Amino acid dipepetide frequency for Actinotalea fermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.546AlaAla: 25.546 ± 0.25	1.005AlaCys: 1.005 ± 0.031	9.82AlaAsp: 9.82 ± 0.112	9.035AlaGlu: 9.035 ± 0.124	3.544AlaPhe: 3.544 ± 0.068	14.864AlaGly: 14.864 ± 0.153	2.767AlaHis: 2.767 ± 0.054	4.188AlaIle: 4.188 ± 0.065	1.851AlaLys: 1.851 ± 0.05	15.866AlaLeu: 15.866 ± 0.142	2.826AlaMet: 2.826 ± 0.053	1.859AlaAsn: 1.859 ± 0.047	8.247AlaPro: 8.247 ± 0.133	4.073AlaGln: 4.073 ± 0.08	11.853AlaArg: 11.853 ± 0.13	6.519AlaSer: 6.519 ± 0.079	8.481AlaThr: 8.481 ± 0.107	14.983AlaVal: 14.983 ± 0.156	2.418AlaTrp: 2.418 ± 0.054	2.477AlaTyr: 2.477 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.857CysAla: 0.857 ± 0.031	0.061CysCys: 0.061 ± 0.01	0.381CysAsp: 0.381 ± 0.022	0.296CysGlu: 0.296 ± 0.016	0.16CysPhe: 0.16 ± 0.011	0.701CysGly: 0.701 ± 0.029	0.154CysHis: 0.154 ± 0.012	0.143CysIle: 0.143 ± 0.011	0.058CysLys: 0.058 ± 0.006	0.541CysLeu: 0.541 ± 0.024	0.092CysMet: 0.092 ± 0.01	0.091CysAsn: 0.091 ± 0.01	0.398CysPro: 0.398 ± 0.021	0.126CysGln: 0.126 ± 0.011	0.443CysArg: 0.443 ± 0.02	0.359CysSer: 0.359 ± 0.016	0.407CysThr: 0.407 ± 0.019	0.527CysVal: 0.527 ± 0.024	0.085CysTrp: 0.085 ± 0.009	0.114CysTyr: 0.114 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	10.057AspAla: 10.057 ± 0.102	0.285AspCys: 0.285 ± 0.018	4.662AspAsp: 4.662 ± 0.08	4.092AspGlu: 4.092 ± 0.073	1.198AspPhe: 1.198 ± 0.037	7.18AspGly: 7.18 ± 0.099	1.201AspHis: 1.201 ± 0.03	1.424AspIle: 1.424 ± 0.034	0.671AspLys: 0.671 ± 0.029	6.845AspLeu: 6.845 ± 0.085	0.805AspMet: 0.805 ± 0.028	0.685AspAsn: 0.685 ± 0.023	4.613AspPro: 4.613 ± 0.076	1.384AspGln: 1.384 ± 0.041	4.472AspArg: 4.472 ± 0.066	1.81AspSer: 1.81 ± 0.048	2.483AspThr: 2.483 ± 0.047	6.985AspVal: 6.985 ± 0.082	0.915AspTrp: 0.915 ± 0.032	0.967AspTyr: 0.967 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.624GluAla: 7.624 ± 0.097	0.241GluCys: 0.241 ± 0.015	2.773GluAsp: 2.773 ± 0.055	2.756GluGlu: 2.756 ± 0.064	1.201GluPhe: 1.201 ± 0.033	4.159GluGly: 4.159 ± 0.075	1.628GluHis: 1.628 ± 0.04	2.096GluIle: 2.096 ± 0.05	0.787GluLys: 0.787 ± 0.033	6.441GluLeu: 6.441 ± 0.086	0.838GluMet: 0.838 ± 0.028	0.842GluAsn: 0.842 ± 0.028	3.716GluPro: 3.716 ± 0.067	2.018GluGln: 2.018 ± 0.053	5.375GluArg: 5.375 ± 0.08	2.131GluSer: 2.131 ± 0.048	2.643GluThr: 2.643 ± 0.054	5.41GluVal: 5.41 ± 0.072	0.706GluTrp: 0.706 ± 0.024	0.964GluTyr: 0.964 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.643PheAla: 3.643 ± 0.057	0.203PheCys: 0.203 ± 0.014	1.787PheAsp: 1.787 ± 0.042	1.328PheGlu: 1.328 ± 0.037	0.783PhePhe: 0.783 ± 0.032	2.707PheGly: 2.707 ± 0.061	0.487PheHis: 0.487 ± 0.025	0.647PheIle: 0.647 ± 0.027	0.301PheLys: 0.301 ± 0.014	2.305PheLeu: 2.305 ± 0.051	0.358PheMet: 0.358 ± 0.019	0.438PheAsn: 0.438 ± 0.019	1.151PhePro: 1.151 ± 0.036	0.533PheGln: 0.533 ± 0.021	1.565PheArg: 1.565 ± 0.039	1.167PheSer: 1.167 ± 0.034	1.614PheThr: 1.614 ± 0.042	2.501PheVal: 2.501 ± 0.054	0.433PheTrp: 0.433 ± 0.026	0.478PheTyr: 0.478 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	12.971GlyAla: 12.971 ± 0.155	0.648GlyCys: 0.648 ± 0.023	5.512GlyAsp: 5.512 ± 0.077	4.973GlyGlu: 4.973 ± 0.065	2.679GlyPhe: 2.679 ± 0.052	8.759GlyGly: 8.759 ± 0.12	2.024GlyHis: 2.024 ± 0.048	3.239GlyIle: 3.239 ± 0.055	1.533GlyLys: 1.533 ± 0.047	9.784GlyLeu: 9.784 ± 0.1	2.053GlyMet: 2.053 ± 0.041	1.39GlyAsn: 1.39 ± 0.049	5.376GlyPro: 5.376 ± 0.078	2.542GlyGln: 2.542 ± 0.054	8.047GlyArg: 8.047 ± 0.098	4.872GlySer: 4.872 ± 0.069	6.267GlyThr: 6.267 ± 0.104	9.076GlyVal: 9.076 ± 0.097	1.836GlyTrp: 1.836 ± 0.045	2.087GlyTyr: 2.087 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.688HisAla: 2.688 ± 0.056	0.135HisCys: 0.135 ± 0.011	1.347HisAsp: 1.347 ± 0.038	1.158HisGlu: 1.158 ± 0.034	0.417HisPhe: 0.417 ± 0.02	2.103HisGly: 2.103 ± 0.055	0.564HisHis: 0.564 ± 0.025	0.425HisIle: 0.425 ± 0.02	0.217HisLys: 0.217 ± 0.016	2.36HisLeu: 2.36 ± 0.05	0.273HisMet: 0.273 ± 0.019	0.296HisAsn: 0.296 ± 0.016	1.509HisPro: 1.509 ± 0.04	0.482HisGln: 0.482 ± 0.023	1.767HisArg: 1.767 ± 0.04	0.651HisSer: 0.651 ± 0.026	0.953HisThr: 0.953 ± 0.029	2.092HisVal: 2.092 ± 0.043	0.32HisTrp: 0.32 ± 0.017	0.343HisTyr: 0.343 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.726IleAla: 4.726 ± 0.082	0.192IleCys: 0.192 ± 0.013	2.195IleAsp: 2.195 ± 0.051	1.822IleGlu: 1.822 ± 0.044	0.662IlePhe: 0.662 ± 0.027	3.232IleGly: 3.232 ± 0.061	0.459IleHis: 0.459 ± 0.021	0.787IleIle: 0.787 ± 0.031	0.477IleLys: 0.477 ± 0.024	2.316IleLeu: 2.316 ± 0.052	0.393IleMet: 0.393 ± 0.023	0.55IleAsn: 0.55 ± 0.022	1.557IlePro: 1.557 ± 0.043	0.629IleGln: 0.629 ± 0.024	1.797IleArg: 1.797 ± 0.04	1.391IleSer: 1.391 ± 0.042	1.981IleThr: 1.981 ± 0.052	2.932IleVal: 2.932 ± 0.052	0.349IleTrp: 0.349 ± 0.02	0.486IleTyr: 0.486 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	1.792LysAla: 1.792 ± 0.051	0.063LysCys: 0.063 ± 0.01	0.729LysAsp: 0.729 ± 0.03	0.639LysGlu: 0.639 ± 0.025	0.255LysPhe: 0.255 ± 0.014	1.078LysGly: 1.078 ± 0.04	0.286LysHis: 0.286 ± 0.018	0.545LysIle: 0.545 ± 0.024	0.358LysLys: 0.358 ± 0.02	1.061LysLeu: 1.061 ± 0.037	0.224LysMet: 0.224 ± 0.014	0.272LysAsn: 0.272 ± 0.017	0.779LysPro: 0.779 ± 0.031	0.394LysGln: 0.394 ± 0.024	0.929LysArg: 0.929 ± 0.036	0.659LysSer: 0.659 ± 0.029	0.739LysThr: 0.739 ± 0.027	1.278LysVal: 1.278 ± 0.038	0.149LysTrp: 0.149 ± 0.011	0.292LysTyr: 0.292 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	17.814LeuAla: 17.814 ± 0.158	0.551LeuCys: 0.551 ± 0.019	6.859LeuAsp: 6.859 ± 0.089	5.253LeuGlu: 5.253 ± 0.075	2.168LeuPhe: 2.168 ± 0.058	9.96LeuGly: 9.96 ± 0.111	1.886LeuHis: 1.886 ± 0.045	2.441LeuIle: 2.441 ± 0.055	1.061LeuLys: 1.061 ± 0.033	10.747LeuLeu: 10.747 ± 0.136	1.485LeuMet: 1.485 ± 0.039	1.315LeuAsn: 1.315 ± 0.039	6.134LeuPro: 6.134 ± 0.072	2.133LeuGln: 2.133 ± 0.042	8.228LeuArg: 8.228 ± 0.098	4.573LeuSer: 4.573 ± 0.078	6.352LeuThr: 6.352 ± 0.077	11.378LeuVal: 11.378 ± 0.116	1.291LeuTrp: 1.291 ± 0.037	1.465LeuTyr: 1.465 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.435MetAla: 2.435 ± 0.047	0.106MetCys: 0.106 ± 0.01	0.831MetAsp: 0.831 ± 0.027	0.623MetGlu: 0.623 ± 0.024	0.397MetPhe: 0.397 ± 0.022	1.272MetGly: 1.272 ± 0.036	0.326MetHis: 0.326 ± 0.016	0.606MetIle: 0.606 ± 0.025	0.258MetLys: 0.258 ± 0.016	1.56MetLeu: 1.56 ± 0.038	0.227MetMet: 0.227 ± 0.017	0.328MetAsn: 0.328 ± 0.016	1.14MetPro: 1.14 ± 0.037	0.36MetGln: 0.36 ± 0.019	1.398MetArg: 1.398 ± 0.044	1.334MetSer: 1.334 ± 0.036	1.698MetThr: 1.698 ± 0.036	1.43MetVal: 1.43 ± 0.034	0.194MetTrp: 0.194 ± 0.013	0.26MetTyr: 0.26 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.956AsnAla: 1.956 ± 0.045	0.097AsnCys: 0.097 ± 0.011	0.816AsnAsp: 0.816 ± 0.026	0.708AsnGlu: 0.708 ± 0.026	0.36AsnPhe: 0.36 ± 0.024	1.45AsnGly: 1.45 ± 0.043	0.304AsnHis: 0.304 ± 0.017	0.472AsnIle: 0.472 ± 0.02	0.242AsnLys: 0.242 ± 0.017	1.573AsnLeu: 1.573 ± 0.04	0.206AsnMet: 0.206 ± 0.018	0.27AsnAsn: 0.27 ± 0.016	1.171AsnPro: 1.171 ± 0.032	0.385AsnGln: 0.385 ± 0.02	0.981AsnArg: 0.981 ± 0.033	0.561AsnSer: 0.561 ± 0.024	0.782AsnThr: 0.782 ± 0.031	1.389AsnVal: 1.389 ± 0.041	0.198AsnTrp: 0.198 ± 0.013	0.316AsnTyr: 0.316 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.67ProAla: 9.67 ± 0.129	0.268ProCys: 0.268 ± 0.017	4.834ProAsp: 4.834 ± 0.069	4.023ProGlu: 4.023 ± 0.063	1.461ProPhe: 1.461 ± 0.038	6.547ProGly: 6.547 ± 0.088	1.115ProHis: 1.115 ± 0.034	1.38ProIle: 1.38 ± 0.039	0.645ProLys: 0.645 ± 0.028	4.959ProLeu: 4.959 ± 0.066	0.974ProMet: 0.974 ± 0.031	0.73ProAsn: 0.73 ± 0.027	3.638ProPro: 3.638 ± 0.09	1.51ProGln: 1.51 ± 0.044	4.088ProArg: 4.088 ± 0.068	3.07ProSer: 3.07 ± 0.056	4.068ProThr: 4.068 ± 0.073	6.109ProVal: 6.109 ± 0.085	1.062ProTrp: 1.062 ± 0.03	1.074ProTyr: 1.074 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.746GlnAla: 3.746 ± 0.065	0.137GlnCys: 0.137 ± 0.011	1.187GlnAsp: 1.187 ± 0.033	1.134GlnGlu: 1.134 ± 0.029	0.593GlnPhe: 0.593 ± 0.025	1.999GlnGly: 1.999 ± 0.045	0.541GlnHis: 0.541 ± 0.024	0.894GlnIle: 0.894 ± 0.029	0.298GlnLys: 0.298 ± 0.018	2.636GlnLeu: 2.636 ± 0.054	0.536GlnMet: 0.536 ± 0.023	0.422GlnAsn: 0.422 ± 0.02	1.622GlnPro: 1.622 ± 0.045	0.965GlnGln: 0.965 ± 0.033	2.302GlnArg: 2.302 ± 0.056	0.996GlnSer: 0.996 ± 0.032	1.336GlnThr: 1.336 ± 0.035	3.0GlnVal: 3.0 ± 0.058	0.397GlnTrp: 0.397 ± 0.02	0.572GlnTyr: 0.572 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	11.519ArgAla: 11.519 ± 0.124	0.426ArgCys: 0.426 ± 0.019	4.42ArgAsp: 4.42 ± 0.068	4.417ArgGlu: 4.417 ± 0.071	2.04ArgPhe: 2.04 ± 0.057	6.11ArgGly: 6.11 ± 0.085	1.816ArgHis: 1.816 ± 0.044	2.631ArgIle: 2.631 ± 0.053	0.959ArgLys: 0.959 ± 0.034	8.532ArgLeu: 8.532 ± 0.092	1.711ArgMet: 1.711 ± 0.045	1.014ArgAsn: 1.014 ± 0.035	4.809ArgPro: 4.809 ± 0.071	1.976ArgGln: 1.976 ± 0.046	8.413ArgArg: 8.413 ± 0.121	3.801ArgSer: 3.801 ± 0.066	5.056ArgThr: 5.056 ± 0.067	7.033ArgVal: 7.033 ± 0.083	1.499ArgTrp: 1.499 ± 0.035	1.543ArgTyr: 1.543 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.601SerAla: 6.601 ± 0.084	0.316SerCys: 0.316 ± 0.017	2.439SerAsp: 2.439 ± 0.049	2.062SerGlu: 2.062 ± 0.045	1.364SerPhe: 1.364 ± 0.036	5.243SerGly: 5.243 ± 0.081	0.777SerHis: 0.777 ± 0.032	1.415SerIle: 1.415 ± 0.042	0.524SerLys: 0.524 ± 0.025	4.404SerLeu: 4.404 ± 0.056	0.966SerMet: 0.966 ± 0.029	0.687SerAsn: 0.687 ± 0.027	2.937SerPro: 2.937 ± 0.046	1.103SerGln: 1.103 ± 0.032	3.371SerArg: 3.371 ± 0.06	2.446SerSer: 2.446 ± 0.056	3.039SerThr: 3.039 ± 0.051	4.251SerVal: 4.251 ± 0.065	0.819SerTrp: 0.819 ± 0.029	0.901SerTyr: 0.901 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.555ThrAla: 8.555 ± 0.104	0.404ThrCys: 0.404 ± 0.023	3.515ThrAsp: 3.515 ± 0.069	2.88ThrGlu: 2.88 ± 0.057	1.8ThrPhe: 1.8 ± 0.042	6.323ThrGly: 6.323 ± 0.092	1.077ThrHis: 1.077 ± 0.03	1.985ThrIle: 1.985 ± 0.048	0.752ThrLys: 0.752 ± 0.027	5.759ThrLeu: 5.759 ± 0.077	0.947ThrMet: 0.947 ± 0.033	0.914ThrAsn: 0.914 ± 0.032	4.422ThrPro: 4.422 ± 0.073	1.451ThrGln: 1.451 ± 0.032	3.88ThrArg: 3.88 ± 0.061	3.234ThrSer: 3.234 ± 0.061	4.309ThrThr: 4.309 ± 0.105	6.241ThrVal: 6.241 ± 0.095	1.089ThrTrp: 1.089 ± 0.034	1.305ThrTyr: 1.305 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	15.606ValAla: 15.606 ± 0.142	0.603ValCys: 0.603 ± 0.022	6.503ValAsp: 6.503 ± 0.085	5.463ValGlu: 5.463 ± 0.072	2.327ValPhe: 2.327 ± 0.047	9.052ValGly: 9.052 ± 0.101	2.025ValHis: 2.025 ± 0.04	2.832ValIle: 2.832 ± 0.058	1.109ValLys: 1.109 ± 0.035	11.385ValLeu: 11.385 ± 0.128	1.391ValMet: 1.391 ± 0.037	1.493ValAsn: 1.493 ± 0.042	6.216ValPro: 6.216 ± 0.082	2.183ValGln: 2.183 ± 0.047	7.835ValArg: 7.835 ± 0.099	4.315ValSer: 4.315 ± 0.064	6.611ValThr: 6.611 ± 0.104	12.91ValVal: 12.91 ± 0.141	1.331ValTrp: 1.331 ± 0.041	1.425ValTyr: 1.425 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	2.018TrpAla: 2.018 ± 0.045	0.133TrpCys: 0.133 ± 0.011	0.896TrpAsp: 0.896 ± 0.029	0.658TrpGlu: 0.658 ± 0.024	0.514TrpPhe: 0.514 ± 0.023	1.141TrpGly: 1.141 ± 0.038	0.362TrpHis: 0.362 ± 0.019	0.441TrpIle: 0.441 ± 0.02	0.186TrpLys: 0.186 ± 0.013	1.933TrpLeu: 1.933 ± 0.043	0.27TrpMet: 0.27 ± 0.015	0.324TrpAsn: 0.324 ± 0.018	0.837TrpPro: 0.837 ± 0.03	0.539TrpGln: 0.539 ± 0.023	1.428TrpArg: 1.428 ± 0.038	0.975TrpSer: 0.975 ± 0.03	1.045TrpThr: 1.045 ± 0.035	1.347TrpVal: 1.347 ± 0.04	0.428TrpTrp: 0.428 ± 0.021	0.308TrpTyr: 0.308 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.398TyrAla: 2.398 ± 0.048	0.119TyrCys: 0.119 ± 0.011	1.227TyrAsp: 1.227 ± 0.052	1.025TyrGlu: 1.025 ± 0.034	0.507TyrPhe: 0.507 ± 0.023	1.788TyrGly: 1.788 ± 0.04	0.302TyrHis: 0.302 ± 0.017	0.342TyrIle: 0.342 ± 0.021	0.237TyrLys: 0.237 ± 0.017	2.086TyrLeu: 2.086 ± 0.047	0.208TyrMet: 0.208 ± 0.014	0.316TyrAsn: 0.316 ± 0.019	0.953TyrPro: 0.953 ± 0.029	0.527TyrGln: 0.527 ± 0.026	1.553TyrArg: 1.553 ± 0.037	0.798TyrSer: 0.798 ± 0.029	0.982TyrThr: 0.982 ± 0.034	1.744TyrVal: 1.744 ± 0.041	0.266TyrTrp: 0.266 ± 0.015	0.378TyrTyr: 0.378 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3422 proteins (1139067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---