Amino acid dipepetide frequency for Pantoea phage vB_PagM_LIET2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.172AlaAla: 13.172 ± 1.032
1.163AlaCys: 1.163 ± 0.267
7.022AlaAsp: 7.022 ± 0.483
6.648AlaGlu: 6.648 ± 0.619
3.324AlaPhe: 3.324 ± 0.477
8.975AlaGly: 8.975 ± 0.787
2.285AlaHis: 2.285 ± 0.381
6.108AlaIle: 6.108 ± 0.53
4.446AlaLys: 4.446 ± 0.508
8.103AlaLeu: 8.103 ± 0.749
2.867AlaMet: 2.867 ± 0.342
3.74AlaAsn: 3.74 ± 0.548
3.574AlaPro: 3.574 ± 0.496
3.158AlaGln: 3.158 ± 0.382
5.028AlaArg: 5.028 ± 0.495
4.488AlaSer: 4.488 ± 0.447
5.984AlaThr: 5.984 ± 0.697
7.022AlaVal: 7.022 ± 0.64
1.704AlaTrp: 1.704 ± 0.314
2.368AlaTyr: 2.368 ± 0.371
0.0AlaXaa: 0.0 ± 0.0
Cys
0.665CysAla: 0.665 ± 0.169
0.374CysCys: 0.374 ± 0.137
0.956CysAsp: 0.956 ± 0.229
0.665CysGlu: 0.665 ± 0.176
0.416CysPhe: 0.416 ± 0.118
1.122CysGly: 1.122 ± 0.225
0.416CysHis: 0.416 ± 0.13
0.457CysIle: 0.457 ± 0.131
0.665CysLys: 0.665 ± 0.157
0.748CysLeu: 0.748 ± 0.183
0.166CysMet: 0.166 ± 0.078
0.623CysAsn: 0.623 ± 0.179
0.582CysPro: 0.582 ± 0.144
0.457CysGln: 0.457 ± 0.13
0.873CysArg: 0.873 ± 0.232
0.873CysSer: 0.873 ± 0.256
0.748CysThr: 0.748 ± 0.21
0.706CysVal: 0.706 ± 0.197
0.208CysTrp: 0.208 ± 0.102
0.374CysTyr: 0.374 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
6.607AspAla: 6.607 ± 0.468
0.873AspCys: 0.873 ± 0.187
3.906AspAsp: 3.906 ± 0.482
3.449AspGlu: 3.449 ± 0.38
2.368AspPhe: 2.368 ± 0.297
5.36AspGly: 5.36 ± 0.53
1.288AspHis: 1.288 ± 0.262
3.615AspIle: 3.615 ± 0.36
3.075AspLys: 3.075 ± 0.318
4.072AspLeu: 4.072 ± 0.406
2.202AspMet: 2.202 ± 0.316
2.202AspAsn: 2.202 ± 0.361
2.493AspPro: 2.493 ± 0.284
1.995AspGln: 1.995 ± 0.313
3.407AspArg: 3.407 ± 0.454
3.532AspSer: 3.532 ± 0.42
3.241AspThr: 3.241 ± 0.353
3.781AspVal: 3.781 ± 0.343
1.039AspTrp: 1.039 ± 0.208
1.537AspTyr: 1.537 ± 0.248
0.0AspXaa: 0.0 ± 0.0
Glu
6.233GluAla: 6.233 ± 0.795
1.205GluCys: 1.205 ± 0.25
3.158GluAsp: 3.158 ± 0.393
3.989GluGlu: 3.989 ± 0.477
2.036GluPhe: 2.036 ± 0.327
3.698GluGly: 3.698 ± 0.37
1.039GluHis: 1.039 ± 0.2
3.615GluIle: 3.615 ± 0.385
2.867GluLys: 2.867 ± 0.378
5.443GluLeu: 5.443 ± 0.581
2.576GluMet: 2.576 ± 0.391
2.161GluAsn: 2.161 ± 0.318
2.078GluPro: 2.078 ± 0.275
2.742GluGln: 2.742 ± 0.385
3.781GluArg: 3.781 ± 0.572
2.742GluSer: 2.742 ± 0.255
2.327GluThr: 2.327 ± 0.303
4.654GluVal: 4.654 ± 0.497
1.33GluTrp: 1.33 ± 0.216
1.662GluTyr: 1.662 ± 0.243
0.0GluXaa: 0.0 ± 0.0
Phe
3.158PheAla: 3.158 ± 0.358
0.582PheCys: 0.582 ± 0.175
2.535PheAsp: 2.535 ± 0.304
2.701PheGlu: 2.701 ± 0.39
1.371PhePhe: 1.371 ± 0.288
3.116PheGly: 3.116 ± 0.377
0.831PheHis: 0.831 ± 0.169
2.161PheIle: 2.161 ± 0.319
1.911PheLys: 1.911 ± 0.275
2.202PheLeu: 2.202 ± 0.318
1.08PheMet: 1.08 ± 0.227
1.454PheAsn: 1.454 ± 0.253
1.87PhePro: 1.87 ± 0.253
1.496PheGln: 1.496 ± 0.201
2.244PheArg: 2.244 ± 0.301
2.202PheSer: 2.202 ± 0.372
3.283PheThr: 3.283 ± 0.386
2.036PheVal: 2.036 ± 0.288
0.416PheTrp: 0.416 ± 0.121
0.748PheTyr: 0.748 ± 0.183
0.0PheXaa: 0.0 ± 0.0
Gly
6.316GlyAla: 6.316 ± 0.686
0.623GlyCys: 0.623 ± 0.152
4.072GlyAsp: 4.072 ± 0.495
4.155GlyGlu: 4.155 ± 0.352
2.909GlyPhe: 2.909 ± 0.395
7.147GlyGly: 7.147 ± 0.747
1.163GlyHis: 1.163 ± 0.218
3.906GlyIle: 3.906 ± 0.365
4.82GlyLys: 4.82 ± 0.437
5.568GlyLeu: 5.568 ± 0.467
2.119GlyMet: 2.119 ± 0.334
3.116GlyAsn: 3.116 ± 0.379
2.701GlyPro: 2.701 ± 0.448
3.033GlyGln: 3.033 ± 0.393
4.155GlyArg: 4.155 ± 0.425
5.152GlySer: 5.152 ± 0.467
5.36GlyThr: 5.36 ± 0.543
6.108GlyVal: 6.108 ± 0.406
1.579GlyTrp: 1.579 ± 0.264
2.493GlyTyr: 2.493 ± 0.339
0.0GlyXaa: 0.0 ± 0.0
His
1.371HisAla: 1.371 ± 0.256
0.166HisCys: 0.166 ± 0.09
1.205HisAsp: 1.205 ± 0.27
0.997HisGlu: 0.997 ± 0.195
1.039HisPhe: 1.039 ± 0.186
1.413HisGly: 1.413 ± 0.246
0.499HisHis: 0.499 ± 0.192
1.33HisIle: 1.33 ± 0.272
0.748HisLys: 0.748 ± 0.182
1.413HisLeu: 1.413 ± 0.238
0.748HisMet: 0.748 ± 0.181
0.956HisAsn: 0.956 ± 0.271
1.413HisPro: 1.413 ± 0.305
1.247HisGln: 1.247 ± 0.216
1.288HisArg: 1.288 ± 0.272
1.163HisSer: 1.163 ± 0.271
0.748HisThr: 0.748 ± 0.221
1.039HisVal: 1.039 ± 0.205
0.416HisTrp: 0.416 ± 0.117
0.706HisTyr: 0.706 ± 0.167
0.0HisXaa: 0.0 ± 0.0
Ile
5.236IleAla: 5.236 ± 0.544
0.665IleCys: 0.665 ± 0.171
4.612IleAsp: 4.612 ± 0.433
4.197IleGlu: 4.197 ± 0.378
1.87IlePhe: 1.87 ± 0.264
3.449IleGly: 3.449 ± 0.547
1.039IleHis: 1.039 ± 0.215
3.574IleIle: 3.574 ± 0.433
3.366IleLys: 3.366 ± 0.362
3.532IleLeu: 3.532 ± 0.384
1.496IleMet: 1.496 ± 0.274
2.867IleAsn: 2.867 ± 0.425
3.075IlePro: 3.075 ± 0.298
1.953IleGln: 1.953 ± 0.282
3.906IleArg: 3.906 ± 0.447
3.449IleSer: 3.449 ± 0.324
4.654IleThr: 4.654 ± 0.429
3.781IleVal: 3.781 ± 0.46
0.914IleTrp: 0.914 ± 0.206
1.87IleTyr: 1.87 ± 0.262
0.0IleXaa: 0.0 ± 0.0
Lys
6.233LysAla: 6.233 ± 0.46
0.623LysCys: 0.623 ± 0.166
2.036LysAsp: 2.036 ± 0.272
2.909LysGlu: 2.909 ± 0.324
1.745LysPhe: 1.745 ± 0.227
3.823LysGly: 3.823 ± 0.416
0.706LysHis: 0.706 ± 0.163
3.2LysIle: 3.2 ± 0.406
3.241LysLys: 3.241 ± 0.403
3.698LysLeu: 3.698 ± 0.396
2.41LysMet: 2.41 ± 0.346
2.119LysAsn: 2.119 ± 0.226
3.532LysPro: 3.532 ± 0.388
1.662LysGln: 1.662 ± 0.239
2.701LysArg: 2.701 ± 0.378
3.241LysSer: 3.241 ± 0.361
3.781LysThr: 3.781 ± 0.333
3.075LysVal: 3.075 ± 0.412
1.039LysTrp: 1.039 ± 0.249
1.413LysTyr: 1.413 ± 0.256
0.0LysXaa: 0.0 ± 0.0
Leu
7.272LeuAla: 7.272 ± 0.595
1.122LeuCys: 1.122 ± 0.17
4.031LeuAsp: 4.031 ± 0.448
4.405LeuGlu: 4.405 ± 0.511
2.576LeuPhe: 2.576 ± 0.339
3.906LeuGly: 3.906 ± 0.415
1.662LeuHis: 1.662 ± 0.248
4.446LeuIle: 4.446 ± 0.411
4.82LeuLys: 4.82 ± 0.425
5.152LeuLeu: 5.152 ± 0.484
1.828LeuMet: 1.828 ± 0.295
4.072LeuAsn: 4.072 ± 0.39
3.116LeuPro: 3.116 ± 0.366
2.826LeuGln: 2.826 ± 0.37
4.114LeuArg: 4.114 ± 0.483
5.277LeuSer: 5.277 ± 0.407
5.028LeuThr: 5.028 ± 0.514
4.695LeuVal: 4.695 ± 0.434
0.457LeuTrp: 0.457 ± 0.145
2.327LeuTyr: 2.327 ± 0.269
0.0LeuXaa: 0.0 ± 0.0
Met
3.989MetAla: 3.989 ± 0.355
0.208MetCys: 0.208 ± 0.087
1.496MetAsp: 1.496 ± 0.264
1.371MetGlu: 1.371 ± 0.314
1.039MetPhe: 1.039 ± 0.192
2.078MetGly: 2.078 ± 0.229
0.499MetHis: 0.499 ± 0.15
1.496MetIle: 1.496 ± 0.213
2.867MetLys: 2.867 ± 0.34
2.41MetLeu: 2.41 ± 0.304
1.039MetMet: 1.039 ± 0.232
1.953MetAsn: 1.953 ± 0.308
1.787MetPro: 1.787 ± 0.249
1.122MetGln: 1.122 ± 0.253
1.413MetArg: 1.413 ± 0.216
2.036MetSer: 2.036 ± 0.259
2.452MetThr: 2.452 ± 0.343
1.496MetVal: 1.496 ± 0.235
0.208MetTrp: 0.208 ± 0.096
0.374MetTyr: 0.374 ± 0.126
0.0MetXaa: 0.0 ± 0.0
Asn
3.698AsnAla: 3.698 ± 0.457
0.249AsnCys: 0.249 ± 0.118
2.078AsnAsp: 2.078 ± 0.292
2.452AsnGlu: 2.452 ± 0.312
1.371AsnPhe: 1.371 ± 0.204
4.82AsnGly: 4.82 ± 0.451
1.288AsnHis: 1.288 ± 0.287
2.493AsnIle: 2.493 ± 0.358
1.953AsnLys: 1.953 ± 0.232
3.407AsnLeu: 3.407 ± 0.396
1.122AsnMet: 1.122 ± 0.202
1.579AsnAsn: 1.579 ± 0.28
2.576AsnPro: 2.576 ± 0.411
1.704AsnGln: 1.704 ± 0.241
2.161AsnArg: 2.161 ± 0.283
2.535AsnSer: 2.535 ± 0.349
3.407AsnThr: 3.407 ± 0.437
2.618AsnVal: 2.618 ± 0.275
0.789AsnTrp: 0.789 ± 0.18
1.247AsnTyr: 1.247 ± 0.176
0.0AsnXaa: 0.0 ± 0.0
Pro
5.485ProAla: 5.485 ± 0.645
0.416ProCys: 0.416 ± 0.13
2.659ProAsp: 2.659 ± 0.319
3.033ProGlu: 3.033 ± 0.639
1.621ProPhe: 1.621 ± 0.283
3.615ProGly: 3.615 ± 0.364
0.914ProHis: 0.914 ± 0.188
2.161ProIle: 2.161 ± 0.309
2.452ProLys: 2.452 ± 0.293
3.2ProLeu: 3.2 ± 0.387
1.33ProMet: 1.33 ± 0.231
2.119ProAsn: 2.119 ± 0.28
2.368ProPro: 2.368 ± 0.323
1.953ProGln: 1.953 ± 0.261
2.119ProArg: 2.119 ± 0.316
2.368ProSer: 2.368 ± 0.404
2.327ProThr: 2.327 ± 0.274
3.532ProVal: 3.532 ± 0.361
0.748ProTrp: 0.748 ± 0.198
1.33ProTyr: 1.33 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
3.823GlnAla: 3.823 ± 0.441
0.332GlnCys: 0.332 ± 0.097
1.745GlnAsp: 1.745 ± 0.296
1.787GlnGlu: 1.787 ± 0.25
1.454GlnPhe: 1.454 ± 0.231
2.576GlnGly: 2.576 ± 0.418
1.08GlnHis: 1.08 ± 0.217
2.119GlnIle: 2.119 ± 0.265
1.496GlnLys: 1.496 ± 0.283
2.826GlnLeu: 2.826 ± 0.377
1.704GlnMet: 1.704 ± 0.228
2.078GlnAsn: 2.078 ± 0.296
2.368GlnPro: 2.368 ± 0.32
2.327GlnGln: 2.327 ± 0.41
3.241GlnArg: 3.241 ± 0.411
1.704GlnSer: 1.704 ± 0.28
1.911GlnThr: 1.911 ± 0.283
2.41GlnVal: 2.41 ± 0.304
0.831GlnTrp: 0.831 ± 0.182
0.997GlnTyr: 0.997 ± 0.192
0.0GlnXaa: 0.0 ± 0.0
Arg
5.069ArgAla: 5.069 ± 0.389
0.873ArgCys: 0.873 ± 0.225
3.864ArgAsp: 3.864 ± 0.456
4.031ArgGlu: 4.031 ± 0.412
2.285ArgPhe: 2.285 ± 0.284
3.906ArgGly: 3.906 ± 0.392
1.247ArgHis: 1.247 ± 0.259
4.197ArgIle: 4.197 ± 0.413
3.324ArgLys: 3.324 ± 0.371
4.82ArgLeu: 4.82 ± 0.495
1.828ArgMet: 1.828 ± 0.266
1.662ArgAsn: 1.662 ± 0.25
2.202ArgPro: 2.202 ± 0.291
2.368ArgGln: 2.368 ± 0.389
3.947ArgArg: 3.947 ± 0.55
2.95ArgSer: 2.95 ± 0.385
2.95ArgThr: 2.95 ± 0.352
3.989ArgVal: 3.989 ± 0.376
0.789ArgTrp: 0.789 ± 0.209
2.036ArgTyr: 2.036 ± 0.29
0.0ArgXaa: 0.0 ± 0.0
Ser
6.399SerAla: 6.399 ± 0.511
0.54SerCys: 0.54 ± 0.176
3.906SerAsp: 3.906 ± 0.373
3.449SerGlu: 3.449 ± 0.318
2.701SerPhe: 2.701 ± 0.327
4.779SerGly: 4.779 ± 0.455
1.288SerHis: 1.288 ± 0.293
3.075SerIle: 3.075 ± 0.357
2.701SerLys: 2.701 ± 0.332
4.82SerLeu: 4.82 ± 0.388
1.454SerMet: 1.454 ± 0.234
2.867SerAsn: 2.867 ± 0.32
2.452SerPro: 2.452 ± 0.291
1.828SerGln: 1.828 ± 0.267
2.826SerArg: 2.826 ± 0.28
3.158SerSer: 3.158 ± 0.356
3.2SerThr: 3.2 ± 0.318
3.449SerVal: 3.449 ± 0.387
0.956SerTrp: 0.956 ± 0.253
1.371SerTyr: 1.371 ± 0.245
0.0SerXaa: 0.0 ± 0.0
Thr
6.731ThrAla: 6.731 ± 0.735
1.039ThrCys: 1.039 ± 0.217
4.82ThrAsp: 4.82 ± 0.386
3.033ThrGlu: 3.033 ± 0.312
2.659ThrPhe: 2.659 ± 0.371
5.402ThrGly: 5.402 ± 0.486
0.914ThrHis: 0.914 ± 0.222
3.449ThrIle: 3.449 ± 0.404
3.116ThrLys: 3.116 ± 0.386
3.823ThrLeu: 3.823 ± 0.442
1.33ThrMet: 1.33 ± 0.254
2.576ThrAsn: 2.576 ± 0.426
3.449ThrPro: 3.449 ± 0.42
1.828ThrGln: 1.828 ± 0.341
3.74ThrArg: 3.74 ± 0.475
3.574ThrSer: 3.574 ± 0.403
3.49ThrThr: 3.49 ± 0.416
4.529ThrVal: 4.529 ± 0.493
0.831ThrTrp: 0.831 ± 0.172
1.953ThrTyr: 1.953 ± 0.272
0.0ThrXaa: 0.0 ± 0.0
Val
6.565ValAla: 6.565 ± 0.582
0.582ValCys: 0.582 ± 0.192
3.116ValAsp: 3.116 ± 0.318
3.74ValGlu: 3.74 ± 0.451
2.535ValPhe: 2.535 ± 0.335
4.114ValGly: 4.114 ± 0.47
0.831ValHis: 0.831 ± 0.197
4.986ValIle: 4.986 ± 0.414
3.366ValLys: 3.366 ± 0.36
4.529ValLeu: 4.529 ± 0.427
2.742ValMet: 2.742 ± 0.323
3.366ValAsn: 3.366 ± 0.403
2.493ValPro: 2.493 ± 0.293
2.867ValGln: 2.867 ± 0.411
3.906ValArg: 3.906 ± 0.392
4.405ValSer: 4.405 ± 0.416
4.82ValThr: 4.82 ± 0.501
4.654ValVal: 4.654 ± 0.594
1.288ValTrp: 1.288 ± 0.218
1.621ValTyr: 1.621 ± 0.295
0.0ValXaa: 0.0 ± 0.0
Trp
1.039TrpAla: 1.039 ± 0.173
0.083TrpCys: 0.083 ± 0.054
0.914TrpAsp: 0.914 ± 0.209
0.873TrpGlu: 0.873 ± 0.193
0.623TrpPhe: 0.623 ± 0.19
1.08TrpGly: 1.08 ± 0.236
0.416TrpHis: 0.416 ± 0.156
1.08TrpIle: 1.08 ± 0.248
0.748TrpLys: 0.748 ± 0.154
1.704TrpLeu: 1.704 ± 0.255
0.54TrpMet: 0.54 ± 0.19
0.706TrpAsn: 0.706 ± 0.2
0.623TrpPro: 0.623 ± 0.195
0.706TrpGln: 0.706 ± 0.172
1.205TrpArg: 1.205 ± 0.264
1.039TrpSer: 1.039 ± 0.183
1.08TrpThr: 1.08 ± 0.214
1.247TrpVal: 1.247 ± 0.254
0.125TrpTrp: 0.125 ± 0.091
0.416TrpTyr: 0.416 ± 0.118
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.119TyrAla: 2.119 ± 0.349
0.374TyrCys: 0.374 ± 0.15
1.911TyrAsp: 1.911 ± 0.31
1.454TyrGlu: 1.454 ± 0.237
1.454TyrPhe: 1.454 ± 0.301
2.119TyrGly: 2.119 ± 0.311
0.499TyrHis: 0.499 ± 0.14
2.036TyrIle: 2.036 ± 0.255
1.205TyrLys: 1.205 ± 0.256
1.662TyrLeu: 1.662 ± 0.314
0.706TyrMet: 0.706 ± 0.151
1.33TyrAsn: 1.33 ± 0.213
0.997TyrPro: 0.997 ± 0.174
1.537TyrGln: 1.537 ± 0.251
2.285TyrArg: 2.285 ± 0.338
1.33TyrSer: 1.33 ± 0.305
1.537TyrThr: 1.537 ± 0.249
1.704TyrVal: 1.704 ± 0.251
0.582TyrTrp: 0.582 ± 0.156
0.831TyrTyr: 0.831 ± 0.162
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 131 proteins (24067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski