Amino acid dipepetide frequency for Klebsiella phage Pylas

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.831AlaAla: 7.831 ± 0.893
0.695AlaCys: 0.695 ± 0.237
4.866AlaAsp: 4.866 ± 0.543
4.727AlaGlu: 4.727 ± 0.539
3.429AlaPhe: 3.429 ± 0.419
5.375AlaGly: 5.375 ± 0.548
1.437AlaHis: 1.437 ± 0.267
5.792AlaIle: 5.792 ± 0.695
4.912AlaLys: 4.912 ± 0.502
6.766AlaLeu: 6.766 ± 0.538
1.9AlaMet: 1.9 ± 0.229
4.31AlaAsn: 4.31 ± 0.418
2.502AlaPro: 2.502 ± 0.314
4.773AlaGln: 4.773 ± 0.654
3.336AlaArg: 3.336 ± 0.43
4.449AlaSer: 4.449 ± 0.473
4.402AlaThr: 4.402 ± 0.806
5.375AlaVal: 5.375 ± 0.591
0.51AlaTrp: 0.51 ± 0.148
2.78AlaTyr: 2.78 ± 0.311
0.0AlaXaa: 0.0 ± 0.0
Cys
0.741CysAla: 0.741 ± 0.254
0.185CysCys: 0.185 ± 0.079
0.602CysAsp: 0.602 ± 0.179
0.788CysGlu: 0.788 ± 0.22
0.51CysPhe: 0.51 ± 0.169
0.602CysGly: 0.602 ± 0.191
0.232CysHis: 0.232 ± 0.108
0.88CysIle: 0.88 ± 0.257
0.741CysLys: 0.741 ± 0.219
1.019CysLeu: 1.019 ± 0.269
0.232CysMet: 0.232 ± 0.098
0.278CysAsn: 0.278 ± 0.123
0.463CysPro: 0.463 ± 0.199
0.463CysGln: 0.463 ± 0.23
0.556CysArg: 0.556 ± 0.164
0.788CysSer: 0.788 ± 0.239
0.602CysThr: 0.602 ± 0.198
0.695CysVal: 0.695 ± 0.212
0.139CysTrp: 0.139 ± 0.083
0.232CysTyr: 0.232 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
4.727AspAla: 4.727 ± 0.529
0.649AspCys: 0.649 ± 0.226
3.568AspAsp: 3.568 ± 0.562
4.402AspGlu: 4.402 ± 0.423
1.807AspPhe: 1.807 ± 0.281
4.402AspGly: 4.402 ± 0.702
0.973AspHis: 0.973 ± 0.171
4.727AspIle: 4.727 ± 0.486
4.032AspLys: 4.032 ± 0.395
5.514AspLeu: 5.514 ± 0.504
1.715AspMet: 1.715 ± 0.238
2.688AspAsn: 2.688 ± 0.317
2.224AspPro: 2.224 ± 0.346
1.297AspGln: 1.297 ± 0.215
2.178AspArg: 2.178 ± 0.239
3.522AspSer: 3.522 ± 0.406
3.661AspThr: 3.661 ± 0.421
3.846AspVal: 3.846 ± 0.386
1.019AspTrp: 1.019 ± 0.235
2.873AspTyr: 2.873 ± 0.492
0.0AspXaa: 0.0 ± 0.0
Glu
6.256GluAla: 6.256 ± 0.59
0.834GluCys: 0.834 ± 0.256
3.29GluAsp: 3.29 ± 0.415
4.078GluGlu: 4.078 ± 0.452
2.549GluPhe: 2.549 ± 0.296
3.336GluGly: 3.336 ± 0.475
0.973GluHis: 0.973 ± 0.254
3.244GluIle: 3.244 ± 0.395
3.892GluLys: 3.892 ± 0.433
7.97GluLeu: 7.97 ± 0.662
2.41GluMet: 2.41 ± 0.305
2.734GluAsn: 2.734 ± 0.423
2.688GluPro: 2.688 ± 0.442
3.753GluGln: 3.753 ± 0.511
2.873GluArg: 2.873 ± 0.395
3.614GluSer: 3.614 ± 0.436
3.939GluThr: 3.939 ± 0.695
4.263GluVal: 4.263 ± 0.534
0.788GluTrp: 0.788 ± 0.243
1.993GluTyr: 1.993 ± 0.312
0.0GluXaa: 0.0 ± 0.0
Phe
2.363PheAla: 2.363 ± 0.328
0.51PheCys: 0.51 ± 0.158
2.271PheAsp: 2.271 ± 0.332
2.085PheGlu: 2.085 ± 0.342
1.205PhePhe: 1.205 ± 0.281
2.78PheGly: 2.78 ± 0.36
0.278PheHis: 0.278 ± 0.124
3.151PheIle: 3.151 ± 0.367
3.151PheLys: 3.151 ± 0.407
2.688PheLeu: 2.688 ± 0.332
1.066PheMet: 1.066 ± 0.254
2.317PheAsn: 2.317 ± 0.372
1.158PhePro: 1.158 ± 0.246
1.205PheGln: 1.205 ± 0.299
1.854PheArg: 1.854 ± 0.255
1.9PheSer: 1.9 ± 0.238
2.039PheThr: 2.039 ± 0.288
2.595PheVal: 2.595 ± 0.332
0.371PheTrp: 0.371 ± 0.143
1.854PheTyr: 1.854 ± 0.297
0.0PheXaa: 0.0 ± 0.0
Gly
4.171GlyAla: 4.171 ± 0.467
0.556GlyCys: 0.556 ± 0.184
3.707GlyAsp: 3.707 ± 0.466
3.336GlyGlu: 3.336 ± 0.449
2.502GlyPhe: 2.502 ± 0.34
2.966GlyGly: 2.966 ± 0.415
1.205GlyHis: 1.205 ± 0.236
4.912GlyIle: 4.912 ± 0.409
5.051GlyLys: 5.051 ± 0.474
5.468GlyLeu: 5.468 ± 0.676
1.576GlyMet: 1.576 ± 0.283
3.707GlyAsn: 3.707 ± 0.357
0.88GlyPro: 0.88 ± 0.168
2.456GlyGln: 2.456 ± 0.354
2.595GlyArg: 2.595 ± 0.381
4.356GlySer: 4.356 ± 0.624
4.402GlyThr: 4.402 ± 0.521
4.588GlyVal: 4.588 ± 0.45
1.019GlyTrp: 1.019 ± 0.249
3.429GlyTyr: 3.429 ± 0.363
0.0GlyXaa: 0.0 ± 0.0
His
0.973HisAla: 0.973 ± 0.209
0.371HisCys: 0.371 ± 0.134
1.019HisAsp: 1.019 ± 0.317
1.483HisGlu: 1.483 ± 0.252
0.602HisPhe: 0.602 ± 0.176
0.834HisGly: 0.834 ± 0.221
0.463HisHis: 0.463 ± 0.249
1.205HisIle: 1.205 ± 0.191
1.483HisLys: 1.483 ± 0.329
1.344HisLeu: 1.344 ± 0.183
0.695HisMet: 0.695 ± 0.188
0.834HisAsn: 0.834 ± 0.217
0.88HisPro: 0.88 ± 0.201
0.556HisGln: 0.556 ± 0.148
0.695HisArg: 0.695 ± 0.197
0.834HisSer: 0.834 ± 0.203
0.927HisThr: 0.927 ± 0.19
0.927HisVal: 0.927 ± 0.21
0.185HisTrp: 0.185 ± 0.123
0.695HisTyr: 0.695 ± 0.179
0.0HisXaa: 0.0 ± 0.0
Ile
6.07IleAla: 6.07 ± 0.491
0.788IleCys: 0.788 ± 0.231
4.773IleAsp: 4.773 ± 0.412
4.819IleGlu: 4.819 ± 0.438
2.271IlePhe: 2.271 ± 0.306
3.985IleGly: 3.985 ± 0.502
1.158IleHis: 1.158 ± 0.257
3.336IleIle: 3.336 ± 0.517
4.356IleLys: 4.356 ± 0.481
4.31IleLeu: 4.31 ± 0.433
1.066IleMet: 1.066 ± 0.214
4.495IleAsn: 4.495 ± 0.559
2.966IlePro: 2.966 ± 0.395
2.78IleGln: 2.78 ± 0.414
3.197IleArg: 3.197 ± 0.34
3.939IleSer: 3.939 ± 0.454
4.217IleThr: 4.217 ± 0.404
3.661IleVal: 3.661 ± 0.487
0.788IleTrp: 0.788 ± 0.212
1.807IleTyr: 1.807 ± 0.293
0.0IleXaa: 0.0 ± 0.0
Lys
5.607LysAla: 5.607 ± 0.467
0.695LysCys: 0.695 ± 0.213
3.707LysAsp: 3.707 ± 0.448
4.958LysGlu: 4.958 ± 0.531
2.78LysPhe: 2.78 ± 0.48
3.892LysGly: 3.892 ± 0.516
1.205LysHis: 1.205 ± 0.345
3.892LysIle: 3.892 ± 0.556
3.29LysLys: 3.29 ± 0.516
6.719LysLeu: 6.719 ± 0.64
2.039LysMet: 2.039 ± 0.31
3.058LysAsn: 3.058 ± 0.445
2.734LysPro: 2.734 ± 0.329
3.105LysGln: 3.105 ± 0.479
2.641LysArg: 2.641 ± 0.351
3.753LysSer: 3.753 ± 0.53
3.383LysThr: 3.383 ± 0.344
4.356LysVal: 4.356 ± 0.463
0.417LysTrp: 0.417 ± 0.132
2.595LysTyr: 2.595 ± 0.299
0.0LysXaa: 0.0 ± 0.0
Leu
6.951LeuAla: 6.951 ± 0.733
1.344LeuCys: 1.344 ± 0.328
6.117LeuAsp: 6.117 ± 0.516
4.078LeuGlu: 4.078 ± 0.474
2.827LeuPhe: 2.827 ± 0.347
5.051LeuGly: 5.051 ± 0.545
1.483LeuHis: 1.483 ± 0.283
5.792LeuIle: 5.792 ± 0.622
5.283LeuLys: 5.283 ± 0.548
6.627LeuLeu: 6.627 ± 0.528
2.734LeuMet: 2.734 ± 0.48
6.07LeuAsn: 6.07 ± 0.63
4.171LeuPro: 4.171 ± 0.462
3.336LeuGln: 3.336 ± 0.392
4.68LeuArg: 4.68 ± 0.506
5.653LeuSer: 5.653 ± 0.484
5.561LeuThr: 5.561 ± 0.457
5.561LeuVal: 5.561 ± 0.413
0.741LeuTrp: 0.741 ± 0.25
2.41LeuTyr: 2.41 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
2.41MetAla: 2.41 ± 0.317
0.324MetCys: 0.324 ± 0.113
1.715MetAsp: 1.715 ± 0.313
1.854MetGlu: 1.854 ± 0.295
0.556MetPhe: 0.556 ± 0.151
1.483MetGly: 1.483 ± 0.244
0.556MetHis: 0.556 ± 0.138
1.158MetIle: 1.158 ± 0.244
2.317MetLys: 2.317 ± 0.394
2.317MetLeu: 2.317 ± 0.366
0.788MetMet: 0.788 ± 0.176
1.529MetAsn: 1.529 ± 0.28
1.205MetPro: 1.205 ± 0.204
1.437MetGln: 1.437 ± 0.209
1.251MetArg: 1.251 ± 0.272
2.224MetSer: 2.224 ± 0.31
1.9MetThr: 1.9 ± 0.288
2.178MetVal: 2.178 ± 0.309
0.093MetTrp: 0.093 ± 0.054
0.788MetTyr: 0.788 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
4.217AsnAla: 4.217 ± 0.424
0.51AsnCys: 0.51 ± 0.182
2.363AsnAsp: 2.363 ± 0.282
3.29AsnGlu: 3.29 ± 0.416
1.622AsnPhe: 1.622 ± 0.307
3.753AsnGly: 3.753 ± 0.396
1.297AsnHis: 1.297 ± 0.232
3.058AsnIle: 3.058 ± 0.596
3.475AsnLys: 3.475 ± 0.505
4.402AsnLeu: 4.402 ± 0.374
1.576AsnMet: 1.576 ± 0.26
3.197AsnAsn: 3.197 ± 0.387
3.614AsnPro: 3.614 ± 0.501
3.336AsnGln: 3.336 ± 0.46
2.78AsnArg: 2.78 ± 0.3
3.846AsnSer: 3.846 ± 0.419
3.522AsnThr: 3.522 ± 0.465
3.336AsnVal: 3.336 ± 0.415
0.232AsnTrp: 0.232 ± 0.088
2.178AsnTyr: 2.178 ± 0.282
0.0AsnXaa: 0.0 ± 0.0
Pro
2.688ProAla: 2.688 ± 0.289
0.371ProCys: 0.371 ± 0.158
3.012ProAsp: 3.012 ± 0.432
3.8ProGlu: 3.8 ± 0.443
1.39ProPhe: 1.39 ± 0.27
2.873ProGly: 2.873 ± 0.343
0.463ProHis: 0.463 ± 0.136
2.41ProIle: 2.41 ± 0.309
2.224ProLys: 2.224 ± 0.313
2.41ProLeu: 2.41 ± 0.369
1.205ProMet: 1.205 ± 0.234
2.224ProAsn: 2.224 ± 0.437
1.066ProPro: 1.066 ± 0.26
1.761ProGln: 1.761 ± 0.242
1.158ProArg: 1.158 ± 0.19
2.688ProSer: 2.688 ± 0.322
3.058ProThr: 3.058 ± 0.341
3.012ProVal: 3.012 ± 0.355
0.324ProTrp: 0.324 ± 0.134
0.973ProTyr: 0.973 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
4.124GlnAla: 4.124 ± 0.669
0.232GlnCys: 0.232 ± 0.102
2.132GlnAsp: 2.132 ± 0.465
3.429GlnGlu: 3.429 ± 0.378
1.761GlnPhe: 1.761 ± 0.249
3.012GlnGly: 3.012 ± 0.42
0.602GlnHis: 0.602 ± 0.165
3.383GlnIle: 3.383 ± 0.479
2.641GlnLys: 2.641 ± 0.369
5.097GlnLeu: 5.097 ± 0.535
1.761GlnMet: 1.761 ± 0.292
1.9GlnAsn: 1.9 ± 0.371
1.529GlnPro: 1.529 ± 0.333
2.178GlnGln: 2.178 ± 0.414
2.039GlnArg: 2.039 ± 0.365
2.456GlnSer: 2.456 ± 0.515
3.29GlnThr: 3.29 ± 0.436
2.271GlnVal: 2.271 ± 0.34
0.463GlnTrp: 0.463 ± 0.137
2.224GlnTyr: 2.224 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
3.707ArgAla: 3.707 ± 0.367
0.417ArgCys: 0.417 ± 0.183
2.966ArgAsp: 2.966 ± 0.293
2.549ArgGlu: 2.549 ± 0.456
1.39ArgPhe: 1.39 ± 0.258
2.502ArgGly: 2.502 ± 0.275
0.788ArgHis: 0.788 ± 0.241
3.151ArgIle: 3.151 ± 0.358
2.688ArgLys: 2.688 ± 0.405
4.171ArgLeu: 4.171 ± 0.4
1.39ArgMet: 1.39 ± 0.222
2.502ArgAsn: 2.502 ± 0.385
1.205ArgPro: 1.205 ± 0.271
2.456ArgGln: 2.456 ± 0.425
1.993ArgArg: 1.993 ± 0.256
2.549ArgSer: 2.549 ± 0.34
2.827ArgThr: 2.827 ± 0.368
3.058ArgVal: 3.058 ± 0.382
0.324ArgTrp: 0.324 ± 0.107
1.39ArgTyr: 1.39 ± 0.267
0.0ArgXaa: 0.0 ± 0.0
Ser
5.19SerAla: 5.19 ± 0.548
0.788SerCys: 0.788 ± 0.231
3.568SerAsp: 3.568 ± 0.38
3.939SerGlu: 3.939 ± 0.408
2.039SerPhe: 2.039 ± 0.325
4.263SerGly: 4.263 ± 0.488
0.973SerHis: 0.973 ± 0.187
3.707SerIle: 3.707 ± 0.314
4.078SerLys: 4.078 ± 0.415
5.607SerLeu: 5.607 ± 0.508
1.761SerMet: 1.761 ± 0.338
3.846SerAsn: 3.846 ± 0.52
2.456SerPro: 2.456 ± 0.454
3.058SerGln: 3.058 ± 0.472
2.502SerArg: 2.502 ± 0.31
3.197SerSer: 3.197 ± 0.468
3.383SerThr: 3.383 ± 0.549
4.078SerVal: 4.078 ± 0.483
0.741SerTrp: 0.741 ± 0.197
1.807SerTyr: 1.807 ± 0.286
0.0SerXaa: 0.0 ± 0.0
Thr
3.753ThrAla: 3.753 ± 0.464
0.371ThrCys: 0.371 ± 0.134
3.244ThrAsp: 3.244 ± 0.393
4.124ThrGlu: 4.124 ± 0.622
2.271ThrPhe: 2.271 ± 0.367
4.727ThrGly: 4.727 ± 0.452
0.927ThrHis: 0.927 ± 0.234
3.475ThrIle: 3.475 ± 0.43
4.032ThrLys: 4.032 ± 0.432
4.495ThrLeu: 4.495 ± 0.545
1.112ThrMet: 1.112 ± 0.198
3.197ThrAsn: 3.197 ± 0.379
2.873ThrPro: 2.873 ± 0.431
3.383ThrGln: 3.383 ± 0.596
2.595ThrArg: 2.595 ± 0.319
3.985ThrSer: 3.985 ± 0.415
3.939ThrThr: 3.939 ± 0.525
5.468ThrVal: 5.468 ± 0.47
1.019ThrTrp: 1.019 ± 0.32
2.595ThrTyr: 2.595 ± 0.377
0.0ThrXaa: 0.0 ± 0.0
Val
5.144ValAla: 5.144 ± 0.525
0.463ValCys: 0.463 ± 0.188
4.449ValAsp: 4.449 ± 0.548
4.634ValGlu: 4.634 ± 0.453
2.641ValPhe: 2.641 ± 0.342
4.217ValGly: 4.217 ± 0.385
0.88ValHis: 0.88 ± 0.206
4.356ValIle: 4.356 ± 0.47
4.541ValLys: 4.541 ± 0.414
5.097ValLeu: 5.097 ± 0.451
1.622ValMet: 1.622 ± 0.319
4.171ValAsn: 4.171 ± 0.608
2.734ValPro: 2.734 ± 0.365
2.873ValGln: 2.873 ± 0.268
3.244ValArg: 3.244 ± 0.504
4.402ValSer: 4.402 ± 0.474
4.032ValThr: 4.032 ± 0.445
4.171ValVal: 4.171 ± 0.573
0.741ValTrp: 0.741 ± 0.216
2.688ValTyr: 2.688 ± 0.321
0.0ValXaa: 0.0 ± 0.0
Trp
0.834TrpAla: 0.834 ± 0.195
0.139TrpCys: 0.139 ± 0.086
0.602TrpAsp: 0.602 ± 0.139
0.695TrpGlu: 0.695 ± 0.147
0.834TrpPhe: 0.834 ± 0.204
0.602TrpGly: 0.602 ± 0.143
0.139TrpHis: 0.139 ± 0.083
0.417TrpIle: 0.417 ± 0.139
0.649TrpLys: 0.649 ± 0.227
0.973TrpLeu: 0.973 ± 0.255
0.139TrpMet: 0.139 ± 0.079
0.927TrpAsn: 0.927 ± 0.286
0.324TrpPro: 0.324 ± 0.118
0.417TrpGln: 0.417 ± 0.175
0.324TrpArg: 0.324 ± 0.154
0.417TrpSer: 0.417 ± 0.132
0.602TrpThr: 0.602 ± 0.174
0.927TrpVal: 0.927 ± 0.231
0.0TrpTrp: 0.0 ± 0.0
0.602TrpTyr: 0.602 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.41TyrAla: 2.41 ± 0.356
0.51TyrCys: 0.51 ± 0.186
1.854TyrAsp: 1.854 ± 0.28
2.41TyrGlu: 2.41 ± 0.286
1.854TyrPhe: 1.854 ± 0.322
2.224TyrGly: 2.224 ± 0.353
0.973TyrHis: 0.973 ± 0.214
2.734TyrIle: 2.734 ± 0.418
2.039TyrLys: 2.039 ± 0.352
3.475TyrLeu: 3.475 ± 0.483
1.251TyrMet: 1.251 ± 0.3
1.622TyrAsn: 1.622 ± 0.271
1.437TyrPro: 1.437 ± 0.369
1.9TyrGln: 1.9 ± 0.334
1.529TyrArg: 1.529 ± 0.241
2.41TyrSer: 2.41 ± 0.272
1.9TyrThr: 1.9 ± 0.253
2.734TyrVal: 2.734 ± 0.391
0.649TyrTrp: 0.649 ± 0.176
1.483TyrTyr: 1.483 ± 0.286
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (21581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski