Amino acid dipepetide frequency for Cedecea neteri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.713AlaAla: 10.713 ± 0.132	1.051AlaCys: 1.051 ± 0.03	5.112AlaAsp: 5.112 ± 0.072	5.949AlaGlu: 5.949 ± 0.071	3.657AlaPhe: 3.657 ± 0.056	8.028AlaGly: 8.028 ± 0.096	1.747AlaHis: 1.747 ± 0.037	5.72AlaIle: 5.72 ± 0.07	3.973AlaLys: 3.973 ± 0.061	12.15AlaLeu: 12.15 ± 0.121	2.99AlaMet: 2.99 ± 0.05	3.255AlaAsn: 3.255 ± 0.06	3.668AlaPro: 3.668 ± 0.065	4.32AlaGln: 4.32 ± 0.062	5.472AlaArg: 5.472 ± 0.074	5.761AlaSer: 5.761 ± 0.075	4.868AlaThr: 4.868 ± 0.075	7.072AlaVal: 7.072 ± 0.082	1.667AlaTrp: 1.667 ± 0.034	1.947AlaTyr: 1.947 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.028	0.174CysCys: 0.174 ± 0.012	0.55CysAsp: 0.55 ± 0.021	0.593CysGlu: 0.593 ± 0.023	0.413CysPhe: 0.413 ± 0.018	1.027CysGly: 1.027 ± 0.031	0.282CysHis: 0.282 ± 0.015	0.514CysIle: 0.514 ± 0.018	0.301CysLys: 0.301 ± 0.015	0.968CysLeu: 0.968 ± 0.028	0.205CysMet: 0.205 ± 0.011	0.308CysAsn: 0.308 ± 0.015	0.467CysPro: 0.467 ± 0.019	0.39CysGln: 0.39 ± 0.016	0.596CysArg: 0.596 ± 0.021	0.653CysSer: 0.653 ± 0.022	0.436CysThr: 0.436 ± 0.019	0.666CysVal: 0.666 ± 0.024	0.167CysTrp: 0.167 ± 0.011	0.306CysTyr: 0.306 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.126AspAla: 5.126 ± 0.078	0.489AspCys: 0.489 ± 0.02	2.816AspAsp: 2.816 ± 0.055	3.552AspGlu: 3.552 ± 0.055	2.094AspPhe: 2.094 ± 0.038	3.923AspGly: 3.923 ± 0.08	0.907AspHis: 0.907 ± 0.026	3.332AspIle: 3.332 ± 0.053	2.613AspLys: 2.613 ± 0.046	4.699AspLeu: 4.699 ± 0.069	1.337AspMet: 1.337 ± 0.035	2.123AspAsn: 2.123 ± 0.043	2.219AspPro: 2.219 ± 0.046	1.448AspGln: 1.448 ± 0.035	2.617AspArg: 2.617 ± 0.047	2.943AspSer: 2.943 ± 0.047	2.489AspThr: 2.489 ± 0.058	3.846AspVal: 3.846 ± 0.053	0.798AspTrp: 0.798 ± 0.027	1.811AspTyr: 1.811 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.658GluAla: 5.658 ± 0.079	0.441GluCys: 0.441 ± 0.018	2.381GluAsp: 2.381 ± 0.048	3.402GluGlu: 3.402 ± 0.076	1.843GluPhe: 1.843 ± 0.038	3.711GluGly: 3.711 ± 0.058	1.418GluHis: 1.418 ± 0.033	3.256GluIle: 3.256 ± 0.05	3.192GluLys: 3.192 ± 0.051	5.991GluLeu: 5.991 ± 0.085	1.783GluMet: 1.783 ± 0.04	2.252GluAsn: 2.252 ± 0.044	2.195GluPro: 2.195 ± 0.045	3.567GluGln: 3.567 ± 0.06	3.635GluArg: 3.635 ± 0.056	2.996GluSer: 2.996 ± 0.046	2.942GluThr: 2.942 ± 0.048	3.956GluVal: 3.956 ± 0.063	0.783GluTrp: 0.783 ± 0.024	1.425GluTyr: 1.425 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.054	0.471PheCys: 0.471 ± 0.019	2.28PheAsp: 2.28 ± 0.037	1.778PheGlu: 1.778 ± 0.042	1.634PhePhe: 1.634 ± 0.041	3.294PheGly: 3.294 ± 0.06	0.77PheHis: 0.77 ± 0.025	2.528PheIle: 2.528 ± 0.052	1.265PheLys: 1.265 ± 0.031	3.298PheLeu: 3.298 ± 0.059	1.003PheMet: 1.003 ± 0.025	1.774PheAsn: 1.774 ± 0.039	1.535PhePro: 1.535 ± 0.032	1.173PheGln: 1.173 ± 0.027	1.829PheArg: 1.829 ± 0.036	3.183PheSer: 3.183 ± 0.052	2.377PheThr: 2.377 ± 0.049	2.576PheVal: 2.576 ± 0.045	0.615PheTrp: 0.615 ± 0.021	1.202PheTyr: 1.202 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.357GlyAla: 6.357 ± 0.083	0.966GlyCys: 0.966 ± 0.028	3.741GlyAsp: 3.741 ± 0.066	4.72GlyGlu: 4.72 ± 0.061	3.341GlyPhe: 3.341 ± 0.048	5.586GlyGly: 5.586 ± 0.091	1.7GlyHis: 1.7 ± 0.036	4.988GlyIle: 4.988 ± 0.057	4.129GlyLys: 4.129 ± 0.058	7.956GlyLeu: 7.956 ± 0.092	2.462GlyMet: 2.462 ± 0.048	2.905GlyAsn: 2.905 ± 0.09	2.126GlyPro: 2.126 ± 0.046	3.069GlyGln: 3.069 ± 0.049	3.792GlyArg: 3.792 ± 0.057	4.549GlySer: 4.549 ± 0.082	3.887GlyThr: 3.887 ± 0.103	6.04GlyVal: 6.04 ± 0.073	1.347GlyTrp: 1.347 ± 0.033	2.586GlyTyr: 2.586 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.891HisAla: 1.891 ± 0.042	0.287HisCys: 0.287 ± 0.015	1.134HisAsp: 1.134 ± 0.027	1.127HisGlu: 1.127 ± 0.029	1.025HisPhe: 1.025 ± 0.027	1.811HisGly: 1.811 ± 0.038	0.726HisHis: 0.726 ± 0.025	1.249HisIle: 1.249 ± 0.029	0.774HisLys: 0.774 ± 0.025	2.266HisLeu: 2.266 ± 0.049	0.507HisMet: 0.507 ± 0.022	0.762HisAsn: 0.762 ± 0.022	1.27HisPro: 1.27 ± 0.029	1.138HisGln: 1.138 ± 0.029	1.254HisArg: 1.254 ± 0.035	1.254HisSer: 1.254 ± 0.029	1.012HisThr: 1.012 ± 0.027	1.256HisVal: 1.256 ± 0.033	0.379HisTrp: 0.379 ± 0.017	0.841HisTyr: 0.841 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.391IleAla: 6.391 ± 0.072	0.618IleCys: 0.618 ± 0.024	3.451IleAsp: 3.451 ± 0.057	3.262IleGlu: 3.262 ± 0.057	1.994IlePhe: 1.994 ± 0.044	4.59IleGly: 4.59 ± 0.068	1.176IleHis: 1.176 ± 0.029	3.228IleIle: 3.228 ± 0.057	2.309IleLys: 2.309 ± 0.04	4.82IleLeu: 4.82 ± 0.068	1.223IleMet: 1.223 ± 0.035	2.563IleAsn: 2.563 ± 0.048	2.583IlePro: 2.583 ± 0.044	1.798IleGln: 1.798 ± 0.041	2.856IleArg: 2.856 ± 0.054	3.859IleSer: 3.859 ± 0.056	3.45IleThr: 3.45 ± 0.069	3.986IleVal: 3.986 ± 0.055	0.688IleTrp: 0.688 ± 0.023	1.449IleTyr: 1.449 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.373LysAla: 4.373 ± 0.059	0.239LysCys: 0.239 ± 0.013	2.139LysAsp: 2.139 ± 0.051	2.402LysGlu: 2.402 ± 0.049	1.172LysPhe: 1.172 ± 0.033	3.028LysGly: 3.028 ± 0.056	0.875LysHis: 0.875 ± 0.025	2.312LysIle: 2.312 ± 0.047	2.183LysLys: 2.183 ± 0.049	4.457LysLeu: 4.457 ± 0.06	1.253LysMet: 1.253 ± 0.032	1.647LysAsn: 1.647 ± 0.037	2.215LysPro: 2.215 ± 0.043	2.064LysGln: 2.064 ± 0.039	2.508LysArg: 2.508 ± 0.044	2.299LysSer: 2.299 ± 0.046	2.523LysThr: 2.523 ± 0.045	3.072LysVal: 3.072 ± 0.057	0.453LysTrp: 0.453 ± 0.019	1.059LysTyr: 1.059 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.882LeuAla: 11.882 ± 0.111	1.203LeuCys: 1.203 ± 0.032	5.459LeuAsp: 5.459 ± 0.074	5.713LeuGlu: 5.713 ± 0.088	4.305LeuPhe: 4.305 ± 0.075	7.611LeuGly: 7.611 ± 0.089	2.25LeuHis: 2.25 ± 0.044	5.774LeuIle: 5.774 ± 0.08	4.731LeuLys: 4.731 ± 0.066	12.4LeuLeu: 12.4 ± 0.153	3.005LeuMet: 3.005 ± 0.058	4.302LeuAsn: 4.302 ± 0.061	5.805LeuPro: 5.805 ± 0.066	4.345LeuGln: 4.345 ± 0.061	6.11LeuArg: 6.11 ± 0.082	7.608LeuSer: 7.608 ± 0.074	6.246LeuThr: 6.246 ± 0.071	7.546LeuVal: 7.546 ± 0.093	1.427LeuTrp: 1.427 ± 0.038	2.536LeuTyr: 2.536 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.848MetAla: 2.848 ± 0.051	0.187MetCys: 0.187 ± 0.012	1.208MetAsp: 1.208 ± 0.028	1.204MetGlu: 1.204 ± 0.033	0.86MetPhe: 0.86 ± 0.027	1.907MetGly: 1.907 ± 0.041	0.507MetHis: 0.507 ± 0.017	1.431MetIle: 1.431 ± 0.037	1.373MetLys: 1.373 ± 0.029	3.229MetLeu: 3.229 ± 0.06	0.863MetMet: 0.863 ± 0.029	1.04MetAsn: 1.04 ± 0.026	1.401MetPro: 1.401 ± 0.034	1.234MetGln: 1.234 ± 0.032	1.468MetArg: 1.468 ± 0.031	1.945MetSer: 1.945 ± 0.037	1.753MetThr: 1.753 ± 0.037	2.002MetVal: 2.002 ± 0.039	0.243MetTrp: 0.243 ± 0.015	0.488MetTyr: 0.488 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.556AsnAla: 3.556 ± 0.064	0.325AsnCys: 0.325 ± 0.015	1.994AsnAsp: 1.994 ± 0.04	1.906AsnGlu: 1.906 ± 0.04	1.317AsnPhe: 1.317 ± 0.034	3.116AsnGly: 3.116 ± 0.079	0.83AsnHis: 0.83 ± 0.025	2.32AsnIle: 2.32 ± 0.046	1.525AsnLys: 1.525 ± 0.031	3.624AsnLeu: 3.624 ± 0.057	0.914AsnMet: 0.914 ± 0.024	1.611AsnAsn: 1.611 ± 0.045	2.114AsnPro: 2.114 ± 0.037	1.648AsnGln: 1.648 ± 0.038	1.935AsnArg: 1.935 ± 0.037	2.102AsnSer: 2.102 ± 0.048	1.941AsnThr: 1.941 ± 0.046	2.629AsnVal: 2.629 ± 0.049	0.562AsnTrp: 0.562 ± 0.02	1.174AsnTyr: 1.174 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.681ProAla: 4.681 ± 0.067	0.345ProCys: 0.345 ± 0.018	2.695ProAsp: 2.695 ± 0.043	3.585ProGlu: 3.585 ± 0.064	1.822ProPhe: 1.822 ± 0.041	3.665ProGly: 3.665 ± 0.054	1.044ProHis: 1.044 ± 0.029	1.833ProIle: 1.833 ± 0.042	1.564ProLys: 1.564 ± 0.031	5.235ProLeu: 5.235 ± 0.07	1.12ProMet: 1.12 ± 0.029	1.308ProAsn: 1.308 ± 0.032	1.67ProPro: 1.67 ± 0.043	2.367ProGln: 2.367 ± 0.049	1.986ProArg: 1.986 ± 0.042	2.103ProSer: 2.103 ± 0.041	2.103ProThr: 2.103 ± 0.059	3.844ProVal: 3.844 ± 0.056	0.755ProTrp: 0.755 ± 0.024	1.108ProTyr: 1.108 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.777GlnAla: 4.777 ± 0.066	0.322GlnCys: 0.322 ± 0.016	1.844GlnAsp: 1.844 ± 0.039	2.104GlnGlu: 2.104 ± 0.044	1.44GlnPhe: 1.44 ± 0.032	3.161GlnGly: 3.161 ± 0.05	1.26GlnHis: 1.26 ± 0.032	2.291GlnIle: 2.291 ± 0.042	1.915GlnLys: 1.915 ± 0.04	5.088GlnLeu: 5.088 ± 0.071	1.22GlnMet: 1.22 ± 0.028	1.495GlnAsn: 1.495 ± 0.035	2.252GlnPro: 2.252 ± 0.045	3.472GlnGln: 3.472 ± 0.067	3.035GlnArg: 3.035 ± 0.054	2.378GlnSer: 2.378 ± 0.044	2.199GlnThr: 2.199 ± 0.04	3.005GlnVal: 3.005 ± 0.044	0.656GlnTrp: 0.656 ± 0.022	1.093GlnTyr: 1.093 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	4.493ArgAla: 4.493 ± 0.057	0.569ArgCys: 0.569 ± 0.021	2.894ArgAsp: 2.894 ± 0.05	3.757ArgGlu: 3.757 ± 0.057	2.549ArgPhe: 2.549 ± 0.047	3.388ArgGly: 3.388 ± 0.052	1.49ArgHis: 1.49 ± 0.038	3.197ArgIle: 3.197 ± 0.058	2.309ArgLys: 2.309 ± 0.04	6.514ArgLeu: 6.514 ± 0.091	1.549ArgMet: 1.549 ± 0.036	1.992ArgAsn: 1.992 ± 0.045	2.226ArgPro: 2.226 ± 0.048	3.014ArgGln: 3.014 ± 0.066	3.433ArgArg: 3.433 ± 0.064	2.925ArgSer: 2.925 ± 0.055	2.456ArgThr: 2.456 ± 0.043	3.789ArgVal: 3.789 ± 0.055	0.961ArgTrp: 0.961 ± 0.029	2.084ArgTyr: 2.084 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.812SerAla: 5.812 ± 0.074	0.54SerCys: 0.54 ± 0.02	3.011SerAsp: 3.011 ± 0.043	3.328SerGlu: 3.328 ± 0.054	2.394SerPhe: 2.394 ± 0.046	5.636SerGly: 5.636 ± 0.083	1.456SerHis: 1.456 ± 0.034	2.97SerIle: 2.97 ± 0.051	2.065SerLys: 2.065 ± 0.044	7.072SerLeu: 7.072 ± 0.075	1.494SerMet: 1.494 ± 0.035	1.958SerAsn: 1.958 ± 0.041	2.783SerPro: 2.783 ± 0.045	2.644SerGln: 2.644 ± 0.05	3.557SerArg: 3.557 ± 0.056	3.771SerSer: 3.771 ± 0.07	3.044SerThr: 3.044 ± 0.051	4.397SerVal: 4.397 ± 0.066	1.089SerTrp: 1.089 ± 0.031	1.68SerTyr: 1.68 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.13ThrAla: 5.13 ± 0.096	0.461ThrCys: 0.461 ± 0.019	2.568ThrAsp: 2.568 ± 0.051	2.581ThrGlu: 2.581 ± 0.041	2.015ThrPhe: 2.015 ± 0.038	4.515ThrGly: 4.515 ± 0.083	1.137ThrHis: 1.137 ± 0.03	2.831ThrIle: 2.831 ± 0.071	1.498ThrLys: 1.498 ± 0.037	7.483ThrLeu: 7.483 ± 0.085	1.119ThrMet: 1.119 ± 0.031	1.574ThrAsn: 1.574 ± 0.04	3.201ThrPro: 3.201 ± 0.053	2.089ThrGln: 2.089 ± 0.041	2.972ThrArg: 2.972 ± 0.045	3.045ThrSer: 3.045 ± 0.062	2.843ThrThr: 2.843 ± 0.077	4.055ThrVal: 4.055 ± 0.124	0.827ThrTrp: 0.827 ± 0.027	1.1ThrTyr: 1.1 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.339ValAla: 7.339 ± 0.08	0.732ValCys: 0.732 ± 0.025	3.799ValAsp: 3.799 ± 0.066	4.119ValGlu: 4.119 ± 0.058	2.616ValPhe: 2.616 ± 0.052	5.08ValGly: 5.08 ± 0.063	1.224ValHis: 1.224 ± 0.032	4.462ValIle: 4.462 ± 0.057	3.129ValLys: 3.129 ± 0.048	7.664ValLeu: 7.664 ± 0.091	2.134ValMet: 2.134 ± 0.043	2.809ValAsn: 2.809 ± 0.051	3.083ValPro: 3.083 ± 0.044	2.429ValGln: 2.429 ± 0.044	3.667ValArg: 3.667 ± 0.048	4.764ValSer: 4.764 ± 0.069	4.471ValThr: 4.471 ± 0.088	5.821ValVal: 5.821 ± 0.08	0.975ValTrp: 0.975 ± 0.027	1.769ValTyr: 1.769 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.055TrpAla: 1.055 ± 0.032	0.169TrpCys: 0.169 ± 0.01	0.607TrpAsp: 0.607 ± 0.02	0.611TrpGlu: 0.611 ± 0.022	0.684TrpPhe: 0.684 ± 0.026	0.928TrpGly: 0.928 ± 0.029	0.46TrpHis: 0.46 ± 0.02	0.721TrpIle: 0.721 ± 0.022	0.497TrpLys: 0.497 ± 0.021	2.372TrpLeu: 2.372 ± 0.056	0.427TrpMet: 0.427 ± 0.02	0.509TrpAsn: 0.509 ± 0.019	0.674TrpPro: 0.674 ± 0.022	1.227TrpGln: 1.227 ± 0.036	1.089TrpArg: 1.089 ± 0.03	0.857TrpSer: 0.857 ± 0.036	0.565TrpThr: 0.565 ± 0.025	0.933TrpVal: 0.933 ± 0.025	0.246TrpTrp: 0.246 ± 0.014	0.416TrpTyr: 0.416 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.389TyrAla: 2.389 ± 0.047	0.336TyrCys: 0.336 ± 0.015	1.497TyrAsp: 1.497 ± 0.037	1.133TyrGlu: 1.133 ± 0.03	1.153TyrPhe: 1.153 ± 0.027	2.239TyrGly: 2.239 ± 0.047	0.705TyrHis: 0.705 ± 0.023	1.334TyrIle: 1.334 ± 0.033	0.924TyrLys: 0.924 ± 0.031	2.969TyrLeu: 2.969 ± 0.056	0.587TyrMet: 0.587 ± 0.022	0.956TyrAsn: 0.956 ± 0.028	1.345TyrPro: 1.345 ± 0.032	1.571TyrGln: 1.571 ± 0.033	1.779TyrArg: 1.779 ± 0.035	1.708TyrSer: 1.708 ± 0.039	1.439TyrThr: 1.439 ± 0.039	1.596TyrVal: 1.596 ± 0.037	0.411TyrTrp: 0.411 ± 0.018	0.873TyrTyr: 0.873 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4293 proteins (1387837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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