Amino acid dipepetide frequency for Clostridium vincentii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.753AlaAla: 3.753 ± 0.07	0.717AlaCys: 0.717 ± 0.028	2.649AlaAsp: 2.649 ± 0.058	3.4AlaGlu: 3.4 ± 0.061	2.612AlaPhe: 2.612 ± 0.055	3.833AlaGly: 3.833 ± 0.084	0.842AlaHis: 0.842 ± 0.029	6.086AlaIle: 6.086 ± 0.093	4.655AlaLys: 4.655 ± 0.077	5.974AlaLeu: 5.974 ± 0.081	1.704AlaMet: 1.704 ± 0.045	2.652AlaAsn: 2.652 ± 0.06	1.378AlaPro: 1.378 ± 0.037	1.625AlaGln: 1.625 ± 0.066	1.912AlaArg: 1.912 ± 0.044	3.341AlaSer: 3.341 ± 0.066	3.044AlaThr: 3.044 ± 0.056	3.887AlaVal: 3.887 ± 0.061	0.379AlaTrp: 0.379 ± 0.019	2.1AlaTyr: 2.1 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.635CysAla: 0.635 ± 0.028	0.207CysCys: 0.207 ± 0.016	0.685CysAsp: 0.685 ± 0.026	0.771CysGlu: 0.771 ± 0.03	0.485CysPhe: 0.485 ± 0.025	1.154CysGly: 1.154 ± 0.039	0.208CysHis: 0.208 ± 0.012	1.124CysIle: 1.124 ± 0.034	0.947CysLys: 0.947 ± 0.03	0.909CysLeu: 0.909 ± 0.03	0.258CysMet: 0.258 ± 0.018	0.771CysAsn: 0.771 ± 0.027	0.474CysPro: 0.474 ± 0.026	0.237CysGln: 0.237 ± 0.016	0.398CysArg: 0.398 ± 0.02	0.787CysSer: 0.787 ± 0.032	0.612CysThr: 0.612 ± 0.023	0.627CysVal: 0.627 ± 0.026	0.076CysTrp: 0.076 ± 0.008	0.488CysTyr: 0.488 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.7AspAla: 2.7 ± 0.062	0.653AspCys: 0.653 ± 0.029	2.774AspAsp: 2.774 ± 0.053	4.726AspGlu: 4.726 ± 0.079	2.709AspPhe: 2.709 ± 0.051	3.587AspGly: 3.587 ± 0.069	0.591AspHis: 0.591 ± 0.027	6.28AspIle: 6.28 ± 0.09	5.258AspLys: 5.258 ± 0.075	5.015AspLeu: 5.015 ± 0.078	1.575AspMet: 1.575 ± 0.044	3.347AspAsn: 3.347 ± 0.059	1.309AspPro: 1.309 ± 0.038	0.996AspGln: 0.996 ± 0.035	1.927AspArg: 1.927 ± 0.046	3.452AspSer: 3.452 ± 0.061	2.68AspThr: 2.68 ± 0.059	3.509AspVal: 3.509 ± 0.063	0.382AspTrp: 0.382 ± 0.019	2.597AspTyr: 2.597 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.197GluAla: 4.197 ± 0.081	0.713GluCys: 0.713 ± 0.029	4.645GluAsp: 4.645 ± 0.071	7.227GluGlu: 7.227 ± 0.12	3.105GluPhe: 3.105 ± 0.066	4.472GluGly: 4.472 ± 0.079	0.902GluHis: 0.902 ± 0.029	7.456GluIle: 7.456 ± 0.103	7.464GluLys: 7.464 ± 0.125	6.953GluLeu: 6.953 ± 0.098	2.035GluMet: 2.035 ± 0.04	5.066GluAsn: 5.066 ± 0.088	1.408GluPro: 1.408 ± 0.036	1.753GluGln: 1.753 ± 0.045	2.487GluArg: 2.487 ± 0.047	3.781GluSer: 3.781 ± 0.06	3.173GluThr: 3.173 ± 0.06	5.046GluVal: 5.046 ± 0.079	0.456GluTrp: 0.456 ± 0.021	2.978GluTyr: 2.978 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.332PheAla: 2.332 ± 0.052	0.585PheCys: 0.585 ± 0.024	2.456PheAsp: 2.456 ± 0.048	2.741PheGlu: 2.741 ± 0.058	1.902PhePhe: 1.902 ± 0.058	2.958PheGly: 2.958 ± 0.066	0.53PheHis: 0.53 ± 0.022	4.677PheIle: 4.677 ± 0.094	3.822PheLys: 3.822 ± 0.071	3.966PheLeu: 3.966 ± 0.082	1.185PheMet: 1.185 ± 0.035	2.848PheAsn: 2.848 ± 0.052	1.154PhePro: 1.154 ± 0.035	1.038PheGln: 1.038 ± 0.031	1.213PheArg: 1.213 ± 0.034	3.263PheSer: 3.263 ± 0.063	2.404PheThr: 2.404 ± 0.044	2.549PheVal: 2.549 ± 0.051	0.283PheTrp: 0.283 ± 0.016	1.751PheTyr: 1.751 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.127GlyAla: 4.127 ± 0.092	0.921GlyCys: 0.921 ± 0.037	3.445GlyAsp: 3.445 ± 0.055	4.587GlyGlu: 4.587 ± 0.075	3.161GlyPhe: 3.161 ± 0.061	4.438GlyGly: 4.438 ± 0.094	0.966GlyHis: 0.966 ± 0.033	7.171GlyIle: 7.171 ± 0.098	5.472GlyLys: 5.472 ± 0.075	5.604GlyLeu: 5.604 ± 0.091	1.834GlyMet: 1.834 ± 0.042	3.299GlyAsn: 3.299 ± 0.061	1.244GlyPro: 1.244 ± 0.045	1.536GlyGln: 1.536 ± 0.04	2.322GlyArg: 2.322 ± 0.055	3.728GlySer: 3.728 ± 0.062	3.613GlyThr: 3.613 ± 0.079	4.767GlyVal: 4.767 ± 0.083	0.57GlyTrp: 0.57 ± 0.029	2.957GlyTyr: 2.957 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.631HisAla: 0.631 ± 0.028	0.219HisCys: 0.219 ± 0.015	0.685HisAsp: 0.685 ± 0.028	0.852HisGlu: 0.852 ± 0.027	0.657HisPhe: 0.657 ± 0.025	1.006HisGly: 1.006 ± 0.033	0.278HisHis: 0.278 ± 0.021	1.316HisIle: 1.316 ± 0.039	1.03HisLys: 1.03 ± 0.033	1.18HisLeu: 1.18 ± 0.035	0.337HisMet: 0.337 ± 0.019	0.78HisAsn: 0.78 ± 0.029	0.591HisPro: 0.591 ± 0.023	0.31HisGln: 0.31 ± 0.017	0.515HisArg: 0.515 ± 0.021	0.851HisSer: 0.851 ± 0.026	0.654HisThr: 0.654 ± 0.025	0.693HisVal: 0.693 ± 0.026	0.105HisTrp: 0.105 ± 0.012	0.54HisTyr: 0.54 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.072IleAla: 6.072 ± 0.097	1.284IleCys: 1.284 ± 0.037	5.825IleAsp: 5.825 ± 0.088	7.396IleGlu: 7.396 ± 0.103	4.289IlePhe: 4.289 ± 0.085	6.418IleGly: 6.418 ± 0.101	1.296IleHis: 1.296 ± 0.035	10.155IleIle: 10.155 ± 0.148	8.901IleLys: 8.901 ± 0.095	9.525IleLeu: 9.525 ± 0.12	2.496IleMet: 2.496 ± 0.058	6.311IleAsn: 6.311 ± 0.086	3.309IlePro: 3.309 ± 0.051	2.355IleGln: 2.355 ± 0.048	3.087IleArg: 3.087 ± 0.056	7.167IleSer: 7.167 ± 0.097	5.273IleThr: 5.273 ± 0.076	6.361IleVal: 6.361 ± 0.085	0.538IleTrp: 0.538 ± 0.027	3.686IleTyr: 3.686 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.815LysAla: 4.815 ± 0.074	0.896LysCys: 0.896 ± 0.037	6.14LysAsp: 6.14 ± 0.083	8.695LysGlu: 8.695 ± 0.109	3.073LysPhe: 3.073 ± 0.057	5.27LysGly: 5.27 ± 0.08	1.039LysHis: 1.039 ± 0.034	8.525LysIle: 8.525 ± 0.108	7.965LysLys: 7.965 ± 0.093	7.398LysLeu: 7.398 ± 0.093	2.301LysMet: 2.301 ± 0.046	5.827LysAsn: 5.827 ± 0.088	1.898LysPro: 1.898 ± 0.044	1.979LysGln: 1.979 ± 0.043	3.033LysArg: 3.033 ± 0.059	5.188LysSer: 5.188 ± 0.076	4.095LysThr: 4.095 ± 0.064	5.843LysVal: 5.843 ± 0.078	0.571LysTrp: 0.571 ± 0.024	3.758LysTyr: 3.758 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	5.404LeuAla: 5.404 ± 0.076	1.102LeuCys: 1.102 ± 0.035	5.243LeuAsp: 5.243 ± 0.079	6.613LeuGlu: 6.613 ± 0.096	3.833LeuPhe: 3.833 ± 0.068	6.199LeuGly: 6.199 ± 0.092	1.09LeuHis: 1.09 ± 0.035	8.658LeuIle: 8.658 ± 0.116	8.511LeuLys: 8.511 ± 0.098	8.087LeuLeu: 8.087 ± 0.124	2.41LeuMet: 2.41 ± 0.048	5.477LeuAsn: 5.477 ± 0.077	2.687LeuPro: 2.687 ± 0.051	2.231LeuGln: 2.231 ± 0.046	3.092LeuArg: 3.092 ± 0.057	6.636LeuSer: 6.636 ± 0.111	4.575LeuThr: 4.575 ± 0.067	5.616LeuVal: 5.616 ± 0.079	0.554LeuTrp: 0.554 ± 0.026	3.162LeuTyr: 3.162 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.795MetAla: 1.795 ± 0.045	0.259MetCys: 0.259 ± 0.017	1.675MetAsp: 1.675 ± 0.041	1.929MetGlu: 1.929 ± 0.041	0.976MetPhe: 0.976 ± 0.035	1.847MetGly: 1.847 ± 0.045	0.333MetHis: 0.333 ± 0.017	2.4MetIle: 2.4 ± 0.054	2.603MetLys: 2.603 ± 0.05	2.218MetLeu: 2.218 ± 0.045	0.727MetMet: 0.727 ± 0.027	1.625MetAsn: 1.625 ± 0.041	0.958MetPro: 0.958 ± 0.033	0.653MetGln: 0.653 ± 0.028	0.877MetArg: 0.877 ± 0.03	1.704MetSer: 1.704 ± 0.04	1.268MetThr: 1.268 ± 0.034	1.756MetVal: 1.756 ± 0.048	0.156MetTrp: 0.156 ± 0.012	0.863MetTyr: 0.863 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.773AsnAla: 2.773 ± 0.065	0.731AsnCys: 0.731 ± 0.033	2.88AsnAsp: 2.88 ± 0.054	4.384AsnGlu: 4.384 ± 0.072	2.524AsnPhe: 2.524 ± 0.054	3.631AsnGly: 3.631 ± 0.066	0.777AsnHis: 0.777 ± 0.027	6.924AsnIle: 6.924 ± 0.098	5.868AsnLys: 5.868 ± 0.093	5.505AsnLeu: 5.505 ± 0.08	1.66AsnMet: 1.66 ± 0.04	4.066AsnAsn: 4.066 ± 0.089	1.987AsnPro: 1.987 ± 0.044	1.399AsnGln: 1.399 ± 0.045	1.994AsnArg: 1.994 ± 0.045	4.006AsnSer: 4.006 ± 0.075	2.82AsnThr: 2.82 ± 0.053	3.416AsnVal: 3.416 ± 0.063	0.446AsnTrp: 0.446 ± 0.025	2.571AsnTyr: 2.571 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	1.374ProAla: 1.374 ± 0.038	0.31ProCys: 0.31 ± 0.018	1.356ProAsp: 1.356 ± 0.037	2.153ProGlu: 2.153 ± 0.054	1.372ProPhe: 1.372 ± 0.037	1.555ProGly: 1.555 ± 0.043	0.449ProHis: 0.449 ± 0.022	2.739ProIle: 2.739 ± 0.055	2.186ProLys: 2.186 ± 0.047	2.571ProLeu: 2.571 ± 0.049	0.7ProMet: 0.7 ± 0.028	1.556ProAsn: 1.556 ± 0.045	0.581ProPro: 0.581 ± 0.024	0.784ProGln: 0.784 ± 0.04	0.8ProArg: 0.8 ± 0.031	1.727ProSer: 1.727 ± 0.05	1.505ProThr: 1.505 ± 0.037	1.849ProVal: 1.849 ± 0.041	0.236ProTrp: 0.236 ± 0.017	1.245ProTyr: 1.245 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	1.375GlnAla: 1.375 ± 0.035	0.265GlnCys: 0.265 ± 0.015	1.305GlnAsp: 1.305 ± 0.032	1.932GlnGlu: 1.932 ± 0.054	0.956GlnPhe: 0.956 ± 0.031	1.786GlnGly: 1.786 ± 0.11	0.303GlnHis: 0.303 ± 0.018	2.181GlnIle: 2.181 ± 0.053	1.962GlnLys: 1.962 ± 0.045	2.089GlnLeu: 2.089 ± 0.047	0.663GlnMet: 0.663 ± 0.025	1.424GlnAsn: 1.424 ± 0.049	0.568GlnPro: 0.568 ± 0.026	0.686GlnGln: 0.686 ± 0.029	0.97GlnArg: 0.97 ± 0.035	1.402GlnSer: 1.402 ± 0.041	1.114GlnThr: 1.114 ± 0.033	1.673GlnVal: 1.673 ± 0.046	0.215GlnTrp: 0.215 ± 0.014	0.961GlnTyr: 0.961 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.948ArgAla: 1.948 ± 0.044	0.361ArgCys: 0.361 ± 0.019	1.973ArgAsp: 1.973 ± 0.044	2.825ArgGlu: 2.825 ± 0.059	1.469ArgPhe: 1.469 ± 0.037	2.082ArgGly: 2.082 ± 0.048	0.448ArgHis: 0.448 ± 0.019	3.291ArgIle: 3.291 ± 0.051	2.843ArgLys: 2.843 ± 0.052	2.863ArgLeu: 2.863 ± 0.056	0.95ArgMet: 0.95 ± 0.031	1.936ArgAsn: 1.936 ± 0.045	0.838ArgPro: 0.838 ± 0.032	0.848ArgGln: 0.848 ± 0.026	1.428ArgArg: 1.428 ± 0.044	1.677ArgSer: 1.677 ± 0.045	1.592ArgThr: 1.592 ± 0.036	2.294ArgVal: 2.294 ± 0.053	0.233ArgTrp: 0.233 ± 0.014	1.371ArgTyr: 1.371 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.184SerAla: 3.184 ± 0.067	0.655SerCys: 0.655 ± 0.026	3.234SerAsp: 3.234 ± 0.062	4.061SerGlu: 4.061 ± 0.068	3.136SerPhe: 3.136 ± 0.058	4.475SerGly: 4.475 ± 0.081	0.908SerHis: 0.908 ± 0.03	6.725SerIle: 6.725 ± 0.088	5.699SerLys: 5.699 ± 0.085	6.245SerLeu: 6.245 ± 0.084	1.684SerMet: 1.684 ± 0.042	3.78SerAsn: 3.78 ± 0.071	1.657SerPro: 1.657 ± 0.045	1.653SerGln: 1.653 ± 0.039	2.1SerArg: 2.1 ± 0.051	4.373SerSer: 4.373 ± 0.08	3.458SerThr: 3.458 ± 0.068	3.835SerVal: 3.835 ± 0.066	0.429SerTrp: 0.429 ± 0.022	2.607SerTyr: 2.607 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.981ThrAla: 2.981 ± 0.059	0.524ThrCys: 0.524 ± 0.023	2.547ThrAsp: 2.547 ± 0.051	3.131ThrGlu: 3.131 ± 0.057	2.265ThrPhe: 2.265 ± 0.049	3.753ThrGly: 3.753 ± 0.06	0.775ThrHis: 0.775 ± 0.026	5.03ThrIle: 5.03 ± 0.081	3.853ThrLys: 3.853 ± 0.057	5.001ThrLeu: 5.001 ± 0.082	1.284ThrMet: 1.284 ± 0.036	2.815ThrAsn: 2.815 ± 0.055	1.753ThrPro: 1.753 ± 0.043	1.224ThrGln: 1.224 ± 0.037	1.514ThrArg: 1.514 ± 0.035	3.35ThrSer: 3.35 ± 0.067	2.85ThrThr: 2.85 ± 0.065	3.448ThrVal: 3.448 ± 0.064	0.364ThrTrp: 0.364 ± 0.02	1.876ThrTyr: 1.876 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.154ValAla: 4.154 ± 0.07	0.824ValCys: 0.824 ± 0.031	3.821ValAsp: 3.821 ± 0.068	4.617ValGlu: 4.617 ± 0.077	2.855ValPhe: 2.855 ± 0.061	4.18ValGly: 4.18 ± 0.068	0.85ValHis: 0.85 ± 0.029	6.467ValIle: 6.467 ± 0.088	5.204ValLys: 5.204 ± 0.08	5.914ValLeu: 5.914 ± 0.068	1.662ValMet: 1.662 ± 0.042	3.665ValAsn: 3.665 ± 0.061	1.85ValPro: 1.85 ± 0.044	1.505ValGln: 1.505 ± 0.044	1.963ValArg: 1.963 ± 0.046	4.184ValSer: 4.184 ± 0.071	3.349ValThr: 3.349 ± 0.054	4.659ValVal: 4.659 ± 0.065	0.363ValTrp: 0.363 ± 0.018	2.282ValTyr: 2.282 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.379TrpAla: 0.379 ± 0.02	0.089TrpCys: 0.089 ± 0.008	0.383TrpAsp: 0.383 ± 0.019	0.437TrpGlu: 0.437 ± 0.023	0.303TrpPhe: 0.303 ± 0.017	0.526TrpGly: 0.526 ± 0.023	0.113TrpHis: 0.113 ± 0.011	0.629TrpIle: 0.629 ± 0.027	0.478TrpLys: 0.478 ± 0.019	0.593TrpLeu: 0.593 ± 0.025	0.212TrpMet: 0.212 ± 0.013	0.425TrpAsn: 0.425 ± 0.025	0.162TrpPro: 0.162 ± 0.014	0.22TrpGln: 0.22 ± 0.015	0.237TrpArg: 0.237 ± 0.017	0.432TrpSer: 0.432 ± 0.023	0.328TrpThr: 0.328 ± 0.018	0.412TrpVal: 0.412 ± 0.023	0.094TrpTrp: 0.094 ± 0.009	0.285TrpTyr: 0.285 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.912TyrAla: 1.912 ± 0.044	0.539TyrCys: 0.539 ± 0.022	2.343TyrAsp: 2.343 ± 0.05	2.84TyrGlu: 2.84 ± 0.054	1.973TyrPhe: 1.973 ± 0.044	2.595TyrGly: 2.595 ± 0.056	0.535TyrHis: 0.535 ± 0.024	3.913TyrIle: 3.913 ± 0.056	3.588TyrLys: 3.588 ± 0.066	3.572TyrLeu: 3.572 ± 0.059	0.943TyrMet: 0.943 ± 0.033	2.693TyrAsn: 2.693 ± 0.053	1.245TyrPro: 1.245 ± 0.039	0.795TyrGln: 0.795 ± 0.031	1.402TyrArg: 1.402 ± 0.043	2.846TyrSer: 2.846 ± 0.058	1.933TyrThr: 1.933 ± 0.043	2.127TyrVal: 2.127 ± 0.037	0.286TyrTrp: 0.286 ± 0.017	1.786TyrTyr: 1.786 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3379 proteins (1015978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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