Amino acid dipepetide frequency for Sphingomonas turrisvirgatae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.467AlaAla: 20.467 ± 0.179
1.049AlaCys: 1.049 ± 0.032
7.759AlaAsp: 7.759 ± 0.091
7.525AlaGlu: 7.525 ± 0.1
4.36AlaPhe: 4.36 ± 0.067
12.041AlaGly: 12.041 ± 0.12
2.276AlaHis: 2.276 ± 0.039
7.098AlaIle: 7.098 ± 0.09
4.092AlaLys: 4.092 ± 0.078
14.118AlaLeu: 14.118 ± 0.124
3.955AlaMet: 3.955 ± 0.053
3.137AlaAsn: 3.137 ± 0.054
6.46AlaPro: 6.46 ± 0.097
4.969AlaGln: 4.969 ± 0.074
10.247AlaArg: 10.247 ± 0.12
6.947AlaSer: 6.947 ± 0.088
6.932AlaThr: 6.932 ± 0.082
8.998AlaVal: 8.998 ± 0.103
1.792AlaTrp: 1.792 ± 0.044
2.544AlaTyr: 2.544 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.983CysAla: 0.983 ± 0.034
0.096CysCys: 0.096 ± 0.01
0.495CysAsp: 0.495 ± 0.021
0.418CysGlu: 0.418 ± 0.02
0.297CysPhe: 0.297 ± 0.018
0.819CysGly: 0.819 ± 0.027
0.208CysHis: 0.208 ± 0.013
0.351CysIle: 0.351 ± 0.018
0.158CysLys: 0.158 ± 0.012
0.661CysLeu: 0.661 ± 0.023
0.139CysMet: 0.139 ± 0.011
0.206CysAsn: 0.206 ± 0.012
0.439CysPro: 0.439 ± 0.018
0.184CysGln: 0.184 ± 0.011
0.574CysArg: 0.574 ± 0.023
0.386CysSer: 0.386 ± 0.019
0.395CysThr: 0.395 ± 0.02
0.538CysVal: 0.538 ± 0.02
0.107CysTrp: 0.107 ± 0.01
0.151CysTyr: 0.151 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.122AspAla: 8.122 ± 0.101
0.465AspCys: 0.465 ± 0.023
3.274AspAsp: 3.274 ± 0.06
3.44AspGlu: 3.44 ± 0.062
2.021AspPhe: 2.021 ± 0.043
5.505AspGly: 5.505 ± 0.081
1.264AspHis: 1.264 ± 0.033
2.717AspIle: 2.717 ± 0.049
1.602AspLys: 1.602 ± 0.041
5.681AspLeu: 5.681 ± 0.067
1.376AspMet: 1.376 ± 0.035
1.246AspAsn: 1.246 ± 0.035
3.944AspPro: 3.944 ± 0.06
1.876AspGln: 1.876 ± 0.048
5.054AspArg: 5.054 ± 0.079
2.255AspSer: 2.255 ± 0.051
2.67AspThr: 2.67 ± 0.045
4.148AspVal: 4.148 ± 0.059
1.134AspTrp: 1.134 ± 0.032
1.536AspTyr: 1.536 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.801GluAla: 7.801 ± 0.105
0.311GluCys: 0.311 ± 0.016
2.471GluAsp: 2.471 ± 0.051
2.511GluGlu: 2.511 ± 0.06
1.464GluPhe: 1.464 ± 0.039
4.302GluGly: 4.302 ± 0.069
1.121GluHis: 1.121 ± 0.033
2.76GluIle: 2.76 ± 0.048
1.77GluLys: 1.77 ± 0.049
5.197GluLeu: 5.197 ± 0.069
1.314GluMet: 1.314 ± 0.033
1.21GluAsn: 1.21 ± 0.033
2.653GluPro: 2.653 ± 0.049
2.075GluGln: 2.075 ± 0.044
5.345GluArg: 5.345 ± 0.084
2.052GluSer: 2.052 ± 0.046
3.052GluThr: 3.052 ± 0.054
3.615GluVal: 3.615 ± 0.062
0.779GluTrp: 0.779 ± 0.025
0.931GluTyr: 0.931 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.836PheAla: 4.836 ± 0.068
0.295PheCys: 0.295 ± 0.016
2.634PheAsp: 2.634 ± 0.047
2.113PheGlu: 2.113 ± 0.039
1.23PhePhe: 1.23 ± 0.038
3.523PheGly: 3.523 ± 0.061
0.675PheHis: 0.675 ± 0.022
1.366PheIle: 1.366 ± 0.037
0.866PheLys: 0.866 ± 0.03
2.991PheLeu: 2.991 ± 0.062
0.725PheMet: 0.725 ± 0.025
0.999PheAsn: 0.999 ± 0.029
1.401PhePro: 1.401 ± 0.033
0.874PheGln: 0.874 ± 0.022
2.169PheArg: 2.169 ± 0.044
1.873PheSer: 1.873 ± 0.043
1.981PheThr: 1.981 ± 0.044
2.674PheVal: 2.674 ± 0.042
0.503PheTrp: 0.503 ± 0.024
0.872PheTyr: 0.872 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.173GlyAla: 10.173 ± 0.111
0.772GlyCys: 0.772 ± 0.028
4.908GlyAsp: 4.908 ± 0.064
5.014GlyGlu: 5.014 ± 0.068
3.523GlyPhe: 3.523 ± 0.063
8.257GlyGly: 8.257 ± 0.131
1.762GlyHis: 1.762 ± 0.045
4.562GlyIle: 4.562 ± 0.069
3.296GlyLys: 3.296 ± 0.058
8.376GlyLeu: 8.376 ± 0.089
2.437GlyMet: 2.437 ± 0.047
2.372GlyAsn: 2.372 ± 0.097
3.634GlyPro: 3.634 ± 0.056
3.143GlyGln: 3.143 ± 0.049
6.525GlyArg: 6.525 ± 0.073
4.91GlySer: 4.91 ± 0.073
4.933GlyThr: 4.933 ± 0.096
6.754GlyVal: 6.754 ± 0.089
1.667GlyTrp: 1.667 ± 0.036
2.333GlyTyr: 2.333 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.427HisAla: 2.427 ± 0.046
0.224HisCys: 0.224 ± 0.015
1.212HisAsp: 1.212 ± 0.034
0.984HisGlu: 0.984 ± 0.026
0.74HisPhe: 0.74 ± 0.025
2.006HisGly: 2.006 ± 0.045
0.542HisHis: 0.542 ± 0.021
0.807HisIle: 0.807 ± 0.027
0.403HisLys: 0.403 ± 0.017
1.845HisLeu: 1.845 ± 0.039
0.395HisMet: 0.395 ± 0.018
0.402HisAsn: 0.402 ± 0.021
1.241HisPro: 1.241 ± 0.033
0.547HisGln: 0.547 ± 0.021
1.51HisArg: 1.51 ± 0.037
0.895HisSer: 0.895 ± 0.029
0.697HisThr: 0.697 ± 0.025
1.438HisVal: 1.438 ± 0.037
0.351HisTrp: 0.351 ± 0.017
0.523HisTyr: 0.523 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
8.208IleAla: 8.208 ± 0.096
0.392IleCys: 0.392 ± 0.019
4.091IleAsp: 4.091 ± 0.066
3.634IleGlu: 3.634 ± 0.058
1.413IlePhe: 1.413 ± 0.039
5.092IleGly: 5.092 ± 0.064
0.838IleHis: 0.838 ± 0.026
1.851IleIle: 1.851 ± 0.04
1.195IleLys: 1.195 ± 0.034
3.915IleLeu: 3.915 ± 0.065
0.85IleMet: 0.85 ± 0.027
1.285IleAsn: 1.285 ± 0.033
2.114IlePro: 2.114 ± 0.034
1.162IleGln: 1.162 ± 0.033
3.157IleArg: 3.157 ± 0.055
2.333IleSer: 2.333 ± 0.048
2.447IleThr: 2.447 ± 0.044
4.229IleVal: 4.229 ± 0.061
0.587IleTrp: 0.587 ± 0.023
0.964IleTyr: 0.964 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.953LysAla: 3.953 ± 0.078
0.147LysCys: 0.147 ± 0.012
1.494LysAsp: 1.494 ± 0.039
1.095LysGlu: 1.095 ± 0.035
0.839LysPhe: 0.839 ± 0.027
2.512LysGly: 2.512 ± 0.05
0.539LysHis: 0.539 ± 0.021
1.315LysIle: 1.315 ± 0.036
0.991LysLys: 0.991 ± 0.039
3.269LysLeu: 3.269 ± 0.06
0.693LysMet: 0.693 ± 0.023
0.666LysAsn: 0.666 ± 0.027
2.018LysPro: 2.018 ± 0.052
0.904LysGln: 0.904 ± 0.03
2.372LysArg: 2.372 ± 0.043
1.48LysSer: 1.48 ± 0.038
1.598LysThr: 1.598 ± 0.042
2.214LysVal: 2.214 ± 0.052
0.423LysTrp: 0.423 ± 0.022
0.539LysTyr: 0.539 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
14.376LeuAla: 14.376 ± 0.124
0.751LeuCys: 0.751 ± 0.024
6.314LeuAsp: 6.314 ± 0.081
4.494LeuGlu: 4.494 ± 0.071
3.503LeuPhe: 3.503 ± 0.06
8.338LeuGly: 8.338 ± 0.092
1.745LeuHis: 1.745 ± 0.041
4.949LeuIle: 4.949 ± 0.071
3.08LeuLys: 3.08 ± 0.053
9.367LeuLeu: 9.367 ± 0.138
2.106LeuMet: 2.106 ± 0.046
2.535LeuAsn: 2.535 ± 0.043
5.529LeuPro: 5.529 ± 0.071
2.476LeuGln: 2.476 ± 0.045
6.899LeuArg: 6.899 ± 0.092
5.727LeuSer: 5.727 ± 0.072
5.725LeuThr: 5.725 ± 0.075
7.113LeuVal: 7.113 ± 0.097
1.239LeuTrp: 1.239 ± 0.039
1.985LeuTyr: 1.985 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.242MetAla: 3.242 ± 0.062
0.146MetCys: 0.146 ± 0.01
1.056MetAsp: 1.056 ± 0.033
0.94MetGlu: 0.94 ± 0.032
0.713MetPhe: 0.713 ± 0.025
1.844MetGly: 1.844 ± 0.041
0.407MetHis: 0.407 ± 0.017
1.336MetIle: 1.336 ± 0.038
0.917MetLys: 0.917 ± 0.028
2.575MetLeu: 2.575 ± 0.047
0.605MetMet: 0.605 ± 0.027
0.67MetAsn: 0.67 ± 0.022
1.509MetPro: 1.509 ± 0.033
0.733MetGln: 0.733 ± 0.022
1.885MetArg: 1.885 ± 0.042
1.393MetSer: 1.393 ± 0.034
1.692MetThr: 1.692 ± 0.039
1.566MetVal: 1.566 ± 0.04
0.258MetTrp: 0.258 ± 0.014
0.287MetTyr: 0.287 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.255AsnAla: 3.255 ± 0.061
0.22AsnCys: 0.22 ± 0.014
1.343AsnAsp: 1.343 ± 0.036
1.11AsnGlu: 1.11 ± 0.031
0.887AsnPhe: 0.887 ± 0.033
2.598AsnGly: 2.598 ± 0.102
0.439AsnHis: 0.439 ± 0.019
1.214AsnIle: 1.214 ± 0.03
0.612AsnLys: 0.612 ± 0.023
2.559AsnLeu: 2.559 ± 0.05
0.51AsnMet: 0.51 ± 0.023
0.664AsnAsn: 0.664 ± 0.026
1.716AsnPro: 1.716 ± 0.044
0.734AsnGln: 0.734 ± 0.029
1.866AsnArg: 1.866 ± 0.046
1.121AsnSer: 1.121 ± 0.038
1.108AsnThr: 1.108 ± 0.033
1.854AsnVal: 1.854 ± 0.046
0.432AsnTrp: 0.432 ± 0.02
0.69AsnTyr: 0.69 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
7.489ProAla: 7.489 ± 0.092
0.304ProCys: 0.304 ± 0.015
3.865ProAsp: 3.865 ± 0.072
3.218ProGlu: 3.218 ± 0.055
1.863ProPhe: 1.863 ± 0.038
5.018ProGly: 5.018 ± 0.073
1.071ProHis: 1.071 ± 0.031
2.553ProIle: 2.553 ± 0.041
1.41ProLys: 1.41 ± 0.04
4.891ProLeu: 4.891 ± 0.069
1.134ProMet: 1.134 ± 0.031
1.303ProAsn: 1.303 ± 0.034
2.799ProPro: 2.799 ± 0.056
1.825ProGln: 1.825 ± 0.04
3.229ProArg: 3.229 ± 0.053
2.692ProSer: 2.692 ± 0.048
2.63ProThr: 2.63 ± 0.055
4.335ProVal: 4.335 ± 0.064
0.704ProTrp: 0.704 ± 0.023
1.09ProTyr: 1.09 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.557GlnAla: 4.557 ± 0.059
0.217GlnCys: 0.217 ± 0.014
1.399GlnAsp: 1.399 ± 0.036
1.183GlnGlu: 1.183 ± 0.035
1.092GlnPhe: 1.092 ± 0.03
2.572GlnGly: 2.572 ± 0.048
0.615GlnHis: 0.615 ± 0.024
1.735GlnIle: 1.735 ± 0.042
0.832GlnLys: 0.832 ± 0.029
3.331GlnLeu: 3.331 ± 0.051
0.788GlnMet: 0.788 ± 0.031
0.732GlnAsn: 0.732 ± 0.027
1.966GlnPro: 1.966 ± 0.043
1.214GlnGln: 1.214 ± 0.037
2.8GlnArg: 2.8 ± 0.056
1.671GlnSer: 1.671 ± 0.036
1.634GlnThr: 1.634 ± 0.041
2.436GlnVal: 2.436 ± 0.05
0.415GlnTrp: 0.415 ± 0.018
0.582GlnTyr: 0.582 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
9.342ArgAla: 9.342 ± 0.119
0.547ArgCys: 0.547 ± 0.023
4.55ArgAsp: 4.55 ± 0.066
4.242ArgGlu: 4.242 ± 0.063
3.031ArgPhe: 3.031 ± 0.055
5.422ArgGly: 5.422 ± 0.076
1.757ArgHis: 1.757 ± 0.042
4.218ArgIle: 4.218 ± 0.06
2.142ArgLys: 2.142 ± 0.051
8.087ArgLeu: 8.087 ± 0.096
2.036ArgMet: 2.036 ± 0.04
1.919ArgAsn: 1.919 ± 0.041
3.805ArgPro: 3.805 ± 0.058
2.555ArgGln: 2.555 ± 0.046
6.154ArgArg: 6.154 ± 0.089
3.779ArgSer: 3.779 ± 0.063
3.757ArgThr: 3.757 ± 0.058
5.269ArgVal: 5.269 ± 0.068
1.239ArgTrp: 1.239 ± 0.03
1.942ArgTyr: 1.942 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.377SerAla: 6.377 ± 0.069
0.393SerCys: 0.393 ± 0.022
3.068SerAsp: 3.068 ± 0.054
2.508SerGlu: 2.508 ± 0.053
2.083SerPhe: 2.083 ± 0.044
5.323SerGly: 5.323 ± 0.081
0.878SerHis: 0.878 ± 0.027
2.663SerIle: 2.663 ± 0.052
1.385SerLys: 1.385 ± 0.038
4.875SerLeu: 4.875 ± 0.066
1.172SerMet: 1.172 ± 0.033
1.365SerAsn: 1.365 ± 0.032
2.81SerPro: 2.81 ± 0.051
1.504SerGln: 1.504 ± 0.036
3.507SerArg: 3.507 ± 0.061
2.719SerSer: 2.719 ± 0.058
2.613SerThr: 2.613 ± 0.054
3.761SerVal: 3.761 ± 0.066
0.808SerTrp: 0.808 ± 0.025
1.317SerTyr: 1.317 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.842ThrAla: 6.842 ± 0.098
0.377ThrCys: 0.377 ± 0.02
2.868ThrAsp: 2.868 ± 0.049
2.102ThrGlu: 2.102 ± 0.037
1.876ThrPhe: 1.876 ± 0.043
5.444ThrGly: 5.444 ± 0.089
0.936ThrHis: 0.936 ± 0.028
3.055ThrIle: 3.055 ± 0.05
1.214ThrLys: 1.214 ± 0.036
5.997ThrLeu: 5.997 ± 0.071
1.18ThrMet: 1.18 ± 0.029
1.313ThrAsn: 1.313 ± 0.041
3.541ThrPro: 3.541 ± 0.049
1.519ThrGln: 1.519 ± 0.04
3.644ThrArg: 3.644 ± 0.049
2.68ThrSer: 2.68 ± 0.051
2.847ThrThr: 2.847 ± 0.066
4.137ThrVal: 4.137 ± 0.082
0.603ThrTrp: 0.603 ± 0.023
1.125ThrTyr: 1.125 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
10.181ValAla: 10.181 ± 0.098
0.54ValCys: 0.54 ± 0.024
4.231ValAsp: 4.231 ± 0.065
4.567ValGlu: 4.567 ± 0.076
2.225ValPhe: 2.225 ± 0.05
5.642ValGly: 5.642 ± 0.077
1.313ValHis: 1.313 ± 0.037
3.722ValIle: 3.722 ± 0.059
2.102ValLys: 2.102 ± 0.051
6.663ValLeu: 6.663 ± 0.084
1.615ValMet: 1.615 ± 0.04
1.916ValAsn: 1.916 ± 0.045
4.104ValPro: 4.104 ± 0.06
2.19ValGln: 2.19 ± 0.053
5.413ValArg: 5.413 ± 0.075
4.135ValSer: 4.135 ± 0.065
4.746ValThr: 4.746 ± 0.09
5.451ValVal: 5.451 ± 0.081
0.871ValTrp: 0.871 ± 0.027
1.391ValTyr: 1.391 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.455TrpAla: 1.455 ± 0.038
0.135TrpCys: 0.135 ± 0.009
0.755TrpAsp: 0.755 ± 0.026
0.587TrpGlu: 0.587 ± 0.023
0.616TrpPhe: 0.616 ± 0.021
1.001TrpGly: 1.001 ± 0.03
0.344TrpHis: 0.344 ± 0.017
0.683TrpIle: 0.683 ± 0.026
0.464TrpLys: 0.464 ± 0.022
1.765TrpLeu: 1.765 ± 0.04
0.348TrpMet: 0.348 ± 0.019
0.435TrpAsn: 0.435 ± 0.018
0.702TrpPro: 0.702 ± 0.023
0.626TrpGln: 0.626 ± 0.023
1.437TrpArg: 1.437 ± 0.036
0.873TrpSer: 0.873 ± 0.026
0.809TrpThr: 0.809 ± 0.022
0.894TrpVal: 0.894 ± 0.03
0.258TrpTrp: 0.258 ± 0.016
0.317TrpTyr: 0.317 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.681TyrAla: 2.681 ± 0.051
0.222TyrCys: 0.222 ± 0.014
1.543TyrAsp: 1.543 ± 0.041
1.048TyrGlu: 1.048 ± 0.03
0.826TyrPhe: 0.826 ± 0.028
2.088TyrGly: 2.088 ± 0.047
0.462TyrHis: 0.462 ± 0.021
0.808TyrIle: 0.808 ± 0.024
0.532TyrLys: 0.532 ± 0.021
2.083TyrLeu: 2.083 ± 0.042
0.395TyrMet: 0.395 ± 0.018
0.557TyrAsn: 0.557 ± 0.022
1.041TyrPro: 1.041 ± 0.032
0.661TyrGln: 0.661 ± 0.024
2.005TyrArg: 2.005 ± 0.042
1.208TyrSer: 1.208 ± 0.039
1.031TyrThr: 1.031 ± 0.032
1.595TyrVal: 1.595 ± 0.035
0.333TyrTrp: 0.333 ± 0.019
0.588TyrTyr: 0.588 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3850 proteins (1203759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski