Amino acid dipepetide frequency for Paracoccus aminophilus JCM 7686

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.275AlaAla: 18.275 ± 0.194	1.01AlaCys: 1.01 ± 0.028	6.621AlaAsp: 6.621 ± 0.078	8.895AlaGlu: 8.895 ± 0.101	4.16AlaPhe: 4.16 ± 0.055	11.131AlaGly: 11.131 ± 0.108	2.275AlaHis: 2.275 ± 0.035	6.252AlaIle: 6.252 ± 0.066	4.049AlaLys: 4.049 ± 0.068	15.094AlaLeu: 15.094 ± 0.144	3.528AlaMet: 3.528 ± 0.048	2.749AlaAsn: 2.749 ± 0.047	6.716AlaPro: 6.716 ± 0.094	4.806AlaGln: 4.806 ± 0.067	9.873AlaArg: 9.873 ± 0.087	6.243AlaSer: 6.243 ± 0.068	6.066AlaThr: 6.066 ± 0.073	8.273AlaVal: 8.273 ± 0.079	1.418AlaTrp: 1.418 ± 0.03	2.382AlaTyr: 2.382 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.028	0.111CysCys: 0.111 ± 0.009	0.526CysAsp: 0.526 ± 0.021	0.379CysGlu: 0.379 ± 0.019	0.304CysPhe: 0.304 ± 0.016	0.823CysGly: 0.823 ± 0.023	0.256CysHis: 0.256 ± 0.014	0.39CysIle: 0.39 ± 0.017	0.18CysLys: 0.18 ± 0.012	0.824CysLeu: 0.824 ± 0.023	0.135CysMet: 0.135 ± 0.01	0.176CysAsn: 0.176 ± 0.012	0.51CysPro: 0.51 ± 0.018	0.233CysGln: 0.233 ± 0.012	0.601CysArg: 0.601 ± 0.022	0.419CysSer: 0.419 ± 0.018	0.393CysThr: 0.393 ± 0.019	0.447CysVal: 0.447 ± 0.019	0.103CysTrp: 0.103 ± 0.008	0.167CysTyr: 0.167 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.48AspAla: 6.48 ± 0.078	0.476AspCys: 0.476 ± 0.018	2.734AspAsp: 2.734 ± 0.061	3.377AspGlu: 3.377 ± 0.054	2.331AspPhe: 2.331 ± 0.042	4.901AspGly: 4.901 ± 0.069	1.38AspHis: 1.38 ± 0.027	2.529AspIle: 2.529 ± 0.048	1.611AspLys: 1.611 ± 0.04	6.71AspLeu: 6.71 ± 0.071	1.326AspMet: 1.326 ± 0.028	1.155AspAsn: 1.155 ± 0.028	3.887AspPro: 3.887 ± 0.059	2.029AspGln: 2.029 ± 0.045	4.217AspArg: 4.217 ± 0.057	2.214AspSer: 2.214 ± 0.043	2.291AspThr: 2.291 ± 0.042	3.324AspVal: 3.324 ± 0.053	1.242AspTrp: 1.242 ± 0.035	1.53AspTyr: 1.53 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.344GluAla: 8.344 ± 0.102	0.292GluCys: 0.292 ± 0.015	2.938GluAsp: 2.938 ± 0.053	3.012GluGlu: 3.012 ± 0.049	1.783GluPhe: 1.783 ± 0.038	4.735GluGly: 4.735 ± 0.059	1.033GluHis: 1.033 ± 0.027	4.041GluIle: 4.041 ± 0.057	2.069GluLys: 2.069 ± 0.045	5.556GluLeu: 5.556 ± 0.064	1.683GluMet: 1.683 ± 0.036	1.554GluAsn: 1.554 ± 0.031	2.598GluPro: 2.598 ± 0.047	1.745GluGln: 1.745 ± 0.033	4.207GluArg: 4.207 ± 0.061	2.345GluSer: 2.345 ± 0.04	3.685GluThr: 3.685 ± 0.053	4.213GluVal: 4.213 ± 0.06	0.67GluTrp: 0.67 ± 0.019	0.922GluTyr: 0.922 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.605PheAla: 4.605 ± 0.054	0.38PheCys: 0.38 ± 0.015	2.5PheAsp: 2.5 ± 0.041	1.889PheGlu: 1.889 ± 0.041	1.291PhePhe: 1.291 ± 0.037	3.617PheGly: 3.617 ± 0.06	0.79PheHis: 0.79 ± 0.023	1.64PheIle: 1.64 ± 0.039	0.869PheLys: 0.869 ± 0.027	3.439PheLeu: 3.439 ± 0.053	0.751PheMet: 0.751 ± 0.022	0.952PheAsn: 0.952 ± 0.03	1.622PhePro: 1.622 ± 0.033	1.009PheGln: 1.009 ± 0.026	2.259PheArg: 2.259 ± 0.043	2.161PheSer: 2.161 ± 0.04	1.943PheThr: 1.943 ± 0.037	2.355PheVal: 2.355 ± 0.045	0.591PheTrp: 0.591 ± 0.022	0.815PheTyr: 0.815 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.439GlyAla: 10.439 ± 0.097	0.731GlyCys: 0.731 ± 0.026	4.279GlyAsp: 4.279 ± 0.073	4.796GlyGlu: 4.796 ± 0.066	3.555GlyPhe: 3.555 ± 0.046	7.321GlyGly: 7.321 ± 0.101	1.882GlyHis: 1.882 ± 0.042	4.467GlyIle: 4.467 ± 0.063	3.292GlyLys: 3.292 ± 0.054	9.707GlyLeu: 9.707 ± 0.088	2.49GlyMet: 2.49 ± 0.042	2.103GlyAsn: 2.103 ± 0.062	3.967GlyPro: 3.967 ± 0.056	3.426GlyGln: 3.426 ± 0.055	6.22GlyArg: 6.22 ± 0.068	4.395GlySer: 4.395 ± 0.06	4.456GlyThr: 4.456 ± 0.078	6.046GlyVal: 6.046 ± 0.075	1.562GlyTrp: 1.562 ± 0.04	2.19GlyTyr: 2.19 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.316HisAla: 2.316 ± 0.041	0.19HisCys: 0.19 ± 0.012	1.297HisAsp: 1.297 ± 0.03	1.048HisGlu: 1.048 ± 0.027	0.823HisPhe: 0.823 ± 0.026	1.837HisGly: 1.837 ± 0.039	0.546HisHis: 0.546 ± 0.02	0.941HisIle: 0.941 ± 0.023	0.422HisLys: 0.422 ± 0.018	2.345HisLeu: 2.345 ± 0.042	0.467HisMet: 0.467 ± 0.018	0.397HisAsn: 0.397 ± 0.015	1.476HisPro: 1.476 ± 0.031	0.627HisGln: 0.627 ± 0.018	1.41HisArg: 1.41 ± 0.033	0.947HisSer: 0.947 ± 0.027	0.681HisThr: 0.681 ± 0.024	1.3HisVal: 1.3 ± 0.033	0.353HisTrp: 0.353 ± 0.015	0.501HisTyr: 0.501 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.678IleAla: 7.678 ± 0.076	0.624IleCys: 0.624 ± 0.018	3.308IleAsp: 3.308 ± 0.045	3.542IleGlu: 3.542 ± 0.048	1.773IlePhe: 1.773 ± 0.036	5.088IleGly: 5.088 ± 0.061	0.983IleHis: 0.983 ± 0.023	2.21IleIle: 2.21 ± 0.043	1.277IleLys: 1.277 ± 0.03	4.938IleLeu: 4.938 ± 0.069	1.049IleMet: 1.049 ± 0.028	1.278IleAsn: 1.278 ± 0.03	2.352IlePro: 2.352 ± 0.035	1.209IleGln: 1.209 ± 0.032	3.708IleArg: 3.708 ± 0.062	3.312IleSer: 3.312 ± 0.044	2.884IleThr: 2.884 ± 0.044	3.537IleVal: 3.537 ± 0.052	0.796IleTrp: 0.796 ± 0.026	1.18IleTyr: 1.18 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.897LysAla: 3.897 ± 0.065	0.149LysCys: 0.149 ± 0.01	1.697LysAsp: 1.697 ± 0.036	1.443LysGlu: 1.443 ± 0.034	0.816LysPhe: 0.816 ± 0.025	2.774LysGly: 2.774 ± 0.051	0.49LysHis: 0.49 ± 0.02	1.679LysIle: 1.679 ± 0.038	1.034LysLys: 1.034 ± 0.034	3.099LysLeu: 3.099 ± 0.048	0.774LysMet: 0.774 ± 0.026	0.799LysAsn: 0.799 ± 0.028	1.766LysPro: 1.766 ± 0.04	0.872LysGln: 0.872 ± 0.028	2.062LysArg: 2.062 ± 0.041	1.727LysSer: 1.727 ± 0.034	1.838LysThr: 1.838 ± 0.035	2.23LysVal: 2.23 ± 0.046	0.401LysTrp: 0.401 ± 0.017	0.577LysTyr: 0.577 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.776LeuAla: 14.776 ± 0.123	0.933LeuCys: 0.933 ± 0.026	6.144LeuAsp: 6.144 ± 0.069	4.876LeuGlu: 4.876 ± 0.057	3.372LeuPhe: 3.372 ± 0.058	9.098LeuGly: 9.098 ± 0.081	1.925LeuHis: 1.925 ± 0.034	5.863LeuIle: 5.863 ± 0.079	3.062LeuLys: 3.062 ± 0.05	9.584LeuLeu: 9.584 ± 0.104	2.538LeuMet: 2.538 ± 0.049	2.625LeuAsn: 2.625 ± 0.044	6.426LeuPro: 6.426 ± 0.079	2.834LeuGln: 2.834 ± 0.039	7.986LeuArg: 7.986 ± 0.08	6.887LeuSer: 6.887 ± 0.069	6.319LeuThr: 6.319 ± 0.066	6.892LeuVal: 6.892 ± 0.079	1.391LeuTrp: 1.391 ± 0.033	1.98LeuTyr: 1.98 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.271MetAla: 3.271 ± 0.048	0.151MetCys: 0.151 ± 0.01	1.15MetAsp: 1.15 ± 0.029	1.109MetGlu: 1.109 ± 0.03	0.713MetPhe: 0.713 ± 0.025	1.935MetGly: 1.935 ± 0.037	0.382MetHis: 0.382 ± 0.016	1.535MetIle: 1.535 ± 0.03	0.926MetLys: 0.926 ± 0.028	2.471MetLeu: 2.471 ± 0.045	0.675MetMet: 0.675 ± 0.023	0.748MetAsn: 0.748 ± 0.023	1.414MetPro: 1.414 ± 0.032	0.852MetGln: 0.852 ± 0.025	1.853MetArg: 1.853 ± 0.037	1.828MetSer: 1.828 ± 0.033	2.032MetThr: 2.032 ± 0.035	1.774MetVal: 1.774 ± 0.035	0.194MetTrp: 0.194 ± 0.01	0.254MetTyr: 0.254 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.91AsnAla: 2.91 ± 0.051	0.227AsnCys: 0.227 ± 0.013	1.374AsnAsp: 1.374 ± 0.042	1.07AsnGlu: 1.07 ± 0.026	0.943AsnPhe: 0.943 ± 0.026	2.309AsnGly: 2.309 ± 0.05	0.503AsnHis: 0.503 ± 0.02	1.31AsnIle: 1.31 ± 0.031	0.612AsnLys: 0.612 ± 0.019	2.616AsnLeu: 2.616 ± 0.045	0.605AsnMet: 0.605 ± 0.02	0.576AsnAsn: 0.576 ± 0.026	1.848AsnPro: 1.848 ± 0.042	0.79AsnGln: 0.79 ± 0.027	1.818AsnArg: 1.818 ± 0.031	1.268AsnSer: 1.268 ± 0.033	1.129AsnThr: 1.129 ± 0.032	1.585AsnVal: 1.585 ± 0.037	0.47AsnTrp: 0.47 ± 0.016	0.572AsnTyr: 0.572 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.049ProAla: 7.049 ± 0.089	0.341ProCys: 0.341 ± 0.014	3.719ProAsp: 3.719 ± 0.06	4.588ProGlu: 4.588 ± 0.058	1.961ProPhe: 1.961 ± 0.034	4.875ProGly: 4.875 ± 0.065	1.104ProHis: 1.104 ± 0.031	2.398ProIle: 2.398 ± 0.044	1.682ProLys: 1.682 ± 0.031	4.973ProLeu: 4.973 ± 0.062	1.266ProMet: 1.266 ± 0.028	1.352ProAsn: 1.352 ± 0.03	2.453ProPro: 2.453 ± 0.055	1.847ProGln: 1.847 ± 0.036	3.301ProArg: 3.301 ± 0.058	2.805ProSer: 2.805 ± 0.047	2.487ProThr: 2.487 ± 0.051	4.362ProVal: 4.362 ± 0.061	0.679ProTrp: 0.679 ± 0.023	1.104ProTyr: 1.104 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.129GlnAla: 4.129 ± 0.059	0.176GlnCys: 0.176 ± 0.011	1.658GlnAsp: 1.658 ± 0.035	1.461GlnGlu: 1.461 ± 0.033	1.019GlnPhe: 1.019 ± 0.029	2.823GlnGly: 2.823 ± 0.046	0.608GlnHis: 0.608 ± 0.021	2.314GlnIle: 2.314 ± 0.042	1.201GlnLys: 1.201 ± 0.036	3.023GlnLeu: 3.023 ± 0.051	0.985GlnMet: 0.985 ± 0.026	0.973GlnAsn: 0.973 ± 0.026	1.934GlnPro: 1.934 ± 0.038	1.126GlnGln: 1.126 ± 0.036	2.266GlnArg: 2.266 ± 0.042	2.039GlnSer: 2.039 ± 0.034	1.812GlnThr: 1.812 ± 0.035	2.223GlnVal: 2.223 ± 0.041	0.385GlnTrp: 0.385 ± 0.016	0.573GlnTyr: 0.573 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.116ArgAla: 9.116 ± 0.085	0.463ArgCys: 0.463 ± 0.019	4.301ArgAsp: 4.301 ± 0.058	4.136ArgGlu: 4.136 ± 0.064	2.716ArgPhe: 2.716 ± 0.046	4.932ArgGly: 4.932 ± 0.066	1.682ArgHis: 1.682 ± 0.039	4.266ArgIle: 4.266 ± 0.06	2.224ArgLys: 2.224 ± 0.044	8.21ArgLeu: 8.21 ± 0.086	2.012ArgMet: 2.012 ± 0.041	1.793ArgAsn: 1.793 ± 0.035	3.812ArgPro: 3.812 ± 0.061	2.65ArgGln: 2.65 ± 0.041	5.618ArgArg: 5.618 ± 0.075	3.504ArgSer: 3.504 ± 0.048	2.721ArgThr: 2.721 ± 0.042	4.667ArgVal: 4.667 ± 0.055	0.983ArgTrp: 0.983 ± 0.024	1.573ArgTyr: 1.573 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.598SerAla: 6.598 ± 0.077	0.447SerCys: 0.447 ± 0.021	3.22SerAsp: 3.22 ± 0.052	2.964SerGlu: 2.964 ± 0.046	2.287SerPhe: 2.287 ± 0.043	5.87SerGly: 5.87 ± 0.068	1.161SerHis: 1.161 ± 0.026	2.437SerIle: 2.437 ± 0.045	1.389SerLys: 1.389 ± 0.033	5.438SerLeu: 5.438 ± 0.071	1.181SerMet: 1.181 ± 0.031	1.303SerAsn: 1.303 ± 0.034	2.821SerPro: 2.821 ± 0.044	1.679SerGln: 1.679 ± 0.034	3.763SerArg: 3.763 ± 0.057	2.866SerSer: 2.866 ± 0.059	2.612SerThr: 2.612 ± 0.046	3.667SerVal: 3.667 ± 0.05	0.838SerTrp: 0.838 ± 0.023	1.363SerTyr: 1.363 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.457ThrAla: 6.457 ± 0.067	0.409ThrCys: 0.409 ± 0.021	2.739ThrAsp: 2.739 ± 0.051	3.031ThrGlu: 3.031 ± 0.048	1.75ThrPhe: 1.75 ± 0.034	5.333ThrGly: 5.333 ± 0.075	1.036ThrHis: 1.036 ± 0.029	2.648ThrIle: 2.648 ± 0.044	1.271ThrLys: 1.271 ± 0.034	5.866ThrLeu: 5.866 ± 0.068	1.109ThrMet: 1.109 ± 0.03	1.22ThrAsn: 1.22 ± 0.033	3.486ThrPro: 3.486 ± 0.052	1.501ThrGln: 1.501 ± 0.035	3.563ThrArg: 3.563 ± 0.048	2.734ThrSer: 2.734 ± 0.044	2.805ThrThr: 2.805 ± 0.058	3.994ThrVal: 3.994 ± 0.059	0.554ThrTrp: 0.554 ± 0.02	1.097ThrTyr: 1.097 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.711ValAla: 8.711 ± 0.082	0.494ValCys: 0.494 ± 0.02	3.426ValAsp: 3.426 ± 0.045	4.134ValGlu: 4.134 ± 0.057	2.507ValPhe: 2.507 ± 0.04	4.889ValGly: 4.889 ± 0.066	1.092ValHis: 1.092 ± 0.029	4.19ValIle: 4.19 ± 0.057	2.013ValLys: 2.013 ± 0.041	7.474ValLeu: 7.474 ± 0.08	1.918ValMet: 1.918 ± 0.036	1.827ValAsn: 1.827 ± 0.042	3.459ValPro: 3.459 ± 0.047	2.053ValGln: 2.053 ± 0.038	3.902ValArg: 3.902 ± 0.059	4.196ValSer: 4.196 ± 0.051	4.658ValThr: 4.658 ± 0.069	5.11ValVal: 5.11 ± 0.059	0.95ValTrp: 0.95 ± 0.028	1.239ValTyr: 1.239 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.385TrpAla: 1.385 ± 0.042	0.128TrpCys: 0.128 ± 0.01	0.685TrpAsp: 0.685 ± 0.025	0.584TrpGlu: 0.584 ± 0.019	0.557TrpPhe: 0.557 ± 0.022	1.028TrpGly: 1.028 ± 0.03	0.356TrpHis: 0.356 ± 0.014	0.711TrpIle: 0.711 ± 0.026	0.444TrpLys: 0.444 ± 0.017	1.832TrpLeu: 1.832 ± 0.036	0.373TrpMet: 0.373 ± 0.016	0.398TrpAsn: 0.398 ± 0.018	0.739TrpPro: 0.739 ± 0.025	0.72TrpGln: 0.72 ± 0.026	1.198TrpArg: 1.198 ± 0.033	0.879TrpSer: 0.879 ± 0.025	0.782TrpThr: 0.782 ± 0.02	0.854TrpVal: 0.854 ± 0.028	0.242TrpTrp: 0.242 ± 0.014	0.269TrpTyr: 0.269 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.418TyrAla: 2.418 ± 0.04	0.21TyrCys: 0.21 ± 0.013	1.427TyrAsp: 1.427 ± 0.03	1.092TyrGlu: 1.092 ± 0.033	0.813TyrPhe: 0.813 ± 0.024	2.005TyrGly: 2.005 ± 0.045	0.44TyrHis: 0.44 ± 0.018	0.906TyrIle: 0.906 ± 0.027	0.497TyrLys: 0.497 ± 0.021	2.312TyrLeu: 2.312 ± 0.041	0.399TyrMet: 0.399 ± 0.018	0.556TyrAsn: 0.556 ± 0.02	1.061TyrPro: 1.061 ± 0.029	0.722TyrGln: 0.722 ± 0.024	1.552TyrArg: 1.552 ± 0.032	1.141TyrSer: 1.141 ± 0.028	1.011TyrThr: 1.011 ± 0.03	1.388TyrVal: 1.388 ± 0.031	0.341TyrTrp: 0.341 ± 0.018	0.522TyrTyr: 0.522 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4462 proteins (1439745 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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