6.582GluAsn: 6.582 ± 0.139
1.127GluPro: 1.127 ± 0.059
2.002GluGln: 2.002 ± 0.092
2.239GluArg: 2.239 ± 0.099
3.205GluSer: 3.205 ± 0.113
3.052GluThr: 3.052 ± 0.113
4.788GluVal: 4.788 ± 0.124
0.411GluTrp: 0.411 ± 0.038
3.432GluTyr: 3.432 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.08PheAla: 2.08 ± 0.067
0.518PheCys: 0.518 ± 0.04
2.854PheAsp: 2.854 ± 0.091
2.718PheGlu: 2.718 ± 0.081
2.591PhePhe: 2.591 ± 0.125
2.468PheGly: 2.468 ± 0.087
0.539PheHis: 0.539 ± 0.039
4.822PheIle: 4.822 ± 0.204
4.27PheLys: 4.27 ± 0.122
5.255PheLeu: 5.255 ± 0.192
0.987PheMet: 0.987 ± 0.054
2.981PheAsn: 2.981 ± 0.103
1.109PhePro: 1.109 ± 0.055
0.935PheGln: 0.935 ± 0.051
1.146PheArg: 1.146 ± 0.053
3.953PheSer: 3.953 ± 0.124
2.403PheThr: 2.403 ± 0.087
2.591PheVal: 2.591 ± 0.1
0.253PheTrp: 0.253 ± 0.025
2.177PheTyr: 2.177 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
3.437GlyAla: 3.437 ± 0.118
0.601GlyCys: 0.601 ± 0.042
2.708GlyAsp: 2.708 ± 0.109
4.229GlyGlu: 4.229 ± 0.125
2.565GlyPhe: 2.565 ± 0.089
3.653GlyGly: 3.653 ± 0.136
0.875GlyHis: 0.875 ± 0.046
5.674GlyIle: 5.674 ± 0.15
5.546GlyLys: 5.546 ± 0.154
4.445GlyLeu: 4.445 ± 0.122
1.307GlyMet: 1.307 ± 0.067
2.802GlyAsn: 2.802 ± 0.094
0.932GlyPro: 0.932 ± 0.055
1.377GlyGln: 1.377 ± 0.064
1.87GlyArg: 1.87 ± 0.08
3.216GlySer: 3.216 ± 0.106
3.02GlyThr: 3.02 ± 0.101
3.932GlyVal: 3.932 ± 0.115
0.432GlyTrp: 0.432 ± 0.05
2.781GlyTyr: 2.781 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
0.68HisAla: 0.68 ± 0.042
0.122HisCys: 0.122 ± 0.02
0.578HisAsp: 0.578 ± 0.042
0.768HisGlu: 0.768 ± 0.05
0.635HisPhe: 0.635 ± 0.036
0.836HisGly: 0.836 ± 0.058
0.297HisHis: 0.297 ± 0.03
1.328HisIle: 1.328 ± 0.064
1.148HisLys: 1.148 ± 0.055
1.182HisLeu: 1.182 ± 0.061
0.245HisMet: 0.245 ± 0.023
0.766HisAsn: 0.766 ± 0.043
0.544HisPro: 0.544 ± 0.039
0.305HisGln: 0.305 ± 0.031
0.51HisArg: 0.51 ± 0.036
0.841HisSer: 0.841 ± 0.046
0.622HisThr: 0.622 ± 0.042
0.654HisVal: 0.654 ± 0.045
0.091HisTrp: 0.091 ± 0.015
0.615HisTyr: 0.615 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.023IleAla: 5.023 ± 0.128
0.989IleCys: 0.989 ± 0.056
5.692IleAsp: 5.692 ± 0.141
7.278IleGlu: 7.278 ± 0.164
5.551IlePhe: 5.551 ± 0.233
5.262IleGly: 5.262 ± 0.146
1.234IleHis: 1.234 ± 0.06
10.392IleIle: 10.392 ± 0.292
11.452IleLys: 11.452 ± 0.22
10.283IleLeu: 10.283 ± 0.277
2.112IleMet: 2.112 ± 0.088
6.991IleAsn: 6.991 ± 0.18
2.95IlePro: 2.95 ± 0.096
2.021IleGln: 2.021 ± 0.074
2.828IleArg: 2.828 ± 0.091
7.827IleSer: 7.827 ± 0.207
5.033IleThr: 5.033 ± 0.132
5.762IleVal: 5.762 ± 0.162
0.469IleTrp: 0.469 ± 0.039
4.281IleTyr: 4.281 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
5.062LysAla: 5.062 ± 0.23
0.672LysCys: 0.672 ± 0.048
6.585LysAsp: 6.585 ± 0.203
12.327LysGlu: 12.327 ± 0.296
4.018LysPhe: 4.018 ± 0.094
4.864LysGly: 4.864 ± 0.139
1.237LysHis: 1.237 ± 0.062
12.259LysIle: 12.259 ± 0.236
13.756LysLys: 13.756 ± 0.214
9.082LysLeu: 9.082 ± 0.173
2.554LysMet: 2.554 ± 0.094
10.29LysAsn: 10.29 ± 0.22
1.963LysPro: 1.963 ± 0.084
2.755LysGln: 2.755 ± 0.109
3.362LysArg: 3.362 ± 0.111
5.317LysSer: 5.317 ± 0.126
5.333LysThr: 5.333 ± 0.141
6.195LysVal: 6.195 ± 0.192
0.505LysTrp: 0.505 ± 0.036
5.088LysTyr: 5.088 ± 0.105
0.0LysXaa: 0.0 ± 0.0
Leu
5.21LeuAla: 5.21 ± 0.142
0.773LeuCys: 0.773 ± 0.046
5.14LeuAsp: 5.14 ± 0.11
7.202LeuGlu: 7.202 ± 0.152
3.979LeuPhe: 3.979 ± 0.149
5.307LeuGly: 5.307 ± 0.126
1.068LeuHis: 1.068 ± 0.056
8.582LeuIle: 8.582 ± 0.27
10.415LeuLys: 10.415 ± 0.194
8.371LeuLeu: 8.371 ± 0.212
1.867LeuMet: 1.867 ± 0.081
5.741LeuAsn: 5.741 ± 0.127
2.781LeuPro: 2.781 ± 0.091
1.997LeuGln: 1.997 ± 0.079
2.64LeuArg: 2.64 ± 0.09
6.882LeuSer: 6.882 ± 0.188
4.843LeuThr: 4.843 ± 0.135
5.145LeuVal: 5.145 ± 0.123
0.463LeuTrp: 0.463 ± 0.037
3.247LeuTyr: 3.247 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.424MetAla: 1.424 ± 0.059
0.221MetCys: 0.221 ± 0.025
1.018MetAsp: 1.018 ± 0.058
1.37MetGlu: 1.37 ± 0.063
0.911MetPhe: 0.911 ± 0.051
1.278MetGly: 1.278 ± 0.064
0.307MetHis: 0.307 ± 0.027
2.018MetIle: 2.018 ± 0.092
2.513MetLys: 2.513 ± 0.095
2.135MetLeu: 2.135 ± 0.089
0.487MetMet: 0.487 ± 0.038
1.346MetAsn: 1.346 ± 0.058
0.651MetPro: 0.651 ± 0.042
0.729MetGln: 0.729 ± 0.049
0.674MetArg: 0.674 ± 0.046
1.453MetSer: 1.453 ± 0.066
1.242MetThr: 1.242 ± 0.059
1.242MetVal: 1.242 ± 0.057
0.089MetTrp: 0.089 ± 0.015
0.766MetTyr: 0.766 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
2.836AsnAla: 2.836 ± 0.1
0.513AsnCys: 0.513 ± 0.041
3.195AsnAsp: 3.195 ± 0.105
4.502AsnGlu: 4.502 ± 0.124
3.414AsnPhe: 3.414 ± 0.113
3.247AsnGly: 3.247 ± 0.121
0.799AsnHis: 0.799 ± 0.053
8.837AsnIle: 8.837 ± 0.263
8.077AsnLys: 8.077 ± 0.196
6.577AsnLeu: 6.577 ± 0.159
1.549AsnMet: 1.549 ± 0.063
5.432AsnAsn: 5.432 ± 0.174
2.036AsnPro: 2.036 ± 0.08
1.482AsnGln: 1.482 ± 0.063
1.646AsnArg: 1.646 ± 0.075
4.052AsnSer: 4.052 ± 0.123
2.825AsnThr: 2.825 ± 0.108
3.622AsnVal: 3.622 ± 0.09
0.325AsnTrp: 0.325 ± 0.029
3.424AsnTyr: 3.424 ± 0.104
0.0AsnXaa: 0.0 ± 0.0
Pro
1.354ProAla: 1.354 ± 0.067
0.195ProCys: 0.195 ± 0.022
1.278ProAsp: 1.278 ± 0.061
1.862ProGlu: 1.862 ± 0.069
1.328ProPhe: 1.328 ± 0.058
1.323ProGly: 1.323 ± 0.062
0.388ProHis: 0.388 ± 0.03
2.437ProIle: 2.437 ± 0.081
2.656ProLys: 2.656 ± 0.097
2.192ProLeu: 2.192 ± 0.072
0.599ProMet: 0.599 ± 0.042
1.599ProAsn: 1.599 ± 0.077
0.471ProPro: 0.471 ± 0.034
0.664ProGln: 0.664 ± 0.041
0.669ProArg: 0.669 ± 0.044
1.653ProSer: 1.653 ± 0.073
1.539ProThr: 1.539 ± 0.069
1.612ProVal: 1.612 ± 0.079
0.151ProTrp: 0.151 ± 0.021
1.073ProTyr: 1.073 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.419GlnAla: 1.419 ± 0.073
0.128GlnCys: 0.128 ± 0.018
1.187GlnAsp: 1.187 ± 0.061
1.88GlnGlu: 1.88 ± 0.09
0.893GlnPhe: 0.893 ± 0.044
1.44GlnGly: 1.44 ± 0.068
0.289GlnHis: 0.289 ± 0.03
2.234GlnIle: 2.234 ± 0.066
2.817GlnLys: 2.817 ± 0.099
1.838GlnLeu: 1.838 ± 0.067
0.544GlnMet: 0.544 ± 0.037
1.565GlnAsn: 1.565 ± 0.065
0.505GlnPro: 0.505 ± 0.038
0.599GlnGln: 0.599 ± 0.044
0.805GlnArg: 0.805 ± 0.044
1.226GlnSer: 1.226 ± 0.061
1.224GlnThr: 1.224 ± 0.067
1.331GlnVal: 1.331 ± 0.057
0.195GlnTrp: 0.195 ± 0.022
0.859GlnTyr: 0.859 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
1.638ArgAla: 1.638 ± 0.072
0.276ArgCys: 0.276 ± 0.03
1.469ArgAsp: 1.469 ± 0.064
2.612ArgGlu: 2.612 ± 0.106
1.25ArgPhe: 1.25 ± 0.065
1.804ArgGly: 1.804 ± 0.073
0.474ArgHis: 0.474 ± 0.039
2.838ArgIle: 2.838 ± 0.091
3.385ArgLys: 3.385 ± 0.086
2.672ArgLeu: 2.672 ± 0.078
0.81ArgMet: 0.81 ± 0.044
1.719ArgAsn: 1.719 ± 0.055
0.841ArgPro: 0.841 ± 0.052
0.828ArgGln: 0.828 ± 0.047
1.364ArgArg: 1.364 ± 0.075
1.398ArgSer: 1.398 ± 0.073
1.297ArgThr: 1.297 ± 0.061
1.961ArgVal: 1.961 ± 0.083
0.182ArgTrp: 0.182 ± 0.027
1.331ArgTyr: 1.331 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
2.864SerAla: 2.864 ± 0.089
0.635SerCys: 0.635 ± 0.044
3.044SerAsp: 3.044 ± 0.094
4.164SerGlu: 4.164 ± 0.112
3.255SerPhe: 3.255 ± 0.114
4.231SerGly: 4.231 ± 0.11
0.87SerHis: 0.87 ± 0.052
6.153SerIle: 6.153 ± 0.157
6.429SerLys: 6.429 ± 0.146
6.322SerLeu: 6.322 ± 0.15
1.396SerMet: 1.396 ± 0.074
3.807SerAsn: 3.807 ± 0.117
1.515SerPro: 1.515 ± 0.061
1.484SerGln: 1.484 ± 0.066
1.94SerArg: 1.94 ± 0.069
4.278SerSer: 4.278 ± 0.141
2.945SerThr: 2.945 ± 0.085
3.63SerVal: 3.63 ± 0.088
0.437SerTrp: 0.437 ± 0.037
3.033SerTyr: 3.033 ± 0.101
0.0SerXaa: 0.0 ± 0.0
Thr
2.651ThrAla: 2.651 ± 0.097
0.367ThrCys: 0.367 ± 0.03
2.432ThrAsp: 2.432 ± 0.108
2.895ThrGlu: 2.895 ± 0.102
2.398ThrPhe: 2.398 ± 0.085
3.112ThrGly: 3.112 ± 0.098
0.771ThrHis: 0.771 ± 0.042
4.874ThrIle: 4.874 ± 0.13
5.127ThrLys: 5.127 ± 0.135
4.838ThrLeu: 4.838 ± 0.105
1.021ThrMet: 1.021 ± 0.052
2.968ThrAsn: 2.968 ± 0.107
1.929ThrPro: 1.929 ± 0.098
1.078ThrGln: 1.078 ± 0.056
1.487ThrArg: 1.487 ± 0.071
3.036ThrSer: 3.036 ± 0.089
2.698ThrThr: 2.698 ± 0.106
3.184ThrVal: 3.184 ± 0.138
0.273ThrTrp: 0.273 ± 0.029
2.179ThrTyr: 2.179 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
3.604ValAla: 3.604 ± 0.114
0.609ValCys: 0.609 ± 0.04
3.408ValAsp: 3.408 ± 0.113
4.614ValGlu: 4.614 ± 0.136
2.7ValPhe: 2.7 ± 0.102
3.635ValGly: 3.635 ± 0.124
0.708ValHis: 0.708 ± 0.045
5.643ValIle: 5.643 ± 0.144
5.77ValLys: 5.77 ± 0.181
5.314ValLeu: 5.314 ± 0.137
1.242ValMet: 1.242 ± 0.067
3.325ValAsn: 3.325 ± 0.095
1.76ValPro: 1.76 ± 0.073
1.234ValGln: 1.234 ± 0.058
1.859ValArg: 1.859 ± 0.088
4.059ValSer: 4.059 ± 0.13
3.198ValThr: 3.198 ± 0.129
3.838ValVal: 3.838 ± 0.127
0.336ValTrp: 0.336 ± 0.032
2.224ValTyr: 2.224 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.26TrpAla: 0.26 ± 0.024
0.049TrpCys: 0.049 ± 0.012
0.307TrpAsp: 0.307 ± 0.031
0.385TrpGlu: 0.385 ± 0.034
0.292TrpPhe: 0.292 ± 0.029
0.359TrpGly: 0.359 ± 0.033
0.096TrpHis: 0.096 ± 0.02
0.508TrpIle: 0.508 ± 0.031
0.404TrpLys: 0.404 ± 0.036
0.555TrpLeu: 0.555 ± 0.037
0.141TrpMet: 0.141 ± 0.019
0.318TrpAsn: 0.318 ± 0.037
0.099TrpPro: 0.099 ± 0.016
0.224TrpGln: 0.224 ± 0.025
0.177TrpArg: 0.177 ± 0.023
0.297TrpSer: 0.297 ± 0.031
0.297TrpThr: 0.297 ± 0.029
0.328TrpVal: 0.328 ± 0.031
0.073TrpTrp: 0.073 ± 0.015
0.344TrpTyr: 0.344 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.919TyrAla: 1.919 ± 0.075
0.359TyrCys: 0.359 ± 0.034
2.619TyrAsp: 2.619 ± 0.096
2.836TyrGlu: 2.836 ± 0.085
2.349TyrPhe: 2.349 ± 0.098
2.317TyrGly: 2.317 ± 0.079
0.544TyrHis: 0.544 ± 0.039
4.169TyrIle: 4.169 ± 0.132
4.919TyrLys: 4.919 ± 0.115
4.343TyrLeu: 4.343 ± 0.13
0.901TyrMet: 0.901 ± 0.054
3.138TyrAsn: 3.138 ± 0.094
1.125TyrPro: 1.125 ± 0.051
1.19TyrGln: 1.19 ± 0.053
1.411TyrArg: 1.411 ± 0.063
3.023TyrSer: 3.023 ± 0.091
2.039TyrThr: 2.039 ± 0.081
2.32TyrVal: 2.32 ± 0.088
0.234TyrTrp: 0.234 ± 0.028
2.049TyrTyr: 2.049 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1251 proteins (384050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski