Amino acid dipepetide frequency for Holcus lanatus-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.347AlaAla: 8.347 ± 2.412	0.0AlaCys: 0.0 ± 0.0	6.678AlaAsp: 6.678 ± 0.957	1.669AlaGlu: 1.669 ± 0.976	3.339AlaPhe: 3.339 ± 0.479	5.008AlaGly: 5.008 ± 1.933	3.339AlaHis: 3.339 ± 1.951	3.339AlaIle: 3.339 ± 0.479	0.0AlaLys: 0.0 ± 0.0	8.347AlaLeu: 8.347 ± 0.018	1.669AlaMet: 1.669 ± 0.976	3.339AlaAsn: 3.339 ± 0.479	3.339AlaPro: 3.339 ± 1.951	1.669AlaGln: 1.669 ± 1.454	5.008AlaArg: 5.008 ± 1.933	3.339AlaSer: 3.339 ± 0.479	3.339AlaThr: 3.339 ± 2.909	5.008AlaVal: 5.008 ± 4.363	1.669AlaTrp: 1.669 ± 0.976	3.339AlaTyr: 3.339 ± 0.479	0.0AlaXaa: 0.0 ± 0.0
Cys	0.0CysAla: 0.0 ± 0.0	0.0CysCys: 0.0 ± 0.0	3.339CysAsp: 3.339 ± 1.951	1.669CysGlu: 1.669 ± 0.976	1.669CysPhe: 1.669 ± 0.976	0.0CysGly: 0.0 ± 0.0	1.669CysHis: 1.669 ± 0.976	0.0CysIle: 0.0 ± 0.0	0.0CysLys: 0.0 ± 0.0	0.0CysLeu: 0.0 ± 0.0	0.0CysMet: 0.0 ± 0.0	0.0CysAsn: 0.0 ± 0.0	1.669CysPro: 1.669 ± 0.976	0.0CysGln: 0.0 ± 0.0	0.0CysArg: 0.0 ± 0.0	0.0CysSer: 0.0 ± 0.0	0.0CysThr: 0.0 ± 0.0	1.669CysVal: 1.669 ± 0.976	0.0CysTrp: 0.0 ± 0.0	1.669CysTyr: 1.669 ± 0.976	0.0CysXaa: 0.0 ± 0.0
Asp	3.339AspAla: 3.339 ± 0.479	3.339AspCys: 3.339 ± 1.951	1.669AspAsp: 1.669 ± 0.976	1.669AspGlu: 1.669 ± 1.454	3.339AspPhe: 3.339 ± 1.951	1.669AspGly: 1.669 ± 0.976	1.669AspHis: 1.669 ± 0.976	5.008AspIle: 5.008 ± 4.363	1.669AspLys: 1.669 ± 1.454	1.669AspLeu: 1.669 ± 1.454	1.669AspMet: 1.669 ± 1.454	3.339AspAsn: 3.339 ± 0.479	1.669AspPro: 1.669 ± 0.976	3.339AspGln: 3.339 ± 1.951	3.339AspArg: 3.339 ± 1.951	1.669AspSer: 1.669 ± 1.454	1.669AspThr: 1.669 ± 0.976	1.669AspVal: 1.669 ± 1.454	5.008AspTrp: 5.008 ± 2.927	1.669AspTyr: 1.669 ± 0.976	0.0AspXaa: 0.0 ± 0.0
Glu	1.669GluAla: 1.669 ± 0.976	0.0GluCys: 0.0 ± 0.0	0.0GluAsp: 0.0 ± 0.0	1.669GluGlu: 1.669 ± 1.454	0.0GluPhe: 0.0 ± 0.0	3.339GluGly: 3.339 ± 0.479	0.0GluHis: 0.0 ± 0.0	0.0GluIle: 0.0 ± 0.0	3.339GluLys: 3.339 ± 1.951	0.0GluLeu: 0.0 ± 0.0	1.669GluMet: 1.669 ± 0.976	0.0GluAsn: 0.0 ± 0.0	1.669GluPro: 1.669 ± 0.976	0.0GluGln: 0.0 ± 0.0	1.669GluArg: 1.669 ± 0.976	1.669GluSer: 1.669 ± 0.976	5.008GluThr: 5.008 ± 0.497	3.339GluVal: 3.339 ± 1.951	0.0GluTrp: 0.0 ± 0.0	1.669GluTyr: 1.669 ± 1.454	0.0GluXaa: 0.0 ± 0.0
Phe	0.0PheAla: 0.0 ± 0.0	0.0PheCys: 0.0 ± 0.0	0.0PheAsp: 0.0 ± 0.0	0.0PheGlu: 0.0 ± 0.0	1.669PhePhe: 1.669 ± 0.976	3.339PheGly: 3.339 ± 1.951	0.0PheHis: 0.0 ± 0.0	1.669PheIle: 1.669 ± 0.976	5.008PheLys: 5.008 ± 1.933	6.678PheLeu: 6.678 ± 0.957	0.0PheMet: 0.0 ± 0.0	3.339PheAsn: 3.339 ± 0.479	0.0PhePro: 0.0 ± 0.0	3.339PheGln: 3.339 ± 2.909	1.669PheArg: 1.669 ± 0.976	0.0PheSer: 0.0 ± 0.0	6.678PheThr: 6.678 ± 3.903	3.339PheVal: 3.339 ± 1.951	0.0PheTrp: 0.0 ± 0.0	3.339PheTyr: 3.339 ± 1.951	0.0PheXaa: 0.0 ± 0.0
Gly	6.678GlyAla: 6.678 ± 3.387	0.0GlyCys: 0.0 ± 0.0	6.678GlyAsp: 6.678 ± 0.957	1.669GlyGlu: 1.669 ± 0.976	3.339GlyPhe: 3.339 ± 1.951	3.339GlyGly: 3.339 ± 0.479	0.0GlyHis: 0.0 ± 0.0	1.669GlyIle: 1.669 ± 0.976	5.008GlyLys: 5.008 ± 0.497	1.669GlyLeu: 1.669 ± 0.976	5.008GlyMet: 5.008 ± 0.497	5.008GlyAsn: 5.008 ± 1.933	3.339GlyPro: 3.339 ± 2.909	5.008GlyGln: 5.008 ± 4.363	1.669GlyArg: 1.669 ± 1.454	6.678GlySer: 6.678 ± 0.957	10.017GlyThr: 10.017 ± 3.866	1.669GlyVal: 1.669 ± 0.976	0.0GlyTrp: 0.0 ± 0.0	6.678GlyTyr: 6.678 ± 3.387	0.0GlyXaa: 0.0 ± 0.0
His	0.0HisAla: 0.0 ± 0.0	1.669HisCys: 1.669 ± 0.976	1.669HisAsp: 1.669 ± 0.976	3.339HisGlu: 3.339 ± 1.951	0.0HisPhe: 0.0 ± 0.0	0.0HisGly: 0.0 ± 0.0	1.669HisHis: 1.669 ± 0.976	1.669HisIle: 1.669 ± 0.976	1.669HisLys: 1.669 ± 0.976	1.669HisLeu: 1.669 ± 0.976	0.0HisMet: 0.0 ± 0.0	1.669HisAsn: 1.669 ± 0.976	0.0HisPro: 0.0 ± 0.0	1.669HisGln: 1.669 ± 0.976	0.0HisArg: 0.0 ± 0.0	1.669HisSer: 1.669 ± 0.976	1.669HisThr: 1.669 ± 0.976	1.669HisVal: 1.669 ± 0.976	1.669HisTrp: 1.669 ± 0.976	3.339HisTyr: 3.339 ± 1.951	0.0HisXaa: 0.0 ± 0.0
Ile	3.339IleAla: 3.339 ± 1.951	1.669IleCys: 1.669 ± 0.976	3.339IleAsp: 3.339 ± 0.479	1.669IleGlu: 1.669 ± 1.454	3.339IlePhe: 3.339 ± 0.479	1.669IleGly: 1.669 ± 1.454	3.339IleHis: 3.339 ± 1.951	1.669IleIle: 1.669 ± 0.976	1.669IleLys: 1.669 ± 0.976	6.678IleLeu: 6.678 ± 3.387	0.0IleMet: 0.0 ± 0.0	3.339IleAsn: 3.339 ± 1.951	0.0IlePro: 0.0 ± 0.0	0.0IleGln: 0.0 ± 0.0	1.669IleArg: 1.669 ± 1.454	1.669IleSer: 1.669 ± 0.976	1.669IleThr: 1.669 ± 1.454	5.008IleVal: 5.008 ± 1.933	1.669IleTrp: 1.669 ± 0.976	1.669IleTyr: 1.669 ± 0.976	0.0IleXaa: 0.0 ± 0.0
Lys	3.339LysAla: 3.339 ± 2.909	0.0LysCys: 0.0 ± 0.0	0.0LysAsp: 0.0 ± 0.0	1.669LysGlu: 1.669 ± 0.976	0.0LysPhe: 0.0 ± 0.0	6.678LysGly: 6.678 ± 1.473	0.0LysHis: 0.0 ± 0.0	1.669LysIle: 1.669 ± 1.454	5.008LysLys: 5.008 ± 0.497	6.678LysLeu: 6.678 ± 1.473	1.669LysMet: 1.669 ± 1.454	3.339LysAsn: 3.339 ± 0.479	5.008LysPro: 5.008 ± 0.497	1.669LysGln: 1.669 ± 0.976	1.669LysArg: 1.669 ± 1.454	5.008LysSer: 5.008 ± 0.497	3.339LysThr: 3.339 ± 1.951	1.669LysVal: 1.669 ± 1.454	0.0LysTrp: 0.0 ± 0.0	1.669LysTyr: 1.669 ± 0.976	0.0LysXaa: 0.0 ± 0.0
Leu	15.025LeuAla: 15.025 ± 0.939	0.0LeuCys: 0.0 ± 0.0	3.339LeuAsp: 3.339 ± 0.479	1.669LeuGlu: 1.669 ± 0.976	1.669LeuPhe: 1.669 ± 0.976	0.0LeuGly: 0.0 ± 0.0	1.669LeuHis: 1.669 ± 0.976	1.669LeuIle: 1.669 ± 0.976	5.008LeuLys: 5.008 ± 1.933	5.008LeuLeu: 5.008 ± 0.497	0.0LeuMet: 0.0 ± 0.0	5.008LeuAsn: 5.008 ± 4.363	8.347LeuPro: 8.347 ± 0.018	5.008LeuGln: 5.008 ± 2.927	1.669LeuArg: 1.669 ± 0.976	1.669LeuSer: 1.669 ± 0.976	6.678LeuThr: 6.678 ± 1.473	10.017LeuVal: 10.017 ± 3.866	1.669LeuTrp: 1.669 ± 1.454	1.669LeuTyr: 1.669 ± 1.454	0.0LeuXaa: 0.0 ± 0.0
Met	0.0MetAla: 0.0 ± 0.0	0.0MetCys: 0.0 ± 0.0	0.0MetAsp: 0.0 ± 0.0	0.0MetGlu: 0.0 ± 0.0	0.0MetPhe: 0.0 ± 0.0	6.678MetGly: 6.678 ± 3.387	0.0MetHis: 0.0 ± 0.0	3.339MetIle: 3.339 ± 2.909	0.0MetLys: 0.0 ± 0.0	3.339MetLeu: 3.339 ± 1.951	1.669MetMet: 1.669 ± 1.454	1.669MetAsn: 1.669 ± 0.976	1.669MetPro: 1.669 ± 0.976	1.669MetGln: 1.669 ± 1.454	1.669MetArg: 1.669 ± 1.454	0.0MetSer: 0.0 ± 0.0	0.0MetThr: 0.0 ± 0.0	1.669MetVal: 1.669 ± 0.976	0.0MetTrp: 0.0 ± 0.0	0.0MetTyr: 0.0 ± 0.0	0.0MetXaa: 0.0 ± 0.0
Asn	0.0AsnAla: 0.0 ± 0.0	0.0AsnCys: 0.0 ± 0.0	3.339AsnAsp: 3.339 ± 2.909	1.669AsnGlu: 1.669 ± 0.976	1.669AsnPhe: 1.669 ± 0.976	3.339AsnGly: 3.339 ± 0.479	3.339AsnHis: 3.339 ± 1.951	3.339AsnIle: 3.339 ± 1.951	1.669AsnLys: 1.669 ± 1.454	3.339AsnLeu: 3.339 ± 0.479	0.0AsnMet: 0.0 ± 0.0	1.669AsnAsn: 1.669 ± 0.976	1.669AsnPro: 1.669 ± 0.976	1.669AsnGln: 1.669 ± 0.976	10.017AsnArg: 10.017 ± 1.436	3.339AsnSer: 3.339 ± 2.909	3.339AsnThr: 3.339 ± 2.909	3.339AsnVal: 3.339 ± 0.479	1.669AsnTrp: 1.669 ± 0.976	5.008AsnTyr: 5.008 ± 2.927	0.0AsnXaa: 0.0 ± 0.0
Pro	5.008ProAla: 5.008 ± 0.497	1.669ProCys: 1.669 ± 0.976	5.008ProAsp: 5.008 ± 2.927	1.669ProGlu: 1.669 ± 0.976	1.669ProPhe: 1.669 ± 0.976	1.669ProGly: 1.669 ± 0.976	1.669ProHis: 1.669 ± 0.976	3.339ProIle: 3.339 ± 1.951	0.0ProLys: 0.0 ± 0.0	1.669ProLeu: 1.669 ± 0.976	3.339ProMet: 3.339 ± 2.909	3.339ProAsn: 3.339 ± 0.479	1.669ProPro: 1.669 ± 0.976	5.008ProGln: 5.008 ± 2.927	8.347ProArg: 8.347 ± 2.448	6.678ProSer: 6.678 ± 0.957	8.347ProThr: 8.347 ± 2.412	1.669ProVal: 1.669 ± 0.976	1.669ProTrp: 1.669 ± 0.976	1.669ProTyr: 1.669 ± 0.976	0.0ProXaa: 0.0 ± 0.0
Gln	3.339GlnAla: 3.339 ± 0.479	0.0GlnCys: 0.0 ± 0.0	1.669GlnAsp: 1.669 ± 0.976	0.0GlnGlu: 0.0 ± 0.0	3.339GlnPhe: 3.339 ± 1.951	5.008GlnGly: 5.008 ± 0.497	1.669GlnHis: 1.669 ± 0.976	1.669GlnIle: 1.669 ± 1.454	1.669GlnLys: 1.669 ± 0.976	8.347GlnLeu: 8.347 ± 0.018	1.669GlnMet: 1.669 ± 1.454	5.008GlnAsn: 5.008 ± 0.497	1.669GlnPro: 1.669 ± 0.976	1.669GlnGln: 1.669 ± 1.454	8.347GlnArg: 8.347 ± 0.018	0.0GlnSer: 0.0 ± 0.0	1.669GlnThr: 1.669 ± 0.976	3.339GlnVal: 3.339 ± 0.479	0.0GlnTrp: 0.0 ± 0.0	3.339GlnTyr: 3.339 ± 0.479	0.0GlnXaa: 0.0 ± 0.0
Arg	3.339ArgAla: 3.339 ± 2.909	0.0ArgCys: 0.0 ± 0.0	3.339ArgAsp: 3.339 ± 1.951	3.339ArgGlu: 3.339 ± 0.479	3.339ArgPhe: 3.339 ± 2.909	8.347ArgGly: 8.347 ± 0.018	1.669ArgHis: 1.669 ± 0.976	1.669ArgIle: 1.669 ± 0.976	0.0ArgLys: 0.0 ± 0.0	1.669ArgLeu: 1.669 ± 0.976	0.0ArgMet: 0.0 ± 0.0	1.669ArgAsn: 1.669 ± 0.976	8.347ArgPro: 8.347 ± 2.412	5.008ArgGln: 5.008 ± 0.497	13.356ArgArg: 13.356 ± 0.515	1.669ArgSer: 1.669 ± 1.454	1.669ArgThr: 1.669 ± 1.454	6.678ArgVal: 6.678 ± 1.473	0.0ArgTrp: 0.0 ± 0.0	3.339ArgTyr: 3.339 ± 1.951	0.0ArgXaa: 0.0 ± 0.0
Ser	8.347SerAla: 8.347 ± 2.448	0.0SerCys: 0.0 ± 0.0	0.0SerAsp: 0.0 ± 0.0	0.0SerGlu: 0.0 ± 0.0	1.669SerPhe: 1.669 ± 0.976	3.339SerGly: 3.339 ± 2.909	1.669SerHis: 1.669 ± 0.976	3.339SerIle: 3.339 ± 1.951	0.0SerLys: 0.0 ± 0.0	3.339SerLeu: 3.339 ± 2.909	0.0SerMet: 0.0 ± 0.0	5.008SerAsn: 5.008 ± 0.497	8.347SerPro: 8.347 ± 2.448	3.339SerGln: 3.339 ± 0.479	1.669SerArg: 1.669 ± 1.454	1.669SerSer: 1.669 ± 1.454	3.339SerThr: 3.339 ± 0.479	5.008SerVal: 5.008 ± 4.363	0.0SerTrp: 0.0 ± 0.0	1.669SerTyr: 1.669 ± 1.454	0.0SerXaa: 0.0 ± 0.0
Thr	5.008ThrAla: 5.008 ± 1.933	0.0ThrCys: 0.0 ± 0.0	3.339ThrAsp: 3.339 ± 0.479	1.669ThrGlu: 1.669 ± 0.976	3.339ThrPhe: 3.339 ± 0.479	13.356ThrGly: 13.356 ± 9.205	1.669ThrHis: 1.669 ± 0.976	6.678ThrIle: 6.678 ± 0.957	5.008ThrLys: 5.008 ± 2.927	5.008ThrLeu: 5.008 ± 0.497	0.0ThrMet: 0.0 ± 0.0	0.0ThrAsn: 0.0 ± 0.0	6.678ThrPro: 6.678 ± 1.473	1.669ThrGln: 1.669 ± 1.454	3.339ThrArg: 3.339 ± 0.479	3.339ThrSer: 3.339 ± 1.951	8.347ThrThr: 8.347 ± 2.412	3.339ThrVal: 3.339 ± 0.479	1.669ThrTrp: 1.669 ± 1.454	0.0ThrTyr: 0.0 ± 0.0	0.0ThrXaa: 0.0 ± 0.0
Val	1.669ValAla: 1.669 ± 1.454	1.669ValCys: 1.669 ± 0.976	5.008ValAsp: 5.008 ± 0.497	0.0ValGlu: 0.0 ± 0.0	5.008ValPhe: 5.008 ± 1.933	6.678ValGly: 6.678 ± 3.387	1.669ValHis: 1.669 ± 0.976	1.669ValIle: 1.669 ± 0.976	3.339ValLys: 3.339 ± 0.479	6.678ValLeu: 6.678 ± 0.957	1.669ValMet: 1.669 ± 0.239	3.339ValAsn: 3.339 ± 0.479	1.669ValPro: 1.669 ± 0.976	5.008ValGln: 5.008 ± 0.497	1.669ValArg: 1.669 ± 0.976	5.008ValSer: 5.008 ± 1.933	5.008ValThr: 5.008 ± 4.363	3.339ValVal: 3.339 ± 1.951	1.669ValTrp: 1.669 ± 0.976	5.008ValTyr: 5.008 ± 1.933	0.0ValXaa: 0.0 ± 0.0
Trp	0.0TrpAla: 0.0 ± 0.0	1.669TrpCys: 1.669 ± 0.976	0.0TrpAsp: 0.0 ± 0.0	1.669TrpGlu: 1.669 ± 0.976	1.669TrpPhe: 1.669 ± 0.976	0.0TrpGly: 0.0 ± 0.0	0.0TrpHis: 0.0 ± 0.0	1.669TrpIle: 1.669 ± 1.454	3.339TrpLys: 3.339 ± 0.479	0.0TrpLeu: 0.0 ± 0.0	0.0TrpMet: 0.0 ± 0.0	1.669TrpAsn: 1.669 ± 0.976	1.669TrpPro: 1.669 ± 0.976	3.339TrpGln: 3.339 ± 1.951	0.0TrpArg: 0.0 ± 0.0	0.0TrpSer: 0.0 ± 0.0	0.0TrpThr: 0.0 ± 0.0	1.669TrpVal: 1.669 ± 0.976	0.0TrpTrp: 0.0 ± 0.0	1.669TrpTyr: 1.669 ± 0.976	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.339TyrAla: 3.339 ± 0.479	1.669TyrCys: 1.669 ± 0.976	1.669TyrAsp: 1.669 ± 1.454	0.0TyrGlu: 0.0 ± 0.0	0.0TyrPhe: 0.0 ± 0.0	1.669TyrGly: 1.669 ± 0.976	0.0TyrHis: 0.0 ± 0.0	0.0TyrIle: 0.0 ± 0.0	6.678TyrLys: 6.678 ± 0.957	5.008TyrLeu: 5.008 ± 1.933	1.669TyrMet: 1.669 ± 0.976	1.669TyrAsn: 1.669 ± 0.976	6.678TyrPro: 6.678 ± 3.903	3.339TyrGln: 3.339 ± 1.951	1.669TyrArg: 1.669 ± 0.976	6.678TyrSer: 6.678 ± 0.957	1.669TyrThr: 1.669 ± 0.976	3.339TyrVal: 3.339 ± 2.909	1.669TyrTrp: 1.669 ± 0.976	0.0TyrTyr: 0.0 ± 0.0	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2 proteins (600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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