Amino acid dipepetide frequency for Planococcus salinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.033AlaAla: 8.033 ± 0.124
0.592AlaCys: 0.592 ± 0.026
4.27AlaAsp: 4.27 ± 0.074
6.343AlaGlu: 6.343 ± 0.105
3.8AlaPhe: 3.8 ± 0.064
6.488AlaGly: 6.488 ± 0.098
1.389AlaHis: 1.389 ± 0.04
6.164AlaIle: 6.164 ± 0.096
4.443AlaLys: 4.443 ± 0.079
7.953AlaLeu: 7.953 ± 0.114
2.443AlaMet: 2.443 ± 0.056
2.665AlaAsn: 2.665 ± 0.054
2.416AlaPro: 2.416 ± 0.055
2.541AlaGln: 2.541 ± 0.051
3.049AlaArg: 3.049 ± 0.064
4.611AlaSer: 4.611 ± 0.074
3.847AlaThr: 3.847 ± 0.072
6.819AlaVal: 6.819 ± 0.11
0.674AlaTrp: 0.674 ± 0.029
2.567AlaTyr: 2.567 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.438CysAla: 0.438 ± 0.022
0.065CysCys: 0.065 ± 0.009
0.314CysAsp: 0.314 ± 0.019
0.372CysGlu: 0.372 ± 0.019
0.261CysPhe: 0.261 ± 0.016
0.617CysGly: 0.617 ± 0.023
0.165CysHis: 0.165 ± 0.014
0.366CysIle: 0.366 ± 0.021
0.241CysLys: 0.241 ± 0.018
0.53CysLeu: 0.53 ± 0.025
0.146CysMet: 0.146 ± 0.011
0.204CysAsn: 0.204 ± 0.013
0.299CysPro: 0.299 ± 0.021
0.169CysGln: 0.169 ± 0.015
0.305CysArg: 0.305 ± 0.02
0.412CysSer: 0.412 ± 0.022
0.328CysThr: 0.328 ± 0.019
0.366CysVal: 0.366 ± 0.021
0.056CysTrp: 0.056 ± 0.007
0.184CysTyr: 0.184 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.909AspAla: 3.909 ± 0.081
0.314AspCys: 0.314 ± 0.019
2.544AspAsp: 2.544 ± 0.056
4.433AspGlu: 4.433 ± 0.071
2.681AspPhe: 2.681 ± 0.055
3.573AspGly: 3.573 ± 0.069
1.138AspHis: 1.138 ± 0.037
3.729AspIle: 3.729 ± 0.071
2.724AspLys: 2.724 ± 0.057
4.999AspLeu: 4.999 ± 0.074
1.557AspMet: 1.557 ± 0.041
1.65AspAsn: 1.65 ± 0.047
2.196AspPro: 2.196 ± 0.05
1.967AspGln: 1.967 ± 0.041
2.501AspArg: 2.501 ± 0.057
2.837AspSer: 2.837 ± 0.057
2.64AspThr: 2.64 ± 0.052
4.001AspVal: 4.001 ± 0.067
0.635AspTrp: 0.635 ± 0.025
2.012AspTyr: 2.012 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.433GluAla: 6.433 ± 0.107
0.313GluCys: 0.313 ± 0.02
4.211GluAsp: 4.211 ± 0.077
8.08GluGlu: 8.08 ± 0.109
2.749GluPhe: 2.749 ± 0.051
4.903GluGly: 4.903 ± 0.074
1.506GluHis: 1.506 ± 0.043
5.174GluIle: 5.174 ± 0.08
6.017GluLys: 6.017 ± 0.107
7.744GluLeu: 7.744 ± 0.11
2.535GluMet: 2.535 ± 0.053
3.373GluAsn: 3.373 ± 0.07
2.313GluPro: 2.313 ± 0.064
4.042GluGln: 4.042 ± 0.074
3.857GluArg: 3.857 ± 0.067
3.759GluSer: 3.759 ± 0.067
4.442GluThr: 4.442 ± 0.062
5.484GluVal: 5.484 ± 0.085
0.9GluTrp: 0.9 ± 0.028
2.059GluTyr: 2.059 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.411PheAla: 3.411 ± 0.068
0.281PheCys: 0.281 ± 0.019
2.532PheAsp: 2.532 ± 0.051
2.98PheGlu: 2.98 ± 0.057
2.374PhePhe: 2.374 ± 0.057
3.64PheGly: 3.64 ± 0.069
1.022PheHis: 1.022 ± 0.035
3.449PheIle: 3.449 ± 0.073
1.998PheLys: 1.998 ± 0.048
4.543PheLeu: 4.543 ± 0.089
1.212PheMet: 1.212 ± 0.031
1.586PheAsn: 1.586 ± 0.042
1.72PhePro: 1.72 ± 0.041
1.589PheGln: 1.589 ± 0.041
1.684PheArg: 1.684 ± 0.047
3.154PheSer: 3.154 ± 0.06
2.685PheThr: 2.685 ± 0.051
3.293PheVal: 3.293 ± 0.069
0.497PheTrp: 0.497 ± 0.026
1.579PheTyr: 1.579 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.567GlyAla: 5.567 ± 0.092
0.486GlyCys: 0.486 ± 0.022
3.436GlyAsp: 3.436 ± 0.063
4.905GlyGlu: 4.905 ± 0.09
3.544GlyPhe: 3.544 ± 0.058
5.319GlyGly: 5.319 ± 0.1
1.577GlyHis: 1.577 ± 0.042
5.869GlyIle: 5.869 ± 0.102
4.771GlyLys: 4.771 ± 0.086
6.872GlyLeu: 6.872 ± 0.105
2.386GlyMet: 2.386 ± 0.049
2.569GlyAsn: 2.569 ± 0.048
1.937GlyPro: 1.937 ± 0.049
2.517GlyGln: 2.517 ± 0.05
2.946GlyArg: 2.946 ± 0.071
4.36GlySer: 4.36 ± 0.065
4.477GlyThr: 4.477 ± 0.075
5.447GlyVal: 5.447 ± 0.082
0.816GlyTrp: 0.816 ± 0.033
2.669GlyTyr: 2.669 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.486HisAla: 1.486 ± 0.041
0.155HisCys: 0.155 ± 0.014
1.019HisAsp: 1.019 ± 0.029
1.413HisGlu: 1.413 ± 0.035
1.035HisPhe: 1.035 ± 0.039
1.428HisGly: 1.428 ± 0.042
0.657HisHis: 0.657 ± 0.029
1.379HisIle: 1.379 ± 0.036
0.888HisLys: 0.888 ± 0.03
2.003HisLeu: 2.003 ± 0.045
0.55HisMet: 0.55 ± 0.022
0.685HisAsn: 0.685 ± 0.026
1.217HisPro: 1.217 ± 0.034
0.852HisGln: 0.852 ± 0.034
0.934HisArg: 0.934 ± 0.033
1.178HisSer: 1.178 ± 0.036
1.098HisThr: 1.098 ± 0.035
1.439HisVal: 1.439 ± 0.034
0.21HisTrp: 0.21 ± 0.014
0.798HisTyr: 0.798 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.276IleAla: 6.276 ± 0.093
0.458IleCys: 0.458 ± 0.02
4.093IleAsp: 4.093 ± 0.065
5.529IleGlu: 5.529 ± 0.085
2.94IlePhe: 2.94 ± 0.066
5.906IleGly: 5.906 ± 0.093
1.551IleHis: 1.551 ± 0.042
4.785IleIle: 4.785 ± 0.084
3.207IleLys: 3.207 ± 0.064
6.378IleLeu: 6.378 ± 0.093
1.699IleMet: 1.699 ± 0.043
2.456IleAsn: 2.456 ± 0.046
3.221IlePro: 3.221 ± 0.061
2.578IleGln: 2.578 ± 0.055
3.143IleArg: 3.143 ± 0.054
4.549IleSer: 4.549 ± 0.072
3.811IleThr: 3.811 ± 0.073
5.289IleVal: 5.289 ± 0.088
0.615IleTrp: 0.615 ± 0.028
2.057IleTyr: 2.057 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.528LysAla: 4.528 ± 0.075
0.228LysCys: 0.228 ± 0.016
3.033LysAsp: 3.033 ± 0.061
5.935LysGlu: 5.935 ± 0.089
1.83LysPhe: 1.83 ± 0.047
4.006LysGly: 4.006 ± 0.066
1.049LysHis: 1.049 ± 0.032
3.618LysIle: 3.618 ± 0.067
4.845LysLys: 4.845 ± 0.076
5.007LysLeu: 5.007 ± 0.067
2.062LysMet: 2.062 ± 0.047
2.551LysAsn: 2.551 ± 0.057
2.125LysPro: 2.125 ± 0.051
2.608LysGln: 2.608 ± 0.057
3.116LysArg: 3.116 ± 0.061
3.063LysSer: 3.063 ± 0.054
3.452LysThr: 3.452 ± 0.059
3.992LysVal: 3.992 ± 0.072
0.708LysTrp: 0.708 ± 0.028
1.687LysTyr: 1.687 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
8.36LeuAla: 8.36 ± 0.113
0.515LeuCys: 0.515 ± 0.024
4.601LeuAsp: 4.601 ± 0.082
7.077LeuGlu: 7.077 ± 0.107
4.665LeuPhe: 4.665 ± 0.09
6.54LeuGly: 6.54 ± 0.096
1.894LeuHis: 1.894 ± 0.05
6.559LeuIle: 6.559 ± 0.1
5.854LeuLys: 5.854 ± 0.088
10.341LeuLeu: 10.341 ± 0.167
2.66LeuMet: 2.66 ± 0.051
3.705LeuAsn: 3.705 ± 0.06
4.205LeuPro: 4.205 ± 0.059
3.609LeuGln: 3.609 ± 0.059
3.805LeuArg: 3.805 ± 0.062
6.491LeuSer: 6.491 ± 0.086
5.634LeuThr: 5.634 ± 0.08
6.807LeuVal: 6.807 ± 0.101
0.891LeuTrp: 0.891 ± 0.031
2.954LeuTyr: 2.954 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.53MetAla: 2.53 ± 0.052
0.12MetCys: 0.12 ± 0.012
1.693MetAsp: 1.693 ± 0.048
2.45MetGlu: 2.45 ± 0.051
1.032MetPhe: 1.032 ± 0.034
1.872MetGly: 1.872 ± 0.05
0.461MetHis: 0.461 ± 0.024
1.976MetIle: 1.976 ± 0.051
2.514MetLys: 2.514 ± 0.047
2.569MetLeu: 2.569 ± 0.053
0.863MetMet: 0.863 ± 0.031
1.386MetAsn: 1.386 ± 0.034
1.213MetPro: 1.213 ± 0.037
0.98MetGln: 0.98 ± 0.027
1.147MetArg: 1.147 ± 0.039
1.641MetSer: 1.641 ± 0.04
1.973MetThr: 1.973 ± 0.041
1.804MetVal: 1.804 ± 0.043
0.218MetTrp: 0.218 ± 0.017
0.73MetTyr: 0.73 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.874AsnAla: 2.874 ± 0.059
0.258AsnCys: 0.258 ± 0.017
1.994AsnAsp: 1.994 ± 0.052
2.984AsnGlu: 2.984 ± 0.06
1.575AsnPhe: 1.575 ± 0.04
3.051AsnGly: 3.051 ± 0.063
0.818AsnHis: 0.818 ± 0.031
2.64AsnIle: 2.64 ± 0.057
2.091AsnLys: 2.091 ± 0.053
3.367AsnLeu: 3.367 ± 0.068
1.094AsnMet: 1.094 ± 0.034
1.422AsnAsn: 1.422 ± 0.046
2.056AsnPro: 2.056 ± 0.047
1.378AsnGln: 1.378 ± 0.042
1.979AsnArg: 1.979 ± 0.046
2.006AsnSer: 2.006 ± 0.047
1.825AsnThr: 1.825 ± 0.047
2.635AsnVal: 2.635 ± 0.051
0.419AsnTrp: 0.419 ± 0.023
1.301AsnTyr: 1.301 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
2.957ProAla: 2.957 ± 0.055
0.166ProCys: 0.166 ± 0.015
2.286ProAsp: 2.286 ± 0.052
3.777ProGlu: 3.777 ± 0.072
1.987ProPhe: 1.987 ± 0.042
2.592ProGly: 2.592 ± 0.056
0.869ProHis: 0.869 ± 0.031
2.601ProIle: 2.601 ± 0.051
2.0ProLys: 2.0 ± 0.05
3.724ProLeu: 3.724 ± 0.068
0.927ProMet: 0.927 ± 0.029
1.45ProAsn: 1.45 ± 0.043
1.117ProPro: 1.117 ± 0.034
1.233ProGln: 1.233 ± 0.042
1.182ProArg: 1.182 ± 0.035
2.319ProSer: 2.319 ± 0.055
1.9ProThr: 1.9 ± 0.052
3.423ProVal: 3.423 ± 0.06
0.384ProTrp: 0.384 ± 0.02
1.388ProTyr: 1.388 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.183GlnAla: 3.183 ± 0.069
0.167GlnCys: 0.167 ± 0.013
1.685GlnAsp: 1.685 ± 0.044
3.079GlnGlu: 3.079 ± 0.058
1.54GlnPhe: 1.54 ± 0.042
2.269GlnGly: 2.269 ± 0.05
0.779GlnHis: 0.779 ± 0.027
2.26GlnIle: 2.26 ± 0.05
2.429GlnLys: 2.429 ± 0.049
4.162GlnLeu: 4.162 ± 0.071
1.197GlnMet: 1.197 ± 0.036
1.483GlnAsn: 1.483 ± 0.036
1.383GlnPro: 1.383 ± 0.045
2.109GlnGln: 2.109 ± 0.057
1.636GlnArg: 1.636 ± 0.038
2.082GlnSer: 2.082 ± 0.045
2.044GlnThr: 2.044 ± 0.053
2.536GlnVal: 2.536 ± 0.05
0.431GlnTrp: 0.431 ± 0.02
1.198GlnTyr: 1.198 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.795ArgAla: 2.795 ± 0.05
0.231ArgCys: 0.231 ± 0.018
2.205ArgAsp: 2.205 ± 0.054
3.392ArgGlu: 3.392 ± 0.06
2.081ArgPhe: 2.081 ± 0.049
2.558ArgGly: 2.558 ± 0.059
0.976ArgHis: 0.976 ± 0.033
3.115ArgIle: 3.115 ± 0.052
3.207ArgLys: 3.207 ± 0.064
4.394ArgLeu: 4.394 ± 0.069
1.334ArgMet: 1.334 ± 0.038
1.896ArgAsn: 1.896 ± 0.046
1.558ArgPro: 1.558 ± 0.043
1.944ArgGln: 1.944 ± 0.041
2.051ArgArg: 2.051 ± 0.055
2.412ArgSer: 2.412 ± 0.055
2.161ArgThr: 2.161 ± 0.046
2.84ArgVal: 2.84 ± 0.059
0.422ArgTrp: 0.422 ± 0.021
1.547ArgTyr: 1.547 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.423SerAla: 4.423 ± 0.071
0.368SerCys: 0.368 ± 0.021
2.908SerAsp: 2.908 ± 0.054
4.176SerGlu: 4.176 ± 0.066
3.211SerPhe: 3.211 ± 0.059
4.875SerGly: 4.875 ± 0.08
1.188SerHis: 1.188 ± 0.043
4.458SerIle: 4.458 ± 0.067
3.14SerLys: 3.14 ± 0.059
5.834SerLeu: 5.834 ± 0.082
1.812SerMet: 1.812 ± 0.047
2.114SerAsn: 2.114 ± 0.052
2.255SerPro: 2.255 ± 0.046
1.871SerGln: 1.871 ± 0.048
2.598SerArg: 2.598 ± 0.051
3.753SerSer: 3.753 ± 0.077
3.013SerThr: 3.013 ± 0.051
4.272SerVal: 4.272 ± 0.067
0.664SerTrp: 0.664 ± 0.026
2.076SerTyr: 2.076 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.031ThrAla: 5.031 ± 0.078
0.301ThrCys: 0.301 ± 0.018
3.092ThrAsp: 3.092 ± 0.059
4.23ThrGlu: 4.23 ± 0.07
2.419ThrPhe: 2.419 ± 0.051
4.852ThrGly: 4.852 ± 0.079
1.064ThrHis: 1.064 ± 0.033
4.109ThrIle: 4.109 ± 0.071
2.8ThrLys: 2.8 ± 0.056
4.976ThrLeu: 4.976 ± 0.082
1.378ThrMet: 1.378 ± 0.04
1.987ThrAsn: 1.987 ± 0.044
2.371ThrPro: 2.371 ± 0.05
1.486ThrGln: 1.486 ± 0.041
2.055ThrArg: 2.055 ± 0.044
3.114ThrSer: 3.114 ± 0.061
2.849ThrThr: 2.849 ± 0.058
4.728ThrVal: 4.728 ± 0.068
0.521ThrTrp: 0.521 ± 0.024
1.719ThrTyr: 1.719 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.768ValAla: 5.768 ± 0.088
0.518ValCys: 0.518 ± 0.028
3.819ValAsp: 3.819 ± 0.067
5.538ValGlu: 5.538 ± 0.09
3.358ValPhe: 3.358 ± 0.058
4.798ValGly: 4.798 ± 0.077
1.432ValHis: 1.432 ± 0.036
5.372ValIle: 5.372 ± 0.079
4.069ValLys: 4.069 ± 0.058
7.501ValLeu: 7.501 ± 0.096
2.114ValMet: 2.114 ± 0.053
2.909ValAsn: 2.909 ± 0.061
2.964ValPro: 2.964 ± 0.061
2.479ValGln: 2.479 ± 0.057
3.001ValArg: 3.001 ± 0.062
4.777ValSer: 4.777 ± 0.073
4.5ValThr: 4.5 ± 0.069
5.388ValVal: 5.388 ± 0.084
0.664ValTrp: 0.664 ± 0.029
2.298ValTyr: 2.298 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.668TrpAla: 0.668 ± 0.027
0.053TrpCys: 0.053 ± 0.007
0.437TrpAsp: 0.437 ± 0.021
0.661TrpGlu: 0.661 ± 0.025
0.5TrpPhe: 0.5 ± 0.022
0.701TrpGly: 0.701 ± 0.029
0.204TrpHis: 0.204 ± 0.014
0.792TrpIle: 0.792 ± 0.036
0.651TrpLys: 0.651 ± 0.024
1.186TrpLeu: 1.186 ± 0.042
0.363TrpMet: 0.363 ± 0.02
0.524TrpAsn: 0.524 ± 0.026
0.3TrpPro: 0.3 ± 0.021
0.437TrpGln: 0.437 ± 0.023
0.433TrpArg: 0.433 ± 0.022
0.614TrpSer: 0.614 ± 0.023
0.591TrpThr: 0.591 ± 0.026
0.663TrpVal: 0.663 ± 0.027
0.148TrpTrp: 0.148 ± 0.013
0.302TrpTyr: 0.302 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.438TyrAla: 2.438 ± 0.053
0.249TyrCys: 0.249 ± 0.016
1.87TyrAsp: 1.87 ± 0.042
2.54TyrGlu: 2.54 ± 0.057
1.644TyrPhe: 1.644 ± 0.044
2.486TyrGly: 2.486 ± 0.055
0.685TyrHis: 0.685 ± 0.03
2.129TyrIle: 2.129 ± 0.056
1.553TyrLys: 1.553 ± 0.045
3.084TyrLeu: 3.084 ± 0.055
0.84TyrMet: 0.84 ± 0.029
1.152TyrAsn: 1.152 ± 0.033
1.413TyrPro: 1.413 ± 0.04
1.264TyrGln: 1.264 ± 0.041
1.693TyrArg: 1.693 ± 0.042
1.877TyrSer: 1.877 ± 0.046
1.813TyrThr: 1.813 ± 0.044
2.04TyrVal: 2.04 ± 0.048
0.355TyrTrp: 0.355 ± 0.019
1.145TyrTyr: 1.145 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3216 proteins (962098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski