Amino acid dipepetide frequency for Gloeocapsa sp. PCC 7428

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.158AlaAla: 9.158 ± 0.103
0.859AlaCys: 0.859 ± 0.024
4.187AlaAsp: 4.187 ± 0.059
5.582AlaGlu: 5.582 ± 0.069
3.149AlaPhe: 3.149 ± 0.053
6.0AlaGly: 6.0 ± 0.075
1.464AlaHis: 1.464 ± 0.03
7.678AlaIle: 7.678 ± 0.079
3.686AlaLys: 3.686 ± 0.054
9.417AlaLeu: 9.417 ± 0.087
1.798AlaMet: 1.798 ± 0.039
3.476AlaAsn: 3.476 ± 0.058
3.325AlaPro: 3.325 ± 0.057
5.324AlaGln: 5.324 ± 0.073
4.194AlaArg: 4.194 ± 0.055
5.191AlaSer: 5.191 ± 0.065
5.545AlaThr: 5.545 ± 0.066
6.184AlaVal: 6.184 ± 0.062
1.108AlaTrp: 1.108 ± 0.032
2.498AlaTyr: 2.498 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.72CysAla: 0.72 ± 0.022
0.152CysCys: 0.152 ± 0.01
0.59CysAsp: 0.59 ± 0.02
0.486CysGlu: 0.486 ± 0.016
0.404CysPhe: 0.404 ± 0.016
0.771CysGly: 0.771 ± 0.02
0.283CysHis: 0.283 ± 0.012
0.608CysIle: 0.608 ± 0.019
0.279CysLys: 0.279 ± 0.013
1.08CysLeu: 1.08 ± 0.026
0.162CysMet: 0.162 ± 0.01
0.366CysAsn: 0.366 ± 0.016
0.54CysPro: 0.54 ± 0.019
0.584CysGln: 0.584 ± 0.019
0.563CysArg: 0.563 ± 0.02
0.551CysSer: 0.551 ± 0.021
0.501CysThr: 0.501 ± 0.02
0.607CysVal: 0.607 ± 0.019
0.147CysTrp: 0.147 ± 0.009
0.342CysTyr: 0.342 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.142AspAla: 4.142 ± 0.055
0.514AspCys: 0.514 ± 0.019
2.268AspAsp: 2.268 ± 0.045
2.809AspGlu: 2.809 ± 0.047
2.206AspPhe: 2.206 ± 0.041
3.132AspGly: 3.132 ± 0.057
0.589AspHis: 0.589 ± 0.019
3.276AspIle: 3.276 ± 0.044
1.668AspLys: 1.668 ± 0.034
5.566AspLeu: 5.566 ± 0.061
0.75AspMet: 0.75 ± 0.023
1.816AspAsn: 1.816 ± 0.034
2.474AspPro: 2.474 ± 0.039
1.772AspGln: 1.772 ± 0.031
3.894AspArg: 3.894 ± 0.048
2.642AspSer: 2.642 ± 0.041
2.815AspThr: 2.815 ± 0.052
3.306AspVal: 3.306 ± 0.044
0.844AspTrp: 0.844 ± 0.021
1.778AspTyr: 1.778 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
5.498GluAla: 5.498 ± 0.067
0.489GluCys: 0.489 ± 0.02
2.654GluAsp: 2.654 ± 0.047
3.605GluGlu: 3.605 ± 0.058
2.385GluPhe: 2.385 ± 0.039
3.054GluGly: 3.054 ± 0.048
1.074GluHis: 1.074 ± 0.027
4.456GluIle: 4.456 ± 0.062
2.8GluLys: 2.8 ± 0.049
6.778GluLeu: 6.778 ± 0.086
1.259GluMet: 1.259 ± 0.029
2.395GluAsn: 2.395 ± 0.04
2.579GluPro: 2.579 ± 0.038
3.77GluGln: 3.77 ± 0.057
3.471GluArg: 3.471 ± 0.053
3.062GluSer: 3.062 ± 0.049
3.356GluThr: 3.356 ± 0.044
4.375GluVal: 4.375 ± 0.055
0.753GluTrp: 0.753 ± 0.021
1.819GluTyr: 1.819 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.441PheAla: 3.441 ± 0.05
0.495PheCys: 0.495 ± 0.015
2.297PheAsp: 2.297 ± 0.039
2.131PheGlu: 2.131 ± 0.045
1.64PhePhe: 1.64 ± 0.033
2.975PheGly: 2.975 ± 0.056
0.743PheHis: 0.743 ± 0.024
2.323PheIle: 2.323 ± 0.043
1.325PheLys: 1.325 ± 0.029
3.994PheLeu: 3.994 ± 0.06
0.66PheMet: 0.66 ± 0.021
1.695PheAsn: 1.695 ± 0.037
1.768PhePro: 1.768 ± 0.038
1.858PheGln: 1.858 ± 0.034
1.916PheArg: 1.916 ± 0.04
2.701PheSer: 2.701 ± 0.043
2.359PheThr: 2.359 ± 0.039
2.649PheVal: 2.649 ± 0.043
0.71PheTrp: 0.71 ± 0.026
1.296PheTyr: 1.296 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
5.053GlyAla: 5.053 ± 0.067
0.745GlyCys: 0.745 ± 0.02
3.329GlyAsp: 3.329 ± 0.057
3.85GlyGlu: 3.85 ± 0.053
3.049GlyPhe: 3.049 ± 0.058
4.684GlyGly: 4.684 ± 0.075
1.186GlyHis: 1.186 ± 0.03
5.181GlyIle: 5.181 ± 0.059
3.379GlyLys: 3.379 ± 0.054
6.762GlyLeu: 6.762 ± 0.072
1.479GlyMet: 1.479 ± 0.034
2.854GlyAsn: 2.854 ± 0.068
1.377GlyPro: 1.377 ± 0.033
2.869GlyGln: 2.869 ± 0.047
3.325GlyArg: 3.325 ± 0.054
4.062GlySer: 4.062 ± 0.062
4.021GlyThr: 4.021 ± 0.065
5.046GlyVal: 5.046 ± 0.059
1.142GlyTrp: 1.142 ± 0.03
2.466GlyTyr: 2.466 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.305HisAla: 1.305 ± 0.031
0.268HisCys: 0.268 ± 0.013
0.832HisAsp: 0.832 ± 0.022
0.92HisGlu: 0.92 ± 0.027
0.874HisPhe: 0.874 ± 0.023
1.138HisGly: 1.138 ± 0.029
0.663HisHis: 0.663 ± 0.026
1.099HisIle: 1.099 ± 0.025
0.74HisLys: 0.74 ± 0.02
2.392HisLeu: 2.392 ± 0.039
0.251HisMet: 0.251 ± 0.014
0.743HisAsn: 0.743 ± 0.025
1.371HisPro: 1.371 ± 0.032
1.274HisGln: 1.274 ± 0.029
1.14HisArg: 1.14 ± 0.026
1.212HisSer: 1.212 ± 0.027
0.974HisThr: 0.974 ± 0.028
0.923HisVal: 0.923 ± 0.026
0.374HisTrp: 0.374 ± 0.015
0.697HisTyr: 0.697 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.225IleAla: 8.225 ± 0.074
0.714IleCys: 0.714 ± 0.02
3.577IleAsp: 3.577 ± 0.049
4.222IleGlu: 4.222 ± 0.058
2.354IlePhe: 2.354 ± 0.046
4.573IleGly: 4.573 ± 0.065
1.251IleHis: 1.251 ± 0.033
3.368IleIle: 3.368 ± 0.054
2.402IleLys: 2.402 ± 0.045
6.628IleLeu: 6.628 ± 0.079
0.8IleMet: 0.8 ± 0.021
2.641IleAsn: 2.641 ± 0.047
3.537IlePro: 3.537 ± 0.046
3.016IleGln: 3.016 ± 0.046
3.171IleArg: 3.171 ± 0.049
3.989IleSer: 3.989 ± 0.052
3.631IleThr: 3.631 ± 0.048
4.758IleVal: 4.758 ± 0.06
0.82IleTrp: 0.82 ± 0.023
1.879IleTyr: 1.879 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.599LysAla: 3.599 ± 0.054
0.283LysCys: 0.283 ± 0.012
1.753LysAsp: 1.753 ± 0.033
2.234LysGlu: 2.234 ± 0.043
1.399LysPhe: 1.399 ± 0.033
2.043LysGly: 2.043 ± 0.039
0.808LysHis: 0.808 ± 0.025
2.737LysIle: 2.737 ± 0.041
1.659LysLys: 1.659 ± 0.04
4.651LysLeu: 4.651 ± 0.053
0.772LysMet: 0.772 ± 0.022
1.558LysAsn: 1.558 ± 0.033
2.129LysPro: 2.129 ± 0.04
2.503LysGln: 2.503 ± 0.045
2.198LysArg: 2.198 ± 0.041
2.333LysSer: 2.333 ± 0.04
2.4LysThr: 2.4 ± 0.041
2.807LysVal: 2.807 ± 0.043
0.4LysTrp: 0.4 ± 0.017
1.168LysTyr: 1.168 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
10.447LeuAla: 10.447 ± 0.078
1.033LeuCys: 1.033 ± 0.027
5.159LeuAsp: 5.159 ± 0.051
6.919LeuGlu: 6.919 ± 0.077
3.873LeuPhe: 3.873 ± 0.054
7.514LeuGly: 7.514 ± 0.083
2.127LeuHis: 2.127 ± 0.035
6.602LeuIle: 6.602 ± 0.07
4.616LeuLys: 4.616 ± 0.062
11.685LeuLeu: 11.685 ± 0.119
1.99LeuMet: 1.99 ± 0.039
4.366LeuAsn: 4.366 ± 0.068
5.952LeuPro: 5.952 ± 0.064
6.331LeuGln: 6.331 ± 0.083
6.022LeuArg: 6.022 ± 0.07
7.382LeuSer: 7.382 ± 0.073
6.375LeuThr: 6.375 ± 0.062
7.38LeuVal: 7.38 ± 0.08
1.46LeuTrp: 1.46 ± 0.035
2.801LeuTyr: 2.801 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
1.655MetAla: 1.655 ± 0.036
0.139MetCys: 0.139 ± 0.008
0.659MetAsp: 0.659 ± 0.019
0.866MetGlu: 0.866 ± 0.024
0.579MetPhe: 0.579 ± 0.021
1.189MetGly: 1.189 ± 0.032
0.379MetHis: 0.379 ± 0.014
0.99MetIle: 0.99 ± 0.028
0.818MetLys: 0.818 ± 0.025
1.952MetLeu: 1.952 ± 0.037
0.449MetMet: 0.449 ± 0.019
0.824MetAsn: 0.824 ± 0.021
0.924MetPro: 0.924 ± 0.024
1.121MetGln: 1.121 ± 0.025
1.095MetArg: 1.095 ± 0.027
1.29MetSer: 1.29 ± 0.025
1.31MetThr: 1.31 ± 0.033
1.209MetVal: 1.209 ± 0.031
0.158MetTrp: 0.158 ± 0.01
0.369MetTyr: 0.369 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.262AsnAla: 3.262 ± 0.051
0.448AsnCys: 0.448 ± 0.018
1.738AsnAsp: 1.738 ± 0.046
1.798AsnGlu: 1.798 ± 0.036
1.728AsnPhe: 1.728 ± 0.032
2.501AsnGly: 2.501 ± 0.058
0.802AsnHis: 0.802 ± 0.024
2.542AsnIle: 2.542 ± 0.049
1.33AsnLys: 1.33 ± 0.032
4.922AsnLeu: 4.922 ± 0.075
0.593AsnMet: 0.593 ± 0.017
1.821AsnAsn: 1.821 ± 0.045
2.659AsnPro: 2.659 ± 0.045
2.426AsnGln: 2.426 ± 0.043
2.383AsnArg: 2.383 ± 0.036
2.668AsnSer: 2.668 ± 0.051
2.343AsnThr: 2.343 ± 0.044
2.372AsnVal: 2.372 ± 0.047
0.679AsnTrp: 0.679 ± 0.022
1.414AsnTyr: 1.414 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.724ProAla: 3.724 ± 0.055
0.353ProCys: 0.353 ± 0.016
2.866ProAsp: 2.866 ± 0.042
3.75ProGlu: 3.75 ± 0.049
1.772ProPhe: 1.772 ± 0.034
3.055ProGly: 3.055 ± 0.048
1.073ProHis: 1.073 ± 0.026
3.053ProIle: 3.053 ± 0.045
1.816ProLys: 1.816 ± 0.04
4.851ProLeu: 4.851 ± 0.057
0.701ProMet: 0.701 ± 0.022
2.133ProAsn: 2.133 ± 0.037
2.433ProPro: 2.433 ± 0.054
3.062ProGln: 3.062 ± 0.051
2.032ProArg: 2.032 ± 0.034
2.844ProSer: 2.844 ± 0.047
3.077ProThr: 3.077 ± 0.058
3.421ProVal: 3.421 ± 0.048
0.623ProTrp: 0.623 ± 0.021
1.413ProTyr: 1.413 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.593GlnAla: 5.593 ± 0.062
0.385GlnCys: 0.385 ± 0.016
2.124GlnAsp: 2.124 ± 0.039
3.436GlnGlu: 3.436 ± 0.057
1.913GlnPhe: 1.913 ± 0.033
3.375GlnGly: 3.375 ± 0.048
1.092GlnHis: 1.092 ± 0.032
3.785GlnIle: 3.785 ± 0.058
2.33GlnLys: 2.33 ± 0.042
6.621GlnLeu: 6.621 ± 0.095
1.129GlnMet: 1.129 ± 0.027
2.099GlnAsn: 2.099 ± 0.04
2.97GlnPro: 2.97 ± 0.047
4.69GlnGln: 4.69 ± 0.089
3.548GlnArg: 3.548 ± 0.062
3.019GlnSer: 3.019 ± 0.044
3.108GlnThr: 3.108 ± 0.04
4.177GlnVal: 4.177 ± 0.054
0.691GlnTrp: 0.691 ± 0.021
1.325GlnTyr: 1.325 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.8ArgAla: 3.8 ± 0.058
0.577ArgCys: 0.577 ± 0.022
2.778ArgAsp: 2.778 ± 0.05
3.347ArgGlu: 3.347 ± 0.054
2.337ArgPhe: 2.337 ± 0.036
3.194ArgGly: 3.194 ± 0.038
1.052ArgHis: 1.052 ± 0.026
3.575ArgIle: 3.575 ± 0.049
2.07ArgLys: 2.07 ± 0.037
6.287ArgLeu: 6.287 ± 0.072
1.062ArgMet: 1.062 ± 0.026
2.315ArgAsn: 2.315 ± 0.043
2.086ArgPro: 2.086 ± 0.042
3.529ArgGln: 3.529 ± 0.052
3.431ArgArg: 3.431 ± 0.055
3.76ArgSer: 3.76 ± 0.055
2.934ArgThr: 2.934 ± 0.044
3.927ArgVal: 3.927 ± 0.049
0.933ArgTrp: 0.933 ± 0.025
2.079ArgTyr: 2.079 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.814SerAla: 4.814 ± 0.062
0.574SerCys: 0.574 ± 0.017
3.169SerAsp: 3.169 ± 0.045
3.396SerGlu: 3.396 ± 0.051
2.48SerPhe: 2.48 ± 0.044
4.425SerGly: 4.425 ± 0.059
1.388SerHis: 1.388 ± 0.028
3.701SerIle: 3.701 ± 0.053
2.092SerLys: 2.092 ± 0.039
7.056SerLeu: 7.056 ± 0.07
1.153SerMet: 1.153 ± 0.03
2.395SerAsn: 2.395 ± 0.046
3.337SerPro: 3.337 ± 0.053
3.445SerGln: 3.445 ± 0.048
3.394SerArg: 3.394 ± 0.051
4.174SerSer: 4.174 ± 0.064
3.565SerThr: 3.565 ± 0.055
4.158SerVal: 4.158 ± 0.053
0.907SerTrp: 0.907 ± 0.026
1.88SerTyr: 1.88 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.385ThrAla: 5.385 ± 0.065
0.491ThrCys: 0.491 ± 0.02
2.676ThrAsp: 2.676 ± 0.052
3.171ThrGlu: 3.171 ± 0.049
2.065ThrPhe: 2.065 ± 0.038
4.386ThrGly: 4.386 ± 0.065
1.085ThrHis: 1.085 ± 0.027
3.738ThrIle: 3.738 ± 0.052
2.017ThrLys: 2.017 ± 0.039
6.699ThrLeu: 6.699 ± 0.065
0.821ThrMet: 0.821 ± 0.022
2.319ThrAsn: 2.319 ± 0.044
3.624ThrPro: 3.624 ± 0.052
3.267ThrGln: 3.267 ± 0.049
2.734ThrArg: 2.734 ± 0.042
3.578ThrSer: 3.578 ± 0.049
3.906ThrThr: 3.906 ± 0.056
4.301ThrVal: 4.301 ± 0.054
0.689ThrTrp: 0.689 ± 0.018
1.736ThrTyr: 1.736 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
6.732ValAla: 6.732 ± 0.077
0.697ValCys: 0.697 ± 0.022
3.574ValAsp: 3.574 ± 0.048
4.605ValGlu: 4.605 ± 0.057
2.781ValPhe: 2.781 ± 0.043
4.877ValGly: 4.877 ± 0.063
1.07ValHis: 1.07 ± 0.027
4.298ValIle: 4.298 ± 0.058
2.864ValLys: 2.864 ± 0.042
7.243ValLeu: 7.243 ± 0.069
1.397ValMet: 1.397 ± 0.034
2.748ValAsn: 2.748 ± 0.046
3.193ValPro: 3.193 ± 0.05
3.27ValGln: 3.27 ± 0.044
3.563ValArg: 3.563 ± 0.047
4.323ValSer: 4.323 ± 0.058
4.161ValThr: 4.161 ± 0.054
5.489ValVal: 5.489 ± 0.059
0.94ValTrp: 0.94 ± 0.028
1.943ValTyr: 1.943 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.93TrpAla: 0.93 ± 0.024
0.142TrpCys: 0.142 ± 0.011
0.574TrpAsp: 0.574 ± 0.023
0.857TrpGlu: 0.857 ± 0.026
0.598TrpPhe: 0.598 ± 0.021
0.916TrpGly: 0.916 ± 0.026
0.37TrpHis: 0.37 ± 0.018
0.886TrpIle: 0.886 ± 0.026
0.506TrpLys: 0.506 ± 0.015
1.916TrpLeu: 1.916 ± 0.043
0.318TrpMet: 0.318 ± 0.013
0.647TrpAsn: 0.647 ± 0.023
0.152TrpPro: 0.152 ± 0.01
1.304TrpGln: 1.304 ± 0.032
0.94TrpArg: 0.94 ± 0.024
0.899TrpSer: 0.899 ± 0.025
0.645TrpThr: 0.645 ± 0.017
0.933TrpVal: 0.933 ± 0.026
0.247TrpTrp: 0.247 ± 0.014
0.419TrpTyr: 0.419 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.339TyrAla: 2.339 ± 0.036
0.378TyrCys: 0.378 ± 0.018
1.458TyrAsp: 1.458 ± 0.032
1.646TyrGlu: 1.646 ± 0.038
1.392TyrPhe: 1.392 ± 0.033
2.055TyrGly: 2.055 ± 0.043
0.693TyrHis: 0.693 ± 0.022
1.659TyrIle: 1.659 ± 0.031
1.038TyrLys: 1.038 ± 0.023
3.533TyrLeu: 3.533 ± 0.053
0.431TyrMet: 0.431 ± 0.019
1.214TyrAsn: 1.214 ± 0.026
1.621TyrPro: 1.621 ± 0.031
1.998TyrGln: 1.998 ± 0.036
2.061TyrArg: 2.061 ± 0.04
1.822TyrSer: 1.822 ± 0.035
1.661TyrThr: 1.661 ± 0.035
1.746TyrVal: 1.746 ± 0.032
0.577TyrTrp: 0.577 ± 0.018
1.08TyrTyr: 1.08 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5003 proteins (1614380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski