Amino acid dipepetide frequency for Brevibacterium linens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.972AlaAla: 16.972 ± 0.166	0.776AlaCys: 0.776 ± 0.027	8.229AlaAsp: 8.229 ± 0.097	9.561AlaGlu: 9.561 ± 0.105	3.559AlaPhe: 3.559 ± 0.062	11.393AlaGly: 11.393 ± 0.121	2.276AlaHis: 2.276 ± 0.049	5.718AlaIle: 5.718 ± 0.079	3.892AlaLys: 3.892 ± 0.068	11.496AlaLeu: 11.496 ± 0.121	2.613AlaMet: 2.613 ± 0.05	2.566AlaAsn: 2.566 ± 0.048	5.207AlaPro: 5.207 ± 0.081	3.639AlaGln: 3.639 ± 0.057	6.921AlaArg: 6.921 ± 0.086	6.711AlaSer: 6.711 ± 0.09	6.409AlaThr: 6.409 ± 0.083	9.598AlaVal: 9.598 ± 0.109	1.486AlaTrp: 1.486 ± 0.038	2.01AlaTyr: 2.01 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.737CysAla: 0.737 ± 0.025	0.07CysCys: 0.07 ± 0.008	0.328CysAsp: 0.328 ± 0.018	0.336CysGlu: 0.336 ± 0.016	0.227CysPhe: 0.227 ± 0.014	0.682CysGly: 0.682 ± 0.025	0.134CysHis: 0.134 ± 0.013	0.265CysIle: 0.265 ± 0.016	0.109CysLys: 0.109 ± 0.009	0.661CysLeu: 0.661 ± 0.026	0.107CysMet: 0.107 ± 0.01	0.126CysAsn: 0.126 ± 0.01	0.366CysPro: 0.366 ± 0.019	0.142CysGln: 0.142 ± 0.012	0.395CysArg: 0.395 ± 0.018	0.41CysSer: 0.41 ± 0.02	0.376CysThr: 0.376 ± 0.02	0.449CysVal: 0.449 ± 0.021	0.084CysTrp: 0.084 ± 0.009	0.14CysTyr: 0.14 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.062AspAla: 7.062 ± 0.092	0.363AspCys: 0.363 ± 0.022	4.711AspAsp: 4.711 ± 0.087	5.115AspGlu: 5.115 ± 0.077	2.359AspPhe: 2.359 ± 0.05	5.533AspGly: 5.533 ± 0.08	1.512AspHis: 1.512 ± 0.029	2.993AspIle: 2.993 ± 0.048	1.658AspLys: 1.658 ± 0.046	6.46AspLeu: 6.46 ± 0.086	1.08AspMet: 1.08 ± 0.03	1.32AspAsn: 1.32 ± 0.039	3.959AspPro: 3.959 ± 0.067	1.776AspGln: 1.776 ± 0.038	4.331AspArg: 4.331 ± 0.072	4.222AspSer: 4.222 ± 0.071	3.329AspThr: 3.329 ± 0.057	4.874AspVal: 4.874 ± 0.06	0.949AspTrp: 0.949 ± 0.027	1.411AspTyr: 1.411 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.149GluAla: 8.149 ± 0.091	0.288GluCys: 0.288 ± 0.016	3.646GluAsp: 3.646 ± 0.058	3.78GluGlu: 3.78 ± 0.07	2.245GluPhe: 2.245 ± 0.051	3.969GluGly: 3.969 ± 0.066	1.506GluHis: 1.506 ± 0.039	3.246GluIle: 3.246 ± 0.055	2.213GluLys: 2.213 ± 0.052	6.622GluLeu: 6.622 ± 0.082	1.154GluMet: 1.154 ± 0.032	1.622GluAsn: 1.622 ± 0.039	2.928GluPro: 2.928 ± 0.047	2.061GluGln: 2.061 ± 0.043	3.918GluArg: 3.918 ± 0.063	4.01GluSer: 4.01 ± 0.059	3.693GluThr: 3.693 ± 0.059	5.343GluVal: 5.343 ± 0.073	0.825GluTrp: 0.825 ± 0.03	1.247GluTyr: 1.247 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.33PheAla: 4.33 ± 0.068	0.25PheCys: 0.25 ± 0.015	2.855PheAsp: 2.855 ± 0.05	1.784PheGlu: 1.784 ± 0.038	1.298PhePhe: 1.298 ± 0.039	3.764PheGly: 3.764 ± 0.055	0.634PheHis: 0.634 ± 0.021	1.69PheIle: 1.69 ± 0.041	0.693PheLys: 0.693 ± 0.029	2.933PheLeu: 2.933 ± 0.056	0.601PheMet: 0.601 ± 0.026	0.887PheAsn: 0.887 ± 0.029	1.447PhePro: 1.447 ± 0.034	0.723PheGln: 0.723 ± 0.023	1.62PheArg: 1.62 ± 0.036	2.231PheSer: 2.231 ± 0.047	2.334PheThr: 2.334 ± 0.048	2.836PheVal: 2.836 ± 0.052	0.467PheTrp: 0.467 ± 0.023	0.688PheTyr: 0.688 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.233GlyAla: 9.233 ± 0.098	0.581GlyCys: 0.581 ± 0.024	4.906GlyAsp: 4.906 ± 0.073	5.128GlyGlu: 5.128 ± 0.067	3.496GlyPhe: 3.496 ± 0.064	7.415GlyGly: 7.415 ± 0.107	1.908GlyHis: 1.908 ± 0.045	5.062GlyIle: 5.062 ± 0.068	2.792GlyLys: 2.792 ± 0.056	9.073GlyLeu: 9.073 ± 0.107	2.109GlyMet: 2.109 ± 0.039	1.968GlyAsn: 1.968 ± 0.041	3.895GlyPro: 3.895 ± 0.069	2.945GlyGln: 2.945 ± 0.075	5.62GlyArg: 5.62 ± 0.076	5.97GlySer: 5.97 ± 0.087	5.544GlyThr: 5.544 ± 0.077	6.817GlyVal: 6.817 ± 0.078	1.432GlyTrp: 1.432 ± 0.038	2.054GlyTyr: 2.054 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.068HisAla: 2.068 ± 0.049	0.169HisCys: 0.169 ± 0.013	1.327HisAsp: 1.327 ± 0.04	1.21HisGlu: 1.21 ± 0.034	0.703HisPhe: 0.703 ± 0.025	1.871HisGly: 1.871 ± 0.045	0.554HisHis: 0.554 ± 0.025	0.883HisIle: 0.883 ± 0.027	0.453HisLys: 0.453 ± 0.019	2.124HisLeu: 2.124 ± 0.047	0.367HisMet: 0.367 ± 0.017	0.46HisAsn: 0.46 ± 0.02	1.446HisPro: 1.446 ± 0.032	0.549HisGln: 0.549 ± 0.023	1.536HisArg: 1.536 ± 0.034	1.339HisSer: 1.339 ± 0.037	1.184HisThr: 1.184 ± 0.034	1.499HisVal: 1.499 ± 0.037	0.28HisTrp: 0.28 ± 0.017	0.399HisTyr: 0.399 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.965IleAla: 6.965 ± 0.093	0.374IleCys: 0.374 ± 0.021	4.083IleAsp: 4.083 ± 0.069	3.009IleGlu: 3.009 ± 0.05	1.62IlePhe: 1.62 ± 0.042	5.256IleGly: 5.256 ± 0.079	0.943IleHis: 0.943 ± 0.033	2.872IleIle: 2.872 ± 0.059	1.096IleLys: 1.096 ± 0.036	4.148IleLeu: 4.148 ± 0.064	0.861IleMet: 0.861 ± 0.029	1.237IleAsn: 1.237 ± 0.039	2.522IlePro: 2.522 ± 0.048	0.947IleGln: 0.947 ± 0.031	2.812IleArg: 2.812 ± 0.05	3.021IleSer: 3.021 ± 0.051	3.282IleThr: 3.282 ± 0.051	4.896IleVal: 4.896 ± 0.073	0.545IleTrp: 0.545 ± 0.018	0.841IleTyr: 0.841 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.373LysAla: 3.373 ± 0.061	0.119LysCys: 0.119 ± 0.011	1.918LysAsp: 1.918 ± 0.055	1.53LysGlu: 1.53 ± 0.046	0.868LysPhe: 0.868 ± 0.026	2.142LysGly: 2.142 ± 0.053	0.606LysHis: 0.606 ± 0.024	1.4LysIle: 1.4 ± 0.033	1.505LysLys: 1.505 ± 0.051	2.465LysLeu: 2.465 ± 0.048	0.641LysMet: 0.641 ± 0.024	0.899LysAsn: 0.899 ± 0.029	1.495LysPro: 1.495 ± 0.045	0.958LysGln: 0.958 ± 0.03	1.884LysArg: 1.884 ± 0.045	2.007LysSer: 2.007 ± 0.058	1.862LysThr: 1.862 ± 0.047	2.245LysVal: 2.245 ± 0.045	0.373LysTrp: 0.373 ± 0.019	0.672LysTyr: 0.672 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.044LeuAla: 12.044 ± 0.126	0.616LeuCys: 0.616 ± 0.025	6.584LeuAsp: 6.584 ± 0.079	5.123LeuGlu: 5.123 ± 0.075	3.006LeuPhe: 3.006 ± 0.055	9.111LeuGly: 9.111 ± 0.092	1.806LeuHis: 1.806 ± 0.045	5.209LeuIle: 5.209 ± 0.089	2.476LeuLys: 2.476 ± 0.05	9.214LeuLeu: 9.214 ± 0.116	1.825LeuMet: 1.825 ± 0.044	2.221LeuAsn: 2.221 ± 0.05	5.143LeuPro: 5.143 ± 0.071	2.253LeuGln: 2.253 ± 0.049	6.158LeuArg: 6.158 ± 0.085	6.427LeuSer: 6.427 ± 0.08	6.407LeuThr: 6.407 ± 0.083	8.05LeuVal: 8.05 ± 0.102	1.114LeuTrp: 1.114 ± 0.037	1.421LeuTyr: 1.421 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.348MetAla: 2.348 ± 0.049	0.133MetCys: 0.133 ± 0.012	0.97MetAsp: 0.97 ± 0.031	0.839MetGlu: 0.839 ± 0.03	0.699MetPhe: 0.699 ± 0.025	1.541MetGly: 1.541 ± 0.036	0.405MetHis: 0.405 ± 0.019	1.093MetIle: 1.093 ± 0.034	0.647MetLys: 0.647 ± 0.026	1.971MetLeu: 1.971 ± 0.048	0.455MetMet: 0.455 ± 0.022	0.646MetAsn: 0.646 ± 0.022	1.146MetPro: 1.146 ± 0.035	0.508MetGln: 0.508 ± 0.02	1.481MetArg: 1.481 ± 0.039	1.919MetSer: 1.919 ± 0.04	1.772MetThr: 1.772 ± 0.038	1.505MetVal: 1.505 ± 0.04	0.239MetTrp: 0.239 ± 0.014	0.339MetTyr: 0.339 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.678AsnAla: 2.678 ± 0.059	0.171AsnCys: 0.171 ± 0.011	1.446AsnAsp: 1.446 ± 0.041	1.275AsnGlu: 1.275 ± 0.036	0.831AsnPhe: 0.831 ± 0.028	2.101AsnGly: 2.101 ± 0.054	0.507AsnHis: 0.507 ± 0.021	1.114AsnIle: 1.114 ± 0.031	0.588AsnLys: 0.588 ± 0.022	2.213AsnLeu: 2.213 ± 0.045	0.46AsnMet: 0.46 ± 0.021	0.632AsnAsn: 0.632 ± 0.027	1.794AsnPro: 1.794 ± 0.038	0.701AsnGln: 0.701 ± 0.025	1.619AsnArg: 1.619 ± 0.036	1.56AsnSer: 1.56 ± 0.038	1.387AsnThr: 1.387 ± 0.041	1.696AsnVal: 1.696 ± 0.042	0.37AsnTrp: 0.37 ± 0.016	0.555AsnTyr: 0.555 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.068ProAla: 6.068 ± 0.07	0.197ProCys: 0.197 ± 0.013	3.763ProAsp: 3.763 ± 0.057	4.181ProGlu: 4.181 ± 0.065	1.632ProPhe: 1.632 ± 0.038	4.948ProGly: 4.948 ± 0.074	1.039ProHis: 1.039 ± 0.031	2.258ProIle: 2.258 ± 0.043	1.581ProLys: 1.581 ± 0.04	4.158ProLeu: 4.158 ± 0.07	1.006ProMet: 1.006 ± 0.027	1.319ProAsn: 1.319 ± 0.043	1.949ProPro: 1.949 ± 0.047	1.705ProGln: 1.705 ± 0.042	2.864ProArg: 2.864 ± 0.051	2.98ProSer: 2.98 ± 0.057	3.177ProThr: 3.177 ± 0.052	4.281ProVal: 4.281 ± 0.065	0.706ProTrp: 0.706 ± 0.024	0.985ProTyr: 0.985 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.509GlnAla: 3.509 ± 0.058	0.143GlnCys: 0.143 ± 0.014	1.309GlnAsp: 1.309 ± 0.035	1.442GlnGlu: 1.442 ± 0.035	0.856GlnPhe: 0.856 ± 0.027	2.048GlnGly: 2.048 ± 0.053	0.567GlnHis: 0.567 ± 0.024	1.651GlnIle: 1.651 ± 0.041	0.947GlnLys: 0.947 ± 0.034	2.9GlnLeu: 2.9 ± 0.049	0.695GlnMet: 0.695 ± 0.024	0.784GlnAsn: 0.784 ± 0.033	1.578GlnPro: 1.578 ± 0.051	1.139GlnGln: 1.139 ± 0.041	1.985GlnArg: 1.985 ± 0.043	1.745GlnSer: 1.745 ± 0.043	1.767GlnThr: 1.767 ± 0.039	2.364GlnVal: 2.364 ± 0.042	0.432GlnTrp: 0.432 ± 0.02	0.546GlnTyr: 0.546 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.742ArgAla: 6.742 ± 0.086	0.355ArgCys: 0.355 ± 0.018	3.506ArgAsp: 3.506 ± 0.058	3.918ArgGlu: 3.918 ± 0.063	2.246ArgPhe: 2.246 ± 0.048	4.552ArgGly: 4.552 ± 0.064	1.344ArgHis: 1.344 ± 0.031	3.54ArgIle: 3.54 ± 0.052	1.874ArgLys: 1.874 ± 0.047	6.456ArgLeu: 6.456 ± 0.092	1.626ArgMet: 1.626 ± 0.036	1.53ArgAsn: 1.53 ± 0.041	3.08ArgPro: 3.08 ± 0.057	1.953ArgGln: 1.953 ± 0.041	5.212ArgArg: 5.212 ± 0.077	4.158ArgSer: 4.158 ± 0.065	4.02ArgThr: 4.02 ± 0.061	4.436ArgVal: 4.436 ± 0.063	0.897ArgTrp: 0.897 ± 0.028	1.31ArgTyr: 1.31 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	8.236SerAla: 8.236 ± 0.098	0.343SerCys: 0.343 ± 0.019	3.845SerAsp: 3.845 ± 0.059	3.705SerGlu: 3.705 ± 0.059	2.096SerPhe: 2.096 ± 0.043	6.477SerGly: 6.477 ± 0.085	1.239SerHis: 1.239 ± 0.031	2.895SerIle: 2.895 ± 0.05	1.8SerLys: 1.8 ± 0.052	5.723SerLeu: 5.723 ± 0.08	1.522SerMet: 1.522 ± 0.039	1.453SerAsn: 1.453 ± 0.033	3.209SerPro: 3.209 ± 0.055	1.891SerGln: 1.891 ± 0.05	3.949SerArg: 3.949 ± 0.065	4.449SerSer: 4.449 ± 0.081	4.394SerThr: 4.394 ± 0.062	4.955SerVal: 4.955 ± 0.066	0.921SerTrp: 0.921 ± 0.033	1.26SerTyr: 1.26 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.694ThrAla: 7.694 ± 0.096	0.327ThrCys: 0.327 ± 0.018	4.017ThrAsp: 4.017 ± 0.064	3.96ThrGlu: 3.96 ± 0.059	1.967ThrPhe: 1.967 ± 0.04	6.041ThrGly: 6.041 ± 0.076	1.198ThrHis: 1.198 ± 0.034	3.244ThrIle: 3.244 ± 0.056	1.688ThrLys: 1.688 ± 0.043	5.415ThrLeu: 5.415 ± 0.068	1.273ThrMet: 1.273 ± 0.032	1.363ThrAsn: 1.363 ± 0.034	3.542ThrPro: 3.542 ± 0.056	1.605ThrGln: 1.605 ± 0.038	3.346ThrArg: 3.346 ± 0.051	3.925ThrSer: 3.925 ± 0.066	4.124ThrThr: 4.124 ± 0.075	5.473ThrVal: 5.473 ± 0.074	0.85ThrTrp: 0.85 ± 0.03	1.179ThrTyr: 1.179 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.461ValAla: 9.461 ± 0.11	0.602ValCys: 0.602 ± 0.021	5.714ValAsp: 5.714 ± 0.071	4.875ValGlu: 4.875 ± 0.067	2.943ValPhe: 2.943 ± 0.059	6.33ValGly: 6.33 ± 0.076	1.575ValHis: 1.575 ± 0.04	4.715ValIle: 4.715 ± 0.068	2.072ValLys: 2.072 ± 0.047	8.534ValLeu: 8.534 ± 0.09	1.586ValMet: 1.586 ± 0.042	1.865ValAsn: 1.865 ± 0.044	4.376ValPro: 4.376 ± 0.062	1.809ValGln: 1.809 ± 0.041	4.794ValArg: 4.794 ± 0.066	5.046ValSer: 5.046 ± 0.059	5.321ValThr: 5.321 ± 0.066	6.999ValVal: 6.999 ± 0.096	0.945ValTrp: 0.945 ± 0.025	1.324ValTyr: 1.324 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.395TrpAla: 1.395 ± 0.037	0.11TrpCys: 0.11 ± 0.009	0.697TrpAsp: 0.697 ± 0.027	0.642TrpGlu: 0.642 ± 0.025	0.582TrpPhe: 0.582 ± 0.022	0.94TrpGly: 0.94 ± 0.027	0.296TrpHis: 0.296 ± 0.019	0.728TrpIle: 0.728 ± 0.029	0.415TrpLys: 0.415 ± 0.018	1.551TrpLeu: 1.551 ± 0.038	0.368TrpMet: 0.368 ± 0.017	0.411TrpAsn: 0.411 ± 0.018	0.642TrpPro: 0.642 ± 0.025	0.507TrpGln: 0.507 ± 0.02	0.865TrpArg: 0.865 ± 0.028	0.891TrpSer: 0.891 ± 0.029	0.82TrpThr: 0.82 ± 0.026	1.067TrpVal: 1.067 ± 0.025	0.3TrpTrp: 0.3 ± 0.017	0.283TrpTyr: 0.283 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.966TyrAla: 1.966 ± 0.036	0.156TyrCys: 0.156 ± 0.012	1.164TyrAsp: 1.164 ± 0.037	1.053TyrGlu: 1.053 ± 0.035	0.83TyrPhe: 0.83 ± 0.026	1.834TyrGly: 1.834 ± 0.046	0.373TyrHis: 0.373 ± 0.018	0.754TyrIle: 0.754 ± 0.03	0.464TyrLys: 0.464 ± 0.024	2.097TyrLeu: 2.097 ± 0.04	0.306TyrMet: 0.306 ± 0.016	0.391TyrAsn: 0.391 ± 0.016	1.072TyrPro: 1.072 ± 0.031	0.594TyrGln: 0.594 ± 0.025	1.444TyrArg: 1.444 ± 0.036	1.343TyrSer: 1.343 ± 0.032	1.025TyrThr: 1.025 ± 0.031	1.502TyrVal: 1.502 ± 0.036	0.296TyrTrp: 0.296 ± 0.013	0.452TyrTyr: 0.452 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3434 proteins (1150451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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