Amino acid dipepetide frequency for Marinobacter similis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.991AlaAla: 9.991 ± 0.15
0.997AlaCys: 0.997 ± 0.039
5.711AlaAsp: 5.711 ± 0.089
6.714AlaGlu: 6.714 ± 0.105
3.656AlaPhe: 3.656 ± 0.08
8.413AlaGly: 8.413 ± 0.137
1.783AlaHis: 1.783 ± 0.048
5.247AlaIle: 5.247 ± 0.093
3.303AlaLys: 3.303 ± 0.068
11.177AlaLeu: 11.177 ± 0.146
2.989AlaMet: 2.989 ± 0.062
3.083AlaAsn: 3.083 ± 0.075
4.026AlaPro: 4.026 ± 0.088
3.745AlaGln: 3.745 ± 0.074
6.103AlaArg: 6.103 ± 0.096
6.155AlaSer: 6.155 ± 0.104
4.743AlaThr: 4.743 ± 0.077
7.231AlaVal: 7.231 ± 0.125
1.357AlaTrp: 1.357 ± 0.042
2.188AlaTyr: 2.188 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.829CysAla: 0.829 ± 0.038
0.136CysCys: 0.136 ± 0.013
0.56CysAsp: 0.56 ± 0.029
0.583CysGlu: 0.583 ± 0.032
0.342CysPhe: 0.342 ± 0.022
0.919CysGly: 0.919 ± 0.044
0.264CysHis: 0.264 ± 0.021
0.397CysIle: 0.397 ± 0.022
0.268CysLys: 0.268 ± 0.021
0.946CysLeu: 0.946 ± 0.039
0.215CysMet: 0.215 ± 0.019
0.258CysAsn: 0.258 ± 0.02
0.524CysPro: 0.524 ± 0.033
0.402CysGln: 0.402 ± 0.022
0.628CysArg: 0.628 ± 0.033
0.617CysSer: 0.617 ± 0.029
0.417CysThr: 0.417 ± 0.025
0.607CysVal: 0.607 ± 0.028
0.136CysTrp: 0.136 ± 0.013
0.224CysTyr: 0.224 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.262AspAla: 5.262 ± 0.102
0.481AspCys: 0.481 ± 0.026
3.694AspAsp: 3.694 ± 0.08
4.053AspGlu: 4.053 ± 0.077
2.223AspPhe: 2.223 ± 0.057
4.519AspGly: 4.519 ± 0.078
1.231AspHis: 1.231 ± 0.044
3.217AspIle: 3.217 ± 0.071
1.948AspLys: 1.948 ± 0.052
5.858AspLeu: 5.858 ± 0.109
1.432AspMet: 1.432 ± 0.047
2.027AspAsn: 2.027 ± 0.065
2.681AspPro: 2.681 ± 0.062
2.636AspGln: 2.636 ± 0.059
3.779AspArg: 3.779 ± 0.073
3.44AspSer: 3.44 ± 0.088
2.98AspThr: 2.98 ± 0.075
4.152AspVal: 4.152 ± 0.082
0.933AspTrp: 0.933 ± 0.036
1.867AspTyr: 1.867 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
6.62GluAla: 6.62 ± 0.108
0.488GluCys: 0.488 ± 0.024
3.344GluAsp: 3.344 ± 0.076
4.107GluGlu: 4.107 ± 0.089
2.289GluPhe: 2.289 ± 0.052
4.379GluGly: 4.379 ± 0.093
1.628GluHis: 1.628 ± 0.053
3.378GluIle: 3.378 ± 0.077
2.794GluLys: 2.794 ± 0.072
7.195GluLeu: 7.195 ± 0.102
1.599GluMet: 1.599 ± 0.05
2.223GluAsn: 2.223 ± 0.058
2.995GluPro: 2.995 ± 0.089
3.643GluGln: 3.643 ± 0.076
4.618GluArg: 4.618 ± 0.096
3.829GluSer: 3.829 ± 0.076
3.565GluThr: 3.565 ± 0.066
4.449GluVal: 4.449 ± 0.09
0.784GluTrp: 0.784 ± 0.035
1.546GluTyr: 1.546 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.478PheAla: 3.478 ± 0.079
0.397PheCys: 0.397 ± 0.023
2.458PheAsp: 2.458 ± 0.066
2.461PheGlu: 2.461 ± 0.068
1.625PhePhe: 1.625 ± 0.05
3.273PheGly: 3.273 ± 0.085
0.784PheHis: 0.784 ± 0.035
1.856PheIle: 1.856 ± 0.055
1.209PheLys: 1.209 ± 0.04
3.64PheLeu: 3.64 ± 0.086
0.98PheMet: 0.98 ± 0.037
1.417PheAsn: 1.417 ± 0.042
1.512PhePro: 1.512 ± 0.041
1.342PheGln: 1.342 ± 0.042
2.364PheArg: 2.364 ± 0.064
2.739PheSer: 2.739 ± 0.062
2.103PheThr: 2.103 ± 0.057
2.881PheVal: 2.881 ± 0.068
0.561PheTrp: 0.561 ± 0.035
1.105PheTyr: 1.105 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
6.746GlyAla: 6.746 ± 0.104
0.912GlyCys: 0.912 ± 0.032
4.364GlyAsp: 4.364 ± 0.092
5.035GlyGlu: 5.035 ± 0.093
3.463GlyPhe: 3.463 ± 0.077
5.875GlyGly: 5.875 ± 0.132
1.764GlyHis: 1.764 ± 0.053
4.458GlyIle: 4.458 ± 0.079
3.27GlyLys: 3.27 ± 0.077
8.207GlyLeu: 8.207 ± 0.116
2.289GlyMet: 2.289 ± 0.066
2.5GlyAsn: 2.5 ± 0.062
2.446GlyPro: 2.446 ± 0.063
3.412GlyGln: 3.412 ± 0.076
4.588GlyArg: 4.588 ± 0.082
4.622GlySer: 4.622 ± 0.085
4.012GlyThr: 4.012 ± 0.096
5.794GlyVal: 5.794 ± 0.107
1.19GlyTrp: 1.19 ± 0.043
2.431GlyTyr: 2.431 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.727HisAla: 1.727 ± 0.049
0.298HisCys: 0.298 ± 0.021
1.098HisAsp: 1.098 ± 0.045
1.243HisGlu: 1.243 ± 0.039
0.893HisPhe: 0.893 ± 0.033
1.746HisGly: 1.746 ± 0.051
0.674HisHis: 0.674 ± 0.033
1.027HisIle: 1.027 ± 0.038
0.739HisLys: 0.739 ± 0.036
2.217HisLeu: 2.217 ± 0.053
0.51HisMet: 0.51 ± 0.023
0.66HisAsn: 0.66 ± 0.034
1.258HisPro: 1.258 ± 0.041
0.995HisGln: 0.995 ± 0.04
1.535HisArg: 1.535 ± 0.047
1.322HisSer: 1.322 ± 0.045
1.037HisThr: 1.037 ± 0.04
1.273HisVal: 1.273 ± 0.036
0.359HisTrp: 0.359 ± 0.02
0.757HisTyr: 0.757 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.587IleAla: 5.587 ± 0.089
0.5IleCys: 0.5 ± 0.027
3.298IleAsp: 3.298 ± 0.077
3.496IleGlu: 3.496 ± 0.075
1.707IlePhe: 1.707 ± 0.063
4.381IleGly: 4.381 ± 0.081
1.052IleHis: 1.052 ± 0.034
2.429IleIle: 2.429 ± 0.068
1.878IleLys: 1.878 ± 0.047
4.765IleLeu: 4.765 ± 0.091
1.111IleMet: 1.111 ± 0.043
1.98IleAsn: 1.98 ± 0.052
2.444IlePro: 2.444 ± 0.064
1.853IleGln: 1.853 ± 0.052
3.47IleArg: 3.47 ± 0.069
3.29IleSer: 3.29 ± 0.07
2.982IleThr: 2.982 ± 0.069
3.592IleVal: 3.592 ± 0.082
0.571IleTrp: 0.571 ± 0.031
1.196IleTyr: 1.196 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
3.981LysAla: 3.981 ± 0.077
0.188LysCys: 0.188 ± 0.018
2.111LysAsp: 2.111 ± 0.065
2.16LysGlu: 2.16 ± 0.056
1.007LysPhe: 1.007 ± 0.034
2.603LysGly: 2.603 ± 0.062
0.789LysHis: 0.789 ± 0.036
1.779LysIle: 1.779 ± 0.057
1.791LysLys: 1.791 ± 0.054
3.843LysLeu: 3.843 ± 0.065
0.906LysMet: 0.906 ± 0.038
1.144LysAsn: 1.144 ± 0.042
2.109LysPro: 2.109 ± 0.06
1.639LysGln: 1.639 ± 0.047
2.387LysArg: 2.387 ± 0.062
2.143LysSer: 2.143 ± 0.058
2.177LysThr: 2.177 ± 0.064
2.829LysVal: 2.829 ± 0.073
0.389LysTrp: 0.389 ± 0.019
0.77LysTyr: 0.77 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
11.922LeuAla: 11.922 ± 0.164
0.974LeuCys: 0.974 ± 0.039
6.211LeuAsp: 6.211 ± 0.099
6.837LeuGlu: 6.837 ± 0.109
3.984LeuPhe: 3.984 ± 0.082
7.748LeuGly: 7.748 ± 0.124
2.025LeuHis: 2.025 ± 0.052
5.545LeuIle: 5.545 ± 0.089
4.329LeuLys: 4.329 ± 0.077
10.678LeuLeu: 10.678 ± 0.169
2.76LeuMet: 2.76 ± 0.063
3.689LeuAsn: 3.689 ± 0.082
5.241LeuPro: 5.241 ± 0.089
3.696LeuGln: 3.696 ± 0.067
6.22LeuArg: 6.22 ± 0.103
7.056LeuSer: 7.056 ± 0.1
6.006LeuThr: 6.006 ± 0.101
7.758LeuVal: 7.758 ± 0.111
1.262LeuTrp: 1.262 ± 0.046
2.318LeuTyr: 2.318 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
3.135MetAla: 3.135 ± 0.063
0.19MetCys: 0.19 ± 0.014
1.355MetAsp: 1.355 ± 0.035
1.489MetGlu: 1.489 ± 0.047
0.734MetPhe: 0.734 ± 0.033
1.88MetGly: 1.88 ± 0.056
0.476MetHis: 0.476 ± 0.024
1.321MetIle: 1.321 ± 0.044
1.205MetLys: 1.205 ± 0.046
2.696MetLeu: 2.696 ± 0.062
0.73MetMet: 0.73 ± 0.035
0.977MetAsn: 0.977 ± 0.041
1.318MetPro: 1.318 ± 0.045
0.942MetGln: 0.942 ± 0.034
1.399MetArg: 1.399 ± 0.04
1.833MetSer: 1.833 ± 0.05
1.708MetThr: 1.708 ± 0.046
1.828MetVal: 1.828 ± 0.05
0.168MetTrp: 0.168 ± 0.013
0.452MetTyr: 0.452 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.171AsnAla: 3.171 ± 0.076
0.318AsnCys: 0.318 ± 0.019
1.874AsnAsp: 1.874 ± 0.053
2.005AsnGlu: 2.005 ± 0.055
1.14AsnPhe: 1.14 ± 0.039
2.575AsnGly: 2.575 ± 0.077
0.746AsnHis: 0.746 ± 0.028
1.677AsnIle: 1.677 ± 0.052
1.026AsnLys: 1.026 ± 0.038
3.59AsnLeu: 3.59 ± 0.063
0.757AsnMet: 0.757 ± 0.03
1.128AsnAsn: 1.128 ± 0.046
2.094AsnPro: 2.094 ± 0.055
1.466AsnGln: 1.466 ± 0.05
2.432AsnArg: 2.432 ± 0.053
1.838AsnSer: 1.838 ± 0.064
1.734AsnThr: 1.734 ± 0.047
2.152AsnVal: 2.152 ± 0.065
0.51AsnTrp: 0.51 ± 0.026
0.895AsnTyr: 0.895 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.598ProAla: 4.598 ± 0.098
0.333ProCys: 0.333 ± 0.026
3.469ProAsp: 3.469 ± 0.076
4.348ProGlu: 4.348 ± 0.086
1.754ProPhe: 1.754 ± 0.048
3.951ProGly: 3.951 ± 0.081
0.921ProHis: 0.921 ± 0.04
2.101ProIle: 2.101 ± 0.056
1.66ProLys: 1.66 ± 0.057
4.521ProLeu: 4.521 ± 0.082
1.148ProMet: 1.148 ± 0.043
1.322ProAsn: 1.322 ± 0.045
1.741ProPro: 1.741 ± 0.057
1.62ProGln: 1.62 ± 0.048
2.189ProArg: 2.189 ± 0.054
2.599ProSer: 2.599 ± 0.064
2.072ProThr: 2.072 ± 0.057
4.124ProVal: 4.124 ± 0.081
0.668ProTrp: 0.668 ± 0.029
1.034ProTyr: 1.034 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.482GlnAla: 4.482 ± 0.086
0.353GlnCys: 0.353 ± 0.023
2.037GlnAsp: 2.037 ± 0.046
2.314GlnGlu: 2.314 ± 0.058
1.45GlnPhe: 1.45 ± 0.048
2.942GlnGly: 2.942 ± 0.057
0.996GlnHis: 0.996 ± 0.032
2.02GlnIle: 2.02 ± 0.058
1.558GlnLys: 1.558 ± 0.048
4.489GlnLeu: 4.489 ± 0.089
1.08GlnMet: 1.08 ± 0.041
1.215GlnAsn: 1.215 ± 0.043
2.111GlnPro: 2.111 ± 0.052
2.258GlnGln: 2.258 ± 0.064
2.871GlnArg: 2.871 ± 0.068
2.48GlnSer: 2.48 ± 0.061
2.033GlnThr: 2.033 ± 0.053
3.208GlnVal: 3.208 ± 0.069
0.635GlnTrp: 0.635 ± 0.029
0.933GlnTyr: 0.933 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
5.375ArgAla: 5.375 ± 0.094
0.614ArgCys: 0.614 ± 0.034
3.53ArgAsp: 3.53 ± 0.075
4.341ArgGlu: 4.341 ± 0.076
2.766ArgPhe: 2.766 ± 0.059
3.741ArgGly: 3.741 ± 0.081
1.571ArgHis: 1.571 ± 0.047
3.568ArgIle: 3.568 ± 0.066
2.711ArgLys: 2.711 ± 0.067
7.103ArgLeu: 7.103 ± 0.117
1.755ArgMet: 1.755 ± 0.054
2.148ArgAsn: 2.148 ± 0.057
2.599ArgPro: 2.599 ± 0.062
3.022ArgGln: 3.022 ± 0.071
4.241ArgArg: 4.241 ± 0.087
3.482ArgSer: 3.482 ± 0.076
3.045ArgThr: 3.045 ± 0.065
4.597ArgVal: 4.597 ± 0.077
0.966ArgTrp: 0.966 ± 0.038
2.014ArgTyr: 2.014 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
6.059SerAla: 6.059 ± 0.089
0.495SerCys: 0.495 ± 0.027
3.709SerAsp: 3.709 ± 0.079
4.148SerGlu: 4.148 ± 0.073
2.506SerPhe: 2.506 ± 0.062
5.627SerGly: 5.627 ± 0.102
1.337SerHis: 1.337 ± 0.041
2.947SerIle: 2.947 ± 0.073
2.026SerLys: 2.026 ± 0.052
6.669SerLeu: 6.669 ± 0.103
1.534SerMet: 1.534 ± 0.048
2.027SerAsn: 2.027 ± 0.06
2.761SerPro: 2.761 ± 0.073
2.501SerGln: 2.501 ± 0.066
3.902SerArg: 3.902 ± 0.076
3.955SerSer: 3.955 ± 0.086
2.853SerThr: 2.853 ± 0.054
4.643SerVal: 4.643 ± 0.085
0.832SerTrp: 0.832 ± 0.036
1.446SerTyr: 1.446 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
5.098ThrAla: 5.098 ± 0.101
0.465ThrCys: 0.465 ± 0.029
3.042ThrAsp: 3.042 ± 0.072
3.334ThrGlu: 3.334 ± 0.075
1.917ThrPhe: 1.917 ± 0.055
4.803ThrGly: 4.803 ± 0.099
1.024ThrHis: 1.024 ± 0.042
2.626ThrIle: 2.626 ± 0.067
1.334ThrLys: 1.334 ± 0.044
6.284ThrLeu: 6.284 ± 0.1
1.149ThrMet: 1.149 ± 0.042
1.598ThrAsn: 1.598 ± 0.048
2.966ThrPro: 2.966 ± 0.073
1.716ThrGln: 1.716 ± 0.048
3.069ThrArg: 3.069 ± 0.066
3.203ThrSer: 3.203 ± 0.071
2.709ThrThr: 2.709 ± 0.064
4.215ThrVal: 4.215 ± 0.097
0.628ThrTrp: 0.628 ± 0.032
1.239ThrTyr: 1.239 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
7.457ValAla: 7.457 ± 0.108
0.681ValCys: 0.681 ± 0.032
4.45ValAsp: 4.45 ± 0.075
4.641ValGlu: 4.641 ± 0.085
3.038ValPhe: 3.038 ± 0.073
5.133ValGly: 5.133 ± 0.091
1.442ValHis: 1.442 ± 0.048
4.226ValIle: 4.226 ± 0.084
2.552ValLys: 2.552 ± 0.063
7.561ValLeu: 7.561 ± 0.113
2.033ValMet: 2.033 ± 0.051
2.473ValAsn: 2.473 ± 0.059
3.348ValPro: 3.348 ± 0.076
2.406ValGln: 2.406 ± 0.058
4.436ValArg: 4.436 ± 0.07
4.996ValSer: 4.996 ± 0.089
4.37ValThr: 4.37 ± 0.083
6.042ValVal: 6.042 ± 0.118
0.931ValTrp: 0.931 ± 0.038
1.694ValTyr: 1.694 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.011TrpAla: 1.011 ± 0.038
0.171TrpCys: 0.171 ± 0.015
0.605TrpAsp: 0.605 ± 0.03
0.618TrpGlu: 0.618 ± 0.03
0.624TrpPhe: 0.624 ± 0.027
0.83TrpGly: 0.83 ± 0.034
0.349TrpHis: 0.349 ± 0.02
0.681TrpIle: 0.681 ± 0.032
0.412TrpLys: 0.412 ± 0.025
1.989TrpLeu: 1.989 ± 0.06
0.367TrpMet: 0.367 ± 0.019
0.42TrpAsn: 0.42 ± 0.023
0.659TrpPro: 0.659 ± 0.028
0.863TrpGln: 0.863 ± 0.029
0.95TrpArg: 0.95 ± 0.038
0.788TrpSer: 0.788 ± 0.034
0.617TrpThr: 0.617 ± 0.032
0.967TrpVal: 0.967 ± 0.037
0.213TrpTrp: 0.213 ± 0.02
0.34TrpTyr: 0.34 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.084TyrAla: 2.084 ± 0.057
0.281TyrCys: 0.281 ± 0.02
1.496TyrAsp: 1.496 ± 0.044
1.542TyrGlu: 1.542 ± 0.051
1.068TyrPhe: 1.068 ± 0.043
2.042TyrGly: 2.042 ± 0.056
0.514TyrHis: 0.514 ± 0.025
1.082TyrIle: 1.082 ± 0.036
0.731TyrLys: 0.731 ± 0.03
2.83TyrLeu: 2.83 ± 0.061
0.489TyrMet: 0.489 ± 0.025
0.838TyrAsn: 0.838 ± 0.034
1.341TyrPro: 1.341 ± 0.042
1.31TyrGln: 1.31 ± 0.048
2.005TyrArg: 2.005 ± 0.059
1.588TyrSer: 1.588 ± 0.049
1.258TyrThr: 1.258 ± 0.057
1.568TyrVal: 1.568 ± 0.049
0.38TyrTrp: 0.38 ± 0.023
0.693TyrTyr: 0.693 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2692 proteins (735979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski