Amino acid dipepetide frequency for Cryobacterium mesophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.913AlaAla: 17.913 ± 0.18	0.641AlaCys: 0.641 ± 0.029	7.474AlaAsp: 7.474 ± 0.124	7.392AlaGlu: 7.392 ± 0.12	3.91AlaPhe: 3.91 ± 0.084	11.543AlaGly: 11.543 ± 0.136	2.268AlaHis: 2.268 ± 0.049	6.919AlaIle: 6.919 ± 0.103	3.416AlaLys: 3.416 ± 0.083	12.985AlaLeu: 12.985 ± 0.147	2.773AlaMet: 2.773 ± 0.062	2.722AlaAsn: 2.722 ± 0.059	5.459AlaPro: 5.459 ± 0.118	3.387AlaGln: 3.387 ± 0.071	8.399AlaArg: 8.399 ± 0.116	7.641AlaSer: 7.641 ± 0.104	7.203AlaThr: 7.203 ± 0.11	10.565AlaVal: 10.565 ± 0.151	1.67AlaTrp: 1.67 ± 0.053	2.007AlaTyr: 2.007 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.612CysAla: 0.612 ± 0.029	0.047CysCys: 0.047 ± 0.009	0.31CysAsp: 0.31 ± 0.02	0.23CysGlu: 0.23 ± 0.019	0.192CysPhe: 0.192 ± 0.017	0.557CysGly: 0.557 ± 0.031	0.124CysHis: 0.124 ± 0.011	0.233CysIle: 0.233 ± 0.018	0.071CysLys: 0.071 ± 0.009	0.52CysLeu: 0.52 ± 0.028	0.073CysMet: 0.073 ± 0.01	0.108CysAsn: 0.108 ± 0.011	0.285CysPro: 0.285 ± 0.021	0.119CysGln: 0.119 ± 0.012	0.301CysArg: 0.301 ± 0.02	0.38CysSer: 0.38 ± 0.023	0.338CysThr: 0.338 ± 0.024	0.422CysVal: 0.422 ± 0.024	0.072CysTrp: 0.072 ± 0.01	0.112CysTyr: 0.112 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.42AspAla: 8.42 ± 0.117	0.247AspCys: 0.247 ± 0.02	3.882AspAsp: 3.882 ± 0.087	3.946AspGlu: 3.946 ± 0.08	2.075AspPhe: 2.075 ± 0.054	5.83AspGly: 5.83 ± 0.103	1.217AspHis: 1.217 ± 0.039	2.85AspIle: 2.85 ± 0.063	1.207AspLys: 1.207 ± 0.05	6.065AspLeu: 6.065 ± 0.096	0.738AspMet: 0.738 ± 0.031	1.165AspAsn: 1.165 ± 0.043	3.819AspPro: 3.819 ± 0.081	1.506AspGln: 1.506 ± 0.043	4.308AspArg: 4.308 ± 0.086	3.235AspSer: 3.235 ± 0.065	2.955AspThr: 2.955 ± 0.065	5.183AspVal: 5.183 ± 0.095	0.986AspTrp: 0.986 ± 0.04	1.399AspTyr: 1.399 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.26GluAla: 6.26 ± 0.101	0.274GluCys: 0.274 ± 0.02	2.628GluAsp: 2.628 ± 0.062	2.901GluGlu: 2.901 ± 0.079	2.075GluPhe: 2.075 ± 0.056	3.605GluGly: 3.605 ± 0.082	1.435GluHis: 1.435 ± 0.049	2.567GluIle: 2.567 ± 0.067	1.642GluLys: 1.642 ± 0.055	7.231GluLeu: 7.231 ± 0.135	0.802GluMet: 0.802 ± 0.034	1.38GluAsn: 1.38 ± 0.046	2.934GluPro: 2.934 ± 0.059	2.006GluGln: 2.006 ± 0.057	4.748GluArg: 4.748 ± 0.094	3.393GluSer: 3.393 ± 0.069	2.767GluThr: 2.767 ± 0.066	4.462GluVal: 4.462 ± 0.093	0.842GluTrp: 0.842 ± 0.036	1.152GluTyr: 1.152 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.26PheAla: 4.26 ± 0.081	0.198PheCys: 0.198 ± 0.017	2.485PheAsp: 2.485 ± 0.06	1.876PheGlu: 1.876 ± 0.055	1.108PhePhe: 1.108 ± 0.045	3.754PheGly: 3.754 ± 0.087	0.611PheHis: 0.611 ± 0.025	1.419PheIle: 1.419 ± 0.047	0.567PheLys: 0.567 ± 0.029	3.025PheLeu: 3.025 ± 0.075	0.517PheMet: 0.517 ± 0.024	0.81PheAsn: 0.81 ± 0.035	1.461PhePro: 1.461 ± 0.043	0.831PheGln: 0.831 ± 0.033	1.902PheArg: 1.902 ± 0.051	1.992PheSer: 1.992 ± 0.05	2.198PheThr: 2.198 ± 0.06	2.925PheVal: 2.925 ± 0.068	0.493PheTrp: 0.493 ± 0.026	0.726PheTyr: 0.726 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.868GlyAla: 9.868 ± 0.123	0.553GlyCys: 0.553 ± 0.03	5.002GlyAsp: 5.002 ± 0.085	4.741GlyGlu: 4.741 ± 0.08	3.359GlyPhe: 3.359 ± 0.062	7.744GlyGly: 7.744 ± 0.128	1.914GlyHis: 1.914 ± 0.058	5.501GlyIle: 5.501 ± 0.092	2.487GlyLys: 2.487 ± 0.065	8.949GlyLeu: 8.949 ± 0.133	2.118GlyMet: 2.118 ± 0.059	1.919GlyAsn: 1.919 ± 0.054	3.728GlyPro: 3.728 ± 0.065	2.479GlyGln: 2.479 ± 0.058	5.934GlyArg: 5.934 ± 0.107	5.836GlySer: 5.836 ± 0.099	5.616GlyThr: 5.616 ± 0.096	7.668GlyVal: 7.668 ± 0.095	1.61GlyTrp: 1.61 ± 0.054	2.293GlyTyr: 2.293 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.186HisAla: 2.186 ± 0.057	0.12HisCys: 0.12 ± 0.013	1.221HisAsp: 1.221 ± 0.04	1.112HisGlu: 1.112 ± 0.042	0.612HisPhe: 0.612 ± 0.028	1.936HisGly: 1.936 ± 0.055	0.593HisHis: 0.593 ± 0.033	0.841HisIle: 0.841 ± 0.031	0.318HisLys: 0.318 ± 0.02	1.903HisLeu: 1.903 ± 0.048	0.303HisMet: 0.303 ± 0.021	0.438HisAsn: 0.438 ± 0.022	1.531HisPro: 1.531 ± 0.049	0.465HisGln: 0.465 ± 0.028	1.592HisArg: 1.592 ± 0.048	1.189HisSer: 1.189 ± 0.043	0.996HisThr: 0.996 ± 0.041	1.499HisVal: 1.499 ± 0.049	0.301HisTrp: 0.301 ± 0.021	0.476HisTyr: 0.476 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.256IleAla: 7.256 ± 0.121	0.233IleCys: 0.233 ± 0.018	3.738IleAsp: 3.738 ± 0.07	3.096IleGlu: 3.096 ± 0.066	1.414IlePhe: 1.414 ± 0.047	4.964IleGly: 4.964 ± 0.095	0.855IleHis: 0.855 ± 0.034	2.217IleIle: 2.217 ± 0.064	0.953IleLys: 0.953 ± 0.039	4.856IleLeu: 4.856 ± 0.095	0.76IleMet: 0.76 ± 0.038	1.074IleAsn: 1.074 ± 0.043	2.846IlePro: 2.846 ± 0.068	1.179IleGln: 1.179 ± 0.045	3.322IleArg: 3.322 ± 0.076	2.663IleSer: 2.663 ± 0.063	3.083IleThr: 3.083 ± 0.07	5.201IleVal: 5.201 ± 0.097	0.497IleTrp: 0.497 ± 0.027	0.859IleTyr: 0.859 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	2.946LysAla: 2.946 ± 0.076	0.08LysCys: 0.08 ± 0.012	1.501LysAsp: 1.501 ± 0.046	1.192LysGlu: 1.192 ± 0.049	0.661LysPhe: 0.661 ± 0.031	1.986LysGly: 1.986 ± 0.053	0.478LysHis: 0.478 ± 0.025	1.058LysIle: 1.058 ± 0.045	1.006LysLys: 1.006 ± 0.047	2.371LysLeu: 2.371 ± 0.056	0.446LysMet: 0.446 ± 0.024	0.728LysAsn: 0.728 ± 0.038	1.427LysPro: 1.427 ± 0.049	0.736LysGln: 0.736 ± 0.032	1.772LysArg: 1.772 ± 0.054	1.553LysSer: 1.553 ± 0.05	1.537LysThr: 1.537 ± 0.049	2.042LysVal: 2.042 ± 0.058	0.31LysTrp: 0.31 ± 0.021	0.577LysTyr: 0.577 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.706LeuAla: 14.706 ± 0.18	0.584LeuCys: 0.584 ± 0.03	6.768LeuAsp: 6.768 ± 0.125	5.627LeuGlu: 5.627 ± 0.09	3.007LeuPhe: 3.007 ± 0.075	9.526LeuGly: 9.526 ± 0.131	1.885LeuHis: 1.885 ± 0.053	4.685LeuIle: 4.685 ± 0.089	2.246LeuLys: 2.246 ± 0.061	10.193LeuLeu: 10.193 ± 0.151	1.65LeuMet: 1.65 ± 0.049	2.134LeuAsn: 2.134 ± 0.055	5.35LeuPro: 5.35 ± 0.074	2.508LeuGln: 2.508 ± 0.059	6.808LeuArg: 6.808 ± 0.108	6.218LeuSer: 6.218 ± 0.108	6.012LeuThr: 6.012 ± 0.087	9.597LeuVal: 9.597 ± 0.128	1.241LeuTrp: 1.241 ± 0.049	1.783LeuTyr: 1.783 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.282MetAla: 2.282 ± 0.059	0.096MetCys: 0.096 ± 0.011	0.866MetAsp: 0.866 ± 0.036	0.682MetGlu: 0.682 ± 0.031	0.553MetPhe: 0.553 ± 0.028	1.319MetGly: 1.319 ± 0.047	0.297MetHis: 0.297 ± 0.022	0.978MetIle: 0.978 ± 0.037	0.494MetLys: 0.494 ± 0.029	1.96MetLeu: 1.96 ± 0.055	0.31MetMet: 0.31 ± 0.024	0.553MetAsn: 0.553 ± 0.03	1.213MetPro: 1.213 ± 0.039	0.516MetGln: 0.516 ± 0.026	1.291MetArg: 1.291 ± 0.041	1.483MetSer: 1.483 ± 0.043	1.725MetThr: 1.725 ± 0.045	1.511MetVal: 1.511 ± 0.048	0.19MetTrp: 0.19 ± 0.016	0.27MetTyr: 0.27 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.647AsnAla: 2.647 ± 0.062	0.156AsnCys: 0.156 ± 0.014	1.32AsnAsp: 1.32 ± 0.046	1.096AsnGlu: 1.096 ± 0.04	0.772AsnPhe: 0.772 ± 0.035	2.197AsnGly: 2.197 ± 0.053	0.41AsnHis: 0.41 ± 0.021	1.012AsnIle: 1.012 ± 0.037	0.501AsnLys: 0.501 ± 0.03	2.336AsnLeu: 2.336 ± 0.057	0.334AsnMet: 0.334 ± 0.019	0.563AsnAsn: 0.563 ± 0.03	1.781AsnPro: 1.781 ± 0.052	0.702AsnGln: 0.702 ± 0.032	1.521AsnArg: 1.521 ± 0.044	1.277AsnSer: 1.277 ± 0.04	1.267AsnThr: 1.267 ± 0.041	1.803AsnVal: 1.803 ± 0.054	0.377AsnTrp: 0.377 ± 0.023	0.605AsnTyr: 0.605 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.345ProAla: 6.345 ± 0.129	0.196ProCys: 0.196 ± 0.015	3.925ProAsp: 3.925 ± 0.076	3.395ProGlu: 3.395 ± 0.066	1.63ProPhe: 1.63 ± 0.044	4.908ProGly: 4.908 ± 0.089	1.054ProHis: 1.054 ± 0.039	2.532ProIle: 2.532 ± 0.056	1.336ProLys: 1.336 ± 0.045	4.693ProLeu: 4.693 ± 0.068	0.975ProMet: 0.975 ± 0.036	1.156ProAsn: 1.156 ± 0.041	2.322ProPro: 2.322 ± 0.073	1.438ProGln: 1.438 ± 0.047	3.021ProArg: 3.021 ± 0.067	3.279ProSer: 3.279 ± 0.068	3.163ProThr: 3.163 ± 0.078	4.725ProVal: 4.725 ± 0.089	0.795ProTrp: 0.795 ± 0.032	1.028ProTyr: 1.028 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.102GlnAla: 3.102 ± 0.062	0.112GlnCys: 0.112 ± 0.011	1.368GlnAsp: 1.368 ± 0.043	1.31GlnGlu: 1.31 ± 0.044	0.941GlnPhe: 0.941 ± 0.038	1.881GlnGly: 1.881 ± 0.05	0.589GlnHis: 0.589 ± 0.03	1.264GlnIle: 1.264 ± 0.044	0.881GlnLys: 0.881 ± 0.039	3.375GlnLeu: 3.375 ± 0.059	0.47GlnMet: 0.47 ± 0.024	0.738GlnAsn: 0.738 ± 0.034	1.348GlnPro: 1.348 ± 0.046	1.076GlnGln: 1.076 ± 0.045	2.201GlnArg: 2.201 ± 0.06	1.624GlnSer: 1.624 ± 0.049	1.323GlnThr: 1.323 ± 0.043	2.444GlnVal: 2.444 ± 0.059	0.43GlnTrp: 0.43 ± 0.025	0.682GlnTyr: 0.682 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.765ArgAla: 7.765 ± 0.113	0.266ArgCys: 0.266 ± 0.019	4.029ArgAsp: 4.029 ± 0.085	4.207ArgGlu: 4.207 ± 0.084	2.504ArgPhe: 2.504 ± 0.059	5.034ArgGly: 5.034 ± 0.09	1.485ArgHis: 1.485 ± 0.04	3.814ArgIle: 3.814 ± 0.083	1.708ArgLys: 1.708 ± 0.049	6.973ArgLeu: 6.973 ± 0.115	1.902ArgMet: 1.902 ± 0.05	1.608ArgAsn: 1.608 ± 0.043	3.128ArgPro: 3.128 ± 0.076	1.971ArgGln: 1.971 ± 0.053	5.721ArgArg: 5.721 ± 0.112	4.28ArgSer: 4.28 ± 0.084	3.822ArgThr: 3.822 ± 0.068	5.631ArgVal: 5.631 ± 0.092	1.04ArgTrp: 1.04 ± 0.039	1.608ArgTyr: 1.608 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	7.547SerAla: 7.547 ± 0.112	0.339SerCys: 0.339 ± 0.024	3.53SerAsp: 3.53 ± 0.063	2.968SerGlu: 2.968 ± 0.066	2.046SerPhe: 2.046 ± 0.058	6.516SerGly: 6.516 ± 0.106	1.038SerHis: 1.038 ± 0.04	3.279SerIle: 3.279 ± 0.076	1.372SerLys: 1.372 ± 0.047	5.842SerLeu: 5.842 ± 0.096	1.267SerMet: 1.267 ± 0.043	1.342SerAsn: 1.342 ± 0.046	3.307SerPro: 3.307 ± 0.069	1.575SerGln: 1.575 ± 0.047	4.056SerArg: 4.056 ± 0.078	3.974SerSer: 3.974 ± 0.074	3.975SerThr: 3.975 ± 0.086	5.165SerVal: 5.165 ± 0.08	0.927SerTrp: 0.927 ± 0.032	1.204SerTyr: 1.204 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.223ThrAla: 7.223 ± 0.093	0.253ThrCys: 0.253 ± 0.019	3.39ThrAsp: 3.39 ± 0.067	2.964ThrGlu: 2.964 ± 0.063	1.865ThrPhe: 1.865 ± 0.059	5.795ThrGly: 5.795 ± 0.091	1.094ThrHis: 1.094 ± 0.043	3.434ThrIle: 3.434 ± 0.085	1.431ThrLys: 1.431 ± 0.047	5.838ThrLeu: 5.838 ± 0.092	1.116ThrMet: 1.116 ± 0.039	1.336ThrAsn: 1.336 ± 0.052	3.625ThrPro: 3.625 ± 0.068	1.378ThrGln: 1.378 ± 0.049	3.533ThrArg: 3.533 ± 0.073	3.671ThrSer: 3.671 ± 0.079	3.836ThrThr: 3.836 ± 0.082	5.872ThrVal: 5.872 ± 0.098	0.863ThrTrp: 0.863 ± 0.041	1.168ThrTyr: 1.168 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	11.377ValAla: 11.377 ± 0.145	0.488ValCys: 0.488 ± 0.025	5.628ValAsp: 5.628 ± 0.087	4.677ValGlu: 4.677 ± 0.093	3.024ValPhe: 3.024 ± 0.063	7.288ValGly: 7.288 ± 0.105	1.617ValHis: 1.617 ± 0.045	4.868ValIle: 4.868 ± 0.094	1.952ValLys: 1.952 ± 0.058	9.194ValLeu: 9.194 ± 0.131	1.469ValMet: 1.469 ± 0.048	1.974ValAsn: 1.974 ± 0.052	4.514ValPro: 4.514 ± 0.087	2.069ValGln: 2.069 ± 0.054	5.33ValArg: 5.33 ± 0.102	5.334ValSer: 5.334 ± 0.084	5.91ValThr: 5.91 ± 0.113	8.533ValVal: 8.533 ± 0.122	1.077ValTrp: 1.077 ± 0.038	1.547ValTyr: 1.547 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.49TrpAla: 1.49 ± 0.049	0.095TrpCys: 0.095 ± 0.01	0.691TrpAsp: 0.691 ± 0.031	0.625TrpGlu: 0.625 ± 0.031	0.609TrpPhe: 0.609 ± 0.031	1.034TrpGly: 1.034 ± 0.045	0.313TrpHis: 0.313 ± 0.024	0.799TrpIle: 0.799 ± 0.033	0.382TrpLys: 0.382 ± 0.022	1.751TrpLeu: 1.751 ± 0.054	0.346TrpMet: 0.346 ± 0.021	0.477TrpAsn: 0.477 ± 0.025	0.73TrpPro: 0.73 ± 0.033	0.536TrpGln: 0.536 ± 0.028	1.068TrpArg: 1.068 ± 0.049	0.918TrpSer: 0.918 ± 0.037	0.819TrpThr: 0.819 ± 0.033	1.106TrpVal: 1.106 ± 0.036	0.378TrpTrp: 0.378 ± 0.024	0.27TrpTyr: 0.27 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.079TyrAla: 2.079 ± 0.051	0.127TyrCys: 0.127 ± 0.013	1.277TyrAsp: 1.277 ± 0.048	1.069TyrGlu: 1.069 ± 0.036	0.798TyrPhe: 0.798 ± 0.03	1.902TyrGly: 1.902 ± 0.055	0.354TyrHis: 0.354 ± 0.025	0.795TyrIle: 0.795 ± 0.037	0.438TyrLys: 0.438 ± 0.026	2.471TyrLeu: 2.471 ± 0.064	0.219TyrMet: 0.219 ± 0.017	0.452TyrAsn: 0.452 ± 0.031	1.108TyrPro: 1.108 ± 0.042	0.683TyrGln: 0.683 ± 0.033	1.666TyrArg: 1.666 ± 0.051	1.331TyrSer: 1.331 ± 0.043	1.143TyrThr: 1.143 ± 0.05	1.517TyrVal: 1.517 ± 0.041	0.337TyrTrp: 0.337 ± 0.023	0.489TyrTyr: 0.489 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2302 proteins (748348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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