Amino acid dipepetide frequency for Pontibacter akesuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.459AlaAla: 8.459 ± 0.115	0.69AlaCys: 0.69 ± 0.024	4.32AlaAsp: 4.32 ± 0.064	5.253AlaGlu: 5.253 ± 0.072	3.79AlaPhe: 3.79 ± 0.054	6.46AlaGly: 6.46 ± 0.087	1.52AlaHis: 1.52 ± 0.033	4.967AlaIle: 4.967 ± 0.07	4.376AlaLys: 4.376 ± 0.062	8.3AlaLeu: 8.3 ± 0.094	2.075AlaMet: 2.075 ± 0.035	3.433AlaAsn: 3.433 ± 0.056	3.42AlaPro: 3.42 ± 0.068	3.728AlaGln: 3.728 ± 0.06	3.414AlaArg: 3.414 ± 0.052	4.911AlaSer: 4.911 ± 0.064	4.902AlaThr: 4.902 ± 0.089	5.915AlaVal: 5.915 ± 0.063	0.853AlaTrp: 0.853 ± 0.022	3.135AlaTyr: 3.135 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.599CysAla: 0.599 ± 0.023	0.12CysCys: 0.12 ± 0.01	0.353CysAsp: 0.353 ± 0.017	0.387CysGlu: 0.387 ± 0.021	0.326CysPhe: 0.326 ± 0.018	0.651CysGly: 0.651 ± 0.035	0.172CysHis: 0.172 ± 0.012	0.452CysIle: 0.452 ± 0.016	0.313CysLys: 0.313 ± 0.016	0.701CysLeu: 0.701 ± 0.025	0.154CysMet: 0.154 ± 0.011	0.31CysAsn: 0.31 ± 0.015	0.323CysPro: 0.323 ± 0.019	0.243CysGln: 0.243 ± 0.014	0.314CysArg: 0.314 ± 0.017	0.506CysSer: 0.506 ± 0.022	0.446CysThr: 0.446 ± 0.024	0.446CysVal: 0.446 ± 0.02	0.063CysTrp: 0.063 ± 0.006	0.245CysTyr: 0.245 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.122AspAla: 4.122 ± 0.06	0.342AspCys: 0.342 ± 0.016	2.26AspAsp: 2.26 ± 0.048	3.451AspGlu: 3.451 ± 0.055	2.815AspPhe: 2.815 ± 0.047	3.39AspGly: 3.39 ± 0.064	0.83AspHis: 0.83 ± 0.028	3.248AspIle: 3.248 ± 0.057	3.41AspLys: 3.41 ± 0.054	4.786AspLeu: 4.786 ± 0.073	1.322AspMet: 1.322 ± 0.03	2.337AspAsn: 2.337 ± 0.051	2.031AspPro: 2.031 ± 0.045	1.703AspGln: 1.703 ± 0.034	2.314AspArg: 2.314 ± 0.049	2.741AspSer: 2.741 ± 0.046	2.676AspThr: 2.676 ± 0.045	3.665AspVal: 3.665 ± 0.058	0.69AspTrp: 0.69 ± 0.023	2.34AspTyr: 2.34 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.891GluAla: 5.891 ± 0.09	0.263GluCys: 0.263 ± 0.016	3.119GluAsp: 3.119 ± 0.049	5.319GluGlu: 5.319 ± 0.078	2.291GluPhe: 2.291 ± 0.039	4.283GluGly: 4.283 ± 0.06	1.334GluHis: 1.334 ± 0.034	3.608GluIle: 3.608 ± 0.053	4.362GluLys: 4.362 ± 0.073	6.73GluLeu: 6.73 ± 0.09	1.615GluMet: 1.615 ± 0.04	3.085GluAsn: 3.085 ± 0.052	2.173GluPro: 2.173 ± 0.047	3.633GluGln: 3.633 ± 0.059	3.382GluArg: 3.382 ± 0.064	2.996GluSer: 2.996 ± 0.044	3.137GluThr: 3.137 ± 0.05	5.129GluVal: 5.129 ± 0.065	0.737GluTrp: 0.737 ± 0.025	2.036GluTyr: 2.036 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.474PheAla: 3.474 ± 0.052	0.365PheCys: 0.365 ± 0.019	2.543PheAsp: 2.543 ± 0.044	2.731PheGlu: 2.731 ± 0.049	2.178PhePhe: 2.178 ± 0.046	3.243PheGly: 3.243 ± 0.059	0.778PheHis: 0.778 ± 0.026	2.731PheIle: 2.731 ± 0.054	2.358PheLys: 2.358 ± 0.047	4.234PheLeu: 4.234 ± 0.071	1.12PheMet: 1.12 ± 0.026	2.2PheAsn: 2.2 ± 0.046	1.642PhePro: 1.642 ± 0.032	1.412PheGln: 1.412 ± 0.034	2.095PheArg: 2.095 ± 0.045	3.296PheSer: 3.296 ± 0.05	2.89PheThr: 2.89 ± 0.055	3.031PheVal: 3.031 ± 0.051	0.623PheTrp: 0.623 ± 0.022	1.886PheTyr: 1.886 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.401GlyAla: 5.401 ± 0.077	0.645GlyCys: 0.645 ± 0.037	3.299GlyAsp: 3.299 ± 0.054	4.134GlyGlu: 4.134 ± 0.06	3.441GlyPhe: 3.441 ± 0.052	5.267GlyGly: 5.267 ± 0.099	1.365GlyHis: 1.365 ± 0.032	4.696GlyIle: 4.696 ± 0.071	4.64GlyLys: 4.64 ± 0.06	6.549GlyLeu: 6.549 ± 0.073	1.938GlyMet: 1.938 ± 0.042	3.333GlyAsn: 3.333 ± 0.058	1.92GlyPro: 1.92 ± 0.054	2.665GlyGln: 2.665 ± 0.048	2.977GlyArg: 2.977 ± 0.049	4.377GlySer: 4.377 ± 0.082	4.458GlyThr: 4.458 ± 0.097	4.867GlyVal: 4.867 ± 0.079	0.925GlyTrp: 0.925 ± 0.03	2.995GlyTyr: 2.995 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.382HisAla: 1.382 ± 0.029	0.178HisCys: 0.178 ± 0.012	0.931HisAsp: 0.931 ± 0.026	1.165HisGlu: 1.165 ± 0.031	1.064HisPhe: 1.064 ± 0.03	1.322HisGly: 1.322 ± 0.032	0.567HisHis: 0.567 ± 0.021	1.219HisIle: 1.219 ± 0.029	0.985HisLys: 0.985 ± 0.028	2.194HisLeu: 2.194 ± 0.041	0.464HisMet: 0.464 ± 0.018	0.943HisAsn: 0.943 ± 0.026	1.114HisPro: 1.114 ± 0.03	0.869HisGln: 0.869 ± 0.027	0.931HisArg: 0.931 ± 0.031	1.101HisSer: 1.101 ± 0.03	1.228HisThr: 1.228 ± 0.033	1.238HisVal: 1.238 ± 0.029	0.232HisTrp: 0.232 ± 0.013	0.867HisTyr: 0.867 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.064IleAla: 5.064 ± 0.064	0.511IleCys: 0.511 ± 0.021	3.216IleAsp: 3.216 ± 0.052	3.448IleGlu: 3.448 ± 0.053	2.463IlePhe: 2.463 ± 0.049	4.455IleGly: 4.455 ± 0.067	1.075IleHis: 1.075 ± 0.024	3.648IleIle: 3.648 ± 0.068	3.475IleLys: 3.475 ± 0.06	5.696IleLeu: 5.696 ± 0.082	1.215IleMet: 1.215 ± 0.028	2.988IleAsn: 2.988 ± 0.051	2.644IlePro: 2.644 ± 0.045	1.97IleGln: 1.97 ± 0.039	2.809IleArg: 2.809 ± 0.05	4.085IleSer: 4.085 ± 0.058	3.771IleThr: 3.771 ± 0.063	3.777IleVal: 3.777 ± 0.063	0.565IleTrp: 0.565 ± 0.022	2.061IleTyr: 2.061 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.076LysAla: 5.076 ± 0.074	0.237LysCys: 0.237 ± 0.014	3.082LysAsp: 3.082 ± 0.062	4.302LysGlu: 4.302 ± 0.071	1.894LysPhe: 1.894 ± 0.041	3.921LysGly: 3.921 ± 0.058	1.145LysHis: 1.145 ± 0.032	3.221LysIle: 3.221 ± 0.059	3.865LysLys: 3.865 ± 0.073	5.766LysLeu: 5.766 ± 0.068	1.473LysMet: 1.473 ± 0.036	2.713LysAsn: 2.713 ± 0.049	2.645LysPro: 2.645 ± 0.048	2.677LysGln: 2.677 ± 0.044	2.754LysArg: 2.754 ± 0.044	3.149LysSer: 3.149 ± 0.053	3.076LysThr: 3.076 ± 0.05	4.211LysVal: 4.211 ± 0.064	0.605LysTrp: 0.605 ± 0.022	2.57LysTyr: 2.57 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	8.368LeuAla: 8.368 ± 0.097	0.793LeuCys: 0.793 ± 0.026	4.733LeuAsp: 4.733 ± 0.06	6.272LeuGlu: 6.272 ± 0.074	4.522LeuPhe: 4.522 ± 0.07	6.375LeuGly: 6.375 ± 0.084	2.226LeuHis: 2.226 ± 0.043	5.313LeuIle: 5.313 ± 0.078	5.862LeuLys: 5.862 ± 0.066	11.963LeuLeu: 11.963 ± 0.158	2.335LeuMet: 2.335 ± 0.044	4.67LeuAsn: 4.67 ± 0.056	4.699LeuPro: 4.699 ± 0.061	5.391LeuGln: 5.391 ± 0.08	4.755LeuArg: 4.755 ± 0.056	6.4LeuSer: 6.4 ± 0.071	5.434LeuThr: 5.434 ± 0.074	6.828LeuVal: 6.828 ± 0.086	1.001LeuTrp: 1.001 ± 0.029	3.702LeuTyr: 3.702 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.305MetAla: 2.305 ± 0.042	0.116MetCys: 0.116 ± 0.01	1.171MetAsp: 1.171 ± 0.031	1.551MetGlu: 1.551 ± 0.036	0.82MetPhe: 0.82 ± 0.027	1.658MetGly: 1.658 ± 0.037	0.541MetHis: 0.541 ± 0.021	1.287MetIle: 1.287 ± 0.033	1.74MetLys: 1.74 ± 0.04	2.567MetLeu: 2.567 ± 0.049	0.629MetMet: 0.629 ± 0.021	1.12MetAsn: 1.12 ± 0.028	1.176MetPro: 1.176 ± 0.027	1.227MetGln: 1.227 ± 0.032	1.269MetArg: 1.269 ± 0.026	1.331MetSer: 1.331 ± 0.031	1.094MetThr: 1.094 ± 0.03	1.631MetVal: 1.631 ± 0.035	0.194MetTrp: 0.194 ± 0.012	0.674MetTyr: 0.674 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.508AsnAla: 3.508 ± 0.055	0.323AsnCys: 0.323 ± 0.017	2.13AsnAsp: 2.13 ± 0.045	2.643AsnGlu: 2.643 ± 0.048	2.158AsnPhe: 2.158 ± 0.046	3.409AsnGly: 3.409 ± 0.079	0.793AsnHis: 0.793 ± 0.025	3.139AsnIle: 3.139 ± 0.051	2.635AsnLys: 2.635 ± 0.04	4.616AsnLeu: 4.616 ± 0.065	1.1AsnMet: 1.1 ± 0.027	2.381AsnAsn: 2.381 ± 0.055	2.527AsnPro: 2.527 ± 0.052	1.729AsnGln: 1.729 ± 0.042	2.329AsnArg: 2.329 ± 0.038	2.865AsnSer: 2.865 ± 0.053	2.771AsnThr: 2.771 ± 0.048	2.891AsnVal: 2.891 ± 0.056	0.672AsnTrp: 0.672 ± 0.025	2.189AsnTyr: 2.189 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.991ProAla: 3.991 ± 0.073	0.22ProCys: 0.22 ± 0.014	2.707ProAsp: 2.707 ± 0.039	3.652ProGlu: 3.652 ± 0.057	1.86ProPhe: 1.86 ± 0.036	2.78ProGly: 2.78 ± 0.051	0.846ProHis: 0.846 ± 0.028	2.196ProIle: 2.196 ± 0.038	2.069ProLys: 2.069 ± 0.036	3.838ProLeu: 3.838 ± 0.05	0.873ProMet: 0.873 ± 0.022	1.943ProAsn: 1.943 ± 0.04	1.259ProPro: 1.259 ± 0.038	1.717ProGln: 1.717 ± 0.04	1.4ProArg: 1.4 ± 0.03	2.252ProSer: 2.252 ± 0.039	2.236ProThr: 2.236 ± 0.047	3.385ProVal: 3.385 ± 0.053	0.435ProTrp: 0.435 ± 0.018	1.707ProTyr: 1.707 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.605GlnAla: 3.605 ± 0.06	0.186GlnCys: 0.186 ± 0.013	2.087GlnAsp: 2.087 ± 0.039	3.507GlnGlu: 3.507 ± 0.06	1.502GlnPhe: 1.502 ± 0.034	2.549GlnGly: 2.549 ± 0.05	1.139GlnHis: 1.139 ± 0.032	2.036GlnIle: 2.036 ± 0.039	2.517GlnLys: 2.517 ± 0.049	4.875GlnLeu: 4.875 ± 0.075	0.946GlnMet: 0.946 ± 0.027	2.022GlnAsn: 2.022 ± 0.041	1.959GlnPro: 1.959 ± 0.039	3.296GlnGln: 3.296 ± 0.069	2.189GlnArg: 2.189 ± 0.042	1.997GlnSer: 1.997 ± 0.035	2.14GlnThr: 2.14 ± 0.042	3.485GlnVal: 3.485 ± 0.054	0.393GlnTrp: 0.393 ± 0.016	1.403GlnTyr: 1.403 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.072ArgAla: 3.072 ± 0.049	0.259ArgCys: 0.259 ± 0.014	2.303ArgAsp: 2.303 ± 0.044	3.232ArgGlu: 3.232 ± 0.053	2.246ArgPhe: 2.246 ± 0.039	2.646ArgGly: 2.646 ± 0.046	1.117ArgHis: 1.117 ± 0.027	3.038ArgIle: 3.038 ± 0.053	2.887ArgLys: 2.887 ± 0.048	4.712ArgLeu: 4.712 ± 0.058	1.334ArgMet: 1.334 ± 0.035	2.453ArgAsn: 2.453 ± 0.043	1.637ArgPro: 1.637 ± 0.044	2.231ArgGln: 2.231 ± 0.045	2.254ArgArg: 2.254 ± 0.048	2.506ArgSer: 2.506 ± 0.043	2.372ArgThr: 2.372 ± 0.043	3.13ArgVal: 3.13 ± 0.05	0.593ArgTrp: 0.593 ± 0.024	1.972ArgTyr: 1.972 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.489SerAla: 4.489 ± 0.067	0.569SerCys: 0.569 ± 0.023	3.01SerAsp: 3.01 ± 0.056	3.439SerGlu: 3.439 ± 0.055	3.183SerPhe: 3.183 ± 0.048	4.694SerGly: 4.694 ± 0.082	1.084SerHis: 1.084 ± 0.028	4.007SerIle: 4.007 ± 0.063	3.243SerLys: 3.243 ± 0.052	5.822SerLeu: 5.822 ± 0.065	1.531SerMet: 1.531 ± 0.034	2.768SerAsn: 2.768 ± 0.06	2.385SerPro: 2.385 ± 0.044	2.043SerGln: 2.043 ± 0.043	2.691SerArg: 2.691 ± 0.045	3.929SerSer: 3.929 ± 0.075	3.43SerThr: 3.43 ± 0.058	3.951SerVal: 3.951 ± 0.06	0.688SerTrp: 0.688 ± 0.02	2.512SerTyr: 2.512 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.123ThrAla: 5.123 ± 0.096	0.372ThrCys: 0.372 ± 0.026	3.083ThrAsp: 3.083 ± 0.049	3.254ThrGlu: 3.254 ± 0.046	2.651ThrPhe: 2.651 ± 0.05	4.541ThrGly: 4.541 ± 0.092	1.079ThrHis: 1.079 ± 0.03	3.472ThrIle: 3.472 ± 0.053	2.688ThrLys: 2.688 ± 0.042	5.632ThrLeu: 5.632 ± 0.067	1.11ThrMet: 1.11 ± 0.026	2.329ThrAsn: 2.329 ± 0.05	2.857ThrPro: 2.857 ± 0.048	1.98ThrGln: 1.98 ± 0.041	2.203ThrArg: 2.203 ± 0.044	3.529ThrSer: 3.529 ± 0.067	3.48ThrThr: 3.48 ± 0.092	4.238ThrVal: 4.238 ± 0.082	0.65ThrTrp: 0.65 ± 0.026	2.469ThrTyr: 2.469 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	6.267ValAla: 6.267 ± 0.076	0.56ValCys: 0.56 ± 0.022	3.42ValAsp: 3.42 ± 0.039	4.502ValGlu: 4.502 ± 0.063	3.008ValPhe: 3.008 ± 0.05	4.608ValGly: 4.608 ± 0.065	1.301ValHis: 1.301 ± 0.033	3.937ValIle: 3.937 ± 0.061	3.972ValLys: 3.972 ± 0.061	7.388ValLeu: 7.388 ± 0.079	1.722ValMet: 1.722 ± 0.04	3.123ValAsn: 3.123 ± 0.048	3.032ValPro: 3.032 ± 0.047	3.155ValGln: 3.155 ± 0.051	3.213ValArg: 3.213 ± 0.052	4.299ValSer: 4.299 ± 0.061	3.944ValThr: 3.944 ± 0.079	5.442ValVal: 5.442 ± 0.072	0.814ValTrp: 0.814 ± 0.028	2.67ValTyr: 2.67 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.858TrpAla: 0.858 ± 0.024	0.092TrpCys: 0.092 ± 0.007	0.567TrpAsp: 0.567 ± 0.021	0.648TrpGlu: 0.648 ± 0.023	0.531TrpPhe: 0.531 ± 0.02	0.78TrpGly: 0.78 ± 0.025	0.258TrpHis: 0.258 ± 0.014	0.572TrpIle: 0.572 ± 0.023	0.619TrpLys: 0.619 ± 0.021	1.339TrpLeu: 1.339 ± 0.039	0.32TrpMet: 0.32 ± 0.016	0.57TrpAsn: 0.57 ± 0.02	0.358TrpPro: 0.358 ± 0.016	0.611TrpGln: 0.611 ± 0.021	0.609TrpArg: 0.609 ± 0.02	0.664TrpSer: 0.664 ± 0.023	0.559TrpThr: 0.559 ± 0.024	0.807TrpVal: 0.807 ± 0.028	0.177TrpTrp: 0.177 ± 0.012	0.44TrpTyr: 0.44 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.865TyrAla: 2.865 ± 0.05	0.283TyrCys: 0.283 ± 0.015	2.14TyrAsp: 2.14 ± 0.045	2.233TyrGlu: 2.233 ± 0.043	2.088TyrPhe: 2.088 ± 0.047	2.858TyrGly: 2.858 ± 0.057	0.825TyrHis: 0.825 ± 0.028	2.149TyrIle: 2.149 ± 0.038	2.367TyrLys: 2.367 ± 0.044	3.937TyrLeu: 3.937 ± 0.06	0.825TyrMet: 0.825 ± 0.024	2.089TyrAsn: 2.089 ± 0.042	1.565TyrPro: 1.565 ± 0.036	1.554TyrGln: 1.554 ± 0.032	2.094TyrArg: 2.094 ± 0.043	2.531TyrSer: 2.531 ± 0.044	2.695TyrThr: 2.695 ± 0.056	2.309TyrVal: 2.309 ± 0.041	0.467TyrTrp: 0.467 ± 0.02	1.732TyrTyr: 1.732 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4073 proteins (1372960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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