Amino acid dipepetide frequency for Coniochaeta sp. 2T2.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.517AlaAla: 10.517 ± 0.048
1.122AlaCys: 1.122 ± 0.01
4.631AlaAsp: 4.631 ± 0.023
5.413AlaGlu: 5.413 ± 0.028
3.12AlaPhe: 3.12 ± 0.017
6.714AlaGly: 6.714 ± 0.029
1.816AlaHis: 1.816 ± 0.014
3.986AlaIle: 3.986 ± 0.022
4.113AlaLys: 4.113 ± 0.022
7.701AlaLeu: 7.701 ± 0.027
2.04AlaMet: 2.04 ± 0.014
2.916AlaAsn: 2.916 ± 0.016
5.27AlaPro: 5.27 ± 0.028
3.354AlaGln: 3.354 ± 0.023
5.293AlaArg: 5.293 ± 0.022
7.283AlaSer: 7.283 ± 0.031
5.675AlaThr: 5.675 ± 0.024
6.093AlaVal: 6.093 ± 0.028
1.252AlaTrp: 1.252 ± 0.012
2.215AlaTyr: 2.215 ± 0.016
0.0AlaXaa: 0.0 ± 0.0
Cys
0.975CysAla: 0.975 ± 0.009
0.285CysCys: 0.285 ± 0.006
0.681CysAsp: 0.681 ± 0.009
0.567CysGlu: 0.567 ± 0.007
0.547CysPhe: 0.547 ± 0.007
1.018CysGly: 1.018 ± 0.011
0.359CysHis: 0.359 ± 0.006
0.661CysIle: 0.661 ± 0.007
0.501CysLys: 0.501 ± 0.007
1.273CysLeu: 1.273 ± 0.014
0.265CysMet: 0.265 ± 0.005
0.428CysAsn: 0.428 ± 0.007
0.721CysPro: 0.721 ± 0.011
0.439CysGln: 0.439 ± 0.006
0.824CysArg: 0.824 ± 0.01
0.932CysSer: 0.932 ± 0.01
0.716CysThr: 0.716 ± 0.009
0.832CysVal: 0.832 ± 0.008
0.223CysTrp: 0.223 ± 0.005
0.366CysTyr: 0.366 ± 0.006
0.0CysXaa: 0.0 ± 0.0
Asp
4.924AspAla: 4.924 ± 0.026
0.637AspCys: 0.637 ± 0.008
4.468AspAsp: 4.468 ± 0.028
4.408AspGlu: 4.408 ± 0.028
2.145AspPhe: 2.145 ± 0.014
4.436AspGly: 4.436 ± 0.021
1.251AspHis: 1.251 ± 0.011
2.842AspIle: 2.842 ± 0.016
2.417AspLys: 2.417 ± 0.019
4.902AspLeu: 4.902 ± 0.025
1.311AspMet: 1.311 ± 0.011
1.892AspAsn: 1.892 ± 0.014
3.377AspPro: 3.377 ± 0.02
1.761AspGln: 1.761 ± 0.014
3.152AspArg: 3.152 ± 0.023
3.833AspSer: 3.833 ± 0.02
2.962AspThr: 2.962 ± 0.017
3.864AspVal: 3.864 ± 0.017
0.915AspTrp: 0.915 ± 0.008
1.575AspTyr: 1.575 ± 0.011
0.0AspXaa: 0.0 ± 0.0
Glu
5.437GluAla: 5.437 ± 0.028
0.616GluCys: 0.616 ± 0.008
4.165GluAsp: 4.165 ± 0.028
5.765GluGlu: 5.765 ± 0.041
1.811GluPhe: 1.811 ± 0.012
4.12GluGly: 4.12 ± 0.023
1.381GluHis: 1.381 ± 0.012
2.632GluIle: 2.632 ± 0.016
3.504GluLys: 3.504 ± 0.021
4.961GluLeu: 4.961 ± 0.026
1.436GluMet: 1.436 ± 0.011
1.886GluAsn: 1.886 ± 0.014
2.796GluPro: 2.796 ± 0.02
2.354GluGln: 2.354 ± 0.017
3.932GluArg: 3.932 ± 0.022
3.726GluSer: 3.726 ± 0.02
3.353GluThr: 3.353 ± 0.018
3.79GluVal: 3.79 ± 0.02
0.887GluTrp: 0.887 ± 0.008
1.594GluTyr: 1.594 ± 0.013
0.0GluXaa: 0.0 ± 0.0
Phe
3.128PheAla: 3.128 ± 0.018
0.54PheCys: 0.54 ± 0.007
2.266PheAsp: 2.266 ± 0.015
2.015PheGlu: 2.015 ± 0.015
1.581PhePhe: 1.581 ± 0.013
2.901PheGly: 2.901 ± 0.021
0.866PheHis: 0.866 ± 0.008
1.628PheIle: 1.628 ± 0.014
1.415PheLys: 1.415 ± 0.01
3.357PheLeu: 3.357 ± 0.019
0.74PheMet: 0.74 ± 0.008
1.344PheAsn: 1.344 ± 0.012
1.981PhePro: 1.981 ± 0.013
1.241PheGln: 1.241 ± 0.011
1.99PheArg: 1.99 ± 0.015
2.749PheSer: 2.749 ± 0.015
2.108PheThr: 2.108 ± 0.014
2.417PheVal: 2.417 ± 0.015
0.651PheTrp: 0.651 ± 0.008
1.058PheTyr: 1.058 ± 0.01
0.0PheXaa: 0.0 ± 0.0
Gly
5.917GlyAla: 5.917 ± 0.03
0.97GlyCys: 0.97 ± 0.011
3.836GlyAsp: 3.836 ± 0.02
4.072GlyGlu: 4.072 ± 0.023
2.81GlyPhe: 2.81 ± 0.019
7.292GlyGly: 7.292 ± 0.047
1.822GlyHis: 1.822 ± 0.014
3.353GlyIle: 3.353 ± 0.019
3.6GlyLys: 3.6 ± 0.02
6.235GlyLeu: 6.235 ± 0.025
1.74GlyMet: 1.74 ± 0.013
2.586GlyAsn: 2.586 ± 0.021
3.655GlyPro: 3.655 ± 0.023
2.722GlyGln: 2.722 ± 0.018
4.68GlyArg: 4.68 ± 0.023
5.87GlySer: 5.87 ± 0.028
4.32GlyThr: 4.32 ± 0.024
4.823GlyVal: 4.823 ± 0.021
1.294GlyTrp: 1.294 ± 0.011
2.23GlyTyr: 2.23 ± 0.017
0.0GlyXaa: 0.0 ± 0.0
His
1.877HisAla: 1.877 ± 0.013
0.35HisCys: 0.35 ± 0.006
1.355HisAsp: 1.355 ± 0.011
1.218HisGlu: 1.218 ± 0.01
0.905HisPhe: 0.905 ± 0.01
1.839HisGly: 1.839 ± 0.013
0.973HisHis: 0.973 ± 0.011
1.139HisIle: 1.139 ± 0.009
0.899HisLys: 0.899 ± 0.01
2.224HisLeu: 2.224 ± 0.015
0.505HisMet: 0.505 ± 0.006
0.867HisAsn: 0.867 ± 0.008
1.747HisPro: 1.747 ± 0.014
1.013HisGln: 1.013 ± 0.012
1.593HisArg: 1.593 ± 0.013
1.739HisSer: 1.739 ± 0.015
1.282HisThr: 1.282 ± 0.011
1.492HisVal: 1.492 ± 0.013
0.346HisTrp: 0.346 ± 0.006
0.675HisTyr: 0.675 ± 0.007
0.0HisXaa: 0.0 ± 0.0
Ile
3.902IleAla: 3.902 ± 0.019
0.688IleCys: 0.688 ± 0.008
2.589IleAsp: 2.589 ± 0.015
2.447IleGlu: 2.447 ± 0.018
1.766IlePhe: 1.766 ± 0.013
2.992IleGly: 2.992 ± 0.02
1.089IleHis: 1.089 ± 0.012
2.142IleIle: 2.142 ± 0.016
1.934IleLys: 1.934 ± 0.014
4.066IleLeu: 4.066 ± 0.022
0.945IleMet: 0.945 ± 0.009
1.61IleAsn: 1.61 ± 0.013
2.92IlePro: 2.92 ± 0.018
1.584IleGln: 1.584 ± 0.012
2.666IleArg: 2.666 ± 0.017
3.356IleSer: 3.356 ± 0.019
2.699IleThr: 2.699 ± 0.017
2.993IleVal: 2.993 ± 0.018
0.705IleTrp: 0.705 ± 0.008
1.285IleTyr: 1.285 ± 0.011
0.0IleXaa: 0.0 ± 0.0
Lys
4.245LysAla: 4.245 ± 0.022
0.486LysCys: 0.486 ± 0.007
2.679LysAsp: 2.679 ± 0.017
3.212LysGlu: 3.212 ± 0.019
1.387LysPhe: 1.387 ± 0.013
3.089LysGly: 3.089 ± 0.018
1.087LysHis: 1.087 ± 0.011
1.983LysIle: 1.983 ± 0.015
3.212LysLys: 3.212 ± 0.025
3.866LysLeu: 3.866 ± 0.019
0.965LysMet: 0.965 ± 0.01
1.54LysAsn: 1.54 ± 0.014
2.768LysPro: 2.768 ± 0.021
1.707LysGln: 1.707 ± 0.014
3.313LysArg: 3.313 ± 0.022
3.13LysSer: 3.13 ± 0.019
2.79LysThr: 2.79 ± 0.019
2.806LysVal: 2.806 ± 0.016
0.672LysTrp: 0.672 ± 0.007
1.253LysTyr: 1.253 ± 0.011
0.0LysXaa: 0.0 ± 0.0
Leu
8.209LeuAla: 8.209 ± 0.03
1.187LeuCys: 1.187 ± 0.012
5.092LeuAsp: 5.092 ± 0.023
5.13LeuGlu: 5.13 ± 0.026
3.19LeuPhe: 3.19 ± 0.019
6.068LeuGly: 6.068 ± 0.023
2.141LeuHis: 2.141 ± 0.015
3.53LeuIle: 3.53 ± 0.018
3.87LeuLys: 3.87 ± 0.02
8.347LeuLeu: 8.347 ± 0.036
1.716LeuMet: 1.716 ± 0.012
2.867LeuAsn: 2.867 ± 0.016
5.717LeuPro: 5.717 ± 0.022
3.504LeuGln: 3.504 ± 0.022
5.77LeuArg: 5.77 ± 0.029
6.937LeuSer: 6.937 ± 0.03
4.894LeuThr: 4.894 ± 0.02
5.604LeuVal: 5.604 ± 0.026
1.199LeuTrp: 1.199 ± 0.01
2.254LeuTyr: 2.254 ± 0.015
0.0LeuXaa: 0.0 ± 0.0
Met
2.331MetAla: 2.331 ± 0.014
0.252MetCys: 0.252 ± 0.005
1.228MetAsp: 1.228 ± 0.011
1.231MetGlu: 1.231 ± 0.011
0.754MetPhe: 0.754 ± 0.008
1.543MetGly: 1.543 ± 0.011
0.461MetHis: 0.461 ± 0.007
0.89MetIle: 0.89 ± 0.01
0.918MetLys: 0.918 ± 0.011
1.832MetLeu: 1.832 ± 0.014
0.574MetMet: 0.574 ± 0.007
0.697MetAsn: 0.697 ± 0.009
1.297MetPro: 1.297 ± 0.012
0.784MetGln: 0.784 ± 0.009
1.315MetArg: 1.315 ± 0.011
1.842MetSer: 1.842 ± 0.013
1.332MetThr: 1.332 ± 0.011
1.386MetVal: 1.386 ± 0.011
0.272MetTrp: 0.272 ± 0.005
0.524MetTyr: 0.524 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
2.955AsnAla: 2.955 ± 0.016
0.45AsnCys: 0.45 ± 0.006
1.803AsnAsp: 1.803 ± 0.013
1.694AsnGlu: 1.694 ± 0.014
1.282AsnPhe: 1.282 ± 0.011
3.006AsnGly: 3.006 ± 0.025
0.824AsnHis: 0.824 ± 0.009
1.763AsnIle: 1.763 ± 0.013
1.46AsnLys: 1.46 ± 0.013
2.994AsnLeu: 2.994 ± 0.017
0.805AsnMet: 0.805 ± 0.009
1.557AsnAsn: 1.557 ± 0.015
2.448AsnPro: 2.448 ± 0.017
1.221AsnGln: 1.221 ± 0.011
1.863AsnArg: 1.863 ± 0.013
2.454AsnSer: 2.454 ± 0.017
2.1AsnThr: 2.1 ± 0.016
2.162AsnVal: 2.162 ± 0.015
0.558AsnTrp: 0.558 ± 0.007
0.981AsnTyr: 0.981 ± 0.01
0.0AsnXaa: 0.0 ± 0.0
Pro
5.993ProAla: 5.993 ± 0.027
0.587ProCys: 0.587 ± 0.008
3.449ProAsp: 3.449 ± 0.02
3.776ProGlu: 3.776 ± 0.019
2.077ProPhe: 2.077 ± 0.013
4.498ProGly: 4.498 ± 0.025
1.381ProHis: 1.381 ± 0.013
2.352ProIle: 2.352 ± 0.015
2.659ProLys: 2.659 ± 0.019
4.888ProLeu: 4.888 ± 0.026
1.06ProMet: 1.06 ± 0.011
2.156ProAsn: 2.156 ± 0.017
5.952ProPro: 5.952 ± 0.052
2.595ProGln: 2.595 ± 0.022
3.624ProArg: 3.624 ± 0.022
6.13ProSer: 6.13 ± 0.034
4.333ProThr: 4.333 ± 0.027
3.867ProVal: 3.867 ± 0.022
0.788ProTrp: 0.788 ± 0.008
1.554ProTyr: 1.554 ± 0.013
0.0ProXaa: 0.0 ± 0.0
Gln
3.542GlnAla: 3.542 ± 0.02
0.439GlnCys: 0.439 ± 0.006
1.939GlnAsp: 1.939 ± 0.014
2.165GlnGlu: 2.165 ± 0.015
1.194GlnPhe: 1.194 ± 0.011
2.48GlnGly: 2.48 ± 0.016
1.131GlnHis: 1.131 ± 0.011
1.654GlnIle: 1.654 ± 0.013
1.735GlnLys: 1.735 ± 0.014
3.306GlnLeu: 3.306 ± 0.019
0.855GlnMet: 0.855 ± 0.01
1.319GlnAsn: 1.319 ± 0.014
2.794GlnPro: 2.794 ± 0.025
2.893GlnGln: 2.893 ± 0.038
2.528GlnArg: 2.528 ± 0.017
2.798GlnSer: 2.798 ± 0.018
2.272GlnThr: 2.272 ± 0.015
2.141GlnVal: 2.141 ± 0.014
0.538GlnTrp: 0.538 ± 0.006
1.09GlnTyr: 1.09 ± 0.011
0.0GlnXaa: 0.0 ± 0.0
Arg
4.933ArgAla: 4.933 ± 0.023
0.779ArgCys: 0.779 ± 0.007
3.526ArgAsp: 3.526 ± 0.022
3.941ArgGlu: 3.941 ± 0.023
2.126ArgPhe: 2.126 ± 0.014
4.095ArgGly: 4.095 ± 0.024
1.71ArgHis: 1.71 ± 0.014
2.72ArgIle: 2.72 ± 0.017
3.388ArgLys: 3.388 ± 0.018
5.56ArgLeu: 5.56 ± 0.028
1.369ArgMet: 1.369 ± 0.011
2.13ArgAsn: 2.13 ± 0.015
3.819ArgPro: 3.819 ± 0.024
2.694ArgGln: 2.694 ± 0.017
5.598ArgArg: 5.598 ± 0.034
4.676ArgSer: 4.676 ± 0.029
3.493ArgThr: 3.493 ± 0.016
3.576ArgVal: 3.576 ± 0.02
1.009ArgTrp: 1.009 ± 0.009
1.672ArgTyr: 1.672 ± 0.013
0.0ArgXaa: 0.0 ± 0.0
Ser
6.707SerAla: 6.707 ± 0.028
0.887SerCys: 0.887 ± 0.011
3.995SerAsp: 3.995 ± 0.021
3.622SerGlu: 3.622 ± 0.02
2.831SerPhe: 2.831 ± 0.018
5.675SerGly: 5.675 ± 0.028
1.919SerHis: 1.919 ± 0.011
3.475SerIle: 3.475 ± 0.018
3.311SerLys: 3.311 ± 0.018
6.826SerLeu: 6.826 ± 0.028
1.582SerMet: 1.582 ± 0.012
2.69SerAsn: 2.69 ± 0.018
5.74SerPro: 5.74 ± 0.037
3.011SerGln: 3.011 ± 0.018
4.968SerArg: 4.968 ± 0.027
8.759SerSer: 8.759 ± 0.049
5.575SerThr: 5.575 ± 0.04
4.607SerVal: 4.607 ± 0.022
1.121SerTrp: 1.121 ± 0.012
1.993SerTyr: 1.993 ± 0.014
0.0SerXaa: 0.0 ± 0.0
Thr
5.687ThrAla: 5.687 ± 0.029
0.813ThrCys: 0.813 ± 0.01
2.899ThrAsp: 2.899 ± 0.018
3.034ThrGlu: 3.034 ± 0.019
2.219ThrPhe: 2.219 ± 0.013
4.529ThrGly: 4.529 ± 0.023
1.272ThrHis: 1.272 ± 0.011
2.871ThrIle: 2.871 ± 0.019
2.503ThrLys: 2.503 ± 0.017
5.124ThrLeu: 5.124 ± 0.026
1.204ThrMet: 1.204 ± 0.01
2.05ThrAsn: 2.05 ± 0.015
4.684ThrPro: 4.684 ± 0.027
2.022ThrGln: 2.022 ± 0.015
3.285ThrArg: 3.285 ± 0.017
5.52ThrSer: 5.52 ± 0.033
5.018ThrThr: 5.018 ± 0.042
4.062ThrVal: 4.062 ± 0.024
0.885ThrTrp: 0.885 ± 0.01
1.645ThrTyr: 1.645 ± 0.014
0.0ThrXaa: 0.0 ± 0.0
Val
5.846ValAla: 5.846 ± 0.026
0.879ValCys: 0.879 ± 0.009
3.851ValAsp: 3.851 ± 0.022
4.065ValGlu: 4.065 ± 0.023
2.515ValPhe: 2.515 ± 0.019
4.399ValGly: 4.399 ± 0.023
1.419ValHis: 1.419 ± 0.011
2.797ValIle: 2.797 ± 0.016
2.934ValLys: 2.934 ± 0.019
5.808ValLeu: 5.808 ± 0.026
1.376ValMet: 1.376 ± 0.011
2.15ValAsn: 2.15 ± 0.016
3.84ValPro: 3.84 ± 0.021
2.311ValGln: 2.311 ± 0.017
3.781ValArg: 3.781 ± 0.02
4.62ValSer: 4.62 ± 0.023
3.814ValThr: 3.814 ± 0.022
4.943ValVal: 4.943 ± 0.027
0.953ValTrp: 0.953 ± 0.01
1.773ValTyr: 1.773 ± 0.014
0.0ValXaa: 0.0 ± 0.0
Trp
1.223TrpAla: 1.223 ± 0.01
0.213TrpCys: 0.213 ± 0.005
0.943TrpAsp: 0.943 ± 0.01
0.891TrpGlu: 0.891 ± 0.008
0.568TrpPhe: 0.568 ± 0.008
0.988TrpGly: 0.988 ± 0.009
0.376TrpHis: 0.376 ± 0.006
0.714TrpIle: 0.714 ± 0.009
0.77TrpLys: 0.77 ± 0.008
1.396TrpLeu: 1.396 ± 0.011
0.382TrpMet: 0.382 ± 0.005
0.604TrpAsn: 0.604 ± 0.007
0.664TrpPro: 0.664 ± 0.007
0.553TrpGln: 0.553 ± 0.006
1.027TrpArg: 1.027 ± 0.01
1.054TrpSer: 1.054 ± 0.01
0.976TrpThr: 0.976 ± 0.01
0.929TrpVal: 0.929 ± 0.01
0.299TrpTrp: 0.299 ± 0.005
0.444TrpTyr: 0.444 ± 0.006
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.174TyrAla: 2.174 ± 0.014
0.431TyrCys: 0.431 ± 0.007
1.673TyrAsp: 1.673 ± 0.013
1.482TyrGlu: 1.482 ± 0.01
1.151TyrPhe: 1.151 ± 0.01
2.141TyrGly: 2.141 ± 0.015
0.758TyrHis: 0.758 ± 0.01
1.249TyrIle: 1.249 ± 0.012
1.049TyrLys: 1.049 ± 0.01
2.563TyrLeu: 2.563 ± 0.017
0.596TyrMet: 0.596 ± 0.008
1.091TyrAsn: 1.091 ± 0.011
1.526TyrPro: 1.526 ± 0.014
1.051TyrGln: 1.051 ± 0.01
1.614TyrArg: 1.614 ± 0.011
1.885TyrSer: 1.885 ± 0.015
1.613TyrThr: 1.613 ± 0.013
1.686TyrVal: 1.686 ± 0.014
0.447TyrTrp: 0.447 ± 0.006
0.93TyrTyr: 0.93 ± 0.01
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24540 proteins (11563170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski