Amino acid dipepetide frequency for Canine coronavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.512AlaAla: 5.512 ± 1.079
2.866AlaCys: 2.866 ± 0.662
1.911AlaAsp: 1.911 ± 0.278
2.425AlaGlu: 2.425 ± 0.389
4.703AlaPhe: 4.703 ± 0.727
3.528AlaGly: 3.528 ± 0.754
1.249AlaHis: 1.249 ± 0.6
5.512AlaIle: 5.512 ± 0.505
4.997AlaLys: 4.997 ± 0.923
4.924AlaLeu: 4.924 ± 0.923
1.543AlaMet: 1.543 ± 0.138
3.748AlaAsn: 3.748 ± 0.46
1.837AlaPro: 1.837 ± 0.366
1.249AlaGln: 1.249 ± 0.5
2.719AlaArg: 2.719 ± 0.333
3.822AlaSer: 3.822 ± 0.477
3.307AlaThr: 3.307 ± 0.509
4.483AlaVal: 4.483 ± 0.479
0.661AlaTrp: 0.661 ± 0.143
3.822AlaTyr: 3.822 ± 1.122
0.0AlaXaa: 0.0 ± 0.0
Cys
1.47CysAla: 1.47 ± 0.454
1.029CysCys: 1.029 ± 0.389
2.058CysAsp: 2.058 ± 0.353
1.249CysGlu: 1.249 ± 0.218
1.543CysPhe: 1.543 ± 0.29
2.646CysGly: 2.646 ± 0.738
0.294CysHis: 0.294 ± 0.187
1.984CysIle: 1.984 ± 0.35
1.69CysLys: 1.69 ± 0.377
2.058CysLeu: 2.058 ± 0.248
0.955CysMet: 0.955 ± 0.309
1.617CysAsn: 1.617 ± 0.368
1.176CysPro: 1.176 ± 0.16
0.22CysGln: 0.22 ± 0.11
0.955CysArg: 0.955 ± 0.286
2.131CysSer: 2.131 ± 0.404
2.058CysThr: 2.058 ± 0.57
2.866CysVal: 2.866 ± 0.405
0.514CysTrp: 0.514 ± 0.179
2.425CysTyr: 2.425 ± 0.428
0.0CysXaa: 0.0 ± 0.0
Asp
3.822AspAla: 3.822 ± 0.56
2.278AspCys: 2.278 ± 0.285
3.013AspAsp: 3.013 ± 0.562
3.087AspGlu: 3.087 ± 0.404
3.748AspPhe: 3.748 ± 0.797
3.234AspGly: 3.234 ± 0.708
0.735AspHis: 0.735 ± 0.228
2.499AspIle: 2.499 ± 0.37
2.278AspLys: 2.278 ± 0.454
5.659AspLeu: 5.659 ± 0.586
1.176AspMet: 1.176 ± 0.254
3.013AspAsn: 3.013 ± 0.3
1.69AspPro: 1.69 ± 0.258
0.955AspGln: 0.955 ± 0.315
1.764AspArg: 1.764 ± 0.296
2.572AspSer: 2.572 ± 0.534
2.131AspThr: 2.131 ± 0.705
5.806AspVal: 5.806 ± 1.036
1.029AspTrp: 1.029 ± 0.36
3.601AspTyr: 3.601 ± 0.353
0.0AspXaa: 0.0 ± 0.0
Glu
3.013GluAla: 3.013 ± 0.393
1.323GluCys: 1.323 ± 0.18
3.087GluAsp: 3.087 ± 0.608
3.528GluGlu: 3.528 ± 0.541
3.16GluPhe: 3.16 ± 0.312
3.16GluGly: 3.16 ± 0.44
1.69GluHis: 1.69 ± 0.358
2.94GluIle: 2.94 ± 0.398
3.234GluLys: 3.234 ± 0.498
3.675GluLeu: 3.675 ± 0.379
0.808GluMet: 0.808 ± 0.287
3.307GluAsn: 3.307 ± 0.602
1.396GluPro: 1.396 ± 0.26
1.984GluGln: 1.984 ± 0.374
2.352GluArg: 2.352 ± 0.446
3.381GluSer: 3.381 ± 0.643
2.058GluThr: 2.058 ± 0.473
4.189GluVal: 4.189 ± 0.567
0.588GluTrp: 0.588 ± 0.257
1.617GluTyr: 1.617 ± 0.276
0.0GluXaa: 0.0 ± 0.0
Phe
1.984PheAla: 1.984 ± 0.264
1.764PheCys: 1.764 ± 0.459
3.16PheAsp: 3.16 ± 0.45
3.381PheGlu: 3.381 ± 0.484
3.087PhePhe: 3.087 ± 0.663
4.042PheGly: 4.042 ± 0.412
0.367PheHis: 0.367 ± 0.174
3.454PheIle: 3.454 ± 0.708
4.263PheLys: 4.263 ± 0.69
2.793PheLeu: 2.793 ± 0.421
1.69PheMet: 1.69 ± 0.456
4.63PheAsn: 4.63 ± 0.717
0.367PhePro: 0.367 ± 0.165
0.882PheGln: 0.882 ± 0.392
0.588PheArg: 0.588 ± 0.152
3.822PheSer: 3.822 ± 0.77
3.307PheThr: 3.307 ± 0.706
7.129PheVal: 7.129 ± 0.848
1.102PheTrp: 1.102 ± 0.429
3.087PheTyr: 3.087 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
4.85GlyAla: 4.85 ± 0.824
1.69GlyCys: 1.69 ± 0.302
5.438GlyAsp: 5.438 ± 0.456
2.793GlyGlu: 2.793 ± 0.618
4.189GlyPhe: 4.189 ± 0.545
3.601GlyGly: 3.601 ± 0.581
0.661GlyHis: 0.661 ± 0.158
2.94GlyIle: 2.94 ± 0.608
4.85GlyLys: 4.85 ± 0.876
4.997GlyLeu: 4.997 ± 0.635
1.323GlyMet: 1.323 ± 0.305
3.675GlyAsn: 3.675 ± 0.456
1.47GlyPro: 1.47 ± 0.383
1.029GlyGln: 1.029 ± 0.429
1.837GlyArg: 1.837 ± 1.114
4.924GlySer: 4.924 ± 1.062
3.454GlyThr: 3.454 ± 0.385
5.953GlyVal: 5.953 ± 0.6
0.22GlyTrp: 0.22 ± 0.239
3.307GlyTyr: 3.307 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
1.543HisAla: 1.543 ± 0.297
0.367HisCys: 0.367 ± 0.166
1.029HisAsp: 1.029 ± 0.559
0.661HisGlu: 0.661 ± 0.209
0.955HisPhe: 0.955 ± 0.183
0.882HisGly: 0.882 ± 0.243
0.367HisHis: 0.367 ± 0.127
0.808HisIle: 0.808 ± 0.145
1.47HisLys: 1.47 ± 0.445
1.764HisLeu: 1.764 ± 0.215
0.441HisMet: 0.441 ± 0.202
1.323HisAsn: 1.323 ± 0.227
0.514HisPro: 0.514 ± 0.171
0.294HisGln: 0.294 ± 0.332
0.514HisArg: 0.514 ± 0.412
1.249HisSer: 1.249 ± 0.572
1.102HisThr: 1.102 ± 0.598
1.837HisVal: 1.837 ± 0.376
0.073HisTrp: 0.073 ± 0.111
0.882HisTyr: 0.882 ± 0.26
0.0HisXaa: 0.0 ± 0.0
Ile
4.483IleAla: 4.483 ± 0.755
1.029IleCys: 1.029 ± 0.251
3.307IleAsp: 3.307 ± 1.057
3.601IleGlu: 3.601 ± 0.523
2.352IlePhe: 2.352 ± 0.2
3.381IleGly: 3.381 ± 0.383
0.661IleHis: 0.661 ± 0.227
3.822IleIle: 3.822 ± 0.996
3.895IleLys: 3.895 ± 0.644
5.144IleLeu: 5.144 ± 1.072
1.617IleMet: 1.617 ± 0.451
3.307IleAsn: 3.307 ± 0.389
2.572IlePro: 2.572 ± 0.604
1.249IleGln: 1.249 ± 0.448
1.543IleArg: 1.543 ± 0.319
3.234IleSer: 3.234 ± 0.559
2.866IleThr: 2.866 ± 0.796
8.525IleVal: 8.525 ± 1.59
0.588IleTrp: 0.588 ± 0.205
2.646IleTyr: 2.646 ± 0.832
0.0IleXaa: 0.0 ± 0.0
Lys
4.483LysAla: 4.483 ± 0.988
2.205LysCys: 2.205 ± 0.677
4.042LysAsp: 4.042 ± 0.603
2.499LysGlu: 2.499 ± 0.537
2.94LysPhe: 2.94 ± 0.596
3.16LysGly: 3.16 ± 0.924
2.205LysHis: 2.205 ± 0.453
3.675LysIle: 3.675 ± 0.587
2.94LysLys: 2.94 ± 0.749
6.688LysLeu: 6.688 ± 0.834
1.837LysMet: 1.837 ± 0.41
3.748LysAsn: 3.748 ± 0.782
3.969LysPro: 3.969 ± 0.941
2.719LysGln: 2.719 ± 0.639
1.47LysArg: 1.47 ± 0.422
4.042LysSer: 4.042 ± 0.704
3.601LysThr: 3.601 ± 0.502
4.777LysVal: 4.777 ± 0.644
0.367LysTrp: 0.367 ± 0.174
2.94LysTyr: 2.94 ± 0.414
0.0LysXaa: 0.0 ± 0.0
Leu
4.924LeuAla: 4.924 ± 0.853
2.719LeuCys: 2.719 ± 0.462
4.042LeuAsp: 4.042 ± 0.403
5.879LeuGlu: 5.879 ± 0.554
4.263LeuPhe: 4.263 ± 0.498
5.218LeuGly: 5.218 ± 0.676
1.396LeuHis: 1.396 ± 0.485
4.116LeuIle: 4.116 ± 1.236
6.1LeuLys: 6.1 ± 0.69
7.79LeuLeu: 7.79 ± 2.656
1.617LeuMet: 1.617 ± 0.358
4.63LeuAsn: 4.63 ± 0.883
3.675LeuPro: 3.675 ± 0.86
3.381LeuGln: 3.381 ± 0.498
1.984LeuArg: 1.984 ± 0.391
7.276LeuSer: 7.276 ± 0.823
4.483LeuThr: 4.483 ± 0.852
5.879LeuVal: 5.879 ± 0.713
1.249LeuTrp: 1.249 ± 0.36
3.307LeuTyr: 3.307 ± 0.634
0.0LeuXaa: 0.0 ± 0.0
Met
1.837MetAla: 1.837 ± 0.587
1.029MetCys: 1.029 ± 0.266
1.029MetAsp: 1.029 ± 0.294
0.294MetGlu: 0.294 ± 0.314
0.735MetPhe: 0.735 ± 0.569
1.47MetGly: 1.47 ± 0.191
0.735MetHis: 0.735 ± 0.253
1.911MetIle: 1.911 ± 0.385
0.882MetLys: 0.882 ± 0.539
2.866MetLeu: 2.866 ± 0.495
0.514MetMet: 0.514 ± 0.197
0.367MetAsn: 0.367 ± 0.265
1.102MetPro: 1.102 ± 0.38
1.029MetGln: 1.029 ± 0.288
1.176MetArg: 1.176 ± 0.327
1.543MetSer: 1.543 ± 0.297
2.058MetThr: 2.058 ± 0.306
1.323MetVal: 1.323 ± 0.532
0.073MetTrp: 0.073 ± 0.244
1.396MetTyr: 1.396 ± 0.196
0.0MetXaa: 0.0 ± 0.0
Asn
4.336AsnAla: 4.336 ± 0.39
1.543AsnCys: 1.543 ± 0.196
2.058AsnAsp: 2.058 ± 0.416
2.94AsnGlu: 2.94 ± 0.492
3.013AsnPhe: 3.013 ± 0.283
6.247AsnGly: 6.247 ± 0.608
0.661AsnHis: 0.661 ± 0.209
3.16AsnIle: 3.16 ± 1.103
2.866AsnLys: 2.866 ± 0.57
4.483AsnLeu: 4.483 ± 0.601
1.69AsnMet: 1.69 ± 0.429
5.512AsnAsn: 5.512 ± 1.039
1.323AsnPro: 1.323 ± 0.354
1.764AsnGln: 1.764 ± 0.699
1.323AsnArg: 1.323 ± 0.397
4.042AsnSer: 4.042 ± 0.541
3.454AsnThr: 3.454 ± 0.711
6.32AsnVal: 6.32 ± 1.301
0.514AsnTrp: 0.514 ± 0.468
2.131AsnTyr: 2.131 ± 0.558
0.0AsnXaa: 0.0 ± 0.0
Pro
1.617ProAla: 1.617 ± 0.497
0.588ProCys: 0.588 ± 0.127
2.058ProAsp: 2.058 ± 0.272
1.47ProGlu: 1.47 ± 0.206
1.617ProPhe: 1.617 ± 0.352
2.205ProGly: 2.205 ± 0.422
0.514ProHis: 0.514 ± 0.162
2.646ProIle: 2.646 ± 0.362
2.352ProLys: 2.352 ± 0.707
2.572ProLeu: 2.572 ± 0.322
0.514ProMet: 0.514 ± 0.431
0.882ProAsn: 0.882 ± 0.393
1.176ProPro: 1.176 ± 0.322
1.249ProGln: 1.249 ± 0.381
0.882ProArg: 0.882 ± 0.425
3.601ProSer: 3.601 ± 0.618
2.425ProThr: 2.425 ± 0.336
2.499ProVal: 2.499 ± 0.429
0.808ProTrp: 0.808 ± 0.189
0.735ProTyr: 0.735 ± 0.332
0.0ProXaa: 0.0 ± 0.0
Gln
2.793GlnAla: 2.793 ± 0.413
0.441GlnCys: 0.441 ± 0.2
1.323GlnAsp: 1.323 ± 0.303
1.984GlnGlu: 1.984 ± 0.56
0.808GlnPhe: 0.808 ± 0.318
1.911GlnGly: 1.911 ± 0.313
0.808GlnHis: 0.808 ± 0.399
2.205GlnIle: 2.205 ± 0.666
1.47GlnLys: 1.47 ± 0.397
3.234GlnLeu: 3.234 ± 0.522
0.441GlnMet: 0.441 ± 0.214
0.808GlnAsn: 0.808 ± 0.167
1.176GlnPro: 1.176 ± 0.31
1.69GlnGln: 1.69 ± 0.806
1.323GlnArg: 1.323 ± 0.658
2.646GlnSer: 2.646 ± 0.697
1.69GlnThr: 1.69 ± 0.479
2.058GlnVal: 2.058 ± 0.528
0.367GlnTrp: 0.367 ± 0.094
1.396GlnTyr: 1.396 ± 0.299
0.0GlnXaa: 0.0 ± 0.0
Arg
2.131ArgAla: 2.131 ± 0.453
1.47ArgCys: 1.47 ± 0.459
1.396ArgAsp: 1.396 ± 0.423
0.441ArgGlu: 0.441 ± 0.173
2.278ArgPhe: 2.278 ± 0.258
1.837ArgGly: 1.837 ± 0.522
0.367ArgHis: 0.367 ± 0.188
1.323ArgIle: 1.323 ± 0.309
2.058ArgLys: 2.058 ± 0.563
2.352ArgLeu: 2.352 ± 0.786
0.661ArgMet: 0.661 ± 0.196
2.131ArgAsn: 2.131 ± 0.42
0.735ArgPro: 0.735 ± 0.238
1.396ArgGln: 1.396 ± 0.607
0.955ArgArg: 0.955 ± 0.399
3.087ArgSer: 3.087 ± 2.018
2.793ArgThr: 2.793 ± 0.75
2.278ArgVal: 2.278 ± 0.518
0.367ArgTrp: 0.367 ± 0.147
1.176ArgTyr: 1.176 ± 0.349
0.0ArgXaa: 0.0 ± 0.0
Ser
4.777SerAla: 4.777 ± 0.334
1.764SerCys: 1.764 ± 0.446
4.042SerAsp: 4.042 ± 0.638
3.087SerGlu: 3.087 ± 0.359
3.675SerPhe: 3.675 ± 0.678
4.263SerGly: 4.263 ± 0.694
1.47SerHis: 1.47 ± 0.65
4.777SerIle: 4.777 ± 1.252
4.263SerLys: 4.263 ± 0.889
5.071SerLeu: 5.071 ± 0.536
2.058SerMet: 2.058 ± 0.395
2.793SerAsn: 2.793 ± 0.339
1.543SerPro: 1.543 ± 0.327
2.352SerGln: 2.352 ± 0.696
2.058SerArg: 2.058 ± 1.385
4.997SerSer: 4.997 ± 0.568
4.703SerThr: 4.703 ± 0.544
6.614SerVal: 6.614 ± 0.979
1.029SerTrp: 1.029 ± 0.817
3.895SerTyr: 3.895 ± 0.699
0.0SerXaa: 0.0 ± 0.0
Thr
3.822ThrAla: 3.822 ± 1.567
2.058ThrCys: 2.058 ± 0.378
2.719ThrAsp: 2.719 ± 0.36
2.499ThrGlu: 2.499 ± 0.491
2.94ThrPhe: 2.94 ± 0.452
4.042ThrGly: 4.042 ± 0.895
0.661ThrHis: 0.661 ± 0.305
3.234ThrIle: 3.234 ± 0.418
2.425ThrLys: 2.425 ± 0.554
5.512ThrLeu: 5.512 ± 1.26
1.102ThrMet: 1.102 ± 0.301
3.601ThrAsn: 3.601 ± 0.357
2.499ThrPro: 2.499 ± 0.298
2.572ThrGln: 2.572 ± 0.238
2.352ThrArg: 2.352 ± 0.323
3.895ThrSer: 3.895 ± 0.478
4.263ThrThr: 4.263 ± 0.59
6.173ThrVal: 6.173 ± 0.675
1.029ThrTrp: 1.029 ± 0.188
1.984ThrTyr: 1.984 ± 0.49
0.0ThrXaa: 0.0 ± 0.0
Val
3.822ValAla: 3.822 ± 0.551
2.646ValCys: 2.646 ± 0.474
4.336ValAsp: 4.336 ± 0.494
5.879ValGlu: 5.879 ± 1.046
4.556ValPhe: 4.556 ± 0.621
4.409ValGly: 4.409 ± 0.419
1.984ValHis: 1.984 ± 0.381
5.732ValIle: 5.732 ± 0.735
7.937ValLys: 7.937 ± 1.576
8.525ValLeu: 8.525 ± 0.861
1.543ValMet: 1.543 ± 0.95
6.467ValAsn: 6.467 ± 0.553
2.131ValPro: 2.131 ± 0.543
3.234ValGln: 3.234 ± 0.858
3.013ValArg: 3.013 ± 0.418
6.394ValSer: 6.394 ± 0.683
6.32ValThr: 6.32 ± 0.497
7.349ValVal: 7.349 ± 0.786
0.514ValTrp: 0.514 ± 0.157
3.748ValTyr: 3.748 ± 0.724
0.0ValXaa: 0.0 ± 0.0
Trp
0.441TrpAla: 0.441 ± 0.202
0.147TrpCys: 0.147 ± 0.1
0.661TrpAsp: 0.661 ± 0.184
0.588TrpGlu: 0.588 ± 0.174
1.543TrpPhe: 1.543 ± 0.183
0.22TrpGly: 0.22 ± 0.183
0.22TrpHis: 0.22 ± 0.239
0.661TrpIle: 0.661 ± 0.226
0.661TrpLys: 0.661 ± 0.216
1.029TrpLeu: 1.029 ± 0.211
0.22TrpMet: 0.22 ± 0.079
1.176TrpAsn: 1.176 ± 0.325
0.661TrpPro: 0.661 ± 0.488
0.22TrpGln: 0.22 ± 0.088
0.367TrpArg: 0.367 ± 0.166
0.661TrpSer: 0.661 ± 0.411
1.029TrpThr: 1.029 ± 0.254
0.367TrpVal: 0.367 ± 0.147
0.073TrpTrp: 0.073 ± 0.244
0.661TrpTyr: 0.661 ± 0.263
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.16TyrAla: 3.16 ± 0.619
1.984TyrCys: 1.984 ± 0.658
3.381TyrAsp: 3.381 ± 0.933
2.205TyrGlu: 2.205 ± 0.306
2.793TyrPhe: 2.793 ± 0.401
3.748TyrGly: 3.748 ± 0.597
1.029TyrHis: 1.029 ± 0.361
2.499TyrIle: 2.499 ± 0.406
3.675TyrLys: 3.675 ± 0.446
2.793TyrLeu: 2.793 ± 0.268
1.543TyrMet: 1.543 ± 0.463
2.646TyrAsn: 2.646 ± 0.788
1.396TyrPro: 1.396 ± 0.349
1.102TyrGln: 1.102 ± 0.239
2.058TyrArg: 2.058 ± 0.566
1.911TyrSer: 1.911 ± 0.437
2.278TyrThr: 2.278 ± 0.368
4.116TyrVal: 4.116 ± 0.873
0.441TyrTrp: 0.441 ± 0.263
2.94TyrTyr: 2.94 ± 0.422
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (13608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski