Amino acid dipepetide frequency for Aliiroseovarius crassostreae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.868AlaAla: 13.868 ± 0.157	1.011AlaCys: 1.011 ± 0.035	6.521AlaAsp: 6.521 ± 0.074	7.624AlaGlu: 7.624 ± 0.092	4.115AlaPhe: 4.115 ± 0.069	9.576AlaGly: 9.576 ± 0.115	2.325AlaHis: 2.325 ± 0.052	5.767AlaIle: 5.767 ± 0.072	4.402AlaLys: 4.402 ± 0.085	12.598AlaLeu: 12.598 ± 0.13	3.648AlaMet: 3.648 ± 0.076	2.855AlaAsn: 2.855 ± 0.054	5.32AlaPro: 5.32 ± 0.085	4.555AlaGln: 4.555 ± 0.071	7.899AlaArg: 7.899 ± 0.109	5.37AlaSer: 5.37 ± 0.081	5.59AlaThr: 5.59 ± 0.074	7.508AlaVal: 7.508 ± 0.1	1.272AlaTrp: 1.272 ± 0.036	2.522AlaTyr: 2.522 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.986CysAla: 0.986 ± 0.038	0.13CysCys: 0.13 ± 0.011	0.661CysAsp: 0.661 ± 0.024	0.467CysGlu: 0.467 ± 0.021	0.369CysPhe: 0.369 ± 0.019	0.946CysGly: 0.946 ± 0.03	0.269CysHis: 0.269 ± 0.018	0.425CysIle: 0.425 ± 0.019	0.254CysLys: 0.254 ± 0.016	0.835CysLeu: 0.835 ± 0.026	0.173CysMet: 0.173 ± 0.013	0.245CysAsn: 0.245 ± 0.017	0.529CysPro: 0.529 ± 0.025	0.294CysGln: 0.294 ± 0.016	0.529CysArg: 0.529 ± 0.027	0.466CysSer: 0.466 ± 0.022	0.43CysThr: 0.43 ± 0.02	0.591CysVal: 0.591 ± 0.025	0.119CysTrp: 0.119 ± 0.01	0.221CysTyr: 0.221 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.644AspAla: 6.644 ± 0.098	0.553AspCys: 0.553 ± 0.023	3.434AspAsp: 3.434 ± 0.084	3.805AspGlu: 3.805 ± 0.07	2.307AspPhe: 2.307 ± 0.049	5.56AspGly: 5.56 ± 0.094	1.532AspHis: 1.532 ± 0.044	3.203AspIle: 3.203 ± 0.056	1.998AspLys: 1.998 ± 0.052	6.682AspLeu: 6.682 ± 0.085	1.805AspMet: 1.805 ± 0.04	1.448AspAsn: 1.448 ± 0.04	3.478AspPro: 3.478 ± 0.066	2.313AspGln: 2.313 ± 0.044	3.998AspArg: 3.998 ± 0.072	2.108AspSer: 2.108 ± 0.054	2.988AspThr: 2.988 ± 0.072	4.274AspVal: 4.274 ± 0.083	1.067AspTrp: 1.067 ± 0.033	1.496AspTyr: 1.496 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.679GluAla: 7.679 ± 0.105	0.424GluCys: 0.424 ± 0.02	3.603GluAsp: 3.603 ± 0.068	4.194GluGlu: 4.194 ± 0.081	2.081GluPhe: 2.081 ± 0.051	5.052GluGly: 5.052 ± 0.071	1.239GluHis: 1.239 ± 0.04	3.959GluIle: 3.959 ± 0.063	2.703GluLys: 2.703 ± 0.051	5.801GluLeu: 5.801 ± 0.074	1.946GluMet: 1.946 ± 0.044	2.1GluAsn: 2.1 ± 0.055	2.229GluPro: 2.229 ± 0.044	2.179GluGln: 2.179 ± 0.049	4.284GluArg: 4.284 ± 0.078	2.094GluSer: 2.094 ± 0.048	3.69GluThr: 3.69 ± 0.06	4.611GluVal: 4.611 ± 0.07	0.689GluTrp: 0.689 ± 0.023	1.184GluTyr: 1.184 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.327PheAla: 4.327 ± 0.069	0.43PheCys: 0.43 ± 0.018	2.888PheAsp: 2.888 ± 0.063	2.345PheGlu: 2.345 ± 0.042	1.476PhePhe: 1.476 ± 0.049	3.695PheGly: 3.695 ± 0.068	0.82PheHis: 0.82 ± 0.026	1.692PheIle: 1.692 ± 0.041	1.168PheLys: 1.168 ± 0.031	3.697PheLeu: 3.697 ± 0.071	0.937PheMet: 0.937 ± 0.03	1.136PheAsn: 1.136 ± 0.039	1.564PhePro: 1.564 ± 0.041	1.133PheGln: 1.133 ± 0.033	2.081PheArg: 2.081 ± 0.053	2.355PheSer: 2.355 ± 0.048	2.073PheThr: 2.073 ± 0.05	2.738PheVal: 2.738 ± 0.054	0.629PheTrp: 0.629 ± 0.026	0.968PheTyr: 0.968 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.362GlyAla: 9.362 ± 0.105	0.823GlyCys: 0.823 ± 0.03	4.853GlyAsp: 4.853 ± 0.098	5.028GlyGlu: 5.028 ± 0.071	3.771GlyPhe: 3.771 ± 0.06	7.26GlyGly: 7.26 ± 0.132	1.897GlyHis: 1.897 ± 0.048	4.409GlyIle: 4.409 ± 0.066	3.747GlyLys: 3.747 ± 0.067	8.646GlyLeu: 8.646 ± 0.091	2.583GlyMet: 2.583 ± 0.054	2.413GlyAsn: 2.413 ± 0.073	3.372GlyPro: 3.372 ± 0.053	3.425GlyGln: 3.425 ± 0.06	5.392GlyArg: 5.392 ± 0.074	4.055GlySer: 4.055 ± 0.07	4.307GlyThr: 4.307 ± 0.072	6.446GlyVal: 6.446 ± 0.083	1.405GlyTrp: 1.405 ± 0.038	2.322GlyTyr: 2.322 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.156HisAla: 2.156 ± 0.048	0.218HisCys: 0.218 ± 0.014	1.303HisAsp: 1.303 ± 0.039	1.173HisGlu: 1.173 ± 0.036	0.883HisPhe: 0.883 ± 0.028	1.873HisGly: 1.873 ± 0.043	0.613HisHis: 0.613 ± 0.029	1.02HisIle: 1.02 ± 0.03	0.708HisLys: 0.708 ± 0.028	2.185HisLeu: 2.185 ± 0.049	0.628HisMet: 0.628 ± 0.027	0.518HisAsn: 0.518 ± 0.022	1.44HisPro: 1.44 ± 0.044	0.653HisGln: 0.653 ± 0.026	1.326HisArg: 1.326 ± 0.042	0.993HisSer: 0.993 ± 0.031	0.892HisThr: 0.892 ± 0.027	1.548HisVal: 1.548 ± 0.037	0.365HisTrp: 0.365 ± 0.019	0.59HisTyr: 0.59 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.549IleAla: 6.549 ± 0.084	0.639IleCys: 0.639 ± 0.027	3.541IleAsp: 3.541 ± 0.063	3.653IleGlu: 3.653 ± 0.064	1.897IlePhe: 1.897 ± 0.045	4.824IleGly: 4.824 ± 0.077	0.988IleHis: 0.988 ± 0.029	2.367IleIle: 2.367 ± 0.054	1.69IleLys: 1.69 ± 0.042	4.852IleLeu: 4.852 ± 0.075	1.185IleMet: 1.185 ± 0.035	1.575IleAsn: 1.575 ± 0.042	2.348IlePro: 2.348 ± 0.05	1.386IleGln: 1.386 ± 0.037	3.331IleArg: 3.331 ± 0.062	3.472IleSer: 3.472 ± 0.058	3.069IleThr: 3.069 ± 0.054	3.534IleVal: 3.534 ± 0.056	0.763IleTrp: 0.763 ± 0.03	1.302IleTyr: 1.302 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.41LysAla: 4.41 ± 0.076	0.24LysCys: 0.24 ± 0.016	2.122LysAsp: 2.122 ± 0.047	2.034LysGlu: 2.034 ± 0.056	1.117LysPhe: 1.117 ± 0.033	3.239LysGly: 3.239 ± 0.056	0.739LysHis: 0.739 ± 0.025	2.086LysIle: 2.086 ± 0.049	1.654LysLys: 1.654 ± 0.049	3.566LysLeu: 3.566 ± 0.06	1.09LysMet: 1.09 ± 0.034	1.078LysAsn: 1.078 ± 0.035	2.02LysPro: 2.02 ± 0.053	1.166LysGln: 1.166 ± 0.039	2.692LysArg: 2.692 ± 0.051	2.307LysSer: 2.307 ± 0.052	2.388LysThr: 2.388 ± 0.044	2.572LysVal: 2.572 ± 0.054	0.469LysTrp: 0.469 ± 0.023	0.794LysTyr: 0.794 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.718LeuAla: 11.718 ± 0.138	0.849LeuCys: 0.849 ± 0.027	5.852LeuAsp: 5.852 ± 0.083	5.762LeuGlu: 5.762 ± 0.08	3.685LeuPhe: 3.685 ± 0.076	8.406LeuGly: 8.406 ± 0.099	1.782LeuHis: 1.782 ± 0.046	5.298LeuIle: 5.298 ± 0.082	3.797LeuLys: 3.797 ± 0.063	8.613LeuLeu: 8.613 ± 0.115	2.669LeuMet: 2.669 ± 0.058	2.89LeuAsn: 2.89 ± 0.051	5.469LeuPro: 5.469 ± 0.076	2.909LeuGln: 2.909 ± 0.06	6.481LeuArg: 6.481 ± 0.102	7.107LeuSer: 7.107 ± 0.085	6.123LeuThr: 6.123 ± 0.079	6.901LeuVal: 6.901 ± 0.098	1.254LeuTrp: 1.254 ± 0.041	2.029LeuTyr: 2.029 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.369MetAla: 3.369 ± 0.061	0.203MetCys: 0.203 ± 0.016	1.479MetAsp: 1.479 ± 0.039	1.463MetGlu: 1.463 ± 0.038	0.896MetPhe: 0.896 ± 0.032	2.413MetGly: 2.413 ± 0.047	0.468MetHis: 0.468 ± 0.021	1.659MetIle: 1.659 ± 0.038	1.222MetLys: 1.222 ± 0.036	2.546MetLeu: 2.546 ± 0.057	0.836MetMet: 0.836 ± 0.03	0.943MetAsn: 0.943 ± 0.029	1.476MetPro: 1.476 ± 0.039	1.004MetGln: 1.004 ± 0.032	1.921MetArg: 1.921 ± 0.042	1.969MetSer: 1.969 ± 0.044	2.008MetThr: 2.008 ± 0.05	1.983MetVal: 1.983 ± 0.041	0.261MetTrp: 0.261 ± 0.016	0.376MetTyr: 0.376 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.392AsnAla: 3.392 ± 0.061	0.29AsnCys: 0.29 ± 0.019	1.618AsnAsp: 1.618 ± 0.053	1.452AsnGlu: 1.452 ± 0.043	1.007AsnPhe: 1.007 ± 0.028	2.639AsnGly: 2.639 ± 0.058	0.567AsnHis: 0.567 ± 0.021	1.489AsnIle: 1.489 ± 0.038	0.91AsnLys: 0.91 ± 0.03	2.817AsnLeu: 2.817 ± 0.052	0.819AsnMet: 0.819 ± 0.029	0.76AsnAsn: 0.76 ± 0.033	1.96AsnPro: 1.96 ± 0.04	0.881AsnGln: 0.881 ± 0.027	1.959AsnArg: 1.959 ± 0.045	1.41AsnSer: 1.41 ± 0.041	1.508AsnThr: 1.508 ± 0.045	1.892AsnVal: 1.892 ± 0.046	0.512AsnTrp: 0.512 ± 0.026	0.68AsnTyr: 0.68 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.19ProAla: 5.19 ± 0.079	0.404ProCys: 0.404 ± 0.019	3.732ProAsp: 3.732 ± 0.054	3.988ProGlu: 3.988 ± 0.068	1.924ProPhe: 1.924 ± 0.041	4.006ProGly: 4.006 ± 0.069	1.079ProHis: 1.079 ± 0.031	2.278ProIle: 2.278 ± 0.043	1.981ProLys: 1.981 ± 0.047	4.413ProLeu: 4.413 ± 0.063	1.294ProMet: 1.294 ± 0.034	1.433ProAsn: 1.433 ± 0.038	2.099ProPro: 2.099 ± 0.058	1.604ProGln: 1.604 ± 0.037	2.508ProArg: 2.508 ± 0.05	2.698ProSer: 2.698 ± 0.056	2.453ProThr: 2.453 ± 0.049	4.035ProVal: 4.035 ± 0.063	0.61ProTrp: 0.61 ± 0.024	1.114ProTyr: 1.114 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.119GlnAla: 4.119 ± 0.068	0.228GlnCys: 0.228 ± 0.013	1.907GlnAsp: 1.907 ± 0.04	1.819GlnGlu: 1.819 ± 0.05	1.201GlnPhe: 1.201 ± 0.034	2.733GlnGly: 2.733 ± 0.056	0.634GlnHis: 0.634 ± 0.024	2.295GlnIle: 2.295 ± 0.051	1.448GlnLys: 1.448 ± 0.039	3.074GlnLeu: 3.074 ± 0.063	1.128GlnMet: 1.128 ± 0.031	1.114GlnAsn: 1.114 ± 0.031	1.623GlnPro: 1.623 ± 0.042	1.11GlnGln: 1.11 ± 0.039	2.122GlnArg: 2.122 ± 0.052	1.929GlnSer: 1.929 ± 0.048	1.919GlnThr: 1.919 ± 0.046	2.512GlnVal: 2.512 ± 0.053	0.405GlnTrp: 0.405 ± 0.018	0.61GlnTyr: 0.61 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.3ArgAla: 7.3 ± 0.101	0.492ArgCys: 0.492 ± 0.023	4.104ArgAsp: 4.104 ± 0.069	4.045ArgGlu: 4.045 ± 0.067	2.694ArgPhe: 2.694 ± 0.048	4.287ArgGly: 4.287 ± 0.061	1.565ArgHis: 1.565 ± 0.045	3.617ArgIle: 3.617 ± 0.06	2.686ArgLys: 2.686 ± 0.055	6.898ArgLeu: 6.898 ± 0.098	1.921ArgMet: 1.921 ± 0.043	1.931ArgAsn: 1.931 ± 0.042	3.054ArgPro: 3.054 ± 0.055	2.34ArgGln: 2.34 ± 0.053	4.41ArgArg: 4.41 ± 0.082	3.216ArgSer: 3.216 ± 0.058	2.777ArgThr: 2.777 ± 0.05	4.518ArgVal: 4.518 ± 0.066	0.895ArgTrp: 0.895 ± 0.031	1.48ArgTyr: 1.48 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.805SerAla: 5.805 ± 0.082	0.483SerCys: 0.483 ± 0.02	3.468SerAsp: 3.468 ± 0.063	3.16SerGlu: 3.16 ± 0.057	2.49SerPhe: 2.49 ± 0.052	5.387SerGly: 5.387 ± 0.083	1.166SerHis: 1.166 ± 0.038	2.618SerIle: 2.618 ± 0.051	1.942SerLys: 1.942 ± 0.043	5.098SerLeu: 5.098 ± 0.073	1.429SerMet: 1.429 ± 0.037	1.547SerAsn: 1.547 ± 0.042	2.584SerPro: 2.584 ± 0.048	1.731SerGln: 1.731 ± 0.04	3.143SerArg: 3.143 ± 0.058	3.023SerSer: 3.023 ± 0.067	2.634SerThr: 2.634 ± 0.051	3.754SerVal: 3.754 ± 0.062	0.749SerTrp: 0.749 ± 0.029	1.39SerTyr: 1.39 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.592ThrAla: 5.592 ± 0.082	0.526ThrCys: 0.526 ± 0.023	3.145ThrAsp: 3.145 ± 0.062	3.002ThrGlu: 3.002 ± 0.057	1.883ThrPhe: 1.883 ± 0.05	5.209ThrGly: 5.209 ± 0.075	1.257ThrHis: 1.257 ± 0.036	2.731ThrIle: 2.731 ± 0.06	1.73ThrLys: 1.73 ± 0.045	5.855ThrLeu: 5.855 ± 0.093	1.3ThrMet: 1.3 ± 0.036	1.416ThrAsn: 1.416 ± 0.036	3.402ThrPro: 3.402 ± 0.063	1.778ThrGln: 1.778 ± 0.045	3.669ThrArg: 3.669 ± 0.057	2.743ThrSer: 2.743 ± 0.053	2.717ThrThr: 2.717 ± 0.055	3.86ThrVal: 3.86 ± 0.068	0.673ThrTrp: 0.673 ± 0.026	1.345ThrTyr: 1.345 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.08ValAla: 8.08 ± 0.108	0.591ValCys: 0.591 ± 0.026	4.126ValAsp: 4.126 ± 0.068	4.662ValGlu: 4.662 ± 0.075	2.875ValPhe: 2.875 ± 0.064	5.311ValGly: 5.311 ± 0.08	1.263ValHis: 1.263 ± 0.036	4.362ValIle: 4.362 ± 0.076	2.558ValLys: 2.558 ± 0.047	7.471ValLeu: 7.471 ± 0.096	2.167ValMet: 2.167 ± 0.051	2.082ValAsn: 2.082 ± 0.048	3.209ValPro: 3.209 ± 0.057	2.084ValGln: 2.084 ± 0.048	3.912ValArg: 3.912 ± 0.058	4.307ValSer: 4.307 ± 0.07	4.505ValThr: 4.505 ± 0.062	5.58ValVal: 5.58 ± 0.087	0.878ValTrp: 0.878 ± 0.031	1.402ValTyr: 1.402 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.352TrpAla: 1.352 ± 0.04	0.138TrpCys: 0.138 ± 0.01	0.76TrpAsp: 0.76 ± 0.031	0.688TrpGlu: 0.688 ± 0.027	0.537TrpPhe: 0.537 ± 0.024	1.006TrpGly: 1.006 ± 0.034	0.32TrpHis: 0.32 ± 0.017	0.71TrpIle: 0.71 ± 0.027	0.502TrpLys: 0.502 ± 0.023	1.548TrpLeu: 1.548 ± 0.043	0.448TrpMet: 0.448 ± 0.02	0.421TrpAsn: 0.421 ± 0.022	0.657TrpPro: 0.657 ± 0.023	0.565TrpGln: 0.565 ± 0.023	1.015TrpArg: 1.015 ± 0.033	0.792TrpSer: 0.792 ± 0.03	0.649TrpThr: 0.649 ± 0.025	1.011TrpVal: 1.011 ± 0.037	0.208TrpTrp: 0.208 ± 0.015	0.261TrpTyr: 0.261 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.448TyrAla: 2.448 ± 0.051	0.265TyrCys: 0.265 ± 0.014	1.575TyrAsp: 1.575 ± 0.042	1.379TyrGlu: 1.379 ± 0.035	0.944TyrPhe: 0.944 ± 0.035	2.098TyrGly: 2.098 ± 0.043	0.564TyrHis: 0.564 ± 0.024	0.983TyrIle: 0.983 ± 0.03	0.682TyrLys: 0.682 ± 0.026	2.4TyrLeu: 2.4 ± 0.047	0.486TyrMet: 0.486 ± 0.02	0.655TyrAsn: 0.655 ± 0.025	1.008TyrPro: 1.008 ± 0.028	0.82TyrGln: 0.82 ± 0.033	1.557TyrArg: 1.557 ± 0.041	1.188TyrSer: 1.188 ± 0.036	1.114TyrThr: 1.114 ± 0.031	1.554TyrVal: 1.554 ± 0.04	0.365TyrTrp: 0.365 ± 0.019	0.587TyrTyr: 0.587 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3465 proteins (1035234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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