Amino acid dipepetide frequency for Cronobacter phage vB_CskP_GAP227

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.047AlaAla: 13.047 ± 1.427
0.844AlaCys: 0.844 ± 0.294
6.83AlaAsp: 6.83 ± 0.931
7.751AlaGlu: 7.751 ± 0.899
3.147AlaPhe: 3.147 ± 0.443
8.672AlaGly: 8.672 ± 0.912
1.688AlaHis: 1.688 ± 0.367
4.375AlaIle: 4.375 ± 0.523
6.677AlaLys: 6.677 ± 0.606
8.135AlaLeu: 8.135 ± 0.787
3.147AlaMet: 3.147 ± 0.505
4.835AlaAsn: 4.835 ± 0.762
3.147AlaPro: 3.147 ± 0.497
5.142AlaGln: 5.142 ± 1.2
5.449AlaArg: 5.449 ± 0.756
5.295AlaSer: 5.295 ± 0.591
4.528AlaThr: 4.528 ± 0.625
7.061AlaVal: 7.061 ± 0.935
1.151AlaTrp: 1.151 ± 0.3
2.916AlaTyr: 2.916 ± 0.503
0.0AlaXaa: 0.0 ± 0.0
Cys
0.46CysAla: 0.46 ± 0.23
0.23CysCys: 0.23 ± 0.147
0.537CysAsp: 0.537 ± 0.148
0.537CysGlu: 0.537 ± 0.241
0.23CysPhe: 0.23 ± 0.122
0.691CysGly: 0.691 ± 0.264
0.153CysHis: 0.153 ± 0.154
0.384CysIle: 0.384 ± 0.232
0.23CysLys: 0.23 ± 0.136
1.074CysLeu: 1.074 ± 0.265
0.46CysMet: 0.46 ± 0.234
0.537CysAsn: 0.537 ± 0.236
0.921CysPro: 0.921 ± 0.33
0.46CysGln: 0.46 ± 0.157
0.844CysArg: 0.844 ± 0.282
0.614CysSer: 0.614 ± 0.211
0.46CysThr: 0.46 ± 0.183
1.228CysVal: 1.228 ± 0.352
0.0CysTrp: 0.0 ± 0.0
0.767CysTyr: 0.767 ± 0.237
0.0CysXaa: 0.0 ± 0.0
Asp
6.523AspAla: 6.523 ± 0.749
0.691AspCys: 0.691 ± 0.176
3.684AspAsp: 3.684 ± 0.563
4.068AspGlu: 4.068 ± 0.559
3.223AspPhe: 3.223 ± 0.486
5.142AspGly: 5.142 ± 0.522
1.151AspHis: 1.151 ± 0.33
3.147AspIle: 3.147 ± 0.484
4.144AspLys: 4.144 ± 0.402
5.065AspLeu: 5.065 ± 0.56
2.226AspMet: 2.226 ± 0.457
2.379AspAsn: 2.379 ± 0.375
2.226AspPro: 2.226 ± 0.353
1.842AspGln: 1.842 ± 0.373
2.916AspArg: 2.916 ± 0.426
2.916AspSer: 2.916 ± 0.534
3.837AspThr: 3.837 ± 0.548
4.835AspVal: 4.835 ± 0.558
0.844AspTrp: 0.844 ± 0.366
2.072AspTyr: 2.072 ± 0.385
0.0AspXaa: 0.0 ± 0.0
Glu
7.061GluAla: 7.061 ± 0.733
0.767GluCys: 0.767 ± 0.281
4.298GluAsp: 4.298 ± 0.554
3.991GluGlu: 3.991 ± 0.653
1.765GluPhe: 1.765 ± 0.334
5.219GluGly: 5.219 ± 0.662
1.305GluHis: 1.305 ± 0.412
2.609GluIle: 2.609 ± 0.437
3.761GluLys: 3.761 ± 0.594
5.372GluLeu: 5.372 ± 0.755
2.302GluMet: 2.302 ± 0.367
2.226GluAsn: 2.226 ± 0.333
1.919GluPro: 1.919 ± 0.461
3.837GluGln: 3.837 ± 0.671
3.53GluArg: 3.53 ± 0.623
2.456GluSer: 2.456 ± 0.46
3.07GluThr: 3.07 ± 0.427
4.682GluVal: 4.682 ± 0.57
1.305GluTrp: 1.305 ± 0.296
2.149GluTyr: 2.149 ± 0.381
0.0GluXaa: 0.0 ± 0.0
Phe
2.149PheAla: 2.149 ± 0.328
0.537PheCys: 0.537 ± 0.17
2.686PheAsp: 2.686 ± 0.455
2.302PheGlu: 2.302 ± 0.487
1.151PhePhe: 1.151 ± 0.233
2.916PheGly: 2.916 ± 0.417
0.691PheHis: 0.691 ± 0.215
1.995PheIle: 1.995 ± 0.431
2.609PheLys: 2.609 ± 0.502
2.993PheLeu: 2.993 ± 0.386
1.228PheMet: 1.228 ± 0.225
2.226PheAsn: 2.226 ± 0.371
1.381PhePro: 1.381 ± 0.323
1.765PheGln: 1.765 ± 0.418
2.072PheArg: 2.072 ± 0.349
1.765PheSer: 1.765 ± 0.277
2.226PheThr: 2.226 ± 0.37
1.688PheVal: 1.688 ± 0.27
0.767PheTrp: 0.767 ± 0.258
1.228PheTyr: 1.228 ± 0.295
0.0PheXaa: 0.0 ± 0.0
Gly
7.061GlyAla: 7.061 ± 0.688
1.074GlyCys: 1.074 ± 0.4
5.602GlyAsp: 5.602 ± 0.546
3.914GlyGlu: 3.914 ± 0.371
2.533GlyPhe: 2.533 ± 0.449
6.83GlyGly: 6.83 ± 1.058
0.998GlyHis: 0.998 ± 0.267
4.605GlyIle: 4.605 ± 0.577
5.219GlyLys: 5.219 ± 0.621
6.677GlyLeu: 6.677 ± 0.811
2.379GlyMet: 2.379 ± 0.353
2.763GlyAsn: 2.763 ± 0.461
1.842GlyPro: 1.842 ± 0.338
3.07GlyGln: 3.07 ± 0.63
4.298GlyArg: 4.298 ± 0.506
5.449GlySer: 5.449 ± 0.726
4.835GlyThr: 4.835 ± 0.755
5.065GlyVal: 5.065 ± 0.628
1.074GlyTrp: 1.074 ± 0.253
3.147GlyTyr: 3.147 ± 0.537
0.0GlyXaa: 0.0 ± 0.0
His
1.842HisAla: 1.842 ± 0.454
0.384HisCys: 0.384 ± 0.162
1.458HisAsp: 1.458 ± 0.397
1.381HisGlu: 1.381 ± 0.463
0.614HisPhe: 0.614 ± 0.202
1.688HisGly: 1.688 ± 0.358
0.537HisHis: 0.537 ± 0.231
1.074HisIle: 1.074 ± 0.264
0.844HisLys: 0.844 ± 0.273
1.305HisLeu: 1.305 ± 0.313
0.537HisMet: 0.537 ± 0.176
0.767HisAsn: 0.767 ± 0.268
0.844HisPro: 0.844 ± 0.269
0.614HisGln: 0.614 ± 0.201
1.074HisArg: 1.074 ± 0.327
0.691HisSer: 0.691 ± 0.235
1.381HisThr: 1.381 ± 0.286
0.921HisVal: 0.921 ± 0.267
0.23HisTrp: 0.23 ± 0.113
0.921HisTyr: 0.921 ± 0.281
0.0HisXaa: 0.0 ± 0.0
Ile
4.758IleAla: 4.758 ± 0.515
0.23IleCys: 0.23 ± 0.12
2.302IleAsp: 2.302 ± 0.355
2.84IleGlu: 2.84 ± 0.493
1.765IlePhe: 1.765 ± 0.347
4.375IleGly: 4.375 ± 0.563
1.842IleHis: 1.842 ± 0.432
2.609IleIle: 2.609 ± 0.497
2.686IleLys: 2.686 ± 0.419
2.609IleLeu: 2.609 ± 0.424
0.998IleMet: 0.998 ± 0.293
2.302IleAsn: 2.302 ± 0.378
2.379IlePro: 2.379 ± 0.273
1.381IleGln: 1.381 ± 0.301
2.916IleArg: 2.916 ± 0.512
2.916IleSer: 2.916 ± 0.482
2.533IleThr: 2.533 ± 0.498
1.688IleVal: 1.688 ± 0.377
0.614IleTrp: 0.614 ± 0.193
1.842IleTyr: 1.842 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
7.291LysAla: 7.291 ± 0.832
0.384LysCys: 0.384 ± 0.191
4.528LysAsp: 4.528 ± 0.662
2.916LysGlu: 2.916 ± 0.542
2.533LysPhe: 2.533 ± 0.399
4.528LysGly: 4.528 ± 0.547
1.151LysHis: 1.151 ± 0.33
1.995LysIle: 1.995 ± 0.406
3.684LysLys: 3.684 ± 0.64
6.14LysLeu: 6.14 ± 0.717
2.226LysMet: 2.226 ± 0.457
1.612LysAsn: 1.612 ± 0.31
2.149LysPro: 2.149 ± 0.416
3.454LysGln: 3.454 ± 0.562
4.068LysArg: 4.068 ± 0.6
2.072LysSer: 2.072 ± 0.412
2.993LysThr: 2.993 ± 0.47
3.607LysVal: 3.607 ± 0.494
0.614LysTrp: 0.614 ± 0.218
1.688LysTyr: 1.688 ± 0.36
0.0LysXaa: 0.0 ± 0.0
Leu
9.056LeuAla: 9.056 ± 0.909
1.228LeuCys: 1.228 ± 0.286
5.909LeuAsp: 5.909 ± 0.711
4.605LeuGlu: 4.605 ± 0.598
2.456LeuPhe: 2.456 ± 0.476
5.756LeuGly: 5.756 ± 0.633
1.612LeuHis: 1.612 ± 0.36
3.377LeuIle: 3.377 ± 0.422
5.219LeuLys: 5.219 ± 0.627
5.602LeuLeu: 5.602 ± 0.773
1.842LeuMet: 1.842 ± 0.334
3.07LeuAsn: 3.07 ± 0.37
4.144LeuPro: 4.144 ± 0.447
4.298LeuGln: 4.298 ± 0.541
4.528LeuArg: 4.528 ± 0.594
4.682LeuSer: 4.682 ± 0.577
5.756LeuThr: 5.756 ± 0.763
4.988LeuVal: 4.988 ± 0.702
1.074LeuTrp: 1.074 ± 0.269
2.609LeuTyr: 2.609 ± 0.51
0.0LeuXaa: 0.0 ± 0.0
Met
4.375MetAla: 4.375 ± 0.6
0.23MetCys: 0.23 ± 0.14
1.612MetAsp: 1.612 ± 0.337
1.381MetGlu: 1.381 ± 0.292
1.842MetPhe: 1.842 ± 0.283
1.995MetGly: 1.995 ± 0.416
0.614MetHis: 0.614 ± 0.206
0.46MetIle: 0.46 ± 0.145
2.226MetLys: 2.226 ± 0.495
2.916MetLeu: 2.916 ± 0.4
0.537MetMet: 0.537 ± 0.177
1.765MetAsn: 1.765 ± 0.418
1.305MetPro: 1.305 ± 0.325
2.072MetGln: 2.072 ± 0.438
1.612MetArg: 1.612 ± 0.276
1.458MetSer: 1.458 ± 0.221
1.842MetThr: 1.842 ± 0.381
1.612MetVal: 1.612 ± 0.342
0.307MetTrp: 0.307 ± 0.146
0.614MetTyr: 0.614 ± 0.204
0.0MetXaa: 0.0 ± 0.0
Asn
4.605AsnAla: 4.605 ± 0.826
0.691AsnCys: 0.691 ± 0.271
2.302AsnAsp: 2.302 ± 0.324
2.149AsnGlu: 2.149 ± 0.335
1.842AsnPhe: 1.842 ± 0.359
4.068AsnGly: 4.068 ± 0.48
0.537AsnHis: 0.537 ± 0.198
2.84AsnIle: 2.84 ± 0.516
2.686AsnLys: 2.686 ± 0.536
3.3AsnLeu: 3.3 ± 0.48
1.612AsnMet: 1.612 ± 0.364
1.995AsnAsn: 1.995 ± 0.398
2.379AsnPro: 2.379 ± 0.317
1.535AsnGln: 1.535 ± 0.271
2.072AsnArg: 2.072 ± 0.466
2.072AsnSer: 2.072 ± 0.384
2.763AsnThr: 2.763 ± 0.546
2.302AsnVal: 2.302 ± 0.523
0.767AsnTrp: 0.767 ± 0.236
0.998AsnTyr: 0.998 ± 0.246
0.0AsnXaa: 0.0 ± 0.0
Pro
4.605ProAla: 4.605 ± 0.531
0.384ProCys: 0.384 ± 0.177
1.995ProAsp: 1.995 ± 0.372
4.682ProGlu: 4.682 ± 0.665
1.074ProPhe: 1.074 ± 0.195
3.07ProGly: 3.07 ± 0.462
0.691ProHis: 0.691 ± 0.214
1.919ProIle: 1.919 ± 0.458
1.765ProLys: 1.765 ± 0.322
2.993ProLeu: 2.993 ± 0.437
1.074ProMet: 1.074 ± 0.401
1.535ProAsn: 1.535 ± 0.356
1.151ProPro: 1.151 ± 0.337
1.688ProGln: 1.688 ± 0.391
1.228ProArg: 1.228 ± 0.276
1.765ProSer: 1.765 ± 0.369
1.688ProThr: 1.688 ± 0.315
3.454ProVal: 3.454 ± 0.545
0.46ProTrp: 0.46 ± 0.155
1.842ProTyr: 1.842 ± 0.436
0.0ProXaa: 0.0 ± 0.0
Gln
5.909GlnAla: 5.909 ± 1.067
0.46GlnCys: 0.46 ± 0.213
2.302GlnAsp: 2.302 ± 0.613
2.533GlnGlu: 2.533 ± 0.567
1.612GlnPhe: 1.612 ± 0.273
3.147GlnGly: 3.147 ± 0.475
0.844GlnHis: 0.844 ± 0.294
2.456GlnIle: 2.456 ± 0.503
2.456GlnLys: 2.456 ± 0.378
3.684GlnLeu: 3.684 ± 0.594
1.919GlnMet: 1.919 ± 0.45
1.151GlnAsn: 1.151 ± 0.372
1.458GlnPro: 1.458 ± 0.357
3.377GlnGln: 3.377 ± 0.621
2.456GlnArg: 2.456 ± 0.399
1.919GlnSer: 1.919 ± 0.412
1.842GlnThr: 1.842 ± 0.365
3.837GlnVal: 3.837 ± 0.564
0.767GlnTrp: 0.767 ± 0.236
1.995GlnTyr: 1.995 ± 0.479
0.0GlnXaa: 0.0 ± 0.0
Arg
3.991ArgAla: 3.991 ± 0.652
0.844ArgCys: 0.844 ± 0.27
3.3ArgAsp: 3.3 ± 0.48
4.144ArgGlu: 4.144 ± 0.55
2.763ArgPhe: 2.763 ± 0.404
3.53ArgGly: 3.53 ± 0.564
1.458ArgHis: 1.458 ± 0.254
2.226ArgIle: 2.226 ± 0.536
3.53ArgLys: 3.53 ± 0.633
4.451ArgLeu: 4.451 ± 0.594
2.072ArgMet: 2.072 ± 0.493
3.837ArgAsn: 3.837 ± 0.639
1.612ArgPro: 1.612 ± 0.379
2.533ArgGln: 2.533 ± 0.421
4.298ArgArg: 4.298 ± 0.684
2.226ArgSer: 2.226 ± 0.403
2.763ArgThr: 2.763 ± 0.453
3.761ArgVal: 3.761 ± 0.388
0.767ArgTrp: 0.767 ± 0.301
2.686ArgTyr: 2.686 ± 0.367
0.0ArgXaa: 0.0 ± 0.0
Ser
5.526SerAla: 5.526 ± 0.468
0.153SerCys: 0.153 ± 0.119
2.916SerAsp: 2.916 ± 0.533
2.686SerGlu: 2.686 ± 0.36
1.535SerPhe: 1.535 ± 0.374
3.607SerGly: 3.607 ± 0.547
0.998SerHis: 0.998 ± 0.243
2.226SerIle: 2.226 ± 0.385
3.147SerLys: 3.147 ± 0.493
4.375SerLeu: 4.375 ± 0.496
1.305SerMet: 1.305 ± 0.333
2.226SerAsn: 2.226 ± 0.383
1.995SerPro: 1.995 ± 0.353
2.226SerGln: 2.226 ± 0.45
2.533SerArg: 2.533 ± 0.543
1.535SerSer: 1.535 ± 0.323
3.223SerThr: 3.223 ± 0.464
3.761SerVal: 3.761 ± 0.407
0.844SerTrp: 0.844 ± 0.225
2.149SerTyr: 2.149 ± 0.511
0.0SerXaa: 0.0 ± 0.0
Thr
5.526ThrAla: 5.526 ± 0.808
0.384ThrCys: 0.384 ± 0.177
2.993ThrAsp: 2.993 ± 0.5
3.991ThrGlu: 3.991 ± 0.584
1.995ThrPhe: 1.995 ± 0.352
5.295ThrGly: 5.295 ± 0.538
0.921ThrHis: 0.921 ± 0.311
2.763ThrIle: 2.763 ± 0.564
2.993ThrLys: 2.993 ± 0.412
4.758ThrLeu: 4.758 ± 0.585
1.612ThrMet: 1.612 ± 0.382
2.533ThrAsn: 2.533 ± 0.534
3.377ThrPro: 3.377 ± 0.551
1.228ThrGln: 1.228 ± 0.288
3.147ThrArg: 3.147 ± 0.45
2.84ThrSer: 2.84 ± 0.489
2.533ThrThr: 2.533 ± 0.706
3.761ThrVal: 3.761 ± 0.655
0.844ThrTrp: 0.844 ± 0.288
2.226ThrTyr: 2.226 ± 0.399
0.0ThrXaa: 0.0 ± 0.0
Val
6.216ValAla: 6.216 ± 0.704
0.384ValCys: 0.384 ± 0.172
3.914ValAsp: 3.914 ± 0.582
5.219ValGlu: 5.219 ± 0.83
2.072ValPhe: 2.072 ± 0.429
4.068ValGly: 4.068 ± 0.761
0.537ValHis: 0.537 ± 0.195
2.993ValIle: 2.993 ± 0.462
3.147ValLys: 3.147 ± 0.547
5.833ValLeu: 5.833 ± 0.602
2.149ValMet: 2.149 ± 0.384
3.147ValAsn: 3.147 ± 0.374
2.456ValPro: 2.456 ± 0.434
3.3ValGln: 3.3 ± 0.528
5.449ValArg: 5.449 ± 0.553
3.837ValSer: 3.837 ± 0.488
4.758ValThr: 4.758 ± 1.039
4.758ValVal: 4.758 ± 0.69
0.614ValTrp: 0.614 ± 0.204
2.379ValTyr: 2.379 ± 0.443
0.0ValXaa: 0.0 ± 0.0
Trp
1.228TrpAla: 1.228 ± 0.252
0.307TrpCys: 0.307 ± 0.167
0.767TrpAsp: 0.767 ± 0.232
1.074TrpGlu: 1.074 ± 0.282
0.921TrpPhe: 0.921 ± 0.177
0.767TrpGly: 0.767 ± 0.241
0.46TrpHis: 0.46 ± 0.201
0.153TrpIle: 0.153 ± 0.128
0.691TrpLys: 0.691 ± 0.187
1.842TrpLeu: 1.842 ± 0.474
0.307TrpMet: 0.307 ± 0.154
0.384TrpAsn: 0.384 ± 0.206
0.46TrpPro: 0.46 ± 0.211
0.614TrpGln: 0.614 ± 0.186
0.537TrpArg: 0.537 ± 0.202
0.767TrpSer: 0.767 ± 0.259
0.614TrpThr: 0.614 ± 0.267
1.305TrpVal: 1.305 ± 0.257
0.691TrpTrp: 0.691 ± 0.224
0.384TrpTyr: 0.384 ± 0.228
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.609TyrAla: 2.609 ± 0.466
0.614TyrCys: 0.614 ± 0.245
2.993TyrAsp: 2.993 ± 0.431
1.458TyrGlu: 1.458 ± 0.366
1.305TyrPhe: 1.305 ± 0.297
3.07TyrGly: 3.07 ± 0.497
0.921TyrHis: 0.921 ± 0.262
1.381TyrIle: 1.381 ± 0.334
1.919TyrLys: 1.919 ± 0.465
2.686TyrLeu: 2.686 ± 0.51
0.767TyrMet: 0.767 ± 0.235
2.226TyrAsn: 2.226 ± 0.316
1.919TyrPro: 1.919 ± 0.442
1.765TyrGln: 1.765 ± 0.325
1.765TyrArg: 1.765 ± 0.347
1.688TyrSer: 1.688 ± 0.297
2.072TyrThr: 2.072 ± 0.507
2.916TyrVal: 2.916 ± 0.545
0.537TyrTrp: 0.537 ± 0.19
0.767TyrTyr: 0.767 ± 0.237
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (13031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski