Amino acid dipepetide frequency for Aquirufa nivalisilvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.539AlaAla: 5.539 ± 0.153
0.743AlaCys: 0.743 ± 0.033
3.681AlaAsp: 3.681 ± 0.08
4.244AlaGlu: 4.244 ± 0.085
3.595AlaPhe: 3.595 ± 0.066
5.428AlaGly: 5.428 ± 0.204
1.442AlaHis: 1.442 ± 0.05
5.363AlaIle: 5.363 ± 0.111
5.184AlaLys: 5.184 ± 0.081
7.057AlaLeu: 7.057 ± 0.117
1.782AlaMet: 1.782 ± 0.063
3.821AlaAsn: 3.821 ± 0.157
2.448AlaPro: 2.448 ± 0.071
3.413AlaGln: 3.413 ± 0.067
2.318AlaArg: 2.318 ± 0.072
5.216AlaSer: 5.216 ± 0.229
4.073AlaThr: 4.073 ± 0.472
4.154AlaVal: 4.154 ± 0.12
0.982AlaTrp: 0.982 ± 0.035
2.901AlaTyr: 2.901 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.465CysAla: 0.465 ± 0.024
0.104CysCys: 0.104 ± 0.012
0.406CysAsp: 0.406 ± 0.023
0.454CysGlu: 0.454 ± 0.023
0.406CysPhe: 0.406 ± 0.023
0.582CysGly: 0.582 ± 0.03
0.252CysHis: 0.252 ± 0.017
0.597CysIle: 0.597 ± 0.032
0.373CysLys: 0.373 ± 0.024
0.915CysLeu: 0.915 ± 0.038
0.189CysMet: 0.189 ± 0.015
0.278CysAsn: 0.278 ± 0.017
0.402CysPro: 0.402 ± 0.024
0.416CysGln: 0.416 ± 0.021
0.286CysArg: 0.286 ± 0.02
0.578CysSer: 0.578 ± 0.026
0.4CysThr: 0.4 ± 0.021
0.459CysVal: 0.459 ± 0.025
0.095CysTrp: 0.095 ± 0.01
0.289CysTyr: 0.289 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.727AspAla: 3.727 ± 0.143
0.39AspCys: 0.39 ± 0.021
2.005AspAsp: 2.005 ± 0.057
3.065AspGlu: 3.065 ± 0.08
3.295AspPhe: 3.295 ± 0.074
3.9AspGly: 3.9 ± 0.159
0.993AspHis: 0.993 ± 0.034
3.421AspIle: 3.421 ± 0.074
3.396AspLys: 3.396 ± 0.062
5.348AspLeu: 5.348 ± 0.126
1.143AspMet: 1.143 ± 0.04
2.086AspAsn: 2.086 ± 0.073
2.103AspPro: 2.103 ± 0.057
2.127AspGln: 2.127 ± 0.056
2.068AspArg: 2.068 ± 0.046
3.107AspSer: 3.107 ± 0.096
2.237AspThr: 2.237 ± 0.081
3.146AspVal: 3.146 ± 0.068
0.91AspTrp: 0.91 ± 0.031
2.308AspTyr: 2.308 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.725GluAla: 4.725 ± 0.116
0.342GluCys: 0.342 ± 0.021
2.615GluAsp: 2.615 ± 0.078
4.084GluGlu: 4.084 ± 0.105
2.692GluPhe: 2.692 ± 0.072
3.59GluGly: 3.59 ± 0.085
1.088GluHis: 1.088 ± 0.045
4.779GluIle: 4.779 ± 0.113
5.258GluLys: 5.258 ± 0.128
5.779GluLeu: 5.779 ± 0.138
1.582GluMet: 1.582 ± 0.052
3.4GluAsn: 3.4 ± 0.09
1.587GluPro: 1.587 ± 0.05
2.273GluGln: 2.273 ± 0.076
2.291GluArg: 2.291 ± 0.07
3.472GluSer: 3.472 ± 0.067
2.625GluThr: 2.625 ± 0.059
3.874GluVal: 3.874 ± 0.096
0.78GluTrp: 0.78 ± 0.035
1.966GluTyr: 1.966 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.258PheAla: 3.258 ± 0.068
0.476PheCys: 0.476 ± 0.027
2.852PheAsp: 2.852 ± 0.068
2.948PheGlu: 2.948 ± 0.078
2.546PhePhe: 2.546 ± 0.089
3.644PheGly: 3.644 ± 0.072
0.985PheHis: 0.985 ± 0.041
3.445PheIle: 3.445 ± 0.096
3.09PheLys: 3.09 ± 0.079
4.872PheLeu: 4.872 ± 0.135
1.126PheMet: 1.126 ± 0.042
2.402PheAsn: 2.402 ± 0.057
2.09PhePro: 2.09 ± 0.062
2.337PheGln: 2.337 ± 0.072
1.722PheArg: 1.722 ± 0.053
4.121PheSer: 4.121 ± 0.092
3.043PheThr: 3.043 ± 0.274
3.007PheVal: 3.007 ± 0.057
0.67PheTrp: 0.67 ± 0.031
1.926PheTyr: 1.926 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.926GlyAla: 4.926 ± 0.213
0.564GlyCys: 0.564 ± 0.028
3.435GlyAsp: 3.435 ± 0.089
3.597GlyGlu: 3.597 ± 0.092
3.739GlyPhe: 3.739 ± 0.08
5.038GlyGly: 5.038 ± 0.11
1.319GlyHis: 1.319 ± 0.043
5.906GlyIle: 5.906 ± 0.108
5.45GlyLys: 5.45 ± 0.125
6.781GlyLeu: 6.781 ± 0.101
1.807GlyMet: 1.807 ± 0.065
3.627GlyAsn: 3.627 ± 0.171
1.872GlyPro: 1.872 ± 0.047
2.56GlyGln: 2.56 ± 0.073
2.437GlyArg: 2.437 ± 0.073
4.609GlySer: 4.609 ± 0.252
4.853GlyThr: 4.853 ± 0.718
4.619GlyVal: 4.619 ± 0.172
0.907GlyTrp: 0.907 ± 0.034
2.705GlyTyr: 2.705 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.375HisAla: 1.375 ± 0.049
0.222HisCys: 0.222 ± 0.018
0.855HisAsp: 0.855 ± 0.039
1.102HisGlu: 1.102 ± 0.039
1.36HisPhe: 1.36 ± 0.049
1.371HisGly: 1.371 ± 0.048
0.586HisHis: 0.586 ± 0.027
1.43HisIle: 1.43 ± 0.055
0.895HisLys: 0.895 ± 0.04
2.131HisLeu: 2.131 ± 0.071
0.377HisMet: 0.377 ± 0.02
0.677HisAsn: 0.677 ± 0.031
1.181HisPro: 1.181 ± 0.042
1.099HisGln: 1.099 ± 0.046
0.84HisArg: 0.84 ± 0.038
1.173HisSer: 1.173 ± 0.04
0.928HisThr: 0.928 ± 0.037
1.291HisVal: 1.291 ± 0.039
0.392HisTrp: 0.392 ± 0.024
0.822HisTyr: 0.822 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.185IleAla: 5.185 ± 0.113
0.786IleCys: 0.786 ± 0.037
4.001IleAsp: 4.001 ± 0.08
4.353IleGlu: 4.353 ± 0.097
3.131IlePhe: 3.131 ± 0.095
4.828IleGly: 4.828 ± 0.124
1.633IleHis: 1.633 ± 0.054
4.774IleIle: 4.774 ± 0.114
4.49IleLys: 4.49 ± 0.116
6.916IleLeu: 6.916 ± 0.159
1.365IleMet: 1.365 ± 0.045
3.414IleAsn: 3.414 ± 0.067
3.819IlePro: 3.819 ± 0.101
3.69IleGln: 3.69 ± 0.108
3.009IleArg: 3.009 ± 0.078
5.884IleSer: 5.884 ± 0.09
3.889IleThr: 3.889 ± 0.228
3.974IleVal: 3.974 ± 0.071
0.893IleTrp: 0.893 ± 0.037
2.459IleTyr: 2.459 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.152LysAla: 5.152 ± 0.102
0.313LysCys: 0.313 ± 0.018
3.816LysAsp: 3.816 ± 0.068
4.892LysGlu: 4.892 ± 0.122
2.557LysPhe: 2.557 ± 0.066
4.404LysGly: 4.404 ± 0.109
1.301LysHis: 1.301 ± 0.044
5.008LysIle: 5.008 ± 0.127
5.471LysLys: 5.471 ± 0.156
5.8LysLeu: 5.8 ± 0.108
2.006LysMet: 2.006 ± 0.059
4.005LysAsn: 4.005 ± 0.089
2.654LysPro: 2.654 ± 0.077
2.857LysGln: 2.857 ± 0.094
2.54LysArg: 2.54 ± 0.074
4.706LysSer: 4.706 ± 0.088
3.679LysThr: 3.679 ± 0.082
4.193LysVal: 4.193 ± 0.084
0.836LysTrp: 0.836 ± 0.036
2.316LysTyr: 2.316 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.748LeuAla: 7.748 ± 0.108
0.809LeuCys: 0.809 ± 0.04
5.158LeuAsp: 5.158 ± 0.131
5.654LeuGlu: 5.654 ± 0.144
5.028LeuPhe: 5.028 ± 0.143
7.044LeuGly: 7.044 ± 0.107
1.885LeuHis: 1.885 ± 0.06
6.606LeuIle: 6.606 ± 0.161
6.577LeuLys: 6.577 ± 0.112
9.165LeuLeu: 9.165 ± 0.234
2.257LeuMet: 2.257 ± 0.074
4.815LeuAsn: 4.815 ± 0.091
4.134LeuPro: 4.134 ± 0.087
3.621LeuGln: 3.621 ± 0.113
3.423LeuArg: 3.423 ± 0.094
7.386LeuSer: 7.386 ± 0.099
5.321LeuThr: 5.321 ± 0.311
5.89LeuVal: 5.89 ± 0.085
1.058LeuTrp: 1.058 ± 0.038
3.002LeuTyr: 3.002 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.078MetAla: 2.078 ± 0.067
0.167MetCys: 0.167 ± 0.011
1.305MetAsp: 1.305 ± 0.04
1.588MetGlu: 1.588 ± 0.049
0.791MetPhe: 0.791 ± 0.034
1.822MetGly: 1.822 ± 0.061
0.436MetHis: 0.436 ± 0.022
1.518MetIle: 1.518 ± 0.042
2.019MetLys: 2.019 ± 0.055
2.012MetLeu: 2.012 ± 0.07
0.682MetMet: 0.682 ± 0.036
1.327MetAsn: 1.327 ± 0.052
1.073MetPro: 1.073 ± 0.03
0.89MetGln: 0.89 ± 0.039
0.937MetArg: 0.937 ± 0.04
1.584MetSer: 1.584 ± 0.045
1.179MetThr: 1.179 ± 0.038
1.48MetVal: 1.48 ± 0.045
0.232MetTrp: 0.232 ± 0.018
0.663MetTyr: 0.663 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.409AsnAla: 3.409 ± 0.081
0.371AsnCys: 0.371 ± 0.022
2.273AsnAsp: 2.273 ± 0.076
2.625AsnGlu: 2.625 ± 0.085
2.571AsnPhe: 2.571 ± 0.057
3.468AsnGly: 3.468 ± 0.152
1.066AsnHis: 1.066 ± 0.037
3.283AsnIle: 3.283 ± 0.067
3.097AsnLys: 3.097 ± 0.065
4.977AsnLeu: 4.977 ± 0.083
1.177AsnMet: 1.177 ± 0.034
2.38AsnAsn: 2.38 ± 0.092
3.094AsnPro: 3.094 ± 0.066
2.602AsnGln: 2.602 ± 0.068
2.102AsnArg: 2.102 ± 0.063
3.321AsnSer: 3.321 ± 0.082
2.866AsnThr: 2.866 ± 0.206
2.769AsnVal: 2.769 ± 0.119
0.793AsnTrp: 0.793 ± 0.036
2.162AsnTyr: 2.162 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
3.046ProAla: 3.046 ± 0.079
0.255ProCys: 0.255 ± 0.017
2.365ProAsp: 2.365 ± 0.071
2.754ProGlu: 2.754 ± 0.074
2.081ProPhe: 2.081 ± 0.067
2.451ProGly: 2.451 ± 0.052
0.826ProHis: 0.826 ± 0.036
3.017ProIle: 3.017 ± 0.081
2.552ProLys: 2.552 ± 0.069
3.426ProLeu: 3.426 ± 0.087
1.021ProMet: 1.021 ± 0.036
2.43ProAsn: 2.43 ± 0.071
0.93ProPro: 0.93 ± 0.039
1.551ProGln: 1.551 ± 0.061
1.162ProArg: 1.162 ± 0.043
2.946ProSer: 2.946 ± 0.055
2.249ProThr: 2.249 ± 0.078
2.695ProVal: 2.695 ± 0.062
0.531ProTrp: 0.531 ± 0.027
1.498ProTyr: 1.498 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
3.524GlnAla: 3.524 ± 0.078
0.246GlnCys: 0.246 ± 0.016
2.076GlnAsp: 2.076 ± 0.057
2.737GlnGlu: 2.737 ± 0.083
1.985GlnPhe: 1.985 ± 0.064
2.816GlnGly: 2.816 ± 0.074
0.915GlnHis: 0.915 ± 0.039
3.43GlnIle: 3.43 ± 0.078
3.248GlnLys: 3.248 ± 0.099
4.083GlnLeu: 4.083 ± 0.107
1.068GlnMet: 1.068 ± 0.038
1.998GlnAsn: 1.998 ± 0.057
1.214GlnPro: 1.214 ± 0.047
1.952GlnGln: 1.952 ± 0.064
1.613GlnArg: 1.613 ± 0.056
2.726GlnSer: 2.726 ± 0.061
2.197GlnThr: 2.197 ± 0.108
3.24GlnVal: 3.24 ± 0.083
0.626GlnTrp: 0.626 ± 0.034
1.45GlnTyr: 1.45 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.331ArgAla: 2.331 ± 0.063
0.204ArgCys: 0.204 ± 0.016
1.768ArgAsp: 1.768 ± 0.054
2.2ArgGlu: 2.2 ± 0.073
2.057ArgPhe: 2.057 ± 0.055
2.26ArgGly: 2.26 ± 0.07
0.657ArgHis: 0.657 ± 0.032
3.11ArgIle: 3.11 ± 0.081
2.659ArgLys: 2.659 ± 0.072
3.67ArgLeu: 3.67 ± 0.07
1.086ArgMet: 1.086 ± 0.04
1.959ArgAsn: 1.959 ± 0.056
1.394ArgPro: 1.394 ± 0.047
1.499ArgGln: 1.499 ± 0.056
1.509ArgArg: 1.509 ± 0.061
2.019ArgSer: 2.019 ± 0.062
1.792ArgThr: 1.792 ± 0.052
2.312ArgVal: 2.312 ± 0.069
0.544ArgTrp: 0.544 ± 0.027
1.464ArgTyr: 1.464 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.488SerAla: 4.488 ± 0.134
0.588SerCys: 0.588 ± 0.027
3.351SerAsp: 3.351 ± 0.091
3.479SerGlu: 3.479 ± 0.08
4.008SerPhe: 4.008 ± 0.083
5.41SerGly: 5.41 ± 0.506
1.37SerHis: 1.37 ± 0.042
5.459SerIle: 5.459 ± 0.08
4.501SerLys: 4.501 ± 0.073
7.32SerLeu: 7.32 ± 0.149
1.567SerMet: 1.567 ± 0.043
3.447SerAsn: 3.447 ± 0.082
3.031SerPro: 3.031 ± 0.142
2.914SerGln: 2.914 ± 0.066
2.231SerArg: 2.231 ± 0.067
5.18SerSer: 5.18 ± 0.249
3.981SerThr: 3.981 ± 0.167
3.992SerVal: 3.992 ± 0.106
0.871SerTrp: 0.871 ± 0.036
2.615SerTyr: 2.615 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.272ThrAla: 4.272 ± 0.58
0.421ThrCys: 0.421 ± 0.024
2.849ThrAsp: 2.849 ± 0.135
2.621ThrGlu: 2.621 ± 0.073
2.805ThrPhe: 2.805 ± 0.268
4.8ThrGly: 4.8 ± 0.557
0.998ThrHis: 0.998 ± 0.034
3.877ThrIle: 3.877 ± 0.186
3.112ThrLys: 3.112 ± 0.081
5.34ThrLeu: 5.34 ± 0.146
1.053ThrMet: 1.053 ± 0.033
2.712ThrAsn: 2.712 ± 0.24
2.36ThrPro: 2.36 ± 0.089
2.231ThrGln: 2.231 ± 0.077
1.7ThrArg: 1.7 ± 0.047
3.924ThrSer: 3.924 ± 0.376
2.766ThrThr: 2.766 ± 0.181
3.455ThrVal: 3.455 ± 0.402
0.843ThrTrp: 0.843 ± 0.035
2.251ThrTyr: 2.251 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.824ValAla: 4.824 ± 0.188
0.536ValCys: 0.536 ± 0.028
3.351ValAsp: 3.351 ± 0.09
3.716ValGlu: 3.716 ± 0.07
3.008ValPhe: 3.008 ± 0.065
4.338ValGly: 4.338 ± 0.075
1.181ValHis: 1.181 ± 0.044
4.362ValIle: 4.362 ± 0.092
4.136ValLys: 4.136 ± 0.097
5.788ValLeu: 5.788 ± 0.096
1.388ValMet: 1.388 ± 0.048
3.273ValAsn: 3.273 ± 0.093
2.373ValPro: 2.373 ± 0.051
2.327ValGln: 2.327 ± 0.06
2.17ValArg: 2.17 ± 0.061
4.559ValSer: 4.559 ± 0.253
3.467ValThr: 3.467 ± 0.467
4.081ValVal: 4.081 ± 0.09
0.768ValTrp: 0.768 ± 0.031
2.181ValTyr: 2.181 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.909TrpAla: 0.909 ± 0.039
0.083TrpCys: 0.083 ± 0.01
0.78TrpAsp: 0.78 ± 0.033
0.864TrpGlu: 0.864 ± 0.033
0.604TrpPhe: 0.604 ± 0.028
0.946TrpGly: 0.946 ± 0.036
0.28TrpHis: 0.28 ± 0.019
0.961TrpIle: 0.961 ± 0.042
1.032TrpLys: 1.032 ± 0.04
1.238TrpLeu: 1.238 ± 0.052
0.413TrpMet: 0.413 ± 0.024
0.803TrpAsn: 0.803 ± 0.032
0.36TrpPro: 0.36 ± 0.022
0.568TrpGln: 0.568 ± 0.028
0.523TrpArg: 0.523 ± 0.03
0.776TrpSer: 0.776 ± 0.033
0.739TrpThr: 0.739 ± 0.029
0.946TrpVal: 0.946 ± 0.039
0.194TrpTrp: 0.194 ± 0.016
0.468TrpTyr: 0.468 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.401TyrAla: 2.401 ± 0.074
0.323TyrCys: 0.323 ± 0.02
1.834TyrAsp: 1.834 ± 0.051
1.823TyrGlu: 1.823 ± 0.061
2.306TyrPhe: 2.306 ± 0.07
2.612TyrGly: 2.612 ± 0.062
0.893TyrHis: 0.893 ± 0.037
2.149TyrIle: 2.149 ± 0.065
1.966TyrLys: 1.966 ± 0.053
3.96TyrLeu: 3.96 ± 0.104
0.697TyrMet: 0.697 ± 0.031
1.554TyrAsn: 1.554 ± 0.054
1.668TyrPro: 1.668 ± 0.049
2.214TyrGln: 2.214 ± 0.067
1.615TyrArg: 1.615 ± 0.053
2.514TyrSer: 2.514 ± 0.061
2.107TyrThr: 2.107 ± 0.093
2.249TyrVal: 2.249 ± 0.068
0.56TyrTrp: 0.56 ± 0.027
1.524TyrTyr: 1.524 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2618 proteins (959162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski