Amino acid dipepetide frequency for Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.227AlaAla: 25.227 ± 0.166	1.055AlaCys: 1.055 ± 0.021	9.351AlaAsp: 9.351 ± 0.071	7.951AlaGlu: 7.951 ± 0.077	3.718AlaPhe: 3.718 ± 0.038	16.046AlaGly: 16.046 ± 0.101	2.653AlaHis: 2.653 ± 0.036	4.177AlaIle: 4.177 ± 0.048	2.188AlaLys: 2.188 ± 0.037	14.396AlaLeu: 14.396 ± 0.113	2.455AlaMet: 2.455 ± 0.034	2.177AlaAsn: 2.177 ± 0.036	8.036AlaPro: 8.036 ± 0.093	3.803AlaGln: 3.803 ± 0.052	11.46AlaArg: 11.46 ± 0.089	6.93AlaSer: 6.93 ± 0.062	8.803AlaThr: 8.803 ± 0.09	12.529AlaVal: 12.529 ± 0.094	1.832AlaTrp: 1.832 ± 0.03	2.35AlaTyr: 2.35 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.063CysAla: 1.063 ± 0.026	0.084CysCys: 0.084 ± 0.007	0.452CysAsp: 0.452 ± 0.014	0.335CysGlu: 0.335 ± 0.011	0.225CysPhe: 0.225 ± 0.009	0.893CysGly: 0.893 ± 0.023	0.186CysHis: 0.186 ± 0.009	0.147CysIle: 0.147 ± 0.007	0.077CysLys: 0.077 ± 0.006	0.735CysLeu: 0.735 ± 0.017	0.103CysMet: 0.103 ± 0.007	0.102CysAsn: 0.102 ± 0.007	0.496CysPro: 0.496 ± 0.029	0.215CysGln: 0.215 ± 0.008	0.529CysArg: 0.529 ± 0.016	0.385CysSer: 0.385 ± 0.014	0.389CysThr: 0.389 ± 0.024	0.625CysVal: 0.625 ± 0.015	0.12CysTrp: 0.12 ± 0.006	0.184CysTyr: 0.184 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.985AspAla: 7.985 ± 0.06	0.383AspCys: 0.383 ± 0.014	3.953AspAsp: 3.953 ± 0.043	3.91AspGlu: 3.91 ± 0.043	1.483AspPhe: 1.483 ± 0.027	6.634AspGly: 6.634 ± 0.063	1.365AspHis: 1.365 ± 0.025	1.749AspIle: 1.749 ± 0.028	0.779AspLys: 0.779 ± 0.019	6.99AspLeu: 6.99 ± 0.053	0.657AspMet: 0.657 ± 0.017	0.87AspAsn: 0.87 ± 0.021	5.018AspPro: 5.018 ± 0.052	1.825AspGln: 1.825 ± 0.033	5.076AspArg: 5.076 ± 0.052	2.209AspSer: 2.209 ± 0.031	2.745AspThr: 2.745 ± 0.034	5.262AspVal: 5.262 ± 0.049	0.987AspTrp: 0.987 ± 0.02	1.178AspTyr: 1.178 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.482GluAla: 6.482 ± 0.061	0.278GluCys: 0.278 ± 0.01	2.254GluAsp: 2.254 ± 0.032	2.09GluGlu: 2.09 ± 0.035	1.357GluPhe: 1.357 ± 0.028	3.051GluGly: 3.051 ± 0.036	1.297GluHis: 1.297 ± 0.025	2.33GluIle: 2.33 ± 0.034	0.935GluLys: 0.935 ± 0.021	6.306GluLeu: 6.306 ± 0.061	0.76GluMet: 0.76 ± 0.019	0.87GluAsn: 0.87 ± 0.019	3.537GluPro: 3.537 ± 0.047	1.817GluGln: 1.817 ± 0.031	4.755GluArg: 4.755 ± 0.056	2.113GluSer: 2.113 ± 0.03	2.718GluThr: 2.718 ± 0.031	4.067GluVal: 4.067 ± 0.045	0.669GluTrp: 0.669 ± 0.017	0.874GluTyr: 0.874 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.839PheAla: 3.839 ± 0.045	0.292PheCys: 0.292 ± 0.012	2.091PheAsp: 2.091 ± 0.029	1.374PheGlu: 1.374 ± 0.024	0.82PhePhe: 0.82 ± 0.021	3.229PheGly: 3.229 ± 0.041	0.603PheHis: 0.603 ± 0.016	0.741PheIle: 0.741 ± 0.017	0.365PheLys: 0.365 ± 0.013	2.54PheLeu: 2.54 ± 0.033	0.351PheMet: 0.351 ± 0.013	0.51PheAsn: 0.51 ± 0.018	1.47PhePro: 1.47 ± 0.022	0.697PheGln: 0.697 ± 0.019	1.714PheArg: 1.714 ± 0.025	1.415PheSer: 1.415 ± 0.03	1.829PheThr: 1.829 ± 0.031	2.348PheVal: 2.348 ± 0.032	0.408PheTrp: 0.408 ± 0.013	0.564PheTyr: 0.564 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.894GlyAla: 11.894 ± 0.081	0.775GlyCys: 0.775 ± 0.019	5.155GlyAsp: 5.155 ± 0.049	4.363GlyGlu: 4.363 ± 0.045	2.847GlyPhe: 2.847 ± 0.044	9.59GlyGly: 9.59 ± 0.078	2.172GlyHis: 2.172 ± 0.031	3.402GlyIle: 3.402 ± 0.046	1.754GlyLys: 1.754 ± 0.029	10.129GlyLeu: 10.129 ± 0.074	1.815GlyMet: 1.815 ± 0.031	1.559GlyAsn: 1.559 ± 0.031	6.662GlyPro: 6.662 ± 0.075	3.248GlyGln: 3.248 ± 0.041	8.348GlyArg: 8.348 ± 0.083	5.617GlySer: 5.617 ± 0.053	5.986GlyThr: 5.986 ± 0.073	7.746GlyVal: 7.746 ± 0.067	1.867GlyTrp: 1.867 ± 0.034	2.431GlyTyr: 2.431 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.459HisAla: 2.459 ± 0.03	0.178HisCys: 0.178 ± 0.01	1.294HisAsp: 1.294 ± 0.022	0.994HisGlu: 0.994 ± 0.019	0.564HisPhe: 0.564 ± 0.015	2.229HisGly: 2.229 ± 0.032	0.619HisHis: 0.619 ± 0.019	0.547HisIle: 0.547 ± 0.014	0.23HisLys: 0.23 ± 0.01	2.276HisLeu: 2.276 ± 0.035	0.254HisMet: 0.254 ± 0.01	0.334HisAsn: 0.334 ± 0.012	1.754HisPro: 1.754 ± 0.029	0.617HisGln: 0.617 ± 0.016	1.911HisArg: 1.911 ± 0.027	0.895HisSer: 0.895 ± 0.019	1.128HisThr: 1.128 ± 0.027	1.598HisVal: 1.598 ± 0.024	0.343HisTrp: 0.343 ± 0.012	0.439HisTyr: 0.439 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.886IleAla: 4.886 ± 0.055	0.297IleCys: 0.297 ± 0.011	2.351IleAsp: 2.351 ± 0.034	1.932IleGlu: 1.932 ± 0.033	0.829IlePhe: 0.829 ± 0.019	3.602IleGly: 3.602 ± 0.044	0.64IleHis: 0.64 ± 0.017	1.026IleIle: 1.026 ± 0.024	0.577IleLys: 0.577 ± 0.018	2.589IleLeu: 2.589 ± 0.037	0.448IleMet: 0.448 ± 0.015	0.723IleAsn: 0.723 ± 0.018	1.922IlePro: 1.922 ± 0.031	0.764IleGln: 0.764 ± 0.019	2.453IleArg: 2.453 ± 0.034	1.812IleSer: 1.812 ± 0.028	2.146IleThr: 2.146 ± 0.031	2.989IleVal: 2.989 ± 0.041	0.398IleTrp: 0.398 ± 0.013	0.592IleTyr: 0.592 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.131LysAla: 2.131 ± 0.032	0.075LysCys: 0.075 ± 0.006	0.814LysAsp: 0.814 ± 0.018	0.684LysGlu: 0.684 ± 0.019	0.347LysPhe: 0.347 ± 0.01	1.146LysGly: 1.146 ± 0.022	0.303LysHis: 0.303 ± 0.011	0.84LysIle: 0.84 ± 0.021	0.38LysLys: 0.38 ± 0.013	1.512LysLeu: 1.512 ± 0.028	0.267LysMet: 0.267 ± 0.011	0.354LysAsn: 0.354 ± 0.014	1.011LysPro: 1.011 ± 0.025	0.443LysGln: 0.443 ± 0.015	0.988LysArg: 0.988 ± 0.024	0.818LysSer: 0.818 ± 0.033	0.944LysThr: 0.944 ± 0.023	1.551LysVal: 1.551 ± 0.024	0.17LysTrp: 0.17 ± 0.01	0.306LysTyr: 0.306 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	17.526LeuAla: 17.526 ± 0.116	0.793LeuCys: 0.793 ± 0.016	6.959LeuAsp: 6.959 ± 0.058	4.121LeuGlu: 4.121 ± 0.046	2.609LeuPhe: 2.609 ± 0.035	9.474LeuGly: 9.474 ± 0.063	1.934LeuHis: 1.934 ± 0.032	3.112LeuIle: 3.112 ± 0.046	1.255LeuLys: 1.255 ± 0.026	10.789LeuLeu: 10.789 ± 0.095	1.337LeuMet: 1.337 ± 0.027	1.573LeuAsn: 1.573 ± 0.028	6.397LeuPro: 6.397 ± 0.064	1.754LeuGln: 1.754 ± 0.03	8.792LeuArg: 8.792 ± 0.078	4.995LeuSer: 4.995 ± 0.045	6.924LeuThr: 6.924 ± 0.061	9.71LeuVal: 9.71 ± 0.071	1.28LeuTrp: 1.28 ± 0.025	1.574LeuTyr: 1.574 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.122MetAla: 2.122 ± 0.031	0.122MetCys: 0.122 ± 0.006	0.726MetAsp: 0.726 ± 0.019	0.534MetGlu: 0.534 ± 0.014	0.482MetPhe: 0.482 ± 0.014	1.09MetGly: 1.09 ± 0.019	0.294MetHis: 0.294 ± 0.01	0.696MetIle: 0.696 ± 0.019	0.302MetLys: 0.302 ± 0.012	1.58MetLeu: 1.58 ± 0.028	0.267MetMet: 0.267 ± 0.013	0.348MetAsn: 0.348 ± 0.013	1.011MetPro: 1.011 ± 0.02	0.319MetGln: 0.319 ± 0.011	1.256MetArg: 1.256 ± 0.025	1.179MetSer: 1.179 ± 0.021	1.566MetThr: 1.566 ± 0.026	1.189MetVal: 1.189 ± 0.021	0.189MetTrp: 0.189 ± 0.007	0.257MetTyr: 0.257 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.195AsnAla: 2.195 ± 0.035	0.141AsnCys: 0.141 ± 0.007	0.879AsnAsp: 0.879 ± 0.02	0.719AsnGlu: 0.719 ± 0.017	0.441AsnPhe: 0.441 ± 0.013	1.823AsnGly: 1.823 ± 0.029	0.366AsnHis: 0.366 ± 0.012	0.632AsnIle: 0.632 ± 0.018	0.286AsnLys: 0.286 ± 0.011	1.764AsnLeu: 1.764 ± 0.029	0.256AsnMet: 0.256 ± 0.01	0.39AsnAsn: 0.39 ± 0.015	1.448AsnPro: 1.448 ± 0.027	0.486AsnGln: 0.486 ± 0.013	1.274AsnArg: 1.274 ± 0.022	0.826AsnSer: 0.826 ± 0.025	0.977AsnThr: 0.977 ± 0.033	1.46AsnVal: 1.46 ± 0.03	0.243AsnTrp: 0.243 ± 0.009	0.406AsnTyr: 0.406 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	11.505ProAla: 11.505 ± 0.115	0.287ProCys: 0.287 ± 0.011	5.007ProAsp: 5.007 ± 0.054	3.479ProGlu: 3.479 ± 0.042	1.659ProPhe: 1.659 ± 0.026	7.37ProGly: 7.37 ± 0.079	1.165ProHis: 1.165 ± 0.025	1.688ProIle: 1.688 ± 0.026	0.961ProLys: 0.961 ± 0.024	5.181ProLeu: 5.181 ± 0.055	0.961ProMet: 0.961 ± 0.02	1.117ProAsn: 1.117 ± 0.023	4.704ProPro: 4.704 ± 0.086	1.29ProGln: 1.29 ± 0.023	4.554ProArg: 4.554 ± 0.057	3.662ProSer: 3.662 ± 0.043	4.24ProThr: 4.24 ± 0.053	5.781ProVal: 5.781 ± 0.071	0.917ProTrp: 0.917 ± 0.02	1.122ProTyr: 1.122 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.881GlnAla: 3.881 ± 0.055	0.143GlnCys: 0.143 ± 0.008	1.21GlnAsp: 1.21 ± 0.022	1.088GlnGlu: 1.088 ± 0.019	0.717GlnPhe: 0.717 ± 0.018	1.933GlnGly: 1.933 ± 0.032	0.549GlnHis: 0.549 ± 0.015	1.099GlnIle: 1.099 ± 0.02	0.424GlnLys: 0.424 ± 0.014	3.041GlnLeu: 3.041 ± 0.038	0.392GlnMet: 0.392 ± 0.013	0.493GlnAsn: 0.493 ± 0.017	2.005GlnPro: 2.005 ± 0.031	0.919GlnGln: 0.919 ± 0.025	2.252GlnArg: 2.252 ± 0.035	1.166GlnSer: 1.166 ± 0.021	1.466GlnThr: 1.466 ± 0.035	2.511GlnVal: 2.511 ± 0.03	0.401GlnTrp: 0.401 ± 0.012	0.495GlnTyr: 0.495 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.118ArgAla: 11.118 ± 0.086	0.546ArgCys: 0.546 ± 0.016	4.636ArgAsp: 4.636 ± 0.053	3.907ArgGlu: 3.907 ± 0.046	2.393ArgPhe: 2.393 ± 0.032	6.138ArgGly: 6.138 ± 0.06	1.996ArgHis: 1.996 ± 0.03	2.896ArgIle: 2.896 ± 0.039	1.101ArgLys: 1.101 ± 0.022	9.244ArgLeu: 9.244 ± 0.084	1.564ArgMet: 1.564 ± 0.028	1.204ArgAsn: 1.204 ± 0.026	5.859ArgPro: 5.859 ± 0.073	2.357ArgGln: 2.357 ± 0.038	8.462ArgArg: 8.462 ± 0.079	4.089ArgSer: 4.089 ± 0.051	4.473ArgThr: 4.473 ± 0.047	6.225ArgVal: 6.225 ± 0.066	1.465ArgTrp: 1.465 ± 0.026	1.809ArgTyr: 1.809 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.998SerAla: 6.998 ± 0.071	0.386SerCys: 0.386 ± 0.011	2.722SerAsp: 2.722 ± 0.033	2.002SerGlu: 2.002 ± 0.031	1.522SerPhe: 1.522 ± 0.034	5.809SerGly: 5.809 ± 0.059	0.939SerHis: 0.939 ± 0.02	1.624SerIle: 1.624 ± 0.027	0.779SerLys: 0.779 ± 0.021	4.709SerLeu: 4.709 ± 0.043	1.003SerMet: 1.003 ± 0.023	0.855SerAsn: 0.855 ± 0.024	3.657SerPro: 3.657 ± 0.044	1.308SerGln: 1.308 ± 0.026	3.951SerArg: 3.951 ± 0.041	3.063SerSer: 3.063 ± 0.046	3.226SerThr: 3.226 ± 0.05	4.208SerVal: 4.208 ± 0.058	0.889SerTrp: 0.889 ± 0.018	1.155SerTyr: 1.155 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	9.026ThrAla: 9.026 ± 0.093	0.443ThrCys: 0.443 ± 0.029	3.499ThrAsp: 3.499 ± 0.041	2.787ThrGlu: 2.787 ± 0.033	1.772ThrPhe: 1.772 ± 0.027	6.821ThrGly: 6.821 ± 0.066	1.123ThrHis: 1.123 ± 0.025	2.181ThrIle: 2.181 ± 0.032	0.957ThrLys: 0.957 ± 0.021	5.744ThrLeu: 5.744 ± 0.076	0.974ThrMet: 0.974 ± 0.022	1.115ThrAsn: 1.115 ± 0.037	4.228ThrPro: 4.228 ± 0.055	1.402ThrGln: 1.402 ± 0.032	4.037ThrArg: 4.037 ± 0.045	3.46ThrSer: 3.46 ± 0.048	4.186ThrThr: 4.186 ± 0.147	5.854ThrVal: 5.854 ± 0.055	0.885ThrTrp: 0.885 ± 0.022	1.174ThrTyr: 1.174 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	12.766ValAla: 12.766 ± 0.076	0.736ValCys: 0.736 ± 0.023	5.575ValAsp: 5.575 ± 0.05	4.641ValGlu: 4.641 ± 0.049	2.362ValPhe: 2.362 ± 0.033	7.568ValGly: 7.568 ± 0.06	1.699ValHis: 1.699 ± 0.028	3.1ValIle: 3.1 ± 0.041	1.197ValLys: 1.197 ± 0.026	9.302ValLeu: 9.302 ± 0.078	1.198ValMet: 1.198 ± 0.026	1.702ValAsn: 1.702 ± 0.027	5.251ValPro: 5.251 ± 0.055	1.77ValGln: 1.77 ± 0.026	6.583ValArg: 6.583 ± 0.058	4.335ValSer: 4.335 ± 0.065	5.912ValThr: 5.912 ± 0.101	8.405ValVal: 8.405 ± 0.078	1.092ValTrp: 1.092 ± 0.024	1.376ValTyr: 1.376 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.712TrpAla: 1.712 ± 0.029	0.157TrpCys: 0.157 ± 0.008	0.872TrpAsp: 0.872 ± 0.022	0.679TrpGlu: 0.679 ± 0.017	0.445TrpPhe: 0.445 ± 0.012	0.964TrpGly: 0.964 ± 0.019	0.362TrpHis: 0.362 ± 0.011	0.535TrpIle: 0.535 ± 0.014	0.272TrpLys: 0.272 ± 0.012	1.823TrpLeu: 1.823 ± 0.029	0.272TrpMet: 0.272 ± 0.011	0.346TrpAsn: 0.346 ± 0.012	0.967TrpPro: 0.967 ± 0.024	0.483TrpGln: 0.483 ± 0.013	1.388TrpArg: 1.388 ± 0.025	0.915TrpSer: 0.915 ± 0.019	0.982TrpThr: 0.982 ± 0.021	1.018TrpVal: 1.018 ± 0.021	0.325TrpTrp: 0.325 ± 0.011	0.284TrpTyr: 0.284 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.324TyrAla: 2.324 ± 0.033	0.175TyrCys: 0.175 ± 0.008	1.259TyrAsp: 1.259 ± 0.03	0.97TyrGlu: 0.97 ± 0.021	0.609TyrPhe: 0.609 ± 0.017	1.949TyrGly: 1.949 ± 0.029	0.398TyrHis: 0.398 ± 0.015	0.454TyrIle: 0.454 ± 0.014	0.267TyrLys: 0.267 ± 0.01	2.256TyrLeu: 2.256 ± 0.033	0.197TyrMet: 0.197 ± 0.009	0.367TyrAsn: 0.367 ± 0.013	1.216TyrPro: 1.216 ± 0.027	0.67TyrGln: 0.67 ± 0.018	1.694TyrArg: 1.694 ± 0.031	0.92TyrSer: 0.92 ± 0.025	1.026TyrThr: 1.026 ± 0.024	1.498TyrVal: 1.498 ± 0.029	0.321TyrTrp: 0.321 ± 0.013	0.436TyrTyr: 0.436 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7079 proteins (2517300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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